Benjamin Oritsemuelebi - Academia.edu (original) (raw)

Uploads

Papers by Benjamin Oritsemuelebi

Deleted Journal, Apr 1, 2024

Pharmacological research. Natural products, Jun 1, 2024

Deleted Journal, Mar 1, 2024

IntechOpen eBooks, Mar 7, 2024

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized of cognitive dysfu... more Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized of cognitive dysfunction. AD is believed to be a global menace with an estimated fourfold increase in prevalence by the year 2050. This increasing prevalence is linked to the unavailability of efficient treatment to halt the disease progression. While several hypotheses have been postulated on AD, oxidative stress, a state of an imbalance between antioxidant and free radical generation, has long been implicated in the pathogenesis of age-dependent late-onset AD. This state induces cognitive decline by stimulating neuronal damage, notably involving increased free radical production, and mitochondrial dysfunction. Pharmacological agents used in AD management have serious adverse effects and inability to halt disease progression. This has led to the emergence of naturally occurring neuroprotective phytochemical agents and herbal supplements as therapeutic option agents. Indeed, emerging studies have revealed the neuroprotective potential of different African herbal products, containing bioflavonoid compounds with central nervous system permeability and high antioxidant actions. Given this background, this chapter aims to discuss some of these African antioxidant bioflavonoids\nutraceuticals, their neuroprotective functions against different epigenetic-derived oxidative stress, and ways ahead to facilitate their translation from "bench to bedside" as primary intervention or co-adjuvant therapies for AD treatment.

Chinese Herbal Medicines, Oct 31, 2023

European journal of pharmacology, Jun 1, 2024

Journal of Psychiatric Research

Toxicology and Environmental Health Sciences

Journal of global health reports, Dec 21, 2021

Background Anthropometric parameters at birth are important indicators of child vulnerability to ... more Background Anthropometric parameters at birth are important indicators of child vulnerability to the risk of childhood illness, and consequently, the chance of survival and risk of diseases late in life. The aim of this study was to investigate correlations between toxic (aluminium, antimony, arsenic, cadmium, lead and mercury) and essential metals (copper, manganese, selenium and zinc) in maternal and umbilical cord blood samples, with newborn anthropometric parameters in a predominantly agricultural community of Ebony State, Nigeria.

Pharmacological Research - Modern Chinese Medicine

Background: Myocyte necrosis and apoptosis can be severely induced by acute adrenergic stimulatio... more Background: Myocyte necrosis and apoptosis can be severely induced by acute adrenergic stimulation due to the activation of several cell signalling pathways. However, uncertainty exists regarding the potential cardioprotective effects of Ginkgo biloba (GBS), a Chinese herbal supplement rich with antioxidants, on isoprenaline (ISO)-induced myocardial infarction. Therefore, this work was designed to investigate the cardioprotective mechanisms of GBS on ISO-induced myocardial infarction. Methods: Animals were selected into four groups. Groups 1 and 2 were pre-treated with normal saline (10 mL/kg i.p) for 28 days. Groups 3 and 4 received GBS (50 mg/kg, i.p) for 28 days. However, groups 2 and 4 were administered ISO (150 mg/kg, s.c) on days 27 and 28 respectively. Following the end of 28-day experiment, animals were euthanised and serum as well as heart tissue were harvested and processed for biochemical and histological examinations. Results: Our results showed that ISO induced cardiac necrosis, evidenced by increased levels of cardiac injury enzymes (LDH, GGT, CK-MB and cT-1), oxidative stress markers such as GSH, SOD, and CAT levels were significantly reduced while MDA and nitrite concntration were significantly increased. Inflammatory cytokines (IL-6 and TNF-α) were significantly increased while decreasing Bcl-2, mTOR and ERK 1/2 cardiac immunoexpressions. Moreso, histological investigation revealed degeneration of cardiomyofibres together with patchy necrosis. However, pre-treatment with GBS significantly inhibited apoptotic processes evidenced by increased antioxidant-mediated activation of Bcl-2, mTOR and ERK 1/2. GBS also suppressed the release of cardiac injury enzymes and histological changes were significantly improved. Conclusion: GBS protects myocardium against ISO-induced infarction by mechanisms related to antioxidantmediated by enhancement of Bcl-2/mTOR/ERK 1/2 activities.

Journal of Health and Pollution, 2019

Background. Environmental impacts from informal e-waste recycling are increasing in Africa. E-was... more Background. Environmental impacts from informal e-waste recycling are increasing in Africa. E-waste handling and disposal exposes people to highly toxic cocktails of heavy metals, brominated flame retardants, non-dioxin-like polychlorinated biphenyls (PCB), polycyclic aromatic hydrocarbons (PAH), polychlorinated dibenzo-p-dioxins (PCDD), polychlorinated dibenzofurans (PBDF) and dioxin-like polychlorinated biphenyls (DL-PCB). Most of these compounds are endocrine disrupters, and most are neuro- and immune-toxic as well. Objectives. Informal e-waste recycling in African countries is a serious public health threat. The present paper reviews the extent of e-waste exposure in Africa and related impacts on people, animals and the environment. Methods. Four electronic databases (PubMed, Science Direct, Scopus, Google Scholar) were searched for publications related to e-waste and human health in Africa. Search terms included ‘e-waste in Africa’, ‘e-waste in developing nations’, ‘public heal...

Journal of Environmental Monitoring, 2009