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Universidad Interamericana para el Desarrollo
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Papers by Barbara Smith
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Jan 20, 2015
The Radiation Therapy Oncology Group 9804 study identified good-risk patients with ductal carcino... more The Radiation Therapy Oncology Group 9804 study identified good-risk patients with ductal carcinoma in situ (DCIS), a breast cancer diagnosis found frequently in mammographically detected cancers, to test the benefit of radiotherapy (RT) after breast-conserving surgery compared with observation. This prospective randomized trial (1998 to 2006) in women with mammographically detected low- or intermediate-grade DCIS, measuring less than 2.5 cm with margins ≥ 3 mm, compared RT with observation after surgery. The study was designed for 1,790 patients but was closed early because of lower than projected accrual. Six hundred thirty-six patients from the United States and Canada were entered; tamoxifen use (62%) was optional. Ipsilateral local failure (LF) was the primary end point; LF and contralateral failure were estimated using cumulative incidence, and overall and disease-free survival were estimated using the Kaplan-Meier method. Median follow-up time was 7.17 years (range, 0.01 to 1...
Annals of Surgical Oncology, 2006
Background Women ≤ 40 years account for 5% of new breast cancer diagnoses. Although there is incr... more Background Women ≤ 40 years account for 5% of new breast cancer diagnoses. Although there is increased awareness of genetic and other breast cancer risk factors, it is not clear whether this has resulted in earlier diagnosis in young women. Methods A database review identified 8892 women treated for breast cancer from 1980 to 2002. We compared 925 women aged ≤ 40 years with 2362 women aged 50 to 60 years. The mean and median tumor size and lymph node status were determined for each group. Results There were significant differences in tumor size and lymph node status in younger versus older women. From 1980 to the mid 1990s, tumor size and nodal status did not differ. Since the mid 1990s, tumor size has decreased more rapidly for women aged 50 to 60 years than for those ≤ 40 years. In 1998 to 2002, the mean tumor size reached a plateau of 1.8 cm in women 50 to 60 years, compared with a plateau of 2.4 cm in women ≤ 40 years (P < .001). The median tumor size in 1998 to 2002 was 1.4 ...
The American Journal of Surgery, Oct 1, 2009
BACKGROUND: The impact of newer breast imaging technologies and genetic testing on the detection ... more BACKGROUND: The impact of newer breast imaging technologies and genetic testing on the detection of breast cancer in women age 40 and younger remains unknown.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Jan 20, 2015
The Radiation Therapy Oncology Group 9804 study identified good-risk patients with ductal carcino... more The Radiation Therapy Oncology Group 9804 study identified good-risk patients with ductal carcinoma in situ (DCIS), a breast cancer diagnosis found frequently in mammographically detected cancers, to test the benefit of radiotherapy (RT) after breast-conserving surgery compared with observation. This prospective randomized trial (1998 to 2006) in women with mammographically detected low- or intermediate-grade DCIS, measuring less than 2.5 cm with margins ≥ 3 mm, compared RT with observation after surgery. The study was designed for 1,790 patients but was closed early because of lower than projected accrual. Six hundred thirty-six patients from the United States and Canada were entered; tamoxifen use (62%) was optional. Ipsilateral local failure (LF) was the primary end point; LF and contralateral failure were estimated using cumulative incidence, and overall and disease-free survival were estimated using the Kaplan-Meier method. Median follow-up time was 7.17 years (range, 0.01 to 1...
Annals of Surgical Oncology, 2006
Background Women ≤ 40 years account for 5% of new breast cancer diagnoses. Although there is incr... more Background Women ≤ 40 years account for 5% of new breast cancer diagnoses. Although there is increased awareness of genetic and other breast cancer risk factors, it is not clear whether this has resulted in earlier diagnosis in young women. Methods A database review identified 8892 women treated for breast cancer from 1980 to 2002. We compared 925 women aged ≤ 40 years with 2362 women aged 50 to 60 years. The mean and median tumor size and lymph node status were determined for each group. Results There were significant differences in tumor size and lymph node status in younger versus older women. From 1980 to the mid 1990s, tumor size and nodal status did not differ. Since the mid 1990s, tumor size has decreased more rapidly for women aged 50 to 60 years than for those ≤ 40 years. In 1998 to 2002, the mean tumor size reached a plateau of 1.8 cm in women 50 to 60 years, compared with a plateau of 2.4 cm in women ≤ 40 years (P < .001). The median tumor size in 1998 to 2002 was 1.4 ...
The American Journal of Surgery, Oct 1, 2009
BACKGROUND: The impact of newer breast imaging technologies and genetic testing on the detection ... more BACKGROUND: The impact of newer breast imaging technologies and genetic testing on the detection of breast cancer in women age 40 and younger remains unknown.