María Barrón - Academia.edu (original) (raw)
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Papers by María Barrón
Al revisar viejos textos de psiquiatría, me encuentro en la segunda edición del Modern Synopsis o... more Al revisar viejos textos de psiquiatría, me encuentro en la segunda edición del Modern Synopsis of Comprehensive Textbook of Psychiatry / II, de Freedman, Kaplan y Sadock, el cual funcionara como una especie de biblia psiquiátrica en los años previos a mi ingreso a la residencia, según lo señalaba mi gran maestro Jaime Barona Gaviria, me encuentro una referencia al DSM-II, en el que, meramente, se hacía un listado de los trastornos de personalidad: 301
International Journal of Molecular Sciences
Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony with the enviro... more Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony with the environmental light/dark cycle. A gradual increase in circulating levels of melatonin occur after lights off, reaching its maximum around the middle of the dark phase. Agonists of melatonin receptors have proved effectiveness as antidepressants in clinical trials. However, there is contradictory evidence about the potential antidepressant effect of melatonin itself. Herein we studied melatonin administration in mice at two zeitgeber times (ZT; ZT = 0 lights on; 12:12 L/D), one hour before the beginning (ZT11) and at the middle (ZT18) of the dark phase after either a single or a three-dose protocol. Behavioral despair was assessed through a forced-swimming test (FST) or a tail suspension test (TST), at ZT18.5. A single dose of 4 mg/kg melatonin at ZT11 was effective to reduce the immobility time in both tests. However, acute administration of melatonin at ZT18 was not effective in mice subjecte...
Al revisar viejos textos de psiquiatría, me encuentro en la segunda edición del Modern Synopsis o... more Al revisar viejos textos de psiquiatría, me encuentro en la segunda edición del Modern Synopsis of Comprehensive Textbook of Psychiatry / II, de Freedman, Kaplan y Sadock, el cual funcionara como una especie de biblia psiquiátrica en los años previos a mi ingreso a la residencia, según lo señalaba mi gran maestro Jaime Barona Gaviria, me encuentro una referencia al DSM-II, en el que, meramente, se hacía un listado de los trastornos de personalidad: 301
International Journal of Molecular Sciences
Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony with the enviro... more Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony with the environmental light/dark cycle. A gradual increase in circulating levels of melatonin occur after lights off, reaching its maximum around the middle of the dark phase. Agonists of melatonin receptors have proved effectiveness as antidepressants in clinical trials. However, there is contradictory evidence about the potential antidepressant effect of melatonin itself. Herein we studied melatonin administration in mice at two zeitgeber times (ZT; ZT = 0 lights on; 12:12 L/D), one hour before the beginning (ZT11) and at the middle (ZT18) of the dark phase after either a single or a three-dose protocol. Behavioral despair was assessed through a forced-swimming test (FST) or a tail suspension test (TST), at ZT18.5. A single dose of 4 mg/kg melatonin at ZT11 was effective to reduce the immobility time in both tests. However, acute administration of melatonin at ZT18 was not effective in mice subjecte...