Banu Salepci - Academia.edu (original) (raw)
Papers by Banu Salepci
Eastern Journal of Medical Sciences
Sleep and control of breathing
Sarcoidosis and other granulomatous ILD/DPLD
Archivos de bronconeumologia, Jan 19, 2018
To evaluate the role of ultrasonography (USG) in the diagnosis of bleomycin-induced pulmonary tox... more To evaluate the role of ultrasonography (USG) in the diagnosis of bleomycin-induced pulmonary toxicity (BT). The study included patients with suspected BT during treatment with bleomycin due to various oncologic diseases between June 2015 and May 2017. The patients initially underwent clinical and high-resolution computed tomography (HRCT) examinations and pulmonary function tests (PFT)-diffusing capacity of the lung for carbon monoxide (DLCO), followed by registration of USG findings-number of comet tail artifact (CTA) images by a different pulmonologist. We compared the findings from USG, HRCT, and PFT-DLCO tests between BT and non-BT groups. With the diagnosis based on clinical-radiologic and PFT-DLCO assessments taken as the gold standard, we determined the sensitivity and specificity of the USG outcomes for diagnosis of BT. The study included a total of 30 patients. Nine patients were diagnosed as having BT according to their clinical and radiologic findings and PFT-DLCO measur...
Lung India : official organ of Indian Chest Society
Asymmetric dimethylarginine (ADMA) has emerged as a risk marker for many conditions related to pu... more Asymmetric dimethylarginine (ADMA) has emerged as a risk marker for many conditions related to pulmonary hypertension (PH); however, little is known about ADMA and symmetric dimethylarginine (SDMA) plasma concentrations in chronic obstructive pulmonary disease (COPD). Our interest centers on the role of ADMA in regulation of endothelial function in COPD and secondary PH. The aim of the present study was to evaluate the serum ADMA, SDMA, and L-arginine concentrations in COPD and its association with PH. Patients with diagnosis of COPD underwent pulmonary function tests, echocardiography, and laboratory investigations including ADMA, SDMA, and L-arginine. Serum concentrations of ADMA, SDMA, and L-arginine tend to increase as COPD progresses. Patients with PH had higher concentrations of ADMA, SDMA, and L-arginine compared to cases with normal pulmonary arterial pressure (PAP); the difference was not statistically significant. Our results show that increased ADMA, SDMA, and L-arginine ...
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, Jan 16, 2016
A recent study reported an association between obstructive sleep apnea (OSA) and low vitamin D le... more A recent study reported an association between obstructive sleep apnea (OSA) and low vitamin D levels. In this study, we measured vitamin D levels in patients referred for evaluation of suspected OSA and sought to identify associated risk factors for vitamin D deficiency. Our objective was to determine whether evaluations of patients with suspected OSA should include routine screening for vitamin D deficiency. Using a cross-sectional study design, we measured vitamin D levels in consecutively enrolled patients referred for an OSA evaluation to Dr. LutfiKirdarKartal Training and Research Hospital in Istanbul, Turkey. We conducted full-night polysomnography and compared vitamin D levels both between patients with OSA and patients without OSA and across the various severity levels of OSA. We evaluated the association between vitamin D levels and various clinical and demographic characteristics, including the apnea-hypopnea index and body mass index. From April 2014 to June 2015, 195 pa...
Neurourology and Urodynamics, 2016
To evaluate the prevalence of Overactive Bladder (OAB) and Urgency Urinary Incontinence (UUI) in ... more To evaluate the prevalence of Overactive Bladder (OAB) and Urgency Urinary Incontinence (UUI) in males with Obstructive Sleep Apnea Syndrome (OSAS) using the OSAS grading system. A total of 194 patients who underwent Polysomnography (PSG) were included in our prospective cross sectional study. Patients were divided into four groups according to Apnea-Hypopnea Index (AHI). Group 1, 35 patients with normal AHI (<5) as a control group; Group 2, 47 patients with mild OSAS (AHI ≥5 and <15); Group 3, 51 patients with moderate OSAS (AHI ≥15 and <30); Group 4, 61 patients with severe OSAS (AHI ≥30). Over Active Bladder (OAB-V8), ICIQ-SF, and IPSS questionnaires were filled out for all patients. Prevalence of OAB, UUI, nocturia, and scores of OAB-V8, ICIQ-SF, IPSS were compared between the study groups. The statistical analysis was adjusted by the demographics of age and BMI. The mean age was 44.6 ± 11.2 years, and the mean BMI was 29.9 ± 4.9 within the whole study group, and both were statistically different between the groups. The scores of OAB-V8 (P = 0.298), ICIQ-SF (P = 0.392), IPSS total, IPSS storage, and IPSS voiding (P = 0.268, P = 0.380, P = 0.167, respectively), the prevalence of OAB (P = 0.078), UUI (P = 0.423), and nocturia (P = 0.096) were not statistically different between the study groups. Our findings demonstrated that there is no increase in prevalence of OAB and UUI in relatively young adult male with OSAS. Furthermore, analysis revealed that the higher OSAS grade does not mean the higher prevalence of OAB.
Archives of Clinical Infectious Diseases, 2016
European Respiratory Journal, Sep 1, 2012
European Respiratory Journal, Sep 1, 2011
European Respiratory Journal, Sep 1, 2012
Annals of Surgical Oncology, Jul 2, 2008
Background: To evaluate the efficacy of iodopovidone as an agent for pleurodesis in malignant ple... more Background: To evaluate the efficacy of iodopovidone as an agent for pleurodesis in malignant pleural effusion (MPE) and to compare the efficacy of small-bore catheter (Pleuracan, Braun, Melsungen, Germany) and conventional large-bore chest tube in pleural fluid drainage and sclerotherapy. Methods: Patients with MPE were prospectively consecutively randomized into two groups between August 2004 and February 2007: pleurodesis via conventional (32F) chest tube (group 1) and small-bore catheter (group 2), both using iodopovidone. After 3 months' follow-up, response rates (complete or partial), complication rates, and duration of procedures within whole group, group 1, and group 2 were compared. Statistical analyses were performed by Mann-Whitney U, v 2 , and Fisher's exact test. Results: Forty-three pleurodeses were performed in 41 patients. The response was complete in 26 (60.5%) and partial in 12 (27.9%), and the overall success rate was 88.4%. The response rate was not associated with the type of inserted tube (P = .750), pleural fluid pH (P = .290), or pleural fluid lactate dehydrogenase (P = .727). In group 1 (n = 20), 12 demonstrated complete and 6 demonstrated partial response, with a 90% success rate; success was 86.9% in group 2, with complete response in 14 and partial response in 6 patients. Success rates were similar in the two groups (P = 1.000). Of 43 procedures, complications were observed in 14 (32.5%), and complication rates were 35% and 30.4% in groups 1 and 2, respectively (P = .750). The most frequent complication was pain (16.2%), followed by fever, subcutaneous emphysema, dyspnea, and hypotension. Conclusion: Iodopovidone is an effective, inexpensive, safe, and easily available alternative in chemical pleurodesis in MPE. The success rates of pleurodesis were found to be similar regardless of the type of the tube inserted.
Turkiye Klinikleri Archives of Lung, 2001
European Respiratory Journal, Sep 1, 2012
European Respiratory Journal, Sep 1, 2013
![Research paper thumbnail of [A rare complication of port catheter]](https://attachments.academia-assets.com/72806258/thumbnails/1.jpg)
](Tuberkuloz Ve Toraks, 2010
Kanser hastalarının uzun süreli tedavilerinde kullanılan kalıcı santral venöz portların nasıl tak... more Kanser hastalarının uzun süreli tedavilerinde kullanılan kalıcı santral venöz portların nasıl takıldığı ve bakımı, daha sonradan çıkabilecek komplikasyonlar açısından çok önemlidir. Kanser hastalarına çok yaygın olarak uygulanmaya başlanan venöz portların deneyimli kişilerce takılması ve port bakımının düzenli ve iyi bir şekilde yapılması gerekmektedir. Port kateter kullanımına bağlı en sık görülen komplikasyonlar; kateter tıkanıklığı, infeksiyon, venöz tromboz ve ekstravazasyondur. Bu olguyu nadir görülen pulmoner port komplikasyonu olması sebebiyle sunduk.
Tuberkuloz Ve Toraks, Feb 1, 2007
Malnutrition increases dyspnea and exercise intolerance in chronic obstructive pulmonary disease ... more Malnutrition increases dyspnea and exercise intolerance in chronic obstructive pulmonary disease (COPD) patients by effecting respiratory muscle strength (RMS) and thereby decreasing quality of life (QoL). This is a prospective study conducted to find out the differences due to pulmonary function tests (PFT), arterial blood gases (ABG), RMS, exercise capacity (EC) and QoL in COPD patients having low and normal body mass index (BMI). The study was carried out between April 2003-June 2004 and included 65 male COPD patients with a mean age of 63.4 +/- 9.6. The patients were grouped into 2: Low BMI group (BMI < 21) and normal BMI group (BMI= 21-28). All patients were investigated with PFT (spirometry, maximal inspiratory and expiratory pressures, diffusion capacity), ABG analyses, Modified Medical Research Council (MMRC) dyspnea scale, determination of EC by 6 minutes walking test (6 MWT) and determination of QoL by Turkish version of St. George Respiratory Questionnaire (SGRQ). Of these cases, 29 (44.6%) had low and 36 (55.4%) had normal BMI; MMRC was higher in the first group without statistical significance (p= 0.074). The first group demonstrated significantly lower diffusion capacity (DLco) and DLco%, PEmax, PEmax%, RMS and RMS% (p< 0.05). ABG analyses, 6 MWT results and SGRQ symptom scores revealed no significant difference. As a conclusion, BMI is closely related to dyspnea score, RMS and QoL in COPD patients, therefore in patients with low BMI pulmonary rehabilitation programs including nutritional support should accompany medical treatment.
European Respiratory Journal, Sep 1, 2013
European Respiratory Journal, Sep 1, 2014
Eastern Journal of Medical Sciences
Sleep and control of breathing
Sarcoidosis and other granulomatous ILD/DPLD
Archivos de bronconeumologia, Jan 19, 2018
To evaluate the role of ultrasonography (USG) in the diagnosis of bleomycin-induced pulmonary tox... more To evaluate the role of ultrasonography (USG) in the diagnosis of bleomycin-induced pulmonary toxicity (BT). The study included patients with suspected BT during treatment with bleomycin due to various oncologic diseases between June 2015 and May 2017. The patients initially underwent clinical and high-resolution computed tomography (HRCT) examinations and pulmonary function tests (PFT)-diffusing capacity of the lung for carbon monoxide (DLCO), followed by registration of USG findings-number of comet tail artifact (CTA) images by a different pulmonologist. We compared the findings from USG, HRCT, and PFT-DLCO tests between BT and non-BT groups. With the diagnosis based on clinical-radiologic and PFT-DLCO assessments taken as the gold standard, we determined the sensitivity and specificity of the USG outcomes for diagnosis of BT. The study included a total of 30 patients. Nine patients were diagnosed as having BT according to their clinical and radiologic findings and PFT-DLCO measur...
Lung India : official organ of Indian Chest Society
Asymmetric dimethylarginine (ADMA) has emerged as a risk marker for many conditions related to pu... more Asymmetric dimethylarginine (ADMA) has emerged as a risk marker for many conditions related to pulmonary hypertension (PH); however, little is known about ADMA and symmetric dimethylarginine (SDMA) plasma concentrations in chronic obstructive pulmonary disease (COPD). Our interest centers on the role of ADMA in regulation of endothelial function in COPD and secondary PH. The aim of the present study was to evaluate the serum ADMA, SDMA, and L-arginine concentrations in COPD and its association with PH. Patients with diagnosis of COPD underwent pulmonary function tests, echocardiography, and laboratory investigations including ADMA, SDMA, and L-arginine. Serum concentrations of ADMA, SDMA, and L-arginine tend to increase as COPD progresses. Patients with PH had higher concentrations of ADMA, SDMA, and L-arginine compared to cases with normal pulmonary arterial pressure (PAP); the difference was not statistically significant. Our results show that increased ADMA, SDMA, and L-arginine ...
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, Jan 16, 2016
A recent study reported an association between obstructive sleep apnea (OSA) and low vitamin D le... more A recent study reported an association between obstructive sleep apnea (OSA) and low vitamin D levels. In this study, we measured vitamin D levels in patients referred for evaluation of suspected OSA and sought to identify associated risk factors for vitamin D deficiency. Our objective was to determine whether evaluations of patients with suspected OSA should include routine screening for vitamin D deficiency. Using a cross-sectional study design, we measured vitamin D levels in consecutively enrolled patients referred for an OSA evaluation to Dr. LutfiKirdarKartal Training and Research Hospital in Istanbul, Turkey. We conducted full-night polysomnography and compared vitamin D levels both between patients with OSA and patients without OSA and across the various severity levels of OSA. We evaluated the association between vitamin D levels and various clinical and demographic characteristics, including the apnea-hypopnea index and body mass index. From April 2014 to June 2015, 195 pa...
Neurourology and Urodynamics, 2016
To evaluate the prevalence of Overactive Bladder (OAB) and Urgency Urinary Incontinence (UUI) in ... more To evaluate the prevalence of Overactive Bladder (OAB) and Urgency Urinary Incontinence (UUI) in males with Obstructive Sleep Apnea Syndrome (OSAS) using the OSAS grading system. A total of 194 patients who underwent Polysomnography (PSG) were included in our prospective cross sectional study. Patients were divided into four groups according to Apnea-Hypopnea Index (AHI). Group 1, 35 patients with normal AHI (&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;5) as a control group; Group 2, 47 patients with mild OSAS (AHI ≥5 and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;15); Group 3, 51 patients with moderate OSAS (AHI ≥15 and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;30); Group 4, 61 patients with severe OSAS (AHI ≥30). Over Active Bladder (OAB-V8), ICIQ-SF, and IPSS questionnaires were filled out for all patients. Prevalence of OAB, UUI, nocturia, and scores of OAB-V8, ICIQ-SF, IPSS were compared between the study groups. The statistical analysis was adjusted by the demographics of age and BMI. The mean age was 44.6 ± 11.2 years, and the mean BMI was 29.9 ± 4.9 within the whole study group, and both were statistically different between the groups. The scores of OAB-V8 (P = 0.298), ICIQ-SF (P = 0.392), IPSS total, IPSS storage, and IPSS voiding (P = 0.268, P = 0.380, P = 0.167, respectively), the prevalence of OAB (P = 0.078), UUI (P = 0.423), and nocturia (P = 0.096) were not statistically different between the study groups. Our findings demonstrated that there is no increase in prevalence of OAB and UUI in relatively young adult male with OSAS. Furthermore, analysis revealed that the higher OSAS grade does not mean the higher prevalence of OAB.
Archives of Clinical Infectious Diseases, 2016
European Respiratory Journal, Sep 1, 2012
European Respiratory Journal, Sep 1, 2011
European Respiratory Journal, Sep 1, 2012
Annals of Surgical Oncology, Jul 2, 2008
Background: To evaluate the efficacy of iodopovidone as an agent for pleurodesis in malignant ple... more Background: To evaluate the efficacy of iodopovidone as an agent for pleurodesis in malignant pleural effusion (MPE) and to compare the efficacy of small-bore catheter (Pleuracan, Braun, Melsungen, Germany) and conventional large-bore chest tube in pleural fluid drainage and sclerotherapy. Methods: Patients with MPE were prospectively consecutively randomized into two groups between August 2004 and February 2007: pleurodesis via conventional (32F) chest tube (group 1) and small-bore catheter (group 2), both using iodopovidone. After 3 months' follow-up, response rates (complete or partial), complication rates, and duration of procedures within whole group, group 1, and group 2 were compared. Statistical analyses were performed by Mann-Whitney U, v 2 , and Fisher's exact test. Results: Forty-three pleurodeses were performed in 41 patients. The response was complete in 26 (60.5%) and partial in 12 (27.9%), and the overall success rate was 88.4%. The response rate was not associated with the type of inserted tube (P = .750), pleural fluid pH (P = .290), or pleural fluid lactate dehydrogenase (P = .727). In group 1 (n = 20), 12 demonstrated complete and 6 demonstrated partial response, with a 90% success rate; success was 86.9% in group 2, with complete response in 14 and partial response in 6 patients. Success rates were similar in the two groups (P = 1.000). Of 43 procedures, complications were observed in 14 (32.5%), and complication rates were 35% and 30.4% in groups 1 and 2, respectively (P = .750). The most frequent complication was pain (16.2%), followed by fever, subcutaneous emphysema, dyspnea, and hypotension. Conclusion: Iodopovidone is an effective, inexpensive, safe, and easily available alternative in chemical pleurodesis in MPE. The success rates of pleurodesis were found to be similar regardless of the type of the tube inserted.
Turkiye Klinikleri Archives of Lung, 2001
European Respiratory Journal, Sep 1, 2012
European Respiratory Journal, Sep 1, 2013
Tuberkuloz Ve Toraks, 2010
Kanser hastalarının uzun süreli tedavilerinde kullanılan kalıcı santral venöz portların nasıl tak... more Kanser hastalarının uzun süreli tedavilerinde kullanılan kalıcı santral venöz portların nasıl takıldığı ve bakımı, daha sonradan çıkabilecek komplikasyonlar açısından çok önemlidir. Kanser hastalarına çok yaygın olarak uygulanmaya başlanan venöz portların deneyimli kişilerce takılması ve port bakımının düzenli ve iyi bir şekilde yapılması gerekmektedir. Port kateter kullanımına bağlı en sık görülen komplikasyonlar; kateter tıkanıklığı, infeksiyon, venöz tromboz ve ekstravazasyondur. Bu olguyu nadir görülen pulmoner port komplikasyonu olması sebebiyle sunduk.
Tuberkuloz Ve Toraks, Feb 1, 2007
Malnutrition increases dyspnea and exercise intolerance in chronic obstructive pulmonary disease ... more Malnutrition increases dyspnea and exercise intolerance in chronic obstructive pulmonary disease (COPD) patients by effecting respiratory muscle strength (RMS) and thereby decreasing quality of life (QoL). This is a prospective study conducted to find out the differences due to pulmonary function tests (PFT), arterial blood gases (ABG), RMS, exercise capacity (EC) and QoL in COPD patients having low and normal body mass index (BMI). The study was carried out between April 2003-June 2004 and included 65 male COPD patients with a mean age of 63.4 +/- 9.6. The patients were grouped into 2: Low BMI group (BMI < 21) and normal BMI group (BMI= 21-28). All patients were investigated with PFT (spirometry, maximal inspiratory and expiratory pressures, diffusion capacity), ABG analyses, Modified Medical Research Council (MMRC) dyspnea scale, determination of EC by 6 minutes walking test (6 MWT) and determination of QoL by Turkish version of St. George Respiratory Questionnaire (SGRQ). Of these cases, 29 (44.6%) had low and 36 (55.4%) had normal BMI; MMRC was higher in the first group without statistical significance (p= 0.074). The first group demonstrated significantly lower diffusion capacity (DLco) and DLco%, PEmax, PEmax%, RMS and RMS% (p< 0.05). ABG analyses, 6 MWT results and SGRQ symptom scores revealed no significant difference. As a conclusion, BMI is closely related to dyspnea score, RMS and QoL in COPD patients, therefore in patients with low BMI pulmonary rehabilitation programs including nutritional support should accompany medical treatment.
European Respiratory Journal, Sep 1, 2013
European Respiratory Journal, Sep 1, 2014