Begoña Martinez-Jarreta - Academia.edu (original) (raw)

Papers by Begoña Martinez-Jarreta

Occupational Medicine, 2018

Introduction Few studies estimated life years lost and lifetime costs resulted from pneumoconiosi... more Introduction Few studies estimated life years lost and lifetime costs resulted from pneumoconiosis. We aimed to assess the expected life years lost (EYLL) and lifetime healthcare expenditures (LTHE) in patients with pneumoconiosis in Taiwan. Methods A cohort of patients with pneumoconiosis was established by recruiting new cases aged 25 or older from the National Health Insurance (NHI) reimbursement dataset. The case was defined by at least 3 times of outpatient clinic visits or hospitalisation with disease diagnosis using ICD-9-CM codes 500-505 for the period 1998-2012. The cohort was linked with National Mortality Registry to verify survival status. Using a semi-parametric method, we extrapolated lifetime survival function under the assumption of constant excess hazard. For each patient, we simulated gender-, and age-matched referents based on the life table from national statistics to estimate the EYLL for the cohort. The LTHE were estimated by multiplying the survival probability with mean monthly costs paid by the NHI for diagnosis and treatment and summing this for the expected lifetime. Results A total of 34 749 pneumoconiosis patients during the 15 years period, approximating an average of 2482 cases per year, were identified through NHI scheme in Taiwan. We estimated that the EYLL due to overall pneumoconiosis was 2.45 ±0.1 years. The average EYLL resulted from asbestosis, silicosis, and coal workers' pneumoconiosis were 3.32±0.7 years, 4.29±0.41 years, 2.66±0.2 years, respectively. The LTHE for pneumoconiosis was NT$708,114±10,859, higher in females than males (749,200 vs 694,518). Asbestosis ranked top among different types of pneumoconiosis. Conclusion The accumulated disease burden in terms of total EYLL for pneumoconiosis was estimated more than 90 000 life years. The disease burden for pneumoconiosis is substantial. We recommend appropriate measures should be taken for prevention of pneumoconiosis.

International Congress Series, 2003

A core set of 10 Y-linked short tandem repeat (STR) polymorphisms has been recently described and... more A core set of 10 Y-linked short tandem repeat (STR) polymorphisms has been recently described and validated by the forensic and scientific community: DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385I, DYS385II, DYS388. The goal of this work was the generation of reliable Y-STR haplotype frequency estimates based on the distribution of these Ylinked short tandem repeat polymorphisms from 120 fresh blood samples collected in Asturias (North Spain). One hundred one different haplotypes were found in 120 samples (haplotype diversity value: 0.9952).

Alcoholism: Clinical and Experimental Research, 2011

Background: Genes ADH1B and ADH1C have certain functional SNPs that are related to alcoholism. Th... more Background: Genes ADH1B and ADH1C have certain functional SNPs that are related to alcoholism. The frequencies of these polymorphisms vary between populations, so studying them in populations made up of groups with different phylogeographic origins requires an individualized analysis of each group. In the Basque Country, various recently arrived foreign groups live side by side with the original Southern European population, particularly North Africans from Morocco and Hispanics from Ecuador. This study sets out to examine the distribution of the frequencies of alleles that encode alcohol dehydrogenase with different metabolization rates, as higher rates make for greater susceptibility to alcoholism. Methods: Four SNPs: rs1229984, rs2066702, rs698, and rs1693482 using Taqman technology with a Rt-PCR were studied in a sample of 114 European individuals originating from the Basque Country, 100 North Africans from Morocco, and 109 Hispanics from Ecuador. The allele and genotype frequencies were calculated using Genepop v4.0. The most frequent haplotypes were estimated using the ELB algorithm with Arlequin v3.01. A breakdown of the complete disequilibrium commonly observed between the 2 missense polymorphisms that distinguish the common ADH1C alleles rs698 and rs1693482 was observed and confirmed by sequencing in 2 individuals from the Basque Country. Results: A higher frequency of protective allele ADH1C*1 was found in the North African population group. Haplotype combinations are also studied, and the rare association of alleles ADH1B*2-ADH1C*2 was observed in the Southern European group in the Basque Country, along with an allele not hitherto described in the ADH1C locus. Conclusions: This study provides the first data published on the allele and genotype frequencies of the ADH1C locus in the Moroccan population and on the ADH1B and ADH1C loci in the Ecuadorian population. The study shows differences in the distribution of the frequency of allele ADH1C*1 between the Basque Country and Moroccan populations, and a new allele not described to date.

Safety and Health at Work, 2022

Female genotypes and male haplotypes for 10 X-chromosome STRs in a Waorani population sampl

EDULEARN Proceedings, 2020

En esta tesis doctoral se presentan los resultados derivados del estudio de la poblacion mestiza ... more En esta tesis doctoral se presentan los resultados derivados del estudio de la poblacion mestiza de Nicaragua mediante el analisis de los principales marcadores geneticos de interes forense y genetico poblacional: ADN mitocondrial, microsatelites autosomicos y de los cromosomas sexuales y polimorfismos de unico nucleotido del cromosoma Y. Los sistemas geneticos de 15 STRs autosomicos, 17 STRs de cromosoma Y y 10 STRs de cromosoma X resultaron altamente polimorficos, generando un poder de discriminacion y una probabilidad de exclusion a priori elevados. Estos parametros indican que estos sistemas constituyen marcadores genetico moleculares de gran rendimiento en la identificacion forense de la poblacion mestiza de Nicaragua. Ademas, el estudio de estos marcadores ha proporcionado diversas evidencias que corroboran lo que narran los textos historicos, por lo que abre nuevas lineas de investigacion sobre la historia genetico-poblacional de Nicaragua. Segun los registros historicos, alg...

In recent years instances of aggression by patients towards health workers have become more frequ... more In recent years instances of aggression by patients towards health workers have become more frequent. In Spain, no scientific studies have been performed so far on this question. We analyzed questionnaires on workplace aggression from a stratified sample of 1826 health professionals at 3 hospitals and 22 rural and urban Primary Care facilities located in the Northeast and East of Spain. We found 11% of health workers had been a victim of physical aggression, 5% on more than one occasion, while 64% had been exposed to threatening behaviour, intimidation or insults. About 34% had suffered threats and intimidation on at least one occasion and 23.8% repeatedly. Over 35% had been subjected to insults on at least one occasion, and 24.3% repeatedly. In general the incidence was higher in large hospitals, with very high levels in services such as Accident and Emergency and Psychiatry. Key words: aggressions, violence, health care workers, Spain. INT J OCCUP ENVIRON HEALTH 2009;15:30‐36

EDULEARN21 Proceedings, 2021

Frontiers in Public Health, 2021

Background: To achieve herd immunity, the acceptance of the COVID-19 vaccine by the population, e... more Background: To achieve herd immunity, the acceptance of the COVID-19 vaccine by the population, especially healthcare professionals, plays a key role. The objective of the present paper is to address the differences in attitudes among Spanish healthcare professionals compared with the general population regarding COVID-19 vaccination.Methods: This cross-sectional study included data from 2,136 adults (n = 664 healthcare professionals) from an online survey conducted from May 6 to June 9, 2021. The Vaccination attitudes examination scale was used to measure the negative attitudes toward vaccines. Four subscales: mistrust of vaccine benefit, worries about the unforeseen future effect, concerns about commercial profiteering, and preference for natural immunity were calculated. Generalized linear mixed models were conducted to study these associations.Results: Between 10.2 and 22.6% of the subjects showed high levels of negative attitudes toward vaccines. However, only 1.5% of our sampl...

Oral Presentation, Aug 1, 2017

International Journal of Environmental Research and Public Health, 2020

Reducing the burden of occupational cancers (OCs) is currently one of the most challenging Occupa... more Reducing the burden of occupational cancers (OCs) is currently one of the most challenging Occupational Health (OH) issues. The European Union (EU) has made efforts to improve the existing legal framework and developed specific legislation aimed at reducing the burden of OC. However, available data suggest that OC are underreported. In August 2019, the European Association of Schools of Occupational Medicine (EASOM) adopted a statement that highlighted the importance of improving the education and training of Medical Doctors (MDs) to facilitate improvements in recognizing and reporting OC. To achieve this, EASOM proposes to promote OH education and training of MDs at undergraduate and postgraduate levels, foster harmonization of OH education and teaching standards and programs across EU countries, and enhance cooperation between universities and international scientific associations. Finally, we suggest that occupational data should be recorded in cancer and medical registers. By en...

Forensic Science International: Genetics Supplement Series, 2019

The study of Y-chromosome SNPs allows to link haplogroups to paternal biogeographical ancestry. T... more The study of Y-chromosome SNPs allows to link haplogroups to paternal biogeographical ancestry. The analysis of haplogroup R1b-M269 and its subhaplogroups in Latin American populations can help to assess the European paternal contribution. The objective of this work was to study the presence of R1b-DF27 in Latin American Mestizo populations. The obtained results reveal an average frequency of 29-35% with a north-south increasing pattern, seeming to agree with the influence of the Spanish commerce routes with America in the colonial era. Thus, the finding of DF27 in a forensic context could be due to individuals of both European and Latin American ancestry. In summary, the present work highlights the interest to further analyze R1b-DF27 in Latin America.

Forensic science international. Genetics, May 1, 2018

Y-specific short tandem repeat (Y-STR) loci display different mutation rates and consequently are... more Y-specific short tandem repeat (Y-STR) loci display different mutation rates and consequently are suitable for forensic, genealogical, and evolutionary studies that require different levels of timelines and resolution. Recent efforts have focused on implementing Rapidly Mutating (RM) Y-STRs to assess male specific profiles. However, due to their high mutation rate their use in kinship testing or in phylogenetic studies may be less reliable. In the present study, a novel Slowly Mutating Y-STR (SM) panel, including DYS388, DYS426, DYS461 (Y-GATA-A7.2), DYS485, DYS525, and DYS561, has been developed and evaluated in a sample set of 628 unrelated males from different worldwide populations. This panel is reproducible, sensitive, and robust for forensic applications and may be useful in conjunction with the common multiplexes, particularly in exclusion of kinship cases where minimal discrimination is reported employing the rapidly mutating Y-STR systems. Furthermore, SM Y-STR data may be ...

$Research paper thumbnail of Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ$

Scientific Reports, 2017

Haplogroup R1b-M269 comprises most Western European Y chromosomes; of its main branches, R1b-DF27... more Haplogroup R1b-M269 comprises most Western European Y chromosomes; of its main branches, R1b-DF27 is by far the least known, and it appears to be highly prevalent only in Iberia. We have genotyped 1072 R1b-DF27 chromosomes for six additional SNPs and 17 Y-STRs in population samples from Spain, Portugal and France in order to further characterize this lineage and, in particular, to ascertain the time and place where it originated, as well as its subsequent dynamics. We found that R1b-DF27 is present in frequencies ~40% in Iberian populations and up to 70% in Basques, but it drops quickly to 6–20% in France. Overall, the age of R1b-DF27 is estimated at ~4,200 years ago, at the transition between the Neolithic and the Bronze Age, when the Y chromosome landscape of W Europe was thoroughly remodeled. In spite of its high frequency in Basques, Y-STR internal diversity of R1b-DF27 is lower there, and results in more recent age estimates; NE Iberia is the most likely place of origin of DF27...

Electrophoresis, Apr 16, 2016

A Y-STR multiplex system has been developed with the purpose of complementing the widely used 17 ... more A Y-STR multiplex system has been developed with the purpose of complementing the widely used 17 Y-STR haplotyping (AmpFlSTR Y Filer® PCR Amplification kit) routinely employed in forensic and population genetic studies. This new multiplex system includes six additional STR loci (DYS576, DYS481, DYS549, DYS533, DYS570, and DYS643) to reach the 23 Y-STR of the PowerPlex® Y23 System. In addition, this kit includes the DYS456 and DYS385 loci for traceability purposes. Male samples from 625 individuals from ten worldwide populations were genotyped, including three sample sets from populations previously published with the 17 Y-STR system to expand their current data. Validation studies demonstrated good performance of the panel set in terms of concordance, sensitivity, and stability in the presence of inhibitors and artificially degraded DNA. The results obtained for haplotype diversity and discrimination capacity with this multiplex system were considerably high, providing further evide...

Forensic Science International: Genetics, 2017