Bhavna Patel - Academia.edu (original) (raw)

Papers by Bhavna Patel

Genomics, 1996

nisms involved in the regulation of the somatic stability of the (CTG) n repeats in DM. ᭧ 1996 Ac... more nisms involved in the regulation of the somatic stability of the (CTG) n repeats in DM. ᭧ 1996 Academic Press, Inc. The mutation associated with myotonic dystrophy (DM) is the expansion of an unstable trinucleotide repeat, (CTG) n , in the 3-untranslated region of the myo-INTRODUCTION tonin protein kinase gene. Although expanded repeats show both germline and somatic instability, the mech-An expansion of an unstable (CTG) n repeat [p(AGC) n anisms of the instability are poorly understood. To esby HGM 10.5 nomenclature] in the 3-untranslated retablish a model system in which somatic instability gion of the myotonin protein kinase (Mt-PK) gene of the DM repeat could be studied in more detail, we (DMPK by GDB nomenclature) is associated with myoestablished lymphoblastoid cell lines (LBCL) from DM tonic dystrophy (DM) (Fu et al., 1992; Mahadevan et patients. Analysis of the DNA from DM LBCL using Brook et al., 1992). In addition to frequently Southern blotting showed that the (CTG) n repeats observed intergenerational repeat size differences, sowere apparently stable up to 29 passages in culture.

Archives of Neurology, 1998

To determine whether the G-to-A substitution at nucleotide 209 (G209A) mutation in the alpha-synu... more To determine whether the G-to-A substitution at nucleotide 209 (G209A) mutation in the alpha-synuclein gene is responsible for familial Parkinson disease (PD) in the US population. Polymerase chain reaction-based DNA analysis of consecutive patients with PD and family history of PD. A university-affiliated movement disorder clinic and a Veterans Affairs clinical research laboratory. Forty-four patients with PD and family history of PD and 29 patients with sporadic PD, all with no known Greek and/or Italian background. None of the DNA samples showed the G209A mutation. The G209A mutation is rare in US patients with familial PD.

Inflammation, 1990

Retinoids have demonstrated antiinflammatory activity in certain animal models and human disease ... more Retinoids have demonstrated antiinflammatory activity in certain animal models and human disease states. The mechanism by which retinoids elicit this activity is unknown. Some retinoids are known to inhibit arachidonic acid (AA) release and metabolism in intact cells in vitro. Retinoids may exert their antiinflammatory effects by inhibiting phospholipase A2 (PLA2) and the resultant production of inflammatory AA metabolites. Retinoids were evaluated in vitro as inhibitors of the PLA2 activity in human synovial fluid (HSF-PLA2). Of the naturally occurring, nonaromatic retinoids tested, all-trans-retinal, all-trans-retinoic acid (all-trans-RA) and 13-cis-RA were the most potent inhibitors (IC50 S 6-15 microM), whereas all-trans-retinol was much less potent. Of the synthetic aromatic retinoids and arotinoids examined, the free carboxylic, sulfonic, and sulfinic acid forms were more than 15-fold more potent inhibitors of HSF-PLA2 than their corresponding ethyl esters. These retinoids also were evaluated as inhibitors of calcium ionophore A23187-induced AA release from rat peritoneal macrophages. All-trans-RA and 13-cis-RA were potent inhibitors of AA release from these cells (IC50 S 4 microM), while the other natural retinoids were inactive. Of the aromatic retinoids and arotinoids tested, the free acid forms (IC50 S 2-6 microM) were 5- to 21-fold more potent inhibitors of AA release from the macrophages than their corresponding ethyl esters. The potencies of the arotinoids as inhibitors of HSF-PLA2 appeared to correlate with their potencies as inhibitors of AA release from A23187-stimulated rat peritoneal macrophages. These data support the hypothesis that one possible mechanism for the known antiinflammatory activity of some retinoids may be by inhibition of phospholipase A2.

Executive Summary The DFID Equity and Rights Team commissioned this scoping study of DFID&#x2... more Executive Summary The DFID Equity and Rights Team commissioned this scoping study of DFID's current policy on human rights in response to recent changes in DFID's human rights policy environment. The study does three things. First, it examines the policy framework for ...

International Journal of Current …, 2011

Transdermal drug delivery system (TDDS) provides a means to sustain drug release as well as reduc... more Transdermal drug delivery system (TDDS) provides a means to sustain drug release as well as reduce the intensity of action and thus reduce the side effects associated with its oral therapy. Transdermal drugs are self-contained,discrete dosage form . Transdermal Drug Delivery System is the system in which the delivery of the active ingredients of the drug occurs by the means of skin. Skin is an effective medium from which absorption of the drug takes place and enters the circulatory system. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin. The patches have been proved effective because of its large advantages over other controlled drug delivery systems. This review article covers a brief outline of the principles of trasdermal permeation, various components of transdermal patch, approaches of transdermal patch, evaluation of transdermal system, when the transdermal patch are used and when their use should be avoid and some of the recent development in the field along with the future aspects in this field.

Rabindranath Tagore: a 125th birth …, 1988

The Internet Journal of Gastroenterology, 2007

... 459 Dubey, Prashant..... 40 Hirani, RR ..... 10 ... 76 Singhal, Niraj..... 443Vaidyanathan, A... more ... 459 Dubey, Prashant..... 40 Hirani, RR ..... 10 ... 76 Singhal, Niraj..... 443Vaidyanathan, A. .... 852 Sodhatar, Sagar H. .... 371 ...

wiego.org

We would especially like to mention Purshottambhai Vanker, who was a senior member of the team.

Malaysian Journal of Analytical Sciences, 2012

Chelating ion-exchange resin (pHFR) has been synthesized by condensing p-hydroxybenzoic acid with... more Chelating ion-exchange resin (pHFR) has been synthesized by condensing p-hydroxybenzoic acid with formaldehyde employing resorcinol as cross linking agent at 80 ± 5 o C using DMF as a solvent. The resin was characterized by elemental analysis, FTIR, 1 H-NMR and XRD. The thermal analysis (TGA, DTA and DTG) was done at the heating rate of 10 o C/min in N 2 atmosphere. The morphology of the resin was studied by optical photographs and scanning electron micrographs (SEM) at different magnifications. The physico-chemical properties have been studied. The uptake behaviour of various metal ions viz. Ni(II), Cu(II), Zn(II), Cd(II) and Pb(II) towards pHFR resin have been studied depending on contact time, pH, metal ion concentration and temperature. The maximum uptake capacity for Ni(II), Cu(II), Zn(II), Cd(II) and Pb(II) are found 1.310, 2.304, 1.690, 1.591 and 2.020 mmol/g respectively. The selectivity order is: Cu(II)>Pb(II)>Zn(II)>Cd(II)>Ni(II). The intra-particle diffusion rate constant (K id ) and external diffusion rate constant (K s ) are calculated by Saphn-Schlunder and Weber-Morris models respectively. Equilibrium adsorption data were analyzed by Langmuir and Freundlich equations. The adsorption process follows first order kinetics and specific rate constant K r was obtained by the application of Lagergan equation. Thermodynamic parameters viz. ∆G o , ∆S o and ∆H o have also been calculated for the metal-resin systems.

European …, 2009

... Journal of Social Psychology, 140, 465472. Dolan, B., Lacey, JH, &amp;amp; Evans, C.... more ... Journal of Social Psychology, 140, 465472. Dolan, B., Lacey, JH, &amp;amp; Evans, C. (1990). Eating behavior and attitudes to weight and shape in British women from three eth-nic groups. ... Annals of Behavioral Medicine, 20, 1324. Forbes, GB, Jobe, RL, &amp;amp; Revak, JA (2006). ...

The purpose of this research was to develop the hydrodynamically balanced delivery system of Clar... more The purpose of this research was to develop the hydrodynamically balanced delivery system of Clarithromycin (CLA) which, after oral administration should have the ability to prolong gastric residence time with the desired in vitro release profile for the localized action in the stomach, in the treatment of Helicobacter pylori (H.pylori) mediated peptic ulcer. By applying wet granulation technique floating tablets of Clarithromycin were prepared. The proportion of sodium bicarbonate was varied to get the least possible lag time, also the polymer part varied to get the desired release. In vivo radiographic studies were performed with Barium sulphate loaded formulation to justify the increased gastric residence time of the dosage form in the stomach, based on the floating principle. The formulation developed using 66.2% Clarithromycin, 12% HPMC K4M polymer, 8% sodium bicarbonate gave floating lag time less than 3 min with a floating time of 12 h, and an in vitro release profile very near to the desired release. X-ray studies showed the enhanced gastric residence time of the tablet to 220 +/- 30 min. The mechanism of release of Clarithromycin from the floating tablets is anomalous diffusion transport and follows zero order kinetics. In vivo radiographic studies suggest that the tablet has increased gastric residence time for the effective localized action of the antibiotic (Clarithromycin) in the treatment of H.pylori mediated peptic ulcer.

Journal of Pharmacy …, 2012

bhj.org

... R Tambwekar*, Kumkum Khadalia*, Viraj S Tambwekar*, Rustom F Ginwalla*, Satish V Khadilkar**,... more ... R Tambwekar*, Kumkum Khadalia*, Viraj S Tambwekar*, Rustom F Ginwalla*, Satish V Khadilkar**, Shishir Kumar***, Anand Gokani***, Khushnuma Mansukhani+, Bhavna ... 7. Turkof E, Tambwekar SR,Kamal S, El-Dharavi M, Mansukhani K, Soliman H, Ciovica R, Mayr N ...

Indian Journal of …, 2009

A noise-modulated ultrawideband covert communication system has been developed in order to concea... more A noise-modulated ultrawideband covert communication system has been developed in order to conceal data sent over wireless channels. The modulated signal containing the coherent carrier is mixed with a sample of an ultrawideband (UWB) random noise signal. The frequency range of the UWB noise signal is chosen such that the lower sideband of the mixing process falls over its own frequency range. The frequency-converted noise-like signal and the noise key are simultaneously transmitted over orthogonal horizontal (H) ...

Journal of the National …, 2009

The aims of our study were to examine the role of colonoscopy as further workup for bowel wall th... more The aims of our study were to examine the role of colonoscopy as further workup for bowel wall thickening reported on computed tomography (CT) scans and to investigate whether there were significant differences in pathology found among the racial groups in our study population. This is a retrospective study from March 2005 and January 2007 of all patients who have undergone colonoscopy for bowel wall thickening found on CT scans of the abdomen. Of 94 patients with bowel wall thickening on CT scans, 7 (8%) had adenocarcinoma, 5 (5%) had large adenomas, 3 (3%) had infectious colitis, 2 (2%) ischemic colitis, 1 (1%) had inflammatory bowel disease, and 1 (1%) had a benign stricture. Bowel wall thickening on CT scan predicted clinical pathology in 34% of African Americans, as compared to 14% of Hispanics. Patients with significant pathology were more likely to have anemia and lower albumin levels. Patients with bowel wall thickening found on CT scans should be referred for colonoscopy, given that significant pathology is found in 20% of the cases. African Americans were 2.5 times more likely to have clinically significant pathology as compared to Hispanics.

Chem. Biol

... hi, what are the different. Submitted by Ritesh Bajaj on Tue, 11/24/2009 - 20:05. hi,. what a... more ... hi, what are the different. Submitted by Ritesh Bajaj on Tue, 11/24/2009 - 20:05. hi,. what are the different categories of genomics? ... Login or register to post comments. ROSHAN KUMARSAHU&amp;#x27;s picture. Justify. Submitted by ROSHAN KUMAR SAHU on Fri, 11/20/2009 - 10:08. ...

Computers, IEEE Transactions on, 1981

A class of interconnection networks based on some existing permutation networks is described with... more A class of interconnection networks based on some existing permutation networks is described with applications to processor to memory communication in multiprocessing systems. These networks, termed delta networks, allow a direct link between any processor to any memory module. The delta networks and full crossbars are analyzed with respect to their effective bandwidth and cost. The analysis shows that delta networks have a far better performance per cost than crossbars in large multiprocessing systems.

ijpsr.com

A simple reverse phase HPLC method was developed for the simultaneous estimation of Ranitidine hy... more A simple reverse phase HPLC method was developed for the simultaneous estimation of Ranitidine hydrochloride and Domperidone present in combined tablet dosage forms. Efficient chromatographic separation was achieved on Phenomenax C 18 stationary phase (250 X 4.6 mm i. d., 5μ particle size) with simple mobile phase combination of phosphate buffer: acetonitrile: methanol 40: 30: 30 (V/V/V) in an isocratic mode at a flow rate of 1.5 mLmin -1 at 210 nm. The retention times were 2.417 and 7.375 (±0.5) min for Ranitidine hydrochloride and Domperidone respectively. The proposed method has been applied successfully for the simultaneous analysis of Ranitidine hydrochloride and Domperidone in combined tablet dosage form with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of Ranitidine hydrochloride and Domperidone in pharmaceutical dosage form.