Aishatu Bello Hassan - Academia.edu (original) (raw)

Papers by Aishatu Bello Hassan

Research paper thumbnail of Treatment of R-3327 prostate tumors with a somatostatin analogue (somatuline) as adjuvant therapy following surgical castration

Cancer research, 1990

This study addresses, in an animal tumor model, the clinical problem of "escape from castrat... more This study addresses, in an animal tumor model, the clinical problem of "escape from castration inhibition." Somatuline (BIM-23014C), an octapeptide analogue of somatostatin with enhanced potency and longer duration of biological activity was administered as a therapeutic agent, over a period of 90 and 197 days, to male Copenhagen rats bearing syngeneic Dunning R-3327-H prostate tumors. Androgen sensitivity was confirmed by the response of tumors to castration and by the significant inhibition of tumor growth in intact animals by treatment with a luteinizing hormone-releasing hormone antagonist (BIM-21009). Inhibition of tumor growth resulting from castration persisted for 102 days, after which progressive regrowth occurred, indicating an escape from castration inhibition. When Somatuline treatment was initiated as an adjuvant therapy 5 days after castration, the rate of tumor regrowth during escape was significantly retarded. During the period of 197 days postcastration, ...

Research paper thumbnail of An Assessment of Alternative Water Source for Domestic Used in Minna Metropolis, Niger State, Nigeria

Journal of environment and earth science, 2014

Making freshwater available in urban centre are major challenge to be faced in 21 st century glob... more Making freshwater available in urban centre are major challenge to be faced in 21 st century globally. Population growth and industrialisation have put a lot of pressure on water resources the world over. Minna, the capital city of Niger State Nigeria, has witnessed population growth due to the influx of people from the various regions to seek greener pastures. The population growths have resulted in an inadequate water supply to the populace by conventional means. These problems result in an individual effort to meet their daily water demand. To explore this problem, structured questionnaire were distributed to two hundred households purposively selected from six areas in the town and semi-structured interviews were administered on five water analyst. Statistical Package for Social Science (SPSS) was used to analyze the data collected. The study reveals that inadequate budgetary allocation to ministry of water resources is the major problem hindering water availability in Minna. Th...

Research paper thumbnail of An Assessment of Alternative Water Source for Domestic Used in Minna Metropolis, Niger State, Nigeria

Journal of Environment and Earth Science, 2014

Making freshwater available in urban centre are major challenge to be faced in 21 st century glob... more Making freshwater available in urban centre are major challenge to be faced in 21 st century globally. Population growth and industrialisation have put a lot of pressure on water resources the world over. Minna, the capital city of Niger State Nigeria, has witnessed population growth due to the influx of people from the various regions to seek greener pastures. The population growths have resulted in an inadequate water supply to the populace by conventional means. These problems result in an individual effort to meet their daily water demand. To explore this problem, structured questionnaire were distributed to two hundred households purposively selected from six areas in the town and semi-structured interviews were administered on five water analyst. Statistical Package for Social Science (SPSS) was used to analyze the data collected. The study reveals that inadequate budgetary allocation to ministry of water resources is the major problem hindering water availability in Minna. The three alternative sources of water supply for domestic use identified were well water, water from vendors and boreholes. Consequently increase in resource allocation to the ministry of water resources in a way of policy framework that guaranty private investment in water sector, among others to improve water availability in the study area.

Research paper thumbnail of Treatment of R-3327 prostate tumors with a somatostatin analogue (somatuline) as adjuvant therapy following surgical castration

Cancer research, 1990

This study addresses, in an animal tumor model, the clinical problem of "escape from castrat... more This study addresses, in an animal tumor model, the clinical problem of "escape from castration inhibition." Somatuline (BIM-23014C), an octapeptide analogue of somatostatin with enhanced potency and longer duration of biological activity was administered as a therapeutic agent, over a period of 90 and 197 days, to male Copenhagen rats bearing syngeneic Dunning R-3327-H prostate tumors. Androgen sensitivity was confirmed by the response of tumors to castration and by the significant inhibition of tumor growth in intact animals by treatment with a luteinizing hormone-releasing hormone antagonist (BIM-21009). Inhibition of tumor growth resulting from castration persisted for 102 days, after which progressive regrowth occurred, indicating an escape from castration inhibition. When Somatuline treatment was initiated as an adjuvant therapy 5 days after castration, the rate of tumor regrowth during escape was significantly retarded. During the period of 197 days postcastration, ...

Research paper thumbnail of An Assessment of Alternative Water Source for Domestic Used in Minna Metropolis, Niger State, Nigeria

Journal of environment and earth science, 2014

Making freshwater available in urban centre are major challenge to be faced in 21 st century glob... more Making freshwater available in urban centre are major challenge to be faced in 21 st century globally. Population growth and industrialisation have put a lot of pressure on water resources the world over. Minna, the capital city of Niger State Nigeria, has witnessed population growth due to the influx of people from the various regions to seek greener pastures. The population growths have resulted in an inadequate water supply to the populace by conventional means. These problems result in an individual effort to meet their daily water demand. To explore this problem, structured questionnaire were distributed to two hundred households purposively selected from six areas in the town and semi-structured interviews were administered on five water analyst. Statistical Package for Social Science (SPSS) was used to analyze the data collected. The study reveals that inadequate budgetary allocation to ministry of water resources is the major problem hindering water availability in Minna. Th...

Research paper thumbnail of An Assessment of Alternative Water Source for Domestic Used in Minna Metropolis, Niger State, Nigeria

Journal of Environment and Earth Science, 2014

Making freshwater available in urban centre are major challenge to be faced in 21 st century glob... more Making freshwater available in urban centre are major challenge to be faced in 21 st century globally. Population growth and industrialisation have put a lot of pressure on water resources the world over. Minna, the capital city of Niger State Nigeria, has witnessed population growth due to the influx of people from the various regions to seek greener pastures. The population growths have resulted in an inadequate water supply to the populace by conventional means. These problems result in an individual effort to meet their daily water demand. To explore this problem, structured questionnaire were distributed to two hundred households purposively selected from six areas in the town and semi-structured interviews were administered on five water analyst. Statistical Package for Social Science (SPSS) was used to analyze the data collected. The study reveals that inadequate budgetary allocation to ministry of water resources is the major problem hindering water availability in Minna. The three alternative sources of water supply for domestic use identified were well water, water from vendors and boreholes. Consequently increase in resource allocation to the ministry of water resources in a way of policy framework that guaranty private investment in water sector, among others to improve water availability in the study area.