Berk Bulut - Academia.edu (original) (raw)

Papers by Berk Bulut

Research paper thumbnail of Systemic lupus erythematosus and pregnancy

Journal of Obstetrics and Gynaecology, 2010

We present a retrospective study of 42 consecutive cases of systemic lupus erythematosus (SLE) an... more We present a retrospective study of 42 consecutive cases of systemic lupus erythematosus (SLE) and pregnancy followed and delivered during the period 2002-2007 in our department. The mean patient age was 28.6 years and the nulliparity rate was 45.2%. Disease flare up occurred in 9.5% of patients. Lupus anticoagulants, anticardiolipin IgG and IgM antibodies were positive in 33%, 16.6% and 19% of patients, respectively. Mean gestational age at delivery was 36.9 +/- 4.2 and mean birth weight was 2,750 +/- 844 g. Stillbirth, fetal growth restriction, pre-eclampsia and pre-term delivery rates were 7.1%, 14.3%, 2.4% and 23.1%, respectively. Cases with uterine artery Doppler abnormalities had significantly poorer obstetric outcomes. Antiphospholipid antibodies, renal involvement and lupus activation did not have any significant influence on poor obstetric outcome. Multidisciplinary approach to the care of pregnant women with SLE is mandatory for good maternal and fetal outcomes. Uterine artery Doppler seems to be a good prognostic factor for adverse obstetric outcomes.

Research paper thumbnail of Sezaryen Skar Gebeliğinin Tek Doz Lokal Metotreksat Uygulaması ile Tedavisi: Olgu Sunumu

Sezaryen skar gebeliği erken gebelik nedeniyle başvuran hastaların yaklaşık 1/1800'ünde saptanmak... more Sezaryen skar gebeliği erken gebelik nedeniyle başvuran hastaların yaklaşık 1/1800'ünde saptanmaktadır. Geçirilmiş sezaryen öyküsü olan hastalarda ektopik gebeliklerin %6.1'ini oluşturmaktadır. Nadir görülmesine rağmen maternal morbidite ve mortaliteye sebep olabilmesi ve son yıllarda sezaryen oranlarındaki artışa bağlı olarak görülme sıklığının artması nedeniyle önem taşımaktadır. Tedavisinde lokal veya sistemik metotreksat, lokal potasyum klorid, histereskopi, laparaskopi, laparatomi, uterin küretaj ve uterin arter embolizasyonu gibi değişik yöntemler kullanılmasına rağmen ilk ve en etkin tedavi seçeneği tartışmalıdır. Olgumuz transvajinal ultrasonografi eşliğinde lokal tek doz metotreksat uygulaması ile komplikasyonsuz bir şekilde tedavi edilmiştir; bu tedavi yöntemi sezaryen skar gebeliğinde ilk tedavi seçeneği olarak önerilebilir.

Research paper thumbnail of Elevated basal progesterone levels are associated with increased preovulatory progesterone rise but not with higher pregnancy rates in ICSI cycles with GnRH antagonists

European Journal of Obstetrics & Gynecology and Reproductive Biology, Sep 1, 2017

To ascertain the association between basal progesterone (P) levels and the occurrence of preovula... more To ascertain the association between basal progesterone (P) levels and the occurrence of preovulatory progesterone rise (PPR) and clinical pregnancy rates (CPRs) in ICSI cycles with GnRH antagonists. Study design: Serum P levels of 464 patients were measured on day 2 and day of hCG of cycles. Cycles with basal P levels > 1.6 ng/mL were cancelled. All embryos were cryopreserved in cycles with P levels ! 2 ng/ mL on the day of hCG. The primary outcome measures were the incidence of PPR (P > 1.5 ng/mL) and CPR with regard to basal P. Results: Basal P levels were significantly higher in cycles with PPR than in those without PPR (0.63 AE 0.31 vs. 0.48 AE 0.28 ng/mL). Area under the curve for basal P according to ROC analysis to discriminate between elevated and normal P levels on the day of hCG was 0.65 (0.58-0.71 95% CI, p < 0.01). The cutoff value for basal P levels that best discriminates between cycles with and without PPR was 0.65 ng/mL. Cycles with basal P levels above 0.65 ng/mL had a significantly higher incidence of PPR (30.9% vs. 13.5%) but similar clinical and cumulative pregnancy rates (38.8% vs. 31.1% and 41.7% vs. 32.6%, respectively) in comparison to cycles with basal P levels below 0.65 ng/mL. In multivariate regression analysis, basal P levels, LH level on the first day of antagonist administration, and estradiol levels on the day of hCG trigger were the variables that predicted PPR. Conclusion: Basal P levels were associated with increased incidence of PPR but not with CPR.

Research paper thumbnail of Sistemik Lupus Eritematozus ve Gebelik: 42 Olgunun Değerlendirilmesi

Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2009

istemik lupus eritematozus (SLE), pek çok değişik organda bozukluğa yol açan, kronik otoimmün bir... more istemik lupus eritematozus (SLE), pek çok değişik organda bozukluğa yol açan, kronik otoimmün bir hastalıktır. 1,2 SLE hafif seyredebileceği gibi, yaşamı tehdit eden komplikasyonlara da yol açabilmektedir. 2,3 Ek

Research paper thumbnail of Serum caveolin-1 levels in patients with preeclampsia

Journal of Maternal-fetal & Neonatal Medicine, Sep 24, 2018

Aim: The expressions of caveolin-1 have only been examined in the placental tissue of patients wi... more Aim: The expressions of caveolin-1 have only been examined in the placental tissue of patients with preeclampsia and were reported to be low. Therefore, we decided to investigate the maternal serum levels of caveolin-1 in patients with preeclampsia. Material and methods: This cross-sectional study was conducted including 87 pregnant women; 32 with normal pregnancy and 55 with preeclampsia. Maternal serum levels of caveolin-1 were measured by using enzyme-linked immunosorbent assay kit (ELISA). Results: The mean serum caveolin-1 level was significantly lower in women with preeclampsia (PE) compared with the control group (11.48 ± 0.92 versus 12.94 ± 1.36 ng/ml) and being lowest in the early onset PE group (11.24 ± 0.74 ng/ml). Serum caveolin-1 concentrations did not correlate with maternal age and BMI. However, caveolin-1 concentrations were negatively correlated with systolic blood pressure (r ¼-0.467, p ¼ .001) and diastolic blood pressure (r ¼-0.441, p ¼ .001) as well as with umbilical artery resistance index (r ¼-0.275, p ¼ .01). Conclusion: Maternal serum caveolin-1 levels are significantly lower in patients with PE than controls. The serum caveolin-1 levels inversely correlate with blood pressure and umbilical artery Doppler parameters.

Research paper thumbnail of Laparoscopic hysterectomy; our experience

SSK Okmeydanı Eğitim Hastanesi tıp dergisi, 2016

Histerektomi en yaygın yapılan majör jinekolojik ameliyattır. Tüm dünyada en sık laparotomi ile y... more Histerektomi en yaygın yapılan majör jinekolojik ameliyattır. Tüm dünyada en sık laparotomi ile yapılmasına rağmen, laparoskopik histerektomi giderek artmaktadır. Bu çalışmada, kliniğimizde total laparoskopik histerektomi yapılan hastalar değerlendirildi. Gereç ve Yöntem: Kliniğimizde Ocak 2014 ile Ocak 2016 tarihleri arasında benign veya malign jinekolojik hastalıklar nedeniyle total laparoskopik histerektomi yapılan hastaların dosyaları retrospektif olarak tarandı. Hastaların yaş, vücut-kitle indeksi, parite, daha önce geçirilmiş operasyon öyküsü gibi demografik verileri kaydedildi. Histerektomi endikasyonu, histerektomiye ek olarak yapılan cerrahiler, toplam operasyon süresi, kan kaybı, preoperatif ve postoperatif hemoglobin değerleri, uterus ağırlığı, perioperatif ve postoperatif komplikasyonlar ile hastanede kalış süreleri kaydedildi. Sonuçlar güncel literatür eşliğinde değerlendirildi.

Research paper thumbnail of Obesity and Pregnancy

SSK Okmeydanı Eğitim Hastanesi tıp dergisi, Aug 25, 2014

Research paper thumbnail of Management of ovulation induction and intrauterine insemination in infertile patients with hypogonadotropic hypogonadism

Journal of gynecology obstetrics and human reproduction, Dec 1, 2019

rates were 12.7% and 28.3% per cycle and per patient, respectively. The pregnancy rate in hCGtrig... more rates were 12.7% and 28.3% per cycle and per patient, respectively. The pregnancy rate in hCGtriggered patients (successful stimulation) was 17.1% per cycle in all patients. Conclusion OI with gonadotropins and IUI is a safe, efficient, and relatively cost-effective treatment option in patients with HH, yielding reasonable pregnancy rates per cycle and per patient. The use of rec FSH + rec LH facilitates cycle management but does not positively contribute to pregnancy rates and is more expensive than some other feasible options.

Research paper thumbnail of Maternal serum autotaxin levels in early- and late-onset preeclampsia

Hypertension in Pregnancy, Oct 2, 2017

We aimed to compare the serum autotaxin levels in early- and late- preeclamptic and healthy pregn... more We aimed to compare the serum autotaxin levels in early- and late- preeclamptic and healthy pregnant patients at a university hospital. A total of 55 singleton preeclamptic women who delivered at Cerrahpasa Medical Faculty were included in the study. The patients were subdivided into two groups: early-onset preeclampsia (n = 31) and late-onset preeclampsia (n = 24). Demographic and clinical data were compared between early-onset and late-onset preeclamptic patients. The control group was composed of 32 healthy pregnant patients. The mean autotaxin levels were 1.16 ± 0.97 and 0.7 ± 0.35 ng/ml in the early- and late-onset preeclampsia groups, respectively. Autotaxin levels were significantly higher in early-onset preeclampsia group compared with late-onset preeclampsia group. Autotaxin levels were found to be significantly higher in preeclamptic patients compared with control group. Serum autotaxin levels showed a significant positive correlation with maternal systolic, diastolic blood pressures and uric acid levels. Autotaxin might be a promising marker for detecting early-onset preeclampsia. However, further studies are necessary to confirm this hypothesis.

Research paper thumbnail of Myomectomy for intramural fibroids during caesarean section: A therapeutic dilemma

Journal of Obstetrics and Gynaecology, Dec 7, 2016

The aim of the present study was to assess the safety of myomectomy for intramural fibroids durin... more The aim of the present study was to assess the safety of myomectomy for intramural fibroids during caesarean section. A retrospective study of 63 women who underwent myomectomy during caesarean section and 63 women who underwent caesarean delivery without myomectomy was conducted. The study group was divided into subgroups according to the volume of fibroids and total incision count. The volume of fibroids, the preoperative and postoperative haemoglobin values and the difference between them, incidence of haemorrhage and blood transfusion, duration of operation and postoperative fever of patients were investigated. Duration of operation was longer (p < .001) and haemoglobin loss was higher (p ¼ .01) in the myomectomy group. There was no difference between one incision and two incisions subgroups in terms of mean haemoglobin change (p ¼ .068). Haemoglobin loss was higher in volume >50 cm 3 group than volume <50 cm 3 and control groups. These differences were statistically significant (p ¼ .02; p ¼ .001, respectively). Although intramural fibroids can be safely removed during caesarean section, large fibroids and extra incisions for myomectomy are risk factors for haemorrhage.

Research paper thumbnail of Preeklampsi Olgularında Birinci Trimester Maternal Serum Metastin Düzeyi, Kitotriozidaz Aktivitesi ve Uterin Arter Doppler Bulguları

Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2012

Research paper thumbnail of Karın Ön Duvarı Defekti Prenatal Tanısı Olan 24 Gebeliğin İrdelenmesi

Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2008

m fa lo sel ve gas tro şi zis ka rın ön du va rı nın en sık gö rü len ya pı sal ano ma li le ri d... more m fa lo sel ve gas tro şi zis ka rın ön du va rı nın en sık gö rü len ya pı sal ano ma li le ri dir. 1 Om fa lo sel 10 000 do ğum da 0.8-3.9 ora nın da rastla nı lan ve ka ra ci ğer, bar sak gi bi ka rın içi or gan la rın pe ri ton ile Karın Ön Duvarı Defekti Prenatal Tanısı Olan 24 Gebeliğin İrdelenmesi ÖZET Amaç: Prenatal dönemde karın ön duvarı defekti tanısı alan olguların klinik özelliklerinin ve perinatal sonuçlarının değerlendirilmesi Gereç ve Yöntemler: Ana Bilim Dalımızda Ocak 1998-Aralık 2006 tarihleri arasında gastroşizis ve omfalosel tanısı alan 24 olgu retrospektif olarak irdelendi. Gebelerin tanı haftası, ilave yapısal ve kromozomal anomali varlığı, doğum hafta ve şekli ile perinatal sonuçları değerlendirildi. Bulgular: Batın ön duvarı defekti olan 24 fetusun 11'inde gastroşizis, 13'ünde omfalosel mevcuttu. Gastroşizis ve omfalosel tanısı alan gebelerin nulliparite oranları ve yaşlarının ortalaması sırasıyla %72.7, 22.5 ± 5.1 ve %53.8, 26.8 ± 2.0 olarak bulundu. Gastroşizis olgularında ilave yapısal ve kromozomal anomali saptanmadı. Omfalosel olgularının ise 4'ünde (%30.8) ilave yapısal anomali ve 1'inde (%7.7) kromozom anomalisi belirlendi. Gastroşizis ve omfalosel için perinatal mortalite oranlarımız sırasıyla %20 ve %44 olarak saptandı. Canlı doğan izole gastroşizis ve omfalosel olgularımızda sağkalım oranlarımız ise sırasıyla %88.8 ve %71.4 olarak belirlendi. Sonuç: Karın ön duvarı defektli fetusların antenatal dönemde tanısının konması, ilave yapısal ve kromozomal anomalilerin belirlenmesi, ekip anlayışı içinde takip edilmeleri ve uygun merkezlerde doğumların gerçekleşmesine olanak sağlaması açısından son derece önemlidir.

Research paper thumbnail of Prenatal Tanılı 24 Konjenital Diyafram Hernili Olgunun İrdelenmesi

Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2008

on je ni tal di yaf ram her ni si (KDH), or ta la ma 4000 (2000 ile 6000) canlı do ğum da bir ras... more on je ni tal di yaf ram her ni si (KDH), or ta la ma 4000 (2000 ile 6000) canlı do ğum da bir rast la nı lan ve di yaf ram da ki do ğum sal bir de fekt ten ba tın için de ki or gan la rın to raks boş lu ğu na fı tık laş ma sı ola rak ta nımla nan bir ano ma li dir. 1 Kon je ni tal di yaf ra ma her ni si izo le ve ya komp leks olabi lir. Komp leks ol gu lar da, di yaf ram da ki de fekt bir sen dro mun par ça sı dır,

Research paper thumbnail of Implications of circulating irisin and Fabp4 levels in patients with polycystic ovary syndrome

Journal of Obstetrics and Gynaecology, May 16, 2016

The aim of the study was to evaluate the fatty acid-binding protein-4 (FABP4) and irisin concentr... more The aim of the study was to evaluate the fatty acid-binding protein-4 (FABP4) and irisin concentrations in women with polycystic ovary syndrome (PCOS). Forty-nine women with PCOS, diagnosed according to Rotterdam criteria and 39 healthy women matched for body mass index (BMI) and age. Serum irisin and plasma FABP4 concentrations were measured in both groups. The association of irisin and FABP4 concentrations with metabolic parameters were also tested. Women with PCOS had significantly lower mean serum irisin concentrations than control subjects (158.5 ± 123.3 versus 222.9 ± 152.2 ng/ml, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). Concentrations of FABP4 in PCOS and control groups were not significantly different (10.5 ± 4.4 versus 10.9 ± 4.2 ng/ml, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). FABP4 concentrations were correlated with BMI, waist-hip ratio (WHR) and HOMA-IR (r = 0.57, p = 0.001; r = 0.26, p = 0.03; r = 0.26, p = 0.03, respectively). No associations between irisin and all the others parameters except serum levels of LH were found. Serum irisin concentrations of women with PCOS were lower compared to the controls. Moreover, there were no difference in plasma FABP4 concentrations between women with PCOS and controls.

Research paper thumbnail of Can M-30, M-65, and IL-6 serum levels be useful markers in the diagnosis of preeclampsia and gestational diabetes?

PubMed, Jun 1, 2023

Objective: We aimed to evaluate the maternal and fetal serum M-30, M-65 and IL-6 levels in preecl... more Objective: We aimed to evaluate the maternal and fetal serum M-30, M-65 and IL-6 levels in preeclampsia and gestational diabetes mellitus (GDM) in both maternal and cord blood. Patients and methods: Women with preeclampsia (n=30), GDM (n=30), and uncomplicated pregnancy (n=28) were evaluated in a cross-sectional study. After clamping during delivery, the serum M-30, M-65, and IL-6 levels were measured in both maternal venous blood and cord blood. Results: The serum M-30, M-65, and IL-6 levels were significantly higher in preeclampsia and GDM patients' maternal blood and cord blood samples compared to the control group. In the preeclampsia group, M-65 was significantly higher in cord blood compared with the level in maternal serum, but there was no significant difference between the GDM and control groups. The control group's IL-6 level in cord blood was statistically significantly lower than the other groups. Although the M-30 value in both maternal and cord blood was statistically lower in the control group than in the GDM group, there was no significant difference between the two groups when compared to the preeclampsia group. Conclusions: M-30 and M-65 molecules appear to have the potential to serve as biochemical markers in placental diseases, particularly preeclampsia and gestational diabetes. Due to the insufficient sample sizes, more research is needed.

Research paper thumbnail of Effect of Taxifolin on Acrylamide-Related Oxidative Ovarian Damage, Infertility and Intrauterine Growth Retardation in Female Rats

International Journal of Pharmacology, Mar 15, 2023

Research paper thumbnail of A viable childbirth after correction of spontaneous uterine dehiscence

The European Research Journal, Mar 4, 2016

We report a case of uterine dehiscence during pregnancy. Uterine dehiscence and rupture are serio... more We report a case of uterine dehiscence during pregnancy. Uterine dehiscence and rupture are serious complications of pregnancy. This situation takes place especially in women that prior uterine operation(s). We represent a 30-year-old woman diagnosed uterine dehiscence at 22 nd gestation week. Uterine dehiscence treated surgically and then medical treatment was given to prevent preterm labour. At 34 th gestation week, the patient was operated because of preterm labour and an alive foetus was born. The result of the pathologic examination of the placenta: Placental adhesion failure was detected. In conclusion women with prior caesarean delivery (one or more), ultrasound measurement should be recommended for measuring the lower uterine segment thickness in order to predict the possibility of uterine dehiscence and rupture.

Research paper thumbnail of Serum collectrin levels in patients with early- and late-onset preeclampsia

Journal of Maternal-fetal & Neonatal Medicine, Aug 2, 2017

The aim of this study is to investigate the maternal levels of collectrin in early-onset preeclam... more The aim of this study is to investigate the maternal levels of collectrin in early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE). To assess the correlation between serum collectrin levels and blood pressure in humans. This cross-sectional study was conducted including 79 pregnant women, 27 with normal pregnancy, 30 with EOPE and 22 with LOPE. Maternal serum levels of collectrin were measured by using enzyme-linked immunosorbent assay kits. The mean serum collectrin level was significantly lower in women with PE compared with the control group (8.49 ± 3.12 ng/ml (EOPE), 9.69 ± 3.01 ng/ml (LOPE) versus 11.51 ± 4.33 ng/ml) and was found to be the lowest in the EOPE group (8.49 ± 3.12 ng/ml). The mean serum urea and uric acid levels were significantly higher in the PE group than the control group. Serum collectrin concentrations did not correlate with maternal age, BMI and serum creatinine levels. However, collectrin concentrations were negatively correlated with systolic blood pressure (r = -0.284, p = .011) and diastolic blood pressure (r = -0.275, p = .014) as well as with maternal serum urea (r = -0.269, p = .017) and uric acid (r = -0.219, p = .049) concentrations. Maternal serum collectrin levels are significantly lower in patients with preeclampsia than in the control group. There is an inverse correlation between serum collectrin levels and blood pressure.

Research paper thumbnail of Unusual uterine metastasis of invasive ductal carcinoma: A case report

Türk jinekoloji ve obstetrik derneği dergisi, Sep 30, 2016

Uterusun metastatik kanserleri genellikle diğer genital sistemlerden kaynaklanmaktadır. Meme gibi... more Uterusun metastatik kanserleri genellikle diğer genital sistemlerden kaynaklanmaktadır. Meme gibi genital bölge dışı bölgelerden metastaz çok nadirdir. Hikayesinde meme kanseri olan 34 yaşındaki kadın hasta olağan kontrol için polikliniğimize başvurdu. Jinekolojik muayene ve görüntüleme yöntemleri sonucu uterusta kitle bulundu ve laparotomi yapılarak kitle çıkarıldı. Patolojik inceleme invaziv duktal karsinom metastazı olduğunu ortaya çıkardı. Hastaya kemoterapi verildi ve 3 yıl kontrolleri sırasında pozitron emisyon tomografi + bilgisayarlı tomografi görüntülemeleri normal olarak bulundu. Tamoksifen tedavisi alan meme kanserli hastalarda sadece primer endometriyal kanser değil ayrıca bazen uterusa metastazın da gelişebileceği akılda tutulmalıdır. Başarılı bir tedavi ile bu hastalar nüks hastalık olmadan hayatta kalabilirler.

Research paper thumbnail of Adolescent pregnancies: complications, birth outcomes and the possible solutions

Ginekologia Polska, Jul 31, 2017

Objectives: In this study we aim to evaluate antenatal, perinatal and postnatal outcomes and comp... more Objectives: In this study we aim to evaluate antenatal, perinatal and postnatal outcomes and complications of adolescent pregnancies, as well as to discuss the social and psychological consequences of these pregnancies. Material and methods: We compare a total of 243 pregnant women at age 14-18 years to a vast control group at age 19-36 who all delivered at Bursa Yüksek Ihtisas Training and Research Hospital between years 2005-2014. Results: Antenatal care (folic acid supplementation, pre-conception counseling) was significantly higher in adolescent pregnancy group. Unplanned pregnancy rate was significantly higher in in study group (p < 0.001). Preterm delivery (before 37 th week) ratio was statistically higher in pregnancy complications. Conclusions: Adolescent pregnancy is a social entity which should be regulated and prevented by legal measures. Planned pregnancies should be promoted and the public should be educated and informed about the Hazards of adolescent pregnancies. Press institutions, public broadcasting services support the efforts to decrease adolescent pregnancies.

Research paper thumbnail of Systemic lupus erythematosus and pregnancy

Journal of Obstetrics and Gynaecology, 2010

We present a retrospective study of 42 consecutive cases of systemic lupus erythematosus (SLE) an... more We present a retrospective study of 42 consecutive cases of systemic lupus erythematosus (SLE) and pregnancy followed and delivered during the period 2002-2007 in our department. The mean patient age was 28.6 years and the nulliparity rate was 45.2%. Disease flare up occurred in 9.5% of patients. Lupus anticoagulants, anticardiolipin IgG and IgM antibodies were positive in 33%, 16.6% and 19% of patients, respectively. Mean gestational age at delivery was 36.9 +/- 4.2 and mean birth weight was 2,750 +/- 844 g. Stillbirth, fetal growth restriction, pre-eclampsia and pre-term delivery rates were 7.1%, 14.3%, 2.4% and 23.1%, respectively. Cases with uterine artery Doppler abnormalities had significantly poorer obstetric outcomes. Antiphospholipid antibodies, renal involvement and lupus activation did not have any significant influence on poor obstetric outcome. Multidisciplinary approach to the care of pregnant women with SLE is mandatory for good maternal and fetal outcomes. Uterine artery Doppler seems to be a good prognostic factor for adverse obstetric outcomes.

Research paper thumbnail of Sezaryen Skar Gebeliğinin Tek Doz Lokal Metotreksat Uygulaması ile Tedavisi: Olgu Sunumu

Sezaryen skar gebeliği erken gebelik nedeniyle başvuran hastaların yaklaşık 1/1800'ünde saptanmak... more Sezaryen skar gebeliği erken gebelik nedeniyle başvuran hastaların yaklaşık 1/1800'ünde saptanmaktadır. Geçirilmiş sezaryen öyküsü olan hastalarda ektopik gebeliklerin %6.1'ini oluşturmaktadır. Nadir görülmesine rağmen maternal morbidite ve mortaliteye sebep olabilmesi ve son yıllarda sezaryen oranlarındaki artışa bağlı olarak görülme sıklığının artması nedeniyle önem taşımaktadır. Tedavisinde lokal veya sistemik metotreksat, lokal potasyum klorid, histereskopi, laparaskopi, laparatomi, uterin küretaj ve uterin arter embolizasyonu gibi değişik yöntemler kullanılmasına rağmen ilk ve en etkin tedavi seçeneği tartışmalıdır. Olgumuz transvajinal ultrasonografi eşliğinde lokal tek doz metotreksat uygulaması ile komplikasyonsuz bir şekilde tedavi edilmiştir; bu tedavi yöntemi sezaryen skar gebeliğinde ilk tedavi seçeneği olarak önerilebilir.

Research paper thumbnail of Elevated basal progesterone levels are associated with increased preovulatory progesterone rise but not with higher pregnancy rates in ICSI cycles with GnRH antagonists

European Journal of Obstetrics & Gynecology and Reproductive Biology, Sep 1, 2017

To ascertain the association between basal progesterone (P) levels and the occurrence of preovula... more To ascertain the association between basal progesterone (P) levels and the occurrence of preovulatory progesterone rise (PPR) and clinical pregnancy rates (CPRs) in ICSI cycles with GnRH antagonists. Study design: Serum P levels of 464 patients were measured on day 2 and day of hCG of cycles. Cycles with basal P levels > 1.6 ng/mL were cancelled. All embryos were cryopreserved in cycles with P levels ! 2 ng/ mL on the day of hCG. The primary outcome measures were the incidence of PPR (P > 1.5 ng/mL) and CPR with regard to basal P. Results: Basal P levels were significantly higher in cycles with PPR than in those without PPR (0.63 AE 0.31 vs. 0.48 AE 0.28 ng/mL). Area under the curve for basal P according to ROC analysis to discriminate between elevated and normal P levels on the day of hCG was 0.65 (0.58-0.71 95% CI, p < 0.01). The cutoff value for basal P levels that best discriminates between cycles with and without PPR was 0.65 ng/mL. Cycles with basal P levels above 0.65 ng/mL had a significantly higher incidence of PPR (30.9% vs. 13.5%) but similar clinical and cumulative pregnancy rates (38.8% vs. 31.1% and 41.7% vs. 32.6%, respectively) in comparison to cycles with basal P levels below 0.65 ng/mL. In multivariate regression analysis, basal P levels, LH level on the first day of antagonist administration, and estradiol levels on the day of hCG trigger were the variables that predicted PPR. Conclusion: Basal P levels were associated with increased incidence of PPR but not with CPR.

Research paper thumbnail of Sistemik Lupus Eritematozus ve Gebelik: 42 Olgunun Değerlendirilmesi

Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2009

istemik lupus eritematozus (SLE), pek çok değişik organda bozukluğa yol açan, kronik otoimmün bir... more istemik lupus eritematozus (SLE), pek çok değişik organda bozukluğa yol açan, kronik otoimmün bir hastalıktır. 1,2 SLE hafif seyredebileceği gibi, yaşamı tehdit eden komplikasyonlara da yol açabilmektedir. 2,3 Ek

Research paper thumbnail of Serum caveolin-1 levels in patients with preeclampsia

Journal of Maternal-fetal & Neonatal Medicine, Sep 24, 2018

Aim: The expressions of caveolin-1 have only been examined in the placental tissue of patients wi... more Aim: The expressions of caveolin-1 have only been examined in the placental tissue of patients with preeclampsia and were reported to be low. Therefore, we decided to investigate the maternal serum levels of caveolin-1 in patients with preeclampsia. Material and methods: This cross-sectional study was conducted including 87 pregnant women; 32 with normal pregnancy and 55 with preeclampsia. Maternal serum levels of caveolin-1 were measured by using enzyme-linked immunosorbent assay kit (ELISA). Results: The mean serum caveolin-1 level was significantly lower in women with preeclampsia (PE) compared with the control group (11.48 ± 0.92 versus 12.94 ± 1.36 ng/ml) and being lowest in the early onset PE group (11.24 ± 0.74 ng/ml). Serum caveolin-1 concentrations did not correlate with maternal age and BMI. However, caveolin-1 concentrations were negatively correlated with systolic blood pressure (r ¼-0.467, p ¼ .001) and diastolic blood pressure (r ¼-0.441, p ¼ .001) as well as with umbilical artery resistance index (r ¼-0.275, p ¼ .01). Conclusion: Maternal serum caveolin-1 levels are significantly lower in patients with PE than controls. The serum caveolin-1 levels inversely correlate with blood pressure and umbilical artery Doppler parameters.

Research paper thumbnail of Laparoscopic hysterectomy; our experience

SSK Okmeydanı Eğitim Hastanesi tıp dergisi, 2016

Histerektomi en yaygın yapılan majör jinekolojik ameliyattır. Tüm dünyada en sık laparotomi ile y... more Histerektomi en yaygın yapılan majör jinekolojik ameliyattır. Tüm dünyada en sık laparotomi ile yapılmasına rağmen, laparoskopik histerektomi giderek artmaktadır. Bu çalışmada, kliniğimizde total laparoskopik histerektomi yapılan hastalar değerlendirildi. Gereç ve Yöntem: Kliniğimizde Ocak 2014 ile Ocak 2016 tarihleri arasında benign veya malign jinekolojik hastalıklar nedeniyle total laparoskopik histerektomi yapılan hastaların dosyaları retrospektif olarak tarandı. Hastaların yaş, vücut-kitle indeksi, parite, daha önce geçirilmiş operasyon öyküsü gibi demografik verileri kaydedildi. Histerektomi endikasyonu, histerektomiye ek olarak yapılan cerrahiler, toplam operasyon süresi, kan kaybı, preoperatif ve postoperatif hemoglobin değerleri, uterus ağırlığı, perioperatif ve postoperatif komplikasyonlar ile hastanede kalış süreleri kaydedildi. Sonuçlar güncel literatür eşliğinde değerlendirildi.

Research paper thumbnail of Obesity and Pregnancy

SSK Okmeydanı Eğitim Hastanesi tıp dergisi, Aug 25, 2014

Research paper thumbnail of Management of ovulation induction and intrauterine insemination in infertile patients with hypogonadotropic hypogonadism

Journal of gynecology obstetrics and human reproduction, Dec 1, 2019

rates were 12.7% and 28.3% per cycle and per patient, respectively. The pregnancy rate in hCGtrig... more rates were 12.7% and 28.3% per cycle and per patient, respectively. The pregnancy rate in hCGtriggered patients (successful stimulation) was 17.1% per cycle in all patients. Conclusion OI with gonadotropins and IUI is a safe, efficient, and relatively cost-effective treatment option in patients with HH, yielding reasonable pregnancy rates per cycle and per patient. The use of rec FSH + rec LH facilitates cycle management but does not positively contribute to pregnancy rates and is more expensive than some other feasible options.

Research paper thumbnail of Maternal serum autotaxin levels in early- and late-onset preeclampsia

Hypertension in Pregnancy, Oct 2, 2017

We aimed to compare the serum autotaxin levels in early- and late- preeclamptic and healthy pregn... more We aimed to compare the serum autotaxin levels in early- and late- preeclamptic and healthy pregnant patients at a university hospital. A total of 55 singleton preeclamptic women who delivered at Cerrahpasa Medical Faculty were included in the study. The patients were subdivided into two groups: early-onset preeclampsia (n = 31) and late-onset preeclampsia (n = 24). Demographic and clinical data were compared between early-onset and late-onset preeclamptic patients. The control group was composed of 32 healthy pregnant patients. The mean autotaxin levels were 1.16 ± 0.97 and 0.7 ± 0.35 ng/ml in the early- and late-onset preeclampsia groups, respectively. Autotaxin levels were significantly higher in early-onset preeclampsia group compared with late-onset preeclampsia group. Autotaxin levels were found to be significantly higher in preeclamptic patients compared with control group. Serum autotaxin levels showed a significant positive correlation with maternal systolic, diastolic blood pressures and uric acid levels. Autotaxin might be a promising marker for detecting early-onset preeclampsia. However, further studies are necessary to confirm this hypothesis.

Research paper thumbnail of Myomectomy for intramural fibroids during caesarean section: A therapeutic dilemma

Journal of Obstetrics and Gynaecology, Dec 7, 2016

The aim of the present study was to assess the safety of myomectomy for intramural fibroids durin... more The aim of the present study was to assess the safety of myomectomy for intramural fibroids during caesarean section. A retrospective study of 63 women who underwent myomectomy during caesarean section and 63 women who underwent caesarean delivery without myomectomy was conducted. The study group was divided into subgroups according to the volume of fibroids and total incision count. The volume of fibroids, the preoperative and postoperative haemoglobin values and the difference between them, incidence of haemorrhage and blood transfusion, duration of operation and postoperative fever of patients were investigated. Duration of operation was longer (p < .001) and haemoglobin loss was higher (p ¼ .01) in the myomectomy group. There was no difference between one incision and two incisions subgroups in terms of mean haemoglobin change (p ¼ .068). Haemoglobin loss was higher in volume >50 cm 3 group than volume <50 cm 3 and control groups. These differences were statistically significant (p ¼ .02; p ¼ .001, respectively). Although intramural fibroids can be safely removed during caesarean section, large fibroids and extra incisions for myomectomy are risk factors for haemorrhage.

Research paper thumbnail of Preeklampsi Olgularında Birinci Trimester Maternal Serum Metastin Düzeyi, Kitotriozidaz Aktivitesi ve Uterin Arter Doppler Bulguları

Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2012

Research paper thumbnail of Karın Ön Duvarı Defekti Prenatal Tanısı Olan 24 Gebeliğin İrdelenmesi

Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2008

m fa lo sel ve gas tro şi zis ka rın ön du va rı nın en sık gö rü len ya pı sal ano ma li le ri d... more m fa lo sel ve gas tro şi zis ka rın ön du va rı nın en sık gö rü len ya pı sal ano ma li le ri dir. 1 Om fa lo sel 10 000 do ğum da 0.8-3.9 ora nın da rastla nı lan ve ka ra ci ğer, bar sak gi bi ka rın içi or gan la rın pe ri ton ile Karın Ön Duvarı Defekti Prenatal Tanısı Olan 24 Gebeliğin İrdelenmesi ÖZET Amaç: Prenatal dönemde karın ön duvarı defekti tanısı alan olguların klinik özelliklerinin ve perinatal sonuçlarının değerlendirilmesi Gereç ve Yöntemler: Ana Bilim Dalımızda Ocak 1998-Aralık 2006 tarihleri arasında gastroşizis ve omfalosel tanısı alan 24 olgu retrospektif olarak irdelendi. Gebelerin tanı haftası, ilave yapısal ve kromozomal anomali varlığı, doğum hafta ve şekli ile perinatal sonuçları değerlendirildi. Bulgular: Batın ön duvarı defekti olan 24 fetusun 11'inde gastroşizis, 13'ünde omfalosel mevcuttu. Gastroşizis ve omfalosel tanısı alan gebelerin nulliparite oranları ve yaşlarının ortalaması sırasıyla %72.7, 22.5 ± 5.1 ve %53.8, 26.8 ± 2.0 olarak bulundu. Gastroşizis olgularında ilave yapısal ve kromozomal anomali saptanmadı. Omfalosel olgularının ise 4'ünde (%30.8) ilave yapısal anomali ve 1'inde (%7.7) kromozom anomalisi belirlendi. Gastroşizis ve omfalosel için perinatal mortalite oranlarımız sırasıyla %20 ve %44 olarak saptandı. Canlı doğan izole gastroşizis ve omfalosel olgularımızda sağkalım oranlarımız ise sırasıyla %88.8 ve %71.4 olarak belirlendi. Sonuç: Karın ön duvarı defektli fetusların antenatal dönemde tanısının konması, ilave yapısal ve kromozomal anomalilerin belirlenmesi, ekip anlayışı içinde takip edilmeleri ve uygun merkezlerde doğumların gerçekleşmesine olanak sağlaması açısından son derece önemlidir.

Research paper thumbnail of Prenatal Tanılı 24 Konjenital Diyafram Hernili Olgunun İrdelenmesi

Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2008

on je ni tal di yaf ram her ni si (KDH), or ta la ma 4000 (2000 ile 6000) canlı do ğum da bir ras... more on je ni tal di yaf ram her ni si (KDH), or ta la ma 4000 (2000 ile 6000) canlı do ğum da bir rast la nı lan ve di yaf ram da ki do ğum sal bir de fekt ten ba tın için de ki or gan la rın to raks boş lu ğu na fı tık laş ma sı ola rak ta nımla nan bir ano ma li dir. 1 Kon je ni tal di yaf ra ma her ni si izo le ve ya komp leks olabi lir. Komp leks ol gu lar da, di yaf ram da ki de fekt bir sen dro mun par ça sı dır,

Research paper thumbnail of Implications of circulating irisin and Fabp4 levels in patients with polycystic ovary syndrome

Journal of Obstetrics and Gynaecology, May 16, 2016

The aim of the study was to evaluate the fatty acid-binding protein-4 (FABP4) and irisin concentr... more The aim of the study was to evaluate the fatty acid-binding protein-4 (FABP4) and irisin concentrations in women with polycystic ovary syndrome (PCOS). Forty-nine women with PCOS, diagnosed according to Rotterdam criteria and 39 healthy women matched for body mass index (BMI) and age. Serum irisin and plasma FABP4 concentrations were measured in both groups. The association of irisin and FABP4 concentrations with metabolic parameters were also tested. Women with PCOS had significantly lower mean serum irisin concentrations than control subjects (158.5 ± 123.3 versus 222.9 ± 152.2 ng/ml, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). Concentrations of FABP4 in PCOS and control groups were not significantly different (10.5 ± 4.4 versus 10.9 ± 4.2 ng/ml, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). FABP4 concentrations were correlated with BMI, waist-hip ratio (WHR) and HOMA-IR (r = 0.57, p = 0.001; r = 0.26, p = 0.03; r = 0.26, p = 0.03, respectively). No associations between irisin and all the others parameters except serum levels of LH were found. Serum irisin concentrations of women with PCOS were lower compared to the controls. Moreover, there were no difference in plasma FABP4 concentrations between women with PCOS and controls.

Research paper thumbnail of Can M-30, M-65, and IL-6 serum levels be useful markers in the diagnosis of preeclampsia and gestational diabetes?

PubMed, Jun 1, 2023

Objective: We aimed to evaluate the maternal and fetal serum M-30, M-65 and IL-6 levels in preecl... more Objective: We aimed to evaluate the maternal and fetal serum M-30, M-65 and IL-6 levels in preeclampsia and gestational diabetes mellitus (GDM) in both maternal and cord blood. Patients and methods: Women with preeclampsia (n=30), GDM (n=30), and uncomplicated pregnancy (n=28) were evaluated in a cross-sectional study. After clamping during delivery, the serum M-30, M-65, and IL-6 levels were measured in both maternal venous blood and cord blood. Results: The serum M-30, M-65, and IL-6 levels were significantly higher in preeclampsia and GDM patients' maternal blood and cord blood samples compared to the control group. In the preeclampsia group, M-65 was significantly higher in cord blood compared with the level in maternal serum, but there was no significant difference between the GDM and control groups. The control group's IL-6 level in cord blood was statistically significantly lower than the other groups. Although the M-30 value in both maternal and cord blood was statistically lower in the control group than in the GDM group, there was no significant difference between the two groups when compared to the preeclampsia group. Conclusions: M-30 and M-65 molecules appear to have the potential to serve as biochemical markers in placental diseases, particularly preeclampsia and gestational diabetes. Due to the insufficient sample sizes, more research is needed.

Research paper thumbnail of Effect of Taxifolin on Acrylamide-Related Oxidative Ovarian Damage, Infertility and Intrauterine Growth Retardation in Female Rats

International Journal of Pharmacology, Mar 15, 2023

Research paper thumbnail of A viable childbirth after correction of spontaneous uterine dehiscence

The European Research Journal, Mar 4, 2016

We report a case of uterine dehiscence during pregnancy. Uterine dehiscence and rupture are serio... more We report a case of uterine dehiscence during pregnancy. Uterine dehiscence and rupture are serious complications of pregnancy. This situation takes place especially in women that prior uterine operation(s). We represent a 30-year-old woman diagnosed uterine dehiscence at 22 nd gestation week. Uterine dehiscence treated surgically and then medical treatment was given to prevent preterm labour. At 34 th gestation week, the patient was operated because of preterm labour and an alive foetus was born. The result of the pathologic examination of the placenta: Placental adhesion failure was detected. In conclusion women with prior caesarean delivery (one or more), ultrasound measurement should be recommended for measuring the lower uterine segment thickness in order to predict the possibility of uterine dehiscence and rupture.

Research paper thumbnail of Serum collectrin levels in patients with early- and late-onset preeclampsia

Journal of Maternal-fetal & Neonatal Medicine, Aug 2, 2017

The aim of this study is to investigate the maternal levels of collectrin in early-onset preeclam... more The aim of this study is to investigate the maternal levels of collectrin in early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE). To assess the correlation between serum collectrin levels and blood pressure in humans. This cross-sectional study was conducted including 79 pregnant women, 27 with normal pregnancy, 30 with EOPE and 22 with LOPE. Maternal serum levels of collectrin were measured by using enzyme-linked immunosorbent assay kits. The mean serum collectrin level was significantly lower in women with PE compared with the control group (8.49 ± 3.12 ng/ml (EOPE), 9.69 ± 3.01 ng/ml (LOPE) versus 11.51 ± 4.33 ng/ml) and was found to be the lowest in the EOPE group (8.49 ± 3.12 ng/ml). The mean serum urea and uric acid levels were significantly higher in the PE group than the control group. Serum collectrin concentrations did not correlate with maternal age, BMI and serum creatinine levels. However, collectrin concentrations were negatively correlated with systolic blood pressure (r = -0.284, p = .011) and diastolic blood pressure (r = -0.275, p = .014) as well as with maternal serum urea (r = -0.269, p = .017) and uric acid (r = -0.219, p = .049) concentrations. Maternal serum collectrin levels are significantly lower in patients with preeclampsia than in the control group. There is an inverse correlation between serum collectrin levels and blood pressure.

Research paper thumbnail of Unusual uterine metastasis of invasive ductal carcinoma: A case report

Türk jinekoloji ve obstetrik derneği dergisi, Sep 30, 2016

Uterusun metastatik kanserleri genellikle diğer genital sistemlerden kaynaklanmaktadır. Meme gibi... more Uterusun metastatik kanserleri genellikle diğer genital sistemlerden kaynaklanmaktadır. Meme gibi genital bölge dışı bölgelerden metastaz çok nadirdir. Hikayesinde meme kanseri olan 34 yaşındaki kadın hasta olağan kontrol için polikliniğimize başvurdu. Jinekolojik muayene ve görüntüleme yöntemleri sonucu uterusta kitle bulundu ve laparotomi yapılarak kitle çıkarıldı. Patolojik inceleme invaziv duktal karsinom metastazı olduğunu ortaya çıkardı. Hastaya kemoterapi verildi ve 3 yıl kontrolleri sırasında pozitron emisyon tomografi + bilgisayarlı tomografi görüntülemeleri normal olarak bulundu. Tamoksifen tedavisi alan meme kanserli hastalarda sadece primer endometriyal kanser değil ayrıca bazen uterusa metastazın da gelişebileceği akılda tutulmalıdır. Başarılı bir tedavi ile bu hastalar nüks hastalık olmadan hayatta kalabilirler.

Research paper thumbnail of Adolescent pregnancies: complications, birth outcomes and the possible solutions

Ginekologia Polska, Jul 31, 2017

Objectives: In this study we aim to evaluate antenatal, perinatal and postnatal outcomes and comp... more Objectives: In this study we aim to evaluate antenatal, perinatal and postnatal outcomes and complications of adolescent pregnancies, as well as to discuss the social and psychological consequences of these pregnancies. Material and methods: We compare a total of 243 pregnant women at age 14-18 years to a vast control group at age 19-36 who all delivered at Bursa Yüksek Ihtisas Training and Research Hospital between years 2005-2014. Results: Antenatal care (folic acid supplementation, pre-conception counseling) was significantly higher in adolescent pregnancy group. Unplanned pregnancy rate was significantly higher in in study group (p < 0.001). Preterm delivery (before 37 th week) ratio was statistically higher in pregnancy complications. Conclusions: Adolescent pregnancy is a social entity which should be regulated and prevented by legal measures. Planned pregnancies should be promoted and the public should be educated and informed about the Hazards of adolescent pregnancies. Press institutions, public broadcasting services support the efforts to decrease adolescent pregnancies.