Basar Sarikaya - Academia.edu (original) (raw)

Papers by Basar Sarikaya

Circulation, 2021

Introduction: Patients resuscitated from out-of-hospital cardiac arrest (OHCA) frequently have sk... more Introduction: Patients resuscitated from out-of-hospital cardiac arrest (OHCA) frequently have skeletal and visceral injuries identifiable by computed tomography, although the prevalence, types of injury, and potential effects on clinical outcomes are poorly characterized. Methods: We assessed the prevalence of resuscitation-attributable injury in a prospective, observational diagnostic utility study of a head-to-pelvis sudden death computed tomography (SDCT) protocol after successful resuscitation from OHCA. SDCT was performed within six hours of arrival at two academic medical centers. CT data were independently analyzed by two blinded radiologists. Primary outcomes included total injuries and time-critical injuries (such as organ laceration). Exploratory outcomes were clinical associations with injury and survival to discharge. Results: Among 104 patients with OHCA (mean age 56 ± 15 years, 31% female), 59% of events were witnessed and 60% had bystander CPR. Initial rhythms were p...

The British Journal of Radiology, 2021

Objective: To assess whether intracranial vessel wall (IVW) MRI luminal measurements are more acc... more Objective: To assess whether intracranial vessel wall (IVW) MRI luminal measurements are more accurate than non-contrast 3D-TOF-MRA measurements for intracranial atherosclerotic stenosis, relative to CTA. Methods: Consecutive patients with non-calcified intracranial atherosclerotic stenosis seen on CTA, who had non-contrast 3D-TOF-MRA and IVW performed between 1 January 2013 and 20 April 2014 were selected, and images with stenosis were pre-selected by a single independent rater. The pre-selected CTA, MRA, and IVW (T1-weighted) images were then reviewed by two independent raters blinded to the other measurements in random order. Measurements were made in a plane perpendicular to the lumen on each modality. MRA and IVW measurements were compared to CTA, to determine which more accurately matched the degree of stenosis. Results: 18 patients with 33 intracranial atherosclerotic stenoses were included. Relative to CTA, IVW had 40% less variance than MRA (p = .004). IVW had a significant...

Journal of Alzheimer's Disease Reports, 2018

Although inappropriate sexual behavior in dementia is not common, it can be extremely troublesome... more Although inappropriate sexual behavior in dementia is not common, it can be extremely troublesome for healthcare professionals and caregivers as well as patients themselves. There is paucity of data in the literature for the management of these behaviors, but the limited available data suggest efficiency of some commonly used treatment modalities. Herein, we present a 74-year old Alzheimer's disease (AD) patient, known to be heterosexual throughout her past life, presenting with a recent display of same-sex inappropriate sexual behavior six years after the initial diagnosis of her disease. This new clinical picture of hypersexuality responded well to aripiprazole and her symptoms gradually diminished and eventually disappeared after onset of medication. This report also constitutes the first reported case of an AD patient in the published literature presenting with hypersexuality of shifted sexual orientation during the course of the disease.

Interventional Neuroradiology, 2008

We present imaging findings of a patient with an incomplete form of the PHACES syndrome with doli... more We present imaging findings of a patient with an incomplete form of the PHACES syndrome with dolichosegmental intracranial arteries as the predominant component, and discuss the etiopathological and clinical significance of this finding.

Yeditepe Medical Journal, 2013

Joubert syndrome is a rare posterior fossa malformation presenting with cerebellar and brainstem ... more Joubert syndrome is a rare posterior fossa malformation presenting with cerebellar and brainstem malfunction. Differential diagnosis should include other posterior fossa malformations. Typical magnetic resonance imaging (MRI) findings of Joubert syndrome including "molar tooth sign" and "batwing appearance" are discussed which strongly suggest the diagnosis.

Emergency Radiology, 2010

The purpose of the study was to determine the frequency of various unenhanced computed tomography... more The purpose of the study was to determine the frequency of various unenhanced computed tomography (CT) findings of early cerebral ischemia within brain parenchyma, which could be useful to the radiologist who is interpreting CT studies by indicating the CT finding that is most likely to be present in early cerebral ischemia. We analyzed articles reporting the use of unenhanced CT in acute cerebral ischemia over the period 1976-2009 for frequency of the following brain parenchyma signs: loss of insular ribbon, obscuration of lentiform nucleus, sulcal effacement, and parenchymal hypodensity. We recorded data for the 2-, 3-, 6-, and 12-h intervals after symptom onset from various studies and (1) calculated percent of time intervals in which >50% of patients exhibited the finding in any study and (2) pooled results for patients reported as having a specific CT finding during a specific time interval. We hypothesized that CT findings indicating brain swelling, which would be expected to be a relatively late phenomenon, would be detected at a lower rate in the first 6 h than changes of decreased density of brain tissue and increased density of arteries. The loss of insular ribbon sign (83% of time intervals reported) and obscuration of lentiform nucleus sign (75%) were the most common signs present in >50% patients in a time interval in any article. Pooled results showed that the two most common findings in the first few hours were loss of insular ribbon (70% at 2 h; 77% at 3 h) and obscuration of lentiform nucleus (60% at 2 h; 82% at 3 h). At 6 h, parenchymal hypodensity (53%), loss of insular ribbon (46%), and obscuration of lentiform nucleus (46%) were most common, which validated our hypothesis. At 12 h, loss of insular ribbon (65%) and sulcal effacement (63%) were most common. Loss of insular ribbon and obscuration of lentiform nucleus appear to be the most common signs of early cerebral ischemia identified on unenhanced CT.

The Canadian Journal of Neurological Sciences, 2009

Objective:To assess the clinical features of several members of the same family diagnosed with bo... more Objective:To assess the clinical features of several members of the same family diagnosed with both hot water epilepsy (HWE) and cerebral lesions.Methods:Age at onset and types of seizure, precipitating factors, EEG findings, and neuroimages were evaluated.Results:The family consisted of six generations, including one consanguineous parent. Of eight family members diagnosed with epilepsy, seven suffered from HWE. Age at onset of seizures ranged within childhood. Seven patients with HWE experienced complex partial seizures, with or without secondary generalization; one experienced simple partial seizures as well as complex partial seizures. Three patients experienced spontaneous seizures as well as HWE. Interictal EEG revealed abnormalities in two patients. Magnetic resonance imaging revealed cerebral lesions in one patient, probably attributable to ischemic changes. Magnetic resonance images were consistent with findings of ischemic gliosis in two patients, and either demyelinating ...

Turkiye Klinikleri Journal of Medical Sciences, 2010

Journal of Gastrointestinal Cancer, 2013

Metastasis to the pituitary gland from solid tumors is quite rare [1, 2]. It is usually detected ... more Metastasis to the pituitary gland from solid tumors is quite rare [1, 2]. It is usually detected in the presence of widespread metastatic disease [1–4]. The most common primaries of metastatic pituitary carcinomas are breast and lung cancers [2, 3]. Pituitary metastases are usually asymptomatic and constitute a small fraction of pituitary masses [3, 4]. Symptoms of pituitary metastasis may vary from visual disturbance to endocrine dysfunction such as diabetes insipidus [2, 5] and are caused by mass effect and compression of surrounding structures [5, 6]. Brain metastasis, particularly to the pituitary gland, from colorectal cancer is infrequent [7, 9]. Herein, we report a case of colon carcinoma with metastasis to the pituitary gland which developed diabetes insipidus and central hypothyroidism during follow-up.

Journal of Oral and Maxillofacial Surgery, 2010

We compared high-resolution ultrasonography with magnetic resonance imaging (MRI), as the gold st... more We compared high-resolution ultrasonography with magnetic resonance imaging (MRI), as the gold standard, to evaluate lateral and anterior capsule-condyle distances to detect disc displacement of the temporomandibular joint. Materials and Methods: This study included 28 patients (19 female and 9 male; age range, 16-51 years; mean age, 32.82 years), and in total, 56 joints were assessed with ultrasonography and MRI. Measurements were obtained for anterior capsule-condyle and lateral capsule-condyle distances in both open-and closed-mouth positions with high-resolution ultrasonography. These findings were also compared with those of MRI taken as reference. Receiver operating characteristic curve analysis was performed to assess our results. We assessed sensitivities, specificities, accuracies, and positive and negative predictive values for both open-and closed-mouth positions. Results: Diagnostic accuracy of ultrasonographic anterior capsule-condyle distance in the closedmouth position to detect MRI-positive disc displacement (area under receiver operating characteristic curve, 0.689; P ϭ .015) was the highest. Conclusions: The measurement of the distance between the most anterior point of the articular capsule and the most anterior point of the condyle can be used to assess disc displacement in diseased joints. However, it is necessary to determine the most accurate threshold value and to set cutoff values. These findings need to be confirmed by further research in a large number of patients to test the interexaminer agreement and the reproducibility of this method.

Journal of Computer Assisted Tomography, 2008

We report the first case of unilateral incus agenesis in the literature. Preoperative diagnosis b... more We report the first case of unilateral incus agenesis in the literature. Preoperative diagnosis by virtual endoscopy further enhances the significance of this case. We present thin-section temporal bone computed tomographic images and 3-dimensional reconstructed views which were all correlated with intraoperative findings. The patient was successfully treated with an ossicular prosthesis replacement.

Journal of Computer Assisted Tomography, 2008

Objective: To compare contrast-enhanced magnetic resonance (MR) cholangiography (CE-MRC) performe... more Objective: To compare contrast-enhanced magnetic resonance (MR) cholangiography (CE-MRC) performed with gadobenate dimeglumine with T2-weighted MRC (T2-MRC) for visualization of the bile ducts in nondilated biliary systems. Materials and Methods: Twenty consecutive patients who underwent MR imaging (MRI) of the liver and pancreas with nondilated intrahepatic ducts were included in this retrospective study. T2weighted MRC was performed using a multislice, high-resolution fat-suppressed half-Fourier acquisition turbo spin-echo sequence. Contrast-enhanced MR cholangiography was performed using a fatsuppressed 3-dimensional fast low-angle shot sequence acquired 1 to 1.5 hour after intravenous administration of gadobenate dimeglumine. For image interpretation, the biliary system was divided into 8 segments. Two readers graded visualization of each segment on T2-MRC and CE-MRC using a 5-point scale (0, nonvisualization; 4, excellent visualization). Final opinion for each sequence was rendered by consensus. Superiority of visualization was assessed using the McNemar test and comparing adequately (visualization scores 3 and 4) and inadequately (visualization scores 0, 1, and 2) visualized segments of the ducts on both sequences. Interobserver variability was assessed with J statistics. Results: Overall and segment-based evaluation revealed superior visualization of biliary segments with CE-MRC compared with T2-MRC. We also found a statistically significant difference between the 2 sequences for overall and for right hepatic duct and cystic channel visualization (P G 0.05). A high concordance between readers 1 and 2 both for T2-MRC and CE-MRC was achieved (85.8% and 89.4%, respectively). Conclusions: Gadobenate dimeglumine can be used as an alternative intrabiliary contrast agent for contrast-enhanced MR cholangiography in nondilated biliary systems in patients with normal excretory liver function tests.

European Journal of Radiology, 2011

Clinical Imaging, 2013

We evaluated the multidetector computed tomography (MDCT) findings of the sternoclavicular joint ... more We evaluated the multidetector computed tomography (MDCT) findings of the sternoclavicular joint in patients with rheumatoid arthritis (RA) and compare them with general population. Chest MDCT scans of RA patients were reviewed. The control group was formed from age and sex-matched individuals. The most common CT findings were cortical irregularity, joint space narrowing, and osteophytes in study group. There were no statistically significant differences in the MDCT findings between the two groups except that osteophytes were observed more often in the control group. It is difficult to distinguish between the involvement of RA and age-related degenerative changes at the sternoclavicular joint.

British Journal of Oral and Maxillofacial Surgery, 2008

We describe a patient with postoperative unilateral hypoglossal nerve paralysis after an uncompli... more We describe a patient with postoperative unilateral hypoglossal nerve paralysis after an uncomplicated intubation. Postoperative evaluation showed that he had an Arnold Chiari type 1 malformation. The paralysis resolved completely by the second postoperative month.

… Klinikleri Journal of …, 2009

Keratocystic odontogenic tumour (KCOT) is a common developmental benign odontogenic neoplasm in t... more Keratocystic odontogenic tumour (KCOT) is a common developmental benign odontogenic neoplasm in the jaws. In this paper, a case of a large KCOT and unusual reconstruction with autologous fat graft are reported. A 73-year-old woman was referred to our clinic with a ...

Circulation, 2021

Introduction: Patients resuscitated from out-of-hospital cardiac arrest (OHCA) frequently have sk... more Introduction: Patients resuscitated from out-of-hospital cardiac arrest (OHCA) frequently have skeletal and visceral injuries identifiable by computed tomography, although the prevalence, types of injury, and potential effects on clinical outcomes are poorly characterized. Methods: We assessed the prevalence of resuscitation-attributable injury in a prospective, observational diagnostic utility study of a head-to-pelvis sudden death computed tomography (SDCT) protocol after successful resuscitation from OHCA. SDCT was performed within six hours of arrival at two academic medical centers. CT data were independently analyzed by two blinded radiologists. Primary outcomes included total injuries and time-critical injuries (such as organ laceration). Exploratory outcomes were clinical associations with injury and survival to discharge. Results: Among 104 patients with OHCA (mean age 56 ± 15 years, 31% female), 59% of events were witnessed and 60% had bystander CPR. Initial rhythms were p...

The British Journal of Radiology, 2021

Objective: To assess whether intracranial vessel wall (IVW) MRI luminal measurements are more acc... more Objective: To assess whether intracranial vessel wall (IVW) MRI luminal measurements are more accurate than non-contrast 3D-TOF-MRA measurements for intracranial atherosclerotic stenosis, relative to CTA. Methods: Consecutive patients with non-calcified intracranial atherosclerotic stenosis seen on CTA, who had non-contrast 3D-TOF-MRA and IVW performed between 1 January 2013 and 20 April 2014 were selected, and images with stenosis were pre-selected by a single independent rater. The pre-selected CTA, MRA, and IVW (T1-weighted) images were then reviewed by two independent raters blinded to the other measurements in random order. Measurements were made in a plane perpendicular to the lumen on each modality. MRA and IVW measurements were compared to CTA, to determine which more accurately matched the degree of stenosis. Results: 18 patients with 33 intracranial atherosclerotic stenoses were included. Relative to CTA, IVW had 40% less variance than MRA (p = .004). IVW had a significant...

Journal of Alzheimer's Disease Reports, 2018

Although inappropriate sexual behavior in dementia is not common, it can be extremely troublesome... more Although inappropriate sexual behavior in dementia is not common, it can be extremely troublesome for healthcare professionals and caregivers as well as patients themselves. There is paucity of data in the literature for the management of these behaviors, but the limited available data suggest efficiency of some commonly used treatment modalities. Herein, we present a 74-year old Alzheimer's disease (AD) patient, known to be heterosexual throughout her past life, presenting with a recent display of same-sex inappropriate sexual behavior six years after the initial diagnosis of her disease. This new clinical picture of hypersexuality responded well to aripiprazole and her symptoms gradually diminished and eventually disappeared after onset of medication. This report also constitutes the first reported case of an AD patient in the published literature presenting with hypersexuality of shifted sexual orientation during the course of the disease.

Interventional Neuroradiology, 2008

We present imaging findings of a patient with an incomplete form of the PHACES syndrome with doli... more We present imaging findings of a patient with an incomplete form of the PHACES syndrome with dolichosegmental intracranial arteries as the predominant component, and discuss the etiopathological and clinical significance of this finding.

Yeditepe Medical Journal, 2013

Joubert syndrome is a rare posterior fossa malformation presenting with cerebellar and brainstem ... more Joubert syndrome is a rare posterior fossa malformation presenting with cerebellar and brainstem malfunction. Differential diagnosis should include other posterior fossa malformations. Typical magnetic resonance imaging (MRI) findings of Joubert syndrome including "molar tooth sign" and "batwing appearance" are discussed which strongly suggest the diagnosis.

Emergency Radiology, 2010

The purpose of the study was to determine the frequency of various unenhanced computed tomography... more The purpose of the study was to determine the frequency of various unenhanced computed tomography (CT) findings of early cerebral ischemia within brain parenchyma, which could be useful to the radiologist who is interpreting CT studies by indicating the CT finding that is most likely to be present in early cerebral ischemia. We analyzed articles reporting the use of unenhanced CT in acute cerebral ischemia over the period 1976-2009 for frequency of the following brain parenchyma signs: loss of insular ribbon, obscuration of lentiform nucleus, sulcal effacement, and parenchymal hypodensity. We recorded data for the 2-, 3-, 6-, and 12-h intervals after symptom onset from various studies and (1) calculated percent of time intervals in which >50% of patients exhibited the finding in any study and (2) pooled results for patients reported as having a specific CT finding during a specific time interval. We hypothesized that CT findings indicating brain swelling, which would be expected to be a relatively late phenomenon, would be detected at a lower rate in the first 6 h than changes of decreased density of brain tissue and increased density of arteries. The loss of insular ribbon sign (83% of time intervals reported) and obscuration of lentiform nucleus sign (75%) were the most common signs present in >50% patients in a time interval in any article. Pooled results showed that the two most common findings in the first few hours were loss of insular ribbon (70% at 2 h; 77% at 3 h) and obscuration of lentiform nucleus (60% at 2 h; 82% at 3 h). At 6 h, parenchymal hypodensity (53%), loss of insular ribbon (46%), and obscuration of lentiform nucleus (46%) were most common, which validated our hypothesis. At 12 h, loss of insular ribbon (65%) and sulcal effacement (63%) were most common. Loss of insular ribbon and obscuration of lentiform nucleus appear to be the most common signs of early cerebral ischemia identified on unenhanced CT.

The Canadian Journal of Neurological Sciences, 2009

Objective:To assess the clinical features of several members of the same family diagnosed with bo... more Objective:To assess the clinical features of several members of the same family diagnosed with both hot water epilepsy (HWE) and cerebral lesions.Methods:Age at onset and types of seizure, precipitating factors, EEG findings, and neuroimages were evaluated.Results:The family consisted of six generations, including one consanguineous parent. Of eight family members diagnosed with epilepsy, seven suffered from HWE. Age at onset of seizures ranged within childhood. Seven patients with HWE experienced complex partial seizures, with or without secondary generalization; one experienced simple partial seizures as well as complex partial seizures. Three patients experienced spontaneous seizures as well as HWE. Interictal EEG revealed abnormalities in two patients. Magnetic resonance imaging revealed cerebral lesions in one patient, probably attributable to ischemic changes. Magnetic resonance images were consistent with findings of ischemic gliosis in two patients, and either demyelinating ...

Turkiye Klinikleri Journal of Medical Sciences, 2010

Journal of Gastrointestinal Cancer, 2013

Metastasis to the pituitary gland from solid tumors is quite rare [1, 2]. It is usually detected ... more Metastasis to the pituitary gland from solid tumors is quite rare [1, 2]. It is usually detected in the presence of widespread metastatic disease [1–4]. The most common primaries of metastatic pituitary carcinomas are breast and lung cancers [2, 3]. Pituitary metastases are usually asymptomatic and constitute a small fraction of pituitary masses [3, 4]. Symptoms of pituitary metastasis may vary from visual disturbance to endocrine dysfunction such as diabetes insipidus [2, 5] and are caused by mass effect and compression of surrounding structures [5, 6]. Brain metastasis, particularly to the pituitary gland, from colorectal cancer is infrequent [7, 9]. Herein, we report a case of colon carcinoma with metastasis to the pituitary gland which developed diabetes insipidus and central hypothyroidism during follow-up.

Journal of Oral and Maxillofacial Surgery, 2010

We compared high-resolution ultrasonography with magnetic resonance imaging (MRI), as the gold st... more We compared high-resolution ultrasonography with magnetic resonance imaging (MRI), as the gold standard, to evaluate lateral and anterior capsule-condyle distances to detect disc displacement of the temporomandibular joint. Materials and Methods: This study included 28 patients (19 female and 9 male; age range, 16-51 years; mean age, 32.82 years), and in total, 56 joints were assessed with ultrasonography and MRI. Measurements were obtained for anterior capsule-condyle and lateral capsule-condyle distances in both open-and closed-mouth positions with high-resolution ultrasonography. These findings were also compared with those of MRI taken as reference. Receiver operating characteristic curve analysis was performed to assess our results. We assessed sensitivities, specificities, accuracies, and positive and negative predictive values for both open-and closed-mouth positions. Results: Diagnostic accuracy of ultrasonographic anterior capsule-condyle distance in the closedmouth position to detect MRI-positive disc displacement (area under receiver operating characteristic curve, 0.689; P ϭ .015) was the highest. Conclusions: The measurement of the distance between the most anterior point of the articular capsule and the most anterior point of the condyle can be used to assess disc displacement in diseased joints. However, it is necessary to determine the most accurate threshold value and to set cutoff values. These findings need to be confirmed by further research in a large number of patients to test the interexaminer agreement and the reproducibility of this method.

Journal of Computer Assisted Tomography, 2008

We report the first case of unilateral incus agenesis in the literature. Preoperative diagnosis b... more We report the first case of unilateral incus agenesis in the literature. Preoperative diagnosis by virtual endoscopy further enhances the significance of this case. We present thin-section temporal bone computed tomographic images and 3-dimensional reconstructed views which were all correlated with intraoperative findings. The patient was successfully treated with an ossicular prosthesis replacement.

Journal of Computer Assisted Tomography, 2008

Objective: To compare contrast-enhanced magnetic resonance (MR) cholangiography (CE-MRC) performe... more Objective: To compare contrast-enhanced magnetic resonance (MR) cholangiography (CE-MRC) performed with gadobenate dimeglumine with T2-weighted MRC (T2-MRC) for visualization of the bile ducts in nondilated biliary systems. Materials and Methods: Twenty consecutive patients who underwent MR imaging (MRI) of the liver and pancreas with nondilated intrahepatic ducts were included in this retrospective study. T2weighted MRC was performed using a multislice, high-resolution fat-suppressed half-Fourier acquisition turbo spin-echo sequence. Contrast-enhanced MR cholangiography was performed using a fatsuppressed 3-dimensional fast low-angle shot sequence acquired 1 to 1.5 hour after intravenous administration of gadobenate dimeglumine. For image interpretation, the biliary system was divided into 8 segments. Two readers graded visualization of each segment on T2-MRC and CE-MRC using a 5-point scale (0, nonvisualization; 4, excellent visualization). Final opinion for each sequence was rendered by consensus. Superiority of visualization was assessed using the McNemar test and comparing adequately (visualization scores 3 and 4) and inadequately (visualization scores 0, 1, and 2) visualized segments of the ducts on both sequences. Interobserver variability was assessed with J statistics. Results: Overall and segment-based evaluation revealed superior visualization of biliary segments with CE-MRC compared with T2-MRC. We also found a statistically significant difference between the 2 sequences for overall and for right hepatic duct and cystic channel visualization (P G 0.05). A high concordance between readers 1 and 2 both for T2-MRC and CE-MRC was achieved (85.8% and 89.4%, respectively). Conclusions: Gadobenate dimeglumine can be used as an alternative intrabiliary contrast agent for contrast-enhanced MR cholangiography in nondilated biliary systems in patients with normal excretory liver function tests.

European Journal of Radiology, 2011

Clinical Imaging, 2013

We evaluated the multidetector computed tomography (MDCT) findings of the sternoclavicular joint ... more We evaluated the multidetector computed tomography (MDCT) findings of the sternoclavicular joint in patients with rheumatoid arthritis (RA) and compare them with general population. Chest MDCT scans of RA patients were reviewed. The control group was formed from age and sex-matched individuals. The most common CT findings were cortical irregularity, joint space narrowing, and osteophytes in study group. There were no statistically significant differences in the MDCT findings between the two groups except that osteophytes were observed more often in the control group. It is difficult to distinguish between the involvement of RA and age-related degenerative changes at the sternoclavicular joint.

British Journal of Oral and Maxillofacial Surgery, 2008

We describe a patient with postoperative unilateral hypoglossal nerve paralysis after an uncompli... more We describe a patient with postoperative unilateral hypoglossal nerve paralysis after an uncomplicated intubation. Postoperative evaluation showed that he had an Arnold Chiari type 1 malformation. The paralysis resolved completely by the second postoperative month.

… Klinikleri Journal of …, 2009

Keratocystic odontogenic tumour (KCOT) is a common developmental benign odontogenic neoplasm in t... more Keratocystic odontogenic tumour (KCOT) is a common developmental benign odontogenic neoplasm in the jaws. In this paper, a case of a large KCOT and unusual reconstruction with autologous fat graft are reported. A 73-year-old woman was referred to our clinic with a ...