Sreebash Bhattacharjee - Academia.edu (original) (raw)

Papers by Sreebash Bhattacharjee

BENTHAM SCIENCE PUBLISHERS eBooks, Nov 23, 2009

Essential oil (0.51%) has been isolated from the rhizomes of Zingiber zerumbet from which a white... more Essential oil (0.51%) has been isolated from the rhizomes of Zingiber zerumbet from which a white crystalline fraction-A (m.p.62 0 C) has been separated and purified. Another fraction-B (m.p. 66 0 C) has been isolated from petroleum ether (40-60 0 C) extract. The fraction-A & B have been analyzed by, IR, GC/MS.

International Letters of Natural Sciences, Sep 1, 2016

Lipid was extracted from the lipid containing muscle of Liner silver grunter (Pomadasys hasta) by... more Lipid was extracted from the lipid containing muscle of Liner silver grunter (Pomadasys hasta) by solvent extraction and then purified by standard method. The physico-chemical properties of lipid sample were determined and compared with those of other standard fats and oils. Fatty acid composition of the lipid sample was investigated by Thin Layer Chromatographic (TLC) examination. Gas Liquid Chromatographic (GLC) examination was performed by the methyl esters mixture prepared from the lipid sample. The de-oiled muscle of the fish was studied for the determination of ash content, fiber content, moisture content and protein content. The lipid containing selected muscle was analyzed quantitatively for the determination of percentages of protein, cholesterol and minerals (N, P, K, Ca, and Na). The lipid containing muscle was also analyzed for the determination of the amount of eleven metals by using Atomic Absorption Spectrophotometric method. The lipid sample was evaluated by microbial activity (bacterial activity against nine bacteria and fungal activity against seven fungi).

International Letters of Natural Sciences, Sep 9, 2016

Journal of Applied Science & Process Engineering, Apr 30, 2022

Monosaccharide derived glucose-aspirin (GA) can be prepared by conjugation between glucose and as... more Monosaccharide derived glucose-aspirin (GA) can be prepared by conjugation between glucose and aspirin (ASA). The GA is reported to show higher analgesic and anti-inflammatory properties than ASA itself. In this perspective, six GAs which are composed of β-D-glucopyranose, ASA and acetyl groups are considered for the present investigations. The glucose unit in these GAs possesses regular chair conformation with slightly lower dipole moments. Molecular orbitals indicated a higher HOMO-LUMO gap of the molecules. All GAs showed more prone to electrophilic interactions than aspirin. Overall, glucose-aspirin esters are found to have better non-steroidal anti-inflammatory properties than the original aspirin. These GAs are better inhibitors of cyclooxygenase-2 (COX2, 5f19) compared to cyclooxygenase-1 (COX1, 6y3c) indicating that these GAs are potential drug candidates for COX2 related inflammation. Additionally, aspirinyl group at C-6 or C-3 position of the glucopyranose unit is found more suitable for anti-inflammatory activities as compared to C-4 position.

Carbohydrate Research, Nov 1, 2019

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Current World Environment, Aug 25, 2017

The current research has been conducted to investigate concentrationsof some toxic metals such as... more The current research has been conducted to investigate concentrationsof some toxic metals such as Mn,Cr,Pb,Cd, Cu,and Co along with essential nutrients K,Ca,Mg,Fe and Zn in twenty two different types of vegetables collected from wholesale market of Chittagong Metropolitan city, Bangladesh. Toxic metals and essential nutrients concentration in the vegetables were determined using Atomic Absorption Spectrometer (AAS) after acid digestion. Percentages of moisture, organic and inorganic matter of these vegetables were also determined. Metals concentration was measured by AAS after wet digestion system. The result of this study showed that the average concentration detected for toxic metals ranged from 0.

Journal of Scientific Research, May 1, 2021

Over the past several decades significant biological activities including brains protective and a... more Over the past several decades significant biological activities including brains protective and antimicrobial activities have made sugar esters (SEs) as a topic of great interest. In this context, unimolar 3-chlorobenzoylation of methyl α-L-rhamnopyranoside (4) using dibutyltin oxide method regioselectively furnished only the 3-O-substitution product 5 in excellent yield. The reaction proceeded via the formation of a cyclic 2,3-Odibutylstannylene intermediate where equatorial hydroxyl group is activated by the tin atom leading to the formation of product 5 only. To get biologically important rhamnopyranoside esters chlorobenzoate 5 was further converted into three newer 2,4-di-O-acyl products 6-9 with other acylating agents using direct acylation method. Prediction of activity spectra for substances (PASS) indicated that these rhamnopyranoside esters have many promising biological profiles including CYP2H substrate, membrane permeability inhibitor and better antifungal activities. Additionally, ADMET and drug likeness properties of SEs 5-8 were predicted and discussed.

Journal of the Turkish Chemical Society, Section A: Chemistry, Feb 28, 2021

Notable biological activities including brains protective activities have made carbohydrate ester... more Notable biological activities including brains protective activities have made carbohydrate esters as a topic of great interest over the past several decades. In this context, unimolecular treatment of methyl α-L-rhamnopyranoside with dibutyltin oxide gave the corresponding 2,3-O-(dibutylstannylene) derivative which was then allowed to react with 3-chlorobenzoyl chloride. The reaction regioselectively furnished the 3-O-substitution product in excellent yield. To get newer rhamnopyranoside esters chlorobenzoate was further converted into four 2,4-di-O-substituted products with other acylating agents using direct acylation technique. Moreover, thermodynamic properties indicated that these sugar esters (SEs) possess better stability, suitable polar nature and higher binding affinity than the non-ester rhamnopyranoside. Prediction of Activity Spectra for Substances (PASS) predication showed that these SEs should be more potent against fungal pathogens than the bacterial organisms. With these encouraging results absorption, distribution, metabolism, excretion, and toxicity (ADMET) and drug-likeness properties of the SEs are also discussed.

Journal of Applied Science & Process Engineering, Oct 31, 2021

Carbohydrate-based molecular scaffolding received significant interest due to its impact on the d... more Carbohydrate-based molecular scaffolding received significant interest due to its impact on the drug discovery and development in synthetic carbohydrate chemistry during the last couple of decades. In this respect, four glucose compounds in the furanose and pyranose forms with ester and ether functionality were selected for their structural, thermodynamic and chemical reactivity studies. PASS predication indicated that the glucose in the six-membered pyranose form was more prone to biological properties compared to their five-membered furanose form. Also, in the pyranose form acetate ester (3) had more potentiality than the ethyl ether (4). The HOMO-LUMO energy gaps were almost similar for both monosubstituted furanose and pyranose glucose indicating their almost similar reactivities. It was also inferred that these 6-O-substituted compounds followed Lipinski's rule with the acceptable range of ADMET levels, and hence, safe from lethal proarrhythmic risks. Hopefully, these results can be used in the near future for their probable pharmaceutical use without any remarkable toxicity.

Medical research archives, 2020

Sugar derived esters (SEs) with potential antimicrobial activity were found to be a better choice... more Sugar derived esters (SEs) with potential antimicrobial activity were found to be a better choice to solve the multidrug resistant (MDR) pathogens due to improved antimicrobial efficacy, biodegradability, non-toxic, and non-allergic properties. In this context, a series of benzyl -Lrhamnopyranoside esters with different chain length (C2-C18) were employed for PASS predication, antiviral, and in vitro antimicrobial activity test. The in vitro antimicrobial tests against four bacterial, and four fungal pathogens along with PASS predication indicated that these sugar esters acted as better antifungals as compared to antibacterial functionality. The study revealed that the incorporation of octanoyl (C8) and lauroyl (C12) group(s) at C-3 position of rhamnopyranoside possessed promising antimicrobial, and anti-carcinogenic potentiality with good pharmacokinetic (pkCSM), and drug likeness properties. Also, attachment of multiple ester groups enhanced various drug likeness, and medicinal chemistry friendliness conditions. Overall, the present findings might be useful for the development of rhamnopyranoside based novel MDR antimicrobial drugs.

DOAJ (DOAJ: Directory of Open Access Journals), Dec 1, 2010

The study was carried out to assess surface and groundwater quality of the greater Chittagong (Ch... more The study was carried out to assess surface and groundwater quality of the greater Chittagong (Chittagong and Cox's Bazar districts) and Chittagong Hill Tracts (Rangamati, Khagrachhari and Bandarban districts) of Bangladesh. To study the various physicochemical and microbiological parameters, surface water samples from the Karnafuli, Halda, Sangu, Matamuhuri, Bakkhali, Naf, Kasalong, Chingri and Mayani Rivers, Kaptai Lake and groundwater samples from almost every Upazilas, smaller administrative unit of Bangladesh, were collected and analyzed. The statistical methods of sampling were used for collecting samples. Samples were preserved using suitable preservation methods. Water samples from the freshwater resources were collected from different points and tide conditions and at different seasons for continuous monitoring during the hydrological years 2008-2009. The collected samples were analyzed for the following parameters: pH, electrical conductivity (EC), total dissolved solids (TDS), total suspended solids (TSS), total solids (TS), dissolved oxygen (DO), transparency, acidity, dissolved carbon dioxide, total alkalinity, total hardness, chloride, ammonia-N, hydrogen sulfide, sulphate-S, o-phosphate-P, biochemical oxygen demand (BOD), chemical oxygen demand (COD), nitrate-N, nitrite-N, total nitrite and nitrate-N, arsenic, iron, manganese, copper, nickel, chromium, cadmium, lead, calcium, magnesium, sodium and potassium using the procedure outlined in the standard methods. Average values of maximum physicochemical and microbiological parameters studied for the Karnafuli River were found higher than the World Health Organization (WHO) guideline. The maximum water quality parameters of Kaptai Lake and other Rivers of Chittagong region were existed within the permissible limits of WHO guideline. The data showed the water quality slightly differs in pre-monsoon and post-monsoon than monsoon season. The concentration of different constituents of most of the groundwater samples were within the permissible limits of BSTI drinking water quality guideline except As, Fe, and Mn. Results of water quality assessment identified the problem areas in respect of arsenic. The results also provided data to understand and quantify the threat of the impact of climate change on freshwater resources of this region. The results also provided data for water quality of surface and groundwater resources of Chittagong region to match national and international standards for drinking, agricultural, industrial and livestock requirements.

Informatics in Medicine Unlocked

Journal of Biodiversity Conservation and Bioresource Management, 2020

During the study, the leaves of two medicinal plants, Polygonum hydropiper and Abrus precatorius ... more During the study, the leaves of two medicinal plants, Polygonum hydropiper and Abrus precatorius were extracted with water, ethanol, methanol and petroleum ether solvents and tested against the rice weevil S. oryzae L. for insecticidal properties. Response varied with plant species. The mortality of adults increased with increasing dose concentrations from 1000 ppm to 5000 ppm each solution, with an exposure time of 72 hours. LC50 values calculated were found to be 15091.436 ppm with water, 5051.534 ppm with ethanol, 5111.063 ppm with methanol and 4305.348 ppm with petroleum ether extracts of P. hydropiper and 9687.292 ppm with water, 6263.849 ppm with ethanol, 4682.683 ppm with methanol and 3222.984 ppm with petroleum ether extracts of Abrus precatorius leaves corresponding their concentrations of the leaf extract solutions at 1000ppm, 2000 ppm, 3000 ppm, 4000 ppm and 5000 ppm respectively. The results of the study showed that methanol and petroleum ether extrcts of P. hydropiper a...

Journal of Applied Science & Process Engineering

International Journal of Applied Pharmaceutics, 2022

The current treatment approaches for allergic rhinitis are practiced over decades, but the patien... more The current treatment approaches for allergic rhinitis are practiced over decades, but the patient quality of life has not yet changed so much. The reasons are research gaps in pathophysiology of the disease, proper management of the disease. Fexofenadine HCl is a second-generation antihistamine drug which has a half-life of about 14.4 h. It is useful in the management of common symptoms like sneezing, itchy throat, and red eyes in individuals suffering from allergic rhinitis. Fexofenadine immediate release or sustained release formulations are available in the market as suspension, tablet and capsule. In this research paper, we have discussed the symptoms associated with allergic rhinitis and treatment approaches. Fexofenadine HCl is being used for the treatment of this disease. But as it has a long half-life, we have discussed the importance of the introduction of sustained-release microsphere formulation of Fexofenadine HCl in the market.

Biosciences Biotechnology Research Asia, 2021

Microspheres, a potential drug delivery approach, has opened a new era for attaining versatile re... more Microspheres, a potential drug delivery approach, has opened a new era for attaining versatile release patterns needed. By optimizing the formulation variables, they can be prepared to obtain targeted release, immediate release, sustained release patterns. The release of the active drug material depends upon a number of formulation parameters such as polymers, stirring speed (rpm), methodology, surfactants, etc. Fexofenadine hydrochloride (HCl) is a second generation antihistamine. Our present research has explored the effects of using different rpm (600- 1000 rpm) in preparing fexofenadine hydrochloride (HCl) microspheres by emulsion solvent evaporation method. The formulation is aimed to provide sustained release for the required long period with a high margin of safety. We used a blended mixture of Hydroxy Propyl Methyl Cellulose (HPMC) K 100 MCR and Eudragit RL100 polymers to have sustained-release microspheres. The impact of different rpm on Yield, drug encapsulation efficiency...

international food research journal, 2014

Magnesium is an essential mineral for its crucial role in many physiological function and metabol... more Magnesium is an essential mineral for its crucial role in many physiological function and metabolism. While magnesium should be present in nutritionally important quantities in regular diets, average Bangladeshi diets frequently fail to contain an adequate supply of the element. Thus, the study aims to determine the amount of magnesium in four different dietary items, bananas, vegetables and pulses, locally available in Chittagong, Bangladesh, using Spectrophotometric method. As per the findings, the magnesium concentration for banana contrasts between 0.843 µg/g and 3.654µg/g. Musa cavendishii from Satkania Upazila contains the highest value while, the lowest amount is found in Musa paradisiaca from Lama Upazila. For arums, the amount varies between 0.476 and 21.3456µg/g. The highest amount was found in arums, Colocasia esculenta (Patiya upazila) i.e. 21.3456µg/g and the lowest amount appears from the same species at Boailkhali upazila. In vegetables, the quantity fluctuates betwee...

International Food Research Journal

Copper is common element in the env.iroDJDeirt. People are exposed to copper by brealhing air, dr... more Copper is common element in the env.iroDJDeirt. People are exposed to copper by brealhing air, drinking water, eating food, and by skin contact with soil, water and other copper-containing substances. Most copper compounds found in air, water, sediment, soil and rock are strongly attached to dust and dirt or imbedded inminerals. It rapidly enters into the bloodstream and is distr:ibuted throughout the body after eating or drinking the copper containing products. Certain substances in foods are eaten with copper can affect the amount of copper that enters into the bloodstream from the gastrointest:inal wet. The present investigation shows that four verities of vital food i.e. pulses, bananas, vegetables and arums contain diverse ammmt of copper in Chittagong area of Bangladesh. This food is taken for survival the life. The amoums of copper in pulses were found to vary from 3.22S 29.653l!J.g/g of that region. The highest and lowest values were found in J'igna muungo (Anowam) and L...

IOSR Journal of Environmental Science, Toxicology and Food Technology, 2012

Zinc is an essential element needed by the body in small amounts as it is the most abundant trace... more Zinc is an essential element needed by the body in small amounts as it is the most abundant trace metals in human. It deficiency is occurring in different climate regions of the world. It has become an important risk factor for plant growth as well as human health throughout the world. In this study, we observed the amount of zinc in different arums, bananas, vegetables and pulses which are locally available in Chittagong region of Bangladesh. The amount of zinc in twenty samples of arums was found to vary from 0.3174-9.0755 µg/g. The highest and lowest value was found in arums of Typhonium trilobatum (Patiya) and Amorphophallus campanulatus (Satkaniya) respectively. In bananas vary from 0.1430 to 2.7360 µg/g. The highest and lowest value was found in banana of Musa acuminata in Satkania and Ramgarh upazila respectively. The amount of zinc in vegetables was found to vary from 0.92-7.59 µg/g. Zinc in pulses were found to vary from 1.2973-29.5008 µg/g. The highest and lowest values were found in Lathyrus sativus and Phaseolus aureus respectively. From four types of food, we see that the highest value of zinc in pulse species of Lathyrus sativus and the lowest value of zinc in banana species of Musa acuminata respectively of Chittagong region, Bangladesh.