Behnaz Yousefghahari - Academia.edu (original) (raw)

Papers by Behnaz Yousefghahari

Research paper thumbnail of Comparison of sensitivity and specificity of anti-CCP and anti-MCV antibodies in an Iranian cohort of patients with rheumatoid arthritis

PubMed, 2013

Background : Anti-CCP is a test commonly used for the diagnosis of rheumatoid arthritis. The aim ... more Background : Anti-CCP is a test commonly used for the diagnosis of rheumatoid arthritis. The aim of this study was to determine the diagnostic values of ACCP compared to anti-MCV in rheumatoid arthritis patients in north of Iran. Methods: The serum samples of 150 RA patients and 75 controls, with the mean age of 49.6+11.8 and 48.8+12 years respectively, were tested using the commercially available ELISA kits for ACCP and anti-MCV. Sensitivity, Specificity were determined and Roc curve were used for comparison between these two groups. Results: The sensitivity of ACCP versus anti-MCV was 85% and 81%, respectively. Specificity was 96% and 95%, respectively. In the RA patients, ACCP was positive in 127 (84.7%) and anti MCV in 121 (80.7%) cases. In the control group, these parameters were positive in 3 (4%) and 4 (5.3%) (p<0.0001 and p<0.0001, respectively). The correlation coefficient for ACCP and anti-MCV was calculated at 0.63 (p<0.001). The area under the curve for ACCP was 0.941±0.015 (p<0.001), anti-MCV was 0.902±0.02 (p<0.001). The measure of agreement (Kappa) for these variables was 0.81. In these patients, there was no correlation between DAS28 and the positivity of these tests. Conclusion: It was concluded, compared to ACCP, anti-MCV has approximately the same accuracy for the diagnosis of rheumatoid arthritis and it does not have additional value.

Research paper thumbnail of The prevalence and correlation of depression and anxiety with disease activity in rheumatoid arthritis

Rheumatology

IntroductionDepression and anxiety share similar symptoms with rheumatoid arthritis (RA) and thes... more IntroductionDepression and anxiety share similar symptoms with rheumatoid arthritis (RA) and these conditions are often not diagnosed or overlooked in RA. This study aimed to determine the prevalence of depression/anxiety in RA and their correlation with RA activity.Material and methodsRheumatoid arthritis patients who presented at a rheumatology clinic were selected consecutively. The diagnosis of RA was confirmed by the ACR/EULAR criteria, disease activity was assessed by Disease Activity Score based on the 28-joint count (DAS28) and patients with DAS28 > 2.6 were considered to have active RA. The diagnosis of depression and anxiety was made by the Hospital Anxiety and Depression Scale (HADS). The Pearson test was used to determine the correlation between DAS28 and HADS scores.ResultsTwo-hundred patients (female, 82%) with a mean age of 53.5 ±10.1 years and mean disease duration of 6.6 ±6.8 years were studied. Depression was diagnosed in 27 (13.5%) patients and anxiety in 38 (1...

Research paper thumbnail of Poster Presentations: P-35: Feasibility of Using Nano Textiles for Hypothermia or Applied to a Part of the Body for Warmth

Research paper thumbnail of Poster Presentations: P-74: Comparison of Serum C3 and C3A, C3D Levels in Systemic Lupus Erythematosus Patients During Active Disease and After Remission

Research paper thumbnail of Increased frequency of activated regulatory T cells in patients with lupus nephritis

Research paper thumbnail of Case Report

Isolated thrombocytopenia; A report of a rare presentation of childhood systemic lupus erythemato... more Isolated thrombocytopenia; A report of a rare presentation of childhood systemic lupus erythematosus (SLE) Background: Systemic lupus erythematosus (SLE) has various presentations in children. Hematologic abnormalities is common in childhood onset of SLE, however, isolated thrombocytopenia is relatively rare. Thus, we present a child with isolated thrombocytopenia as a rare presentation of SLE. Case presentation: A 12-year-old boy with chief complaints of loss of appetite, weight loss, decreased platelet count (8000/µL) and lymph node enlargement was referred to our hospital. Biopsy of lymph node showed reactive lymphadenopathy. Investigations regarding infectious disease was negative. Platelet count remained low after low dose steroidned therapy. Antinuclear antibody (ANA) and anti-double stranded DNA antibody screening tests were positive with titer of 1/62 and 1/54, respectively. Therefore, juvenile SLE was considered as the final diagnosis and raising the dose of prednisolone to...

Research paper thumbnail of Three cases of alkaptonuria in one family in Mazandaran Province, Iran

Caspian journal of internal medicine, 2013

Alkaptonuria is a rare genetic disease leading to the accumulation of homogentesic acid in joint ... more Alkaptonuria is a rare genetic disease leading to the accumulation of homogentesic acid in joint and ear cartilage, sclera and some other tissues causing significant morbidity in these patients. In this paper, we report three cases of Alkaptonuria among the family or household members. A 51-year-old man with mechanical low back and knee pain was referred to Rheumatology Clinic of Babol University of Medical Sciences. The physical examination showed thoracic kyphosis and limitation of motion in thoraco-lumbar spine, severe knee osteoarthritis and blue-black discoloration of ear cartilages. There was intervertebral disc calcification in plain radiography, and mitral valve calcification in echocardiography. His urine sample was tested positive in Benedict's test. The diagnosis was confirmed by qualitative assessment of homogentesic acid (HGA) that was highly positive. In addition, we found two more cases of Alkaptonuria in his family. Although alkaptonuria is a rare disease, but it...

Research paper thumbnail of Frequency of ocular involvement in 100 cases of Behcet syndrome in Babol, North of Iran

Caspian Journal of Internal Medicine, Jan 15, 2010

Research paper thumbnail of Comparison of Sensitivity and Specificity of Alvarado Score with Modified Alvarado Score in Patients with Acute Appendicitis: In a Tertiary Care Hospital Rims, Srikakulam

Journal of Evolution of Medical and Dental Sciences, 2016

Research paper thumbnail of Hearing status in patients with rheumatoid arthritis

Caspian Journal of Internal Medicine, 2019

Background: Previous studies showed that one of the complications of rheumatoid arthritis disease... more Background: Previous studies showed that one of the complications of rheumatoid arthritis disease was auditory disorder. The goal of the present study was to compare the auditory status in patients with rheumatoid arthritis and healthy individuals. Methods: In the present case-control study, 30 normal persons and 60 persons with rheumatoid arthritis with mean age of 46.72 and standard deviation of 6.76 of both genders were appraised using pure tone audiometry, tympanometry and speech audiometry. The mean disease duration in patients with rheumatoid arthritis was 12.51±6.09 years. Results: The frequency of hearing loss in rheumatoid arthritis group was significantly more than the control group (p=0.001). All patients had sensorineural hearing loss. Only in 5% of rheumatoid arthritis group, abnormal tympanometry (as type) was reported. Speech discrimination score analysis showed significant difference between the patients with rheumatoid arthritis and controls. In terms of hearing thr...

Research paper thumbnail of AB1243 Comparison of the sensitivity and specificity of ACCP and anti MCV in rhematoid artheritis patients

Annals of the Rheumatic Diseases, 2013

Background Rheumatoid arthritis is a systemic inflammatory disease that mainly affects small join... more Background Rheumatoid arthritis is a systemic inflammatory disease that mainly affects small joints. It has a destructive potential, then early diagnosis and treatment can prevent deformities and extra articular manifestations. According to the studies ACCP test is the most sensitive and specific biological marker of the disease, but in some studies Anti MCV is comparable with ACCP as a specific marker. Objectives In this study we compared the sensitivity and specificity of the above mentioned tests. Methods This cross sectional study was carried out on 150 rheumatoid arthritis patients and 75 controls. In the patients group there were 34 males and 116 females with the mean age of 49.57±11.98 and in the control group 17 males and 58 females with mean age of 48.85±11.98years old. For each and every subject approximately 8cc of blood was drawn, serums were separated. Then, ACCP and Anti MCV by using Elisa method were measured. The results were analyzed with SPSS software. Results In t...

Research paper thumbnail of Squamous cell carcinoma of lung with unusual site of metastasis

Caspian journal of internal medicine, 2012

BACKGROUND Lung cancer ranks among the most common and most lethal malignancies worldwide. Once v... more BACKGROUND Lung cancer ranks among the most common and most lethal malignancies worldwide. Once vascular or lymphatic invasions occur, metastatic dissemination to distant sites is common. Bone, liver, adrenals, and brain are the most frequent sites of the distant disease. In this study we present a case of squamous cell carcinoma of lung with metastasis of the left knee bursa. CASE PRESENTATION A smoker man presented with cough and hemoptysis and squamous cell carcinoma of lung was diagnosed. Fourteen months later he developed pain and swelling of left knee. The biopsy and pathologic examination of the left knee bursa showed involvement of the bursa. CONCLUSION Squamous cell carcinoma of lung can metastasize in the unusual sites of the body.

Research paper thumbnail of Effects of Rheumatoid Arthritis on the Larynx

Introduction: The aim of the present study was to compare the videolaryngostroboscopic findings b... more Introduction: The aim of the present study was to compare the videolaryngostroboscopic findings between patients with rheumatoid arthritis and vocally healthy controls. Materials and Methods: This case-control descriptive study was performed on 113 people, including 50 patients with rheumatoid arthritis and 63 controls. The participants were subjected to videolaryngostroboscopic examinations in order to evaluate fundamental frequency, different structural vocal lesions, patterns of glottal closure, subglottal changes, supraglottis appearance, and movement patterns of the arytenoid cartilage. The obtained results were compared between the two research groups. Data analysis was performed in the Statistical Package for the Social Sciences, version 24.0. A p-value less than 0.05 was considered statistically significant. Results: The results revealed a statistically significant difference between the two groups in terms of the complete pattern (P=0.00) and strained state of glottal closu...

Research paper thumbnail of Comparison of sensitivity and specificity of anti-CCP and anti-MCV antibodies in an Iranian cohort of patients with rheumatoid arthritis

Caspian journal of internal medicine, 2013

Background : Anti-CCP is a test commonly used for the diagnosis of rheumatoid arthritis. The aim ... more Background : Anti-CCP is a test commonly used for the diagnosis of rheumatoid arthritis. The aim of this study was to determine the diagnostic values of ACCP compared to anti-MCV in rheumatoid arthritis patients in north of Iran. The serum samples of 150 RA patients and 75 controls, with the mean age of 49.6+11.8 and 48.8+12 years respectively, were tested using the commercially available ELISA kits for ACCP and anti-MCV. Sensitivity, Specificity were determined and Roc curve were used for comparison between these two groups. The sensitivity of ACCP versus anti-MCV was 85% and 81%, respectively. Specificity was 96% and 95%, respectively. In the RA patients, ACCP was positive in 127 (84.7%) and anti MCV in 121 (80.7%) cases. In the control group, these parameters were positive in 3 (4%) and 4 (5.3%) (p<0.0001 and p<0.0001, respectively). The correlation coefficient for ACCP and anti-MCV was calculated at 0.63 (p<0.001). The area under the curve for ACCP was 0.941±0.015 (p&lt...

Research paper thumbnail of Three cases of alkaptonuria in one family in Mazandaran Province, Iran

Caspian journal of internal medicine, 2013

Alkaptonuria is a rare genetic disease leading to the accumulation of homogentesic acid in joint ... more Alkaptonuria is a rare genetic disease leading to the accumulation of homogentesic acid in joint and ear cartilage, sclera and some other tissues causing significant morbidity in these patients. In this paper, we report three cases of Alkaptonuria among the family or household members. A 51-year-old man with mechanical low back and knee pain was referred to Rheumatology Clinic of Babol University of Medical Sciences. The physical examination showed thoracic kyphosis and limitation of motion in thoraco-lumbar spine, severe knee osteoarthritis and blue-black discoloration of ear cartilages. There was intervertebral disc calcification in plain radiography, and mitral valve calcification in echocardiography. His urine sample was tested positive in Benedict's test. The diagnosis was confirmed by qualitative assessment of homogentesic acid (HGA) that was highly positive. In addition, we found two more cases of Alkaptonuria in his family. Although alkaptonuria is a rare disease, but it...

Research paper thumbnail of Restorative effect of vitamin D deficiency on knee pain and quadriceps muscle strength in knee osteoarthritis

Research paper thumbnail of Squamous cell carcinoma of lung with unusual site of metastasis

Caspian journal of internal medicine, 2012

Lung cancer ranks among the most common and most lethal malignancies worldwide. Once vascular or ... more Lung cancer ranks among the most common and most lethal malignancies worldwide. Once vascular or lymphatic invasions occur, metastatic dissemination to distant sites is common. Bone, liver, adrenals, and brain are the most frequent sites of the distant disease. In this study we present a case of squamous cell carcinoma of lung with metastasis of the left knee bursa. A smoker man presented with cough and hemoptysis and squamous cell carcinoma of lung was diagnosed. Fourteen months later he developed pain and swelling of left knee. The biopsy and pathologic examination of the left knee bursa showed involvement of the bursa. Squamous cell carcinoma of lung can metastasize in the unusual sites of the body.

Research paper thumbnail of Takayasu arteritis in a young female

Caspian journal of internal medicine, 2011

Takayasu arteritis is a granulomatous vasculitis which mainly involves the large arterial vessels... more Takayasu arteritis is a granulomatous vasculitis which mainly involves the large arterial vessels. The disease is rare and it is more common in females aged between 15-30 years old. In this paper, we report a case of takayasu arteritis in Babol, north of Iran. A 22 - year old female was admitted to the Department of Infectious Diseases of Rouhani Teaching Hospital due to anemia, high erythrocyte sedimentation rate (ESR), low grade fever and weight loss in the early summer of 2011. Her problems started four years ago and was hospitalized in another hospital and after full investigation, no diagnosis was found. Physical exam showed a vascular problem, then MRI angiography was done and showed an involvement of right carotid, abdominal aorta and right iliac arteries and the diagnosis of Takayasu Arthritis was confirmed. Prednisolone was administered, her fever subsided and ESR, CRP and hemoglobin were normalized. Takayasu arteritis should be considered in the differential diagnosis of p...

Research paper thumbnail of Theoretical Study of Central Nervous Systems to Control Body Posture despite Redundancy

ABSTRACT Finding the algorithm which central nervous system(CNS) uses to maintain a posture or pr... more ABSTRACT Finding the algorithm which central nervous system(CNS) uses to maintain a posture or predict the body postures during different movements despite kinematic redundancy is one of interest of the researchers who works in fields such as rheumatology, Biomechanics and biomedical engineering. Some malformation arouse in musculoskeletal system which is resulted in inaccurately function of muscle activation and control. Therefore it is so important to know that how the CNS controls the variation of body posture during different tasks. Since the optimization-based solution provides an appropriate framework to solve these type of problems, so one of this sort methods which named predictive dynamics is used to simulate the manual lifting task as a case study.

Research paper thumbnail of Risk of COVID-19 infection in patients with rheumatic disease taking disease-modifying anti-rheumatic drugs

Research paper thumbnail of Comparison of sensitivity and specificity of anti-CCP and anti-MCV antibodies in an Iranian cohort of patients with rheumatoid arthritis

PubMed, 2013

Background : Anti-CCP is a test commonly used for the diagnosis of rheumatoid arthritis. The aim ... more Background : Anti-CCP is a test commonly used for the diagnosis of rheumatoid arthritis. The aim of this study was to determine the diagnostic values of ACCP compared to anti-MCV in rheumatoid arthritis patients in north of Iran. Methods: The serum samples of 150 RA patients and 75 controls, with the mean age of 49.6+11.8 and 48.8+12 years respectively, were tested using the commercially available ELISA kits for ACCP and anti-MCV. Sensitivity, Specificity were determined and Roc curve were used for comparison between these two groups. Results: The sensitivity of ACCP versus anti-MCV was 85% and 81%, respectively. Specificity was 96% and 95%, respectively. In the RA patients, ACCP was positive in 127 (84.7%) and anti MCV in 121 (80.7%) cases. In the control group, these parameters were positive in 3 (4%) and 4 (5.3%) (p<0.0001 and p<0.0001, respectively). The correlation coefficient for ACCP and anti-MCV was calculated at 0.63 (p<0.001). The area under the curve for ACCP was 0.941±0.015 (p<0.001), anti-MCV was 0.902±0.02 (p<0.001). The measure of agreement (Kappa) for these variables was 0.81. In these patients, there was no correlation between DAS28 and the positivity of these tests. Conclusion: It was concluded, compared to ACCP, anti-MCV has approximately the same accuracy for the diagnosis of rheumatoid arthritis and it does not have additional value.

Research paper thumbnail of The prevalence and correlation of depression and anxiety with disease activity in rheumatoid arthritis

Rheumatology

IntroductionDepression and anxiety share similar symptoms with rheumatoid arthritis (RA) and thes... more IntroductionDepression and anxiety share similar symptoms with rheumatoid arthritis (RA) and these conditions are often not diagnosed or overlooked in RA. This study aimed to determine the prevalence of depression/anxiety in RA and their correlation with RA activity.Material and methodsRheumatoid arthritis patients who presented at a rheumatology clinic were selected consecutively. The diagnosis of RA was confirmed by the ACR/EULAR criteria, disease activity was assessed by Disease Activity Score based on the 28-joint count (DAS28) and patients with DAS28 > 2.6 were considered to have active RA. The diagnosis of depression and anxiety was made by the Hospital Anxiety and Depression Scale (HADS). The Pearson test was used to determine the correlation between DAS28 and HADS scores.ResultsTwo-hundred patients (female, 82%) with a mean age of 53.5 ±10.1 years and mean disease duration of 6.6 ±6.8 years were studied. Depression was diagnosed in 27 (13.5%) patients and anxiety in 38 (1...

Research paper thumbnail of Poster Presentations: P-35: Feasibility of Using Nano Textiles for Hypothermia or Applied to a Part of the Body for Warmth

Research paper thumbnail of Poster Presentations: P-74: Comparison of Serum C3 and C3A, C3D Levels in Systemic Lupus Erythematosus Patients During Active Disease and After Remission

Research paper thumbnail of Increased frequency of activated regulatory T cells in patients with lupus nephritis

Research paper thumbnail of Case Report

Isolated thrombocytopenia; A report of a rare presentation of childhood systemic lupus erythemato... more Isolated thrombocytopenia; A report of a rare presentation of childhood systemic lupus erythematosus (SLE) Background: Systemic lupus erythematosus (SLE) has various presentations in children. Hematologic abnormalities is common in childhood onset of SLE, however, isolated thrombocytopenia is relatively rare. Thus, we present a child with isolated thrombocytopenia as a rare presentation of SLE. Case presentation: A 12-year-old boy with chief complaints of loss of appetite, weight loss, decreased platelet count (8000/µL) and lymph node enlargement was referred to our hospital. Biopsy of lymph node showed reactive lymphadenopathy. Investigations regarding infectious disease was negative. Platelet count remained low after low dose steroidned therapy. Antinuclear antibody (ANA) and anti-double stranded DNA antibody screening tests were positive with titer of 1/62 and 1/54, respectively. Therefore, juvenile SLE was considered as the final diagnosis and raising the dose of prednisolone to...

Research paper thumbnail of Three cases of alkaptonuria in one family in Mazandaran Province, Iran

Caspian journal of internal medicine, 2013

Alkaptonuria is a rare genetic disease leading to the accumulation of homogentesic acid in joint ... more Alkaptonuria is a rare genetic disease leading to the accumulation of homogentesic acid in joint and ear cartilage, sclera and some other tissues causing significant morbidity in these patients. In this paper, we report three cases of Alkaptonuria among the family or household members. A 51-year-old man with mechanical low back and knee pain was referred to Rheumatology Clinic of Babol University of Medical Sciences. The physical examination showed thoracic kyphosis and limitation of motion in thoraco-lumbar spine, severe knee osteoarthritis and blue-black discoloration of ear cartilages. There was intervertebral disc calcification in plain radiography, and mitral valve calcification in echocardiography. His urine sample was tested positive in Benedict's test. The diagnosis was confirmed by qualitative assessment of homogentesic acid (HGA) that was highly positive. In addition, we found two more cases of Alkaptonuria in his family. Although alkaptonuria is a rare disease, but it...

Research paper thumbnail of Frequency of ocular involvement in 100 cases of Behcet syndrome in Babol, North of Iran

Caspian Journal of Internal Medicine, Jan 15, 2010

Research paper thumbnail of Comparison of Sensitivity and Specificity of Alvarado Score with Modified Alvarado Score in Patients with Acute Appendicitis: In a Tertiary Care Hospital Rims, Srikakulam

Journal of Evolution of Medical and Dental Sciences, 2016

Research paper thumbnail of Hearing status in patients with rheumatoid arthritis

Caspian Journal of Internal Medicine, 2019

Background: Previous studies showed that one of the complications of rheumatoid arthritis disease... more Background: Previous studies showed that one of the complications of rheumatoid arthritis disease was auditory disorder. The goal of the present study was to compare the auditory status in patients with rheumatoid arthritis and healthy individuals. Methods: In the present case-control study, 30 normal persons and 60 persons with rheumatoid arthritis with mean age of 46.72 and standard deviation of 6.76 of both genders were appraised using pure tone audiometry, tympanometry and speech audiometry. The mean disease duration in patients with rheumatoid arthritis was 12.51±6.09 years. Results: The frequency of hearing loss in rheumatoid arthritis group was significantly more than the control group (p=0.001). All patients had sensorineural hearing loss. Only in 5% of rheumatoid arthritis group, abnormal tympanometry (as type) was reported. Speech discrimination score analysis showed significant difference between the patients with rheumatoid arthritis and controls. In terms of hearing thr...

Research paper thumbnail of AB1243 Comparison of the sensitivity and specificity of ACCP and anti MCV in rhematoid artheritis patients

Annals of the Rheumatic Diseases, 2013

Background Rheumatoid arthritis is a systemic inflammatory disease that mainly affects small join... more Background Rheumatoid arthritis is a systemic inflammatory disease that mainly affects small joints. It has a destructive potential, then early diagnosis and treatment can prevent deformities and extra articular manifestations. According to the studies ACCP test is the most sensitive and specific biological marker of the disease, but in some studies Anti MCV is comparable with ACCP as a specific marker. Objectives In this study we compared the sensitivity and specificity of the above mentioned tests. Methods This cross sectional study was carried out on 150 rheumatoid arthritis patients and 75 controls. In the patients group there were 34 males and 116 females with the mean age of 49.57±11.98 and in the control group 17 males and 58 females with mean age of 48.85±11.98years old. For each and every subject approximately 8cc of blood was drawn, serums were separated. Then, ACCP and Anti MCV by using Elisa method were measured. The results were analyzed with SPSS software. Results In t...

Research paper thumbnail of Squamous cell carcinoma of lung with unusual site of metastasis

Caspian journal of internal medicine, 2012

BACKGROUND Lung cancer ranks among the most common and most lethal malignancies worldwide. Once v... more BACKGROUND Lung cancer ranks among the most common and most lethal malignancies worldwide. Once vascular or lymphatic invasions occur, metastatic dissemination to distant sites is common. Bone, liver, adrenals, and brain are the most frequent sites of the distant disease. In this study we present a case of squamous cell carcinoma of lung with metastasis of the left knee bursa. CASE PRESENTATION A smoker man presented with cough and hemoptysis and squamous cell carcinoma of lung was diagnosed. Fourteen months later he developed pain and swelling of left knee. The biopsy and pathologic examination of the left knee bursa showed involvement of the bursa. CONCLUSION Squamous cell carcinoma of lung can metastasize in the unusual sites of the body.

Research paper thumbnail of Effects of Rheumatoid Arthritis on the Larynx

Introduction: The aim of the present study was to compare the videolaryngostroboscopic findings b... more Introduction: The aim of the present study was to compare the videolaryngostroboscopic findings between patients with rheumatoid arthritis and vocally healthy controls. Materials and Methods: This case-control descriptive study was performed on 113 people, including 50 patients with rheumatoid arthritis and 63 controls. The participants were subjected to videolaryngostroboscopic examinations in order to evaluate fundamental frequency, different structural vocal lesions, patterns of glottal closure, subglottal changes, supraglottis appearance, and movement patterns of the arytenoid cartilage. The obtained results were compared between the two research groups. Data analysis was performed in the Statistical Package for the Social Sciences, version 24.0. A p-value less than 0.05 was considered statistically significant. Results: The results revealed a statistically significant difference between the two groups in terms of the complete pattern (P=0.00) and strained state of glottal closu...

Research paper thumbnail of Comparison of sensitivity and specificity of anti-CCP and anti-MCV antibodies in an Iranian cohort of patients with rheumatoid arthritis

Caspian journal of internal medicine, 2013

Background : Anti-CCP is a test commonly used for the diagnosis of rheumatoid arthritis. The aim ... more Background : Anti-CCP is a test commonly used for the diagnosis of rheumatoid arthritis. The aim of this study was to determine the diagnostic values of ACCP compared to anti-MCV in rheumatoid arthritis patients in north of Iran. The serum samples of 150 RA patients and 75 controls, with the mean age of 49.6+11.8 and 48.8+12 years respectively, were tested using the commercially available ELISA kits for ACCP and anti-MCV. Sensitivity, Specificity were determined and Roc curve were used for comparison between these two groups. The sensitivity of ACCP versus anti-MCV was 85% and 81%, respectively. Specificity was 96% and 95%, respectively. In the RA patients, ACCP was positive in 127 (84.7%) and anti MCV in 121 (80.7%) cases. In the control group, these parameters were positive in 3 (4%) and 4 (5.3%) (p<0.0001 and p<0.0001, respectively). The correlation coefficient for ACCP and anti-MCV was calculated at 0.63 (p<0.001). The area under the curve for ACCP was 0.941±0.015 (p&lt...

Research paper thumbnail of Three cases of alkaptonuria in one family in Mazandaran Province, Iran

Caspian journal of internal medicine, 2013

Alkaptonuria is a rare genetic disease leading to the accumulation of homogentesic acid in joint ... more Alkaptonuria is a rare genetic disease leading to the accumulation of homogentesic acid in joint and ear cartilage, sclera and some other tissues causing significant morbidity in these patients. In this paper, we report three cases of Alkaptonuria among the family or household members. A 51-year-old man with mechanical low back and knee pain was referred to Rheumatology Clinic of Babol University of Medical Sciences. The physical examination showed thoracic kyphosis and limitation of motion in thoraco-lumbar spine, severe knee osteoarthritis and blue-black discoloration of ear cartilages. There was intervertebral disc calcification in plain radiography, and mitral valve calcification in echocardiography. His urine sample was tested positive in Benedict's test. The diagnosis was confirmed by qualitative assessment of homogentesic acid (HGA) that was highly positive. In addition, we found two more cases of Alkaptonuria in his family. Although alkaptonuria is a rare disease, but it...

Research paper thumbnail of Restorative effect of vitamin D deficiency on knee pain and quadriceps muscle strength in knee osteoarthritis

Research paper thumbnail of Squamous cell carcinoma of lung with unusual site of metastasis

Caspian journal of internal medicine, 2012

Lung cancer ranks among the most common and most lethal malignancies worldwide. Once vascular or ... more Lung cancer ranks among the most common and most lethal malignancies worldwide. Once vascular or lymphatic invasions occur, metastatic dissemination to distant sites is common. Bone, liver, adrenals, and brain are the most frequent sites of the distant disease. In this study we present a case of squamous cell carcinoma of lung with metastasis of the left knee bursa. A smoker man presented with cough and hemoptysis and squamous cell carcinoma of lung was diagnosed. Fourteen months later he developed pain and swelling of left knee. The biopsy and pathologic examination of the left knee bursa showed involvement of the bursa. Squamous cell carcinoma of lung can metastasize in the unusual sites of the body.

Research paper thumbnail of Takayasu arteritis in a young female

Caspian journal of internal medicine, 2011

Takayasu arteritis is a granulomatous vasculitis which mainly involves the large arterial vessels... more Takayasu arteritis is a granulomatous vasculitis which mainly involves the large arterial vessels. The disease is rare and it is more common in females aged between 15-30 years old. In this paper, we report a case of takayasu arteritis in Babol, north of Iran. A 22 - year old female was admitted to the Department of Infectious Diseases of Rouhani Teaching Hospital due to anemia, high erythrocyte sedimentation rate (ESR), low grade fever and weight loss in the early summer of 2011. Her problems started four years ago and was hospitalized in another hospital and after full investigation, no diagnosis was found. Physical exam showed a vascular problem, then MRI angiography was done and showed an involvement of right carotid, abdominal aorta and right iliac arteries and the diagnosis of Takayasu Arthritis was confirmed. Prednisolone was administered, her fever subsided and ESR, CRP and hemoglobin were normalized. Takayasu arteritis should be considered in the differential diagnosis of p...

Research paper thumbnail of Theoretical Study of Central Nervous Systems to Control Body Posture despite Redundancy

ABSTRACT Finding the algorithm which central nervous system(CNS) uses to maintain a posture or pr... more ABSTRACT Finding the algorithm which central nervous system(CNS) uses to maintain a posture or predict the body postures during different movements despite kinematic redundancy is one of interest of the researchers who works in fields such as rheumatology, Biomechanics and biomedical engineering. Some malformation arouse in musculoskeletal system which is resulted in inaccurately function of muscle activation and control. Therefore it is so important to know that how the CNS controls the variation of body posture during different tasks. Since the optimization-based solution provides an appropriate framework to solve these type of problems, so one of this sort methods which named predictive dynamics is used to simulate the manual lifting task as a case study.

Research paper thumbnail of Risk of COVID-19 infection in patients with rheumatic disease taking disease-modifying anti-rheumatic drugs