M. Bendersky - Academia.edu (original) (raw)
Papers by M. Bendersky
American Journal Cardiovascular Drugs, 2010
Current Therapeutic Research, 2002
... Enalapril in the Treatment of Isolated Systolic Hypertension in the Elderly: An OpenLabel, Ra... more ... Enalapril in the Treatment of Isolated Systolic Hypertension in the Elderly: An OpenLabel, Randomized, ParallelGroup Study Mario Bendersky, MD ... Laboratories, Buenos Aires, Argentina) at an initial dose of 5 mg once daily, or enalapril (GliotenO, Bago Laboratories, Buenos ...
Surgical and Radiologic Anatomy, 2012
Your article is protected by copyright and all rights are held exclusively by Springer-Verlag. Th... more Your article is protected by copyright and all rights are held exclusively by Springer-Verlag. This e-offprint is for personal use only and shall not be self-archived in electronic repositories. If you wish to self-archive your work, please use the accepted author's version for posting to your own website or your institution's repository. You may further deposit the accepted author's version on a funder's repository at a funder's request, provided it is not made publicly available until 12 months after publication.
Hipertensión y Riesgo Vascular, 2019
Resumen El presente articulo resume los conceptos principales del Consenso Argentino de Hipertens... more Resumen El presente articulo resume los conceptos principales del Consenso Argentino de Hipertension Arterial, realizado por primera vez en forma conjunta por las 3 principales sociedades cientificas relacionadas al diagnostico y tratamiento de la hipertension arterial en Argentina (Sociedad Argentina de Hipertension Arterial, Sociedad Argentina de Cardiologia y Federacion Argentina de Cardiologia). Entre sus puntos principales se enfatiza la necesidad de mejorar el diagnostico y control de la hipertension arterial, la utilizacion de tecnicas de medicion ambulatoria de la presion arterial, la importancia de la estratificacion de riesgo del paciente hipertenso y el uso precoz de combinaciones farmacologicas en el tratamiento como medio de alcanzar rapidamente el control. Finalmente se enumeran las principales recomendaciones del manejo de la hipertension en poblaciones especiales como embarazadas, adultos mayores, diabeticos, hipertensos resistentes y pacientes con enfermedad renal cronica.
American Journal of Hypertension, 2002
The contribution of hypertension to the cardiovascular events in diabetes resulted in recommendat... more The contribution of hypertension to the cardiovascular events in diabetes resulted in recommendations for aggressive treatment in patients with diabetes and hypertension. In this study, the efficacy and safety of perindopril on sitting blood pressure (BP) were analyzed in a subset of hypertensive patients maintained on concomitant oral hypoglycemic agents (nϭ899), from a 12 week, open-label, large community trial. All patients were treated with perindopril 4 mg QD for 6 weeks and could be uptitrated by the investigator to perindopril 8 mg QD for an additional 6 weeks depending on BP response. Seated BPs were measured at Baseline (antihypertensives withdrawn), Week 6, and Week 12. Perindopril treatment (4 to 8 mg QD) for 12 weeks produced a significant reduction in SBP and DBP. In patients with inadequate response at Week 6 (Group 2), increase in perindopril dose to 8 mg QD produced additional decrease in SBP and DBP, supporting the titration approach. At Week 12, BP control with perindopril defined as SBP/DBP Ͻ140/90 mmHg, SBP Ͻ140 mmHg or DBP Ͻ90 mmHg, SBP Ͻ140 mmHg, and DBP Ͻ90 mmHg was achieved in 42%, 80%, 47%, and 75%; respectively. Based on JNC VI classification (systolic/diastolic), an increase in shift of patients from Baseline to Week 12 in nonhypertensive BP categories was: Optimal 1%/14% to 9%/33%; Normal 3%/13% to 15%/27%; and High-Normal 5%/8% to 23%/15%. There were 1.3% cardiovascular adverse events, of which 0.4% were serious. Cough and angioedema were reported in 6.4% and 0.1%, respectively. In conclusion, perindopril was effective as an antihypertensive and well tolerated in hypertensive patients maintained on oral hypoglycemic agents.
Hipertensión y Riesgo Vascular, 2015
Ritmo circadiano de la presión; Cronoterapia; Presión nocturna; Ascenso matinal Resumen En la act... more Ritmo circadiano de la presión; Cronoterapia; Presión nocturna; Ascenso matinal Resumen En la actualidad conocemos el perfil tensional en la mayoría de los sujetos normoe hipertensos, y el impacto que sus modificaciones inducen sobre el riesgo cardio-y cerebrovascular. La monitorización ambulatoria de presión arterial (MAPA) ha contribuido en gran medida al conocimiento de estos parámetros. Se intenta corregir con cambios en el horario de la administración de fármacos (cronoterapia) alguno de los componentes del perfil tensional que presentan mejor correlación con el riesgo, entre ellos, el descenso nocturno y el ascenso brusco matinal de la presión. Las investigaciones en ese sentido son todavía escasas, y es necesario programar trabajos multicéntricos que puedan contestar acerca del verdadero impacto preventivo de dichas modificaciones.
Revista de la Facultad de Ciencias Médicas (Córdoba, Argentina), 1983
American Journal of Hypertension, 2005
device was analyzed for evidence of digit prejudice. Within each target treatment group, the dist... more device was analyzed for evidence of digit prejudice. Within each target treatment group, the distribution of SBP and DBP was tabulated and a kernel density estimator was used to overlay a log-normal distribution. These tabulations were then visually examined to determine if there is a suggestion of digit prejudice near the target levels for the two groups. Our study had 372 pts. with 8735 blood pressure measurements for analysis (Baseline Nϭ3061, Medication titration Nϭ1944, Quarterly visits Nϭ3730). No evidence of skipped digit for SBP in the range of 82-230 mm Hg nor for DBP in range of 40-120 mm Hg was found. 272 pts. had at least one quarterly visit while on active antiplatelet therapy (SBPϽ 130 mm HG Nϭ135, SBP 130-149 mm Hg Nϭ137) where digit prejudice could be analyzed. For SBPϽ 130 mm Hg no digit prejudice was found. For SBP130-149 mm Hg there is a suggestion of abnormal distribution of SBP 130-134 (Figure 1) with a smaller abnormal peak at 144-150 mm Hg. The Collins Pressmate algorithm does not have skipped digits as seen with DINAMAP. Clustering of SBP in the SBP 130-149 Mm Hg is worrisome for digit prejudice. Continued monitoring at 6 months intervals during the trial is needed to confirm this finding.
fac.org.ar
... Bendersky M, Kuschnir E: El MAPA en la evaluación de la efectividad de drogas antihipertensiv... more ... Bendersky M, Kuschnir E: El MAPA en la evaluación de la efectividad de drogas antihipertensivas (Editorial ... Comité HTA, FAC Trelew), MARCOS MARIN (Policlínico Bancario, Buenos Aires), FELIPE RAMOS (Fundación Favaloro, Buenos Aires), GABRIEL WAISSMAN (Hospital ...
fac.org.ar
Index La hipertensión arterial (HTA) es una enferme-dad compleja en su fisiopatologí a en la cual... more Index La hipertensión arterial (HTA) es una enferme-dad compleja en su fisiopatologí a en la cual concurren, sobre una base genética, una serie de anormalidades de los mecanismos de regulación tensional que generan cambios precoces en el sistema vascular del individuo y, sólo en forma tardía, una elevación persistente de las cifras tensionales. La HTA es un factor de riesgo para distintas situaciones patológicas cardiovasculares, como la enfermedad coronaria, el accidente cerebrovascular (ACV), la arteriopatía periférica y la insuficiencia cardíaca. La presencia de HTA duplica y a veces triplica el riesgo, especialmente en varones (Figura 1). El tratamiento de la HTA tiene como principal objetivo la reducción de la morbimortalidad cardiovascular, conservando una buena calidad de vida.
Rev Fed Arg Cardiol, 2004
... Lípidos. El diseño y la coordinación de la reunión estuvo a cargo del doctor MarioBendersky. ... more ... Lípidos. El diseño y la coordinación de la reunión estuvo a cargo del doctor MarioBendersky. Se ... cardiovascular? Ricardo Esper, Luis Juncos, Daniel Piskorz, Bernardo Spitz, Alejandro Ugarte, Jorge Villariño, Gabriel Waisman Los ...
Journal of Hypertension, 2000
Journal of Cardiovascular Pharmacology, 1988
Twenty patients (aged 33-60 years) with mild to moderate essential hypertension were studied to a... more Twenty patients (aged 33-60 years) with mild to moderate essential hypertension were studied to assess systolic ventricular function, diastolic ventricular function, and peripheral hemodynamic changes induced by nitrendipine during rest and effort, comparing the acute and chronic treatment phases. We used a randomized, placebo-controlled, double-blind, crossover protocol in the acute phase and a paired, placebo group controlled study, with 20 mg single oral daily dose for a 3-week treatment period (chronic phase). The cardiac and peripheral hemodynamic parameters were quantified by noninvasive radionuclides techniques. During acute treatment, peripheral hemodynamics showed a predominantly arteriolar vasodilatory effect with a significant fall in the previously elevated forearm vascular resistance values (-38%, p less than 0.01) and an important increase in forearm blood flow (+49%, p less than 0.01) without any changes in venous capacity. Simultaneously, nitrendipine produced a significant drop in total peripheral resistance (-36%, p less than 0.01), systolic blood pressure (-13%, p less than 0.01), and diastolic blood pressured (-17%, p less than 0.01). The sudden reduction in left ventricular (LV) afterload caused a reflex increase in heart rate (HR) (+12%, p less than 0.01), cardiac index (+37%, p less than 0.01), LV ejection fraction (+17%, p less than 0.01), and peak ejection rate, with an important decrease in LV end systolic volume (-30%, p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Hypertension, 1992
The aims of the present study were 1) to evaluate blood pressure (BP) and its distribution curve ... more The aims of the present study were 1) to evaluate blood pressure (BP) and its distribution curve in a highly representative population of children and adolescents from Cordoba, Argentina, to determine the normal BP pattern, and 2) to establish the relation between other factors and BP levels. BP data recorded during the years 1984-1987 were evaluated in 280,584 children and adolescents aged 5-15 years (52.1% boys and 47.9% girls) corresponding to the nine sanitary districts of the province (urban, rural, mountain, and plains areas), which represent 75% of the children of the whole province. Recordings were carried out by trained physicians who used pediatric BP cuffs and calibrated sphygmomanometers. Korotkoff periods 1 and 5 were considered as the systolic and diastolic BP, respectively. BP was recorded in groups of three to five students with students in a sitting position as part of the routine physical examination and after a thorough explanation of the methodology. For statisti...
Clinical Therapeutics, 1996
This study examined child care patterns during the summer months among 6-to 12-year-old children ... more This study examined child care patterns during the summer months among 6-to 12-year-old children with employed parents or primary caretakers. Using interview data from the 1999 National Survey of Americas Families, the study analyzed two key aspects of summer child care: the types of arrangements for school-age children and the amount families with school-age children spend on child care. The study divided child care arrangements into three categories: supervised arrangements, self-care, and parent/other (e.g., parents working at home, or use of lessons, clubs or other activities not usually thought of as childcare). Data showed both the percentage of families using each kind of care and the time spent in child care. Arrangements were considered for children ages 6 to 9 and 10 to 12. Data on arrangements and costs were also disaggregated by family income. The study found that nearly three-quarters of all school-age children with employed primary caretakers are in supervised child care during the summer. The summer months see a large increase in care by relatives and in the time spent in organized care. Average summer child care expenses for higher-income families were found to be more than twice the average spent by lower-income families. One surprising finding is that low-income families spend less on child care during the summer than during the school year. Based on the findings, it was recommended that policymakers be aware of seasonal patterns Copyright June 2002. The Urban Institute. All rights reserved. Except for short quotes, no part of this book may be reproduced in any form or utilized in any form by any means, electronic or mechanical, including photocopying, recording, or by information storage or retrieval system, without written permission from the Urban Institute. This paper is part of the Urban Institute's Assessing the New Federalism project, a multiyear project to monitor and assess the devolution of social programs from the federal to the state and local levels. Alan Weil is the project director. The project analyzes changes in income support, social services, and health programs. In collaboration with Child Trends, the project studies child and family well-being.
Antihypertensive drugs action should last at least 24 h in order to enhance adherence, with posit... more Antihypertensive drugs action should last at least 24 h in order to enhance adherence, with positive impact on CV mo rbimortality. ABPM allow us to evaluate duration of action of drugs, against placebo, using Trough:Peak Ratio, antihypertensive effect in the last 4 h interdosis, and calculating the rate of BP morning surge. Losartan is an Antagonist At1 with good antihypertensive efficacy and renal, cardiac and cerebrovascular protection. Some studies shows less than 24 hs of action, that suggest twice a day dosing. The merge of a new formulation, Losartan Cronos, a bilayer tablet containing 50 mg of Losartan immediate release (IR) and 50 mg extended release (ER) would allow 24 h coverage, maintaining the previous advantages. Objectives: To assess antihypertensive duration of action of Losartan Cronos in patients with essential hypertension throughout a 24-h dosing interval, using ABPM and response rates, AASI and Smoothness Index. Methods: 97 essential hypertensives, where included...
American Journal of Hypertension, 2005
La falta de adherencia al tratamiento es una de las causas principales del pobre control de la pr... more La falta de adherencia al tratamiento es una de las causas principales del pobre control de la presión arterial. Los autoinformes de los pacientes sobre adherencia, como el test de Morisky-Green-Levine, han demostrado capacidad para predecir el control en la presión. El objetivo de este estudio fue evaluar la adherencia al tratamiento utilizando dicho test y, en base a ello, evaluar el control tensional en hipertensos esenciales crónicos. Secundariamente se valoró el uso de las diferentes drogas antihipertensivas. Se incorporaron al estudio 1.784 pacientes (999 mujeres) bajo tratamiento no menor de 6 meses, de los cuales el 48,15% fue adherente y el 51,85% no-adherente. Los no-adherentes mostraron una mayor falta de control (60%), no significativa, en la presión sistodiastólica comparados con los adherentes (56%), p = 0,84. Sin embargo, las tensiones arteriales sistólica y diastólica aisladas mostraron una mayor falta de control en el grupo no-adherente: 55% vs 49%, p = 0,032 y 34% vs 28%, p = 0,0086. Los hombres adherentes tuvieron un mejor control de la presión arterial que los no-adherentes, pero no ocurrió lo mismo con las mujeres. Los pacientes con obra social fueron menos no-adherentes (27%) que aquellos sin obra social (33%) (p = 0,026). La adherencia no superó el 50% luego de 6 meses de tratamiento. Los fármacos más utilizados fueron los inhibidores de la enzima de conversión (30,31%) seguidos por los betabloqueantes (22,34%). El test de Morisky-Green-Levine demostró utilidad para determinar la adherencia y los sujetos que fallan en contestar tendrían un menor control tensional.
The Journal of Clinical Hypertension, 2008
Revista De La Facultad De Ciencias Medicas, Jun 14, 2013
American Journal Cardiovascular Drugs, 2010
Current Therapeutic Research, 2002
... Enalapril in the Treatment of Isolated Systolic Hypertension in the Elderly: An OpenLabel, Ra... more ... Enalapril in the Treatment of Isolated Systolic Hypertension in the Elderly: An OpenLabel, Randomized, ParallelGroup Study Mario Bendersky, MD ... Laboratories, Buenos Aires, Argentina) at an initial dose of 5 mg once daily, or enalapril (GliotenO, Bago Laboratories, Buenos ...
Surgical and Radiologic Anatomy, 2012
Your article is protected by copyright and all rights are held exclusively by Springer-Verlag. Th... more Your article is protected by copyright and all rights are held exclusively by Springer-Verlag. This e-offprint is for personal use only and shall not be self-archived in electronic repositories. If you wish to self-archive your work, please use the accepted author's version for posting to your own website or your institution's repository. You may further deposit the accepted author's version on a funder's repository at a funder's request, provided it is not made publicly available until 12 months after publication.
Hipertensión y Riesgo Vascular, 2019
Resumen El presente articulo resume los conceptos principales del Consenso Argentino de Hipertens... more Resumen El presente articulo resume los conceptos principales del Consenso Argentino de Hipertension Arterial, realizado por primera vez en forma conjunta por las 3 principales sociedades cientificas relacionadas al diagnostico y tratamiento de la hipertension arterial en Argentina (Sociedad Argentina de Hipertension Arterial, Sociedad Argentina de Cardiologia y Federacion Argentina de Cardiologia). Entre sus puntos principales se enfatiza la necesidad de mejorar el diagnostico y control de la hipertension arterial, la utilizacion de tecnicas de medicion ambulatoria de la presion arterial, la importancia de la estratificacion de riesgo del paciente hipertenso y el uso precoz de combinaciones farmacologicas en el tratamiento como medio de alcanzar rapidamente el control. Finalmente se enumeran las principales recomendaciones del manejo de la hipertension en poblaciones especiales como embarazadas, adultos mayores, diabeticos, hipertensos resistentes y pacientes con enfermedad renal cronica.
American Journal of Hypertension, 2002
The contribution of hypertension to the cardiovascular events in diabetes resulted in recommendat... more The contribution of hypertension to the cardiovascular events in diabetes resulted in recommendations for aggressive treatment in patients with diabetes and hypertension. In this study, the efficacy and safety of perindopril on sitting blood pressure (BP) were analyzed in a subset of hypertensive patients maintained on concomitant oral hypoglycemic agents (nϭ899), from a 12 week, open-label, large community trial. All patients were treated with perindopril 4 mg QD for 6 weeks and could be uptitrated by the investigator to perindopril 8 mg QD for an additional 6 weeks depending on BP response. Seated BPs were measured at Baseline (antihypertensives withdrawn), Week 6, and Week 12. Perindopril treatment (4 to 8 mg QD) for 12 weeks produced a significant reduction in SBP and DBP. In patients with inadequate response at Week 6 (Group 2), increase in perindopril dose to 8 mg QD produced additional decrease in SBP and DBP, supporting the titration approach. At Week 12, BP control with perindopril defined as SBP/DBP Ͻ140/90 mmHg, SBP Ͻ140 mmHg or DBP Ͻ90 mmHg, SBP Ͻ140 mmHg, and DBP Ͻ90 mmHg was achieved in 42%, 80%, 47%, and 75%; respectively. Based on JNC VI classification (systolic/diastolic), an increase in shift of patients from Baseline to Week 12 in nonhypertensive BP categories was: Optimal 1%/14% to 9%/33%; Normal 3%/13% to 15%/27%; and High-Normal 5%/8% to 23%/15%. There were 1.3% cardiovascular adverse events, of which 0.4% were serious. Cough and angioedema were reported in 6.4% and 0.1%, respectively. In conclusion, perindopril was effective as an antihypertensive and well tolerated in hypertensive patients maintained on oral hypoglycemic agents.
Hipertensión y Riesgo Vascular, 2015
Ritmo circadiano de la presión; Cronoterapia; Presión nocturna; Ascenso matinal Resumen En la act... more Ritmo circadiano de la presión; Cronoterapia; Presión nocturna; Ascenso matinal Resumen En la actualidad conocemos el perfil tensional en la mayoría de los sujetos normoe hipertensos, y el impacto que sus modificaciones inducen sobre el riesgo cardio-y cerebrovascular. La monitorización ambulatoria de presión arterial (MAPA) ha contribuido en gran medida al conocimiento de estos parámetros. Se intenta corregir con cambios en el horario de la administración de fármacos (cronoterapia) alguno de los componentes del perfil tensional que presentan mejor correlación con el riesgo, entre ellos, el descenso nocturno y el ascenso brusco matinal de la presión. Las investigaciones en ese sentido son todavía escasas, y es necesario programar trabajos multicéntricos que puedan contestar acerca del verdadero impacto preventivo de dichas modificaciones.
Revista de la Facultad de Ciencias Médicas (Córdoba, Argentina), 1983
American Journal of Hypertension, 2005
device was analyzed for evidence of digit prejudice. Within each target treatment group, the dist... more device was analyzed for evidence of digit prejudice. Within each target treatment group, the distribution of SBP and DBP was tabulated and a kernel density estimator was used to overlay a log-normal distribution. These tabulations were then visually examined to determine if there is a suggestion of digit prejudice near the target levels for the two groups. Our study had 372 pts. with 8735 blood pressure measurements for analysis (Baseline Nϭ3061, Medication titration Nϭ1944, Quarterly visits Nϭ3730). No evidence of skipped digit for SBP in the range of 82-230 mm Hg nor for DBP in range of 40-120 mm Hg was found. 272 pts. had at least one quarterly visit while on active antiplatelet therapy (SBPϽ 130 mm HG Nϭ135, SBP 130-149 mm Hg Nϭ137) where digit prejudice could be analyzed. For SBPϽ 130 mm Hg no digit prejudice was found. For SBP130-149 mm Hg there is a suggestion of abnormal distribution of SBP 130-134 (Figure 1) with a smaller abnormal peak at 144-150 mm Hg. The Collins Pressmate algorithm does not have skipped digits as seen with DINAMAP. Clustering of SBP in the SBP 130-149 Mm Hg is worrisome for digit prejudice. Continued monitoring at 6 months intervals during the trial is needed to confirm this finding.
fac.org.ar
... Bendersky M, Kuschnir E: El MAPA en la evaluación de la efectividad de drogas antihipertensiv... more ... Bendersky M, Kuschnir E: El MAPA en la evaluación de la efectividad de drogas antihipertensivas (Editorial ... Comité HTA, FAC Trelew), MARCOS MARIN (Policlínico Bancario, Buenos Aires), FELIPE RAMOS (Fundación Favaloro, Buenos Aires), GABRIEL WAISSMAN (Hospital ...
fac.org.ar
Index La hipertensión arterial (HTA) es una enferme-dad compleja en su fisiopatologí a en la cual... more Index La hipertensión arterial (HTA) es una enferme-dad compleja en su fisiopatologí a en la cual concurren, sobre una base genética, una serie de anormalidades de los mecanismos de regulación tensional que generan cambios precoces en el sistema vascular del individuo y, sólo en forma tardía, una elevación persistente de las cifras tensionales. La HTA es un factor de riesgo para distintas situaciones patológicas cardiovasculares, como la enfermedad coronaria, el accidente cerebrovascular (ACV), la arteriopatía periférica y la insuficiencia cardíaca. La presencia de HTA duplica y a veces triplica el riesgo, especialmente en varones (Figura 1). El tratamiento de la HTA tiene como principal objetivo la reducción de la morbimortalidad cardiovascular, conservando una buena calidad de vida.
Rev Fed Arg Cardiol, 2004
... Lípidos. El diseño y la coordinación de la reunión estuvo a cargo del doctor MarioBendersky. ... more ... Lípidos. El diseño y la coordinación de la reunión estuvo a cargo del doctor MarioBendersky. Se ... cardiovascular? Ricardo Esper, Luis Juncos, Daniel Piskorz, Bernardo Spitz, Alejandro Ugarte, Jorge Villariño, Gabriel Waisman Los ...
Journal of Hypertension, 2000
Journal of Cardiovascular Pharmacology, 1988
Twenty patients (aged 33-60 years) with mild to moderate essential hypertension were studied to a... more Twenty patients (aged 33-60 years) with mild to moderate essential hypertension were studied to assess systolic ventricular function, diastolic ventricular function, and peripheral hemodynamic changes induced by nitrendipine during rest and effort, comparing the acute and chronic treatment phases. We used a randomized, placebo-controlled, double-blind, crossover protocol in the acute phase and a paired, placebo group controlled study, with 20 mg single oral daily dose for a 3-week treatment period (chronic phase). The cardiac and peripheral hemodynamic parameters were quantified by noninvasive radionuclides techniques. During acute treatment, peripheral hemodynamics showed a predominantly arteriolar vasodilatory effect with a significant fall in the previously elevated forearm vascular resistance values (-38%, p less than 0.01) and an important increase in forearm blood flow (+49%, p less than 0.01) without any changes in venous capacity. Simultaneously, nitrendipine produced a significant drop in total peripheral resistance (-36%, p less than 0.01), systolic blood pressure (-13%, p less than 0.01), and diastolic blood pressured (-17%, p less than 0.01). The sudden reduction in left ventricular (LV) afterload caused a reflex increase in heart rate (HR) (+12%, p less than 0.01), cardiac index (+37%, p less than 0.01), LV ejection fraction (+17%, p less than 0.01), and peak ejection rate, with an important decrease in LV end systolic volume (-30%, p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Hypertension, 1992
The aims of the present study were 1) to evaluate blood pressure (BP) and its distribution curve ... more The aims of the present study were 1) to evaluate blood pressure (BP) and its distribution curve in a highly representative population of children and adolescents from Cordoba, Argentina, to determine the normal BP pattern, and 2) to establish the relation between other factors and BP levels. BP data recorded during the years 1984-1987 were evaluated in 280,584 children and adolescents aged 5-15 years (52.1% boys and 47.9% girls) corresponding to the nine sanitary districts of the province (urban, rural, mountain, and plains areas), which represent 75% of the children of the whole province. Recordings were carried out by trained physicians who used pediatric BP cuffs and calibrated sphygmomanometers. Korotkoff periods 1 and 5 were considered as the systolic and diastolic BP, respectively. BP was recorded in groups of three to five students with students in a sitting position as part of the routine physical examination and after a thorough explanation of the methodology. For statisti...
Clinical Therapeutics, 1996
This study examined child care patterns during the summer months among 6-to 12-year-old children ... more This study examined child care patterns during the summer months among 6-to 12-year-old children with employed parents or primary caretakers. Using interview data from the 1999 National Survey of Americas Families, the study analyzed two key aspects of summer child care: the types of arrangements for school-age children and the amount families with school-age children spend on child care. The study divided child care arrangements into three categories: supervised arrangements, self-care, and parent/other (e.g., parents working at home, or use of lessons, clubs or other activities not usually thought of as childcare). Data showed both the percentage of families using each kind of care and the time spent in child care. Arrangements were considered for children ages 6 to 9 and 10 to 12. Data on arrangements and costs were also disaggregated by family income. The study found that nearly three-quarters of all school-age children with employed primary caretakers are in supervised child care during the summer. The summer months see a large increase in care by relatives and in the time spent in organized care. Average summer child care expenses for higher-income families were found to be more than twice the average spent by lower-income families. One surprising finding is that low-income families spend less on child care during the summer than during the school year. Based on the findings, it was recommended that policymakers be aware of seasonal patterns Copyright June 2002. The Urban Institute. All rights reserved. Except for short quotes, no part of this book may be reproduced in any form or utilized in any form by any means, electronic or mechanical, including photocopying, recording, or by information storage or retrieval system, without written permission from the Urban Institute. This paper is part of the Urban Institute's Assessing the New Federalism project, a multiyear project to monitor and assess the devolution of social programs from the federal to the state and local levels. Alan Weil is the project director. The project analyzes changes in income support, social services, and health programs. In collaboration with Child Trends, the project studies child and family well-being.
Antihypertensive drugs action should last at least 24 h in order to enhance adherence, with posit... more Antihypertensive drugs action should last at least 24 h in order to enhance adherence, with positive impact on CV mo rbimortality. ABPM allow us to evaluate duration of action of drugs, against placebo, using Trough:Peak Ratio, antihypertensive effect in the last 4 h interdosis, and calculating the rate of BP morning surge. Losartan is an Antagonist At1 with good antihypertensive efficacy and renal, cardiac and cerebrovascular protection. Some studies shows less than 24 hs of action, that suggest twice a day dosing. The merge of a new formulation, Losartan Cronos, a bilayer tablet containing 50 mg of Losartan immediate release (IR) and 50 mg extended release (ER) would allow 24 h coverage, maintaining the previous advantages. Objectives: To assess antihypertensive duration of action of Losartan Cronos in patients with essential hypertension throughout a 24-h dosing interval, using ABPM and response rates, AASI and Smoothness Index. Methods: 97 essential hypertensives, where included...
American Journal of Hypertension, 2005
La falta de adherencia al tratamiento es una de las causas principales del pobre control de la pr... more La falta de adherencia al tratamiento es una de las causas principales del pobre control de la presión arterial. Los autoinformes de los pacientes sobre adherencia, como el test de Morisky-Green-Levine, han demostrado capacidad para predecir el control en la presión. El objetivo de este estudio fue evaluar la adherencia al tratamiento utilizando dicho test y, en base a ello, evaluar el control tensional en hipertensos esenciales crónicos. Secundariamente se valoró el uso de las diferentes drogas antihipertensivas. Se incorporaron al estudio 1.784 pacientes (999 mujeres) bajo tratamiento no menor de 6 meses, de los cuales el 48,15% fue adherente y el 51,85% no-adherente. Los no-adherentes mostraron una mayor falta de control (60%), no significativa, en la presión sistodiastólica comparados con los adherentes (56%), p = 0,84. Sin embargo, las tensiones arteriales sistólica y diastólica aisladas mostraron una mayor falta de control en el grupo no-adherente: 55% vs 49%, p = 0,032 y 34% vs 28%, p = 0,0086. Los hombres adherentes tuvieron un mejor control de la presión arterial que los no-adherentes, pero no ocurrió lo mismo con las mujeres. Los pacientes con obra social fueron menos no-adherentes (27%) que aquellos sin obra social (33%) (p = 0,026). La adherencia no superó el 50% luego de 6 meses de tratamiento. Los fármacos más utilizados fueron los inhibidores de la enzima de conversión (30,31%) seguidos por los betabloqueantes (22,34%). El test de Morisky-Green-Levine demostró utilidad para determinar la adherencia y los sujetos que fallan en contestar tendrían un menor control tensional.
The Journal of Clinical Hypertension, 2008
Revista De La Facultad De Ciencias Medicas, Jun 14, 2013