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Papers by Bina Kashyap

Metabolites, Mar 29, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

International Journal of Oral-Medical Sciences

it may affect oral functions (7). Xerostomia, the perception, or symptom of dry mouth is often se... more it may affect oral functions (7). Xerostomia, the perception, or symptom of dry mouth is often seen in patients with OLP. Nonkeratotic OLP is associated with xerostomia and is sometimes the main patient complaint. Howev

Biomedicines

Purpose: It is well established that cancer cells exploit aberrant synthesis of mucin 1 (MUC1) an... more Purpose: It is well established that cancer cells exploit aberrant synthesis of mucin 1 (MUC1) and hyaluronan (HA) synthesis along with HA’s physiological cell surface receptor CD44. However, their role in irradiated oral tissue has not been reported previously. We, therefore, aimed to study MUC1, CD44 and HA immunohistochemically in irradiated oral mucosa and their role in the long-term effects after radiotherapy. Materials and Methods: Oral mucosal biopsies were obtained from healthy subjects as controls and from patients after radiotherapy for head and neck cancer (irradiated group) during dental implant surgery. The presence of MUC1, CD44, and HA in oral mucosa was studied by immunohistochemical methods. The differences in the localization and intensity in the oral epithelium between control and irradiated tissue were analyzed. Results: The staining intensity of MUC1 was confined to the superficial epithelial layer, whereas HA and CD44 were found in the cell membranes in the epi...

Online Journal of Health and Allied Sciences

Intraoral lipomas are benign and relatively rare tumors, although they occur with higher frequenc... more Intraoral lipomas are benign and relatively rare tumors, although they occur with higher frequencies in other areas, most especially the back, abdomen and shoulders of adults. They have no gender predilection and predominantly affect the buccal mucosa. This paper describes a case of intramuscular (infiltrating) lipoma on the buccal mucosa of a 60-year old male which is relatively rare when compared to simple lipoma of buccal mucosa, and review pertinent literature.

Journal of Molecular and Genetic Medicine, 2014

Journal of maxillofacial and oral surgery, 2011

Genioplasty is often performed to esthetically improve patient's profiles in the lower facial... more Genioplasty is often performed to esthetically improve patient's profiles in the lower facial third. Many factors account for the variability in soft tissue response like dissection technique, magnitude and direction of movement and stability of the genial segment. Optimum treatment planning thus requires an understanding of the soft tissue response to various genial procedures. To determine the stability, ratio of hard and soft tissues and changes in the lower facial profile after advancement genioplasty. Ten patients were evaluated cephalometrically for the soft tissue changes in relation to hard tissues after advancement genioplasty. Pre operative, immediate post operative and 6 months post operative lateral cephalogram were taken. Pre operative tracings were superimposed with post operative cephalograms to produce a composite tracing. Changes in the osseous tissues are assessed and related to the net changes in the soft tissues. The ratio of horizontal changes of osseous to ...

European Journal of General Dentistry, 2012

Background: Exfoliative cytology is the study of cells that are shed or scrapped off from mucosal... more Background: Exfoliative cytology is the study of cells that are shed or scrapped off from mucosal surfaces. Centrifuged Liquid based cytology is a modified technique employed in the present study. Aims: To compare the utility of centrifuged liquid based cytology with conventional cytology in oral lesions after staining with Papanicolaou (PAP) stain. Materials and Methods: 50 cases of oral lesions comprising of normal mucosa (n=14), hyperkeratotic lesions (n=17), ulcerated lesions (n=7) and atrophic lesions (n=12) were selected. Two smears were obtained from the lesion using a cytological brush. One was spread on the slide using conventional technique, fixed immediately in 95% ethyl alcohol. Second sample was suspended in suspending solution for 10 minutes then spun in centrifuge for 10 minutes. The supernatant was poured off and the obtained cell pellet was used to prepare a smear by sedimentation and left to dry overnight. Both the smears were stained by PAP. The stained smears wer...

European Journal of General Dentistry, 2014

Background: The complexity of root canal morphology has fascinated the imaginations of many. Seve... more Background: The complexity of root canal morphology has fascinated the imaginations of many. Several techniques have been tried in the past to view the three-dimensional anatomy of the pulp canal system with varied success. It has been hypothesized in the present study that a combination of decalcifying agent and clearing agent can be used to prepare transparent tooth model. Aims: The aim of the present study was to access the efficacy of two decalcifying agent (formic acid and nitric acid) and two clearing agents (methyl salicylate and eugenol) to prepare transparent tooth model. Materials and Methods: The study material included 80 freshly extracted teeth both maxillary and mandibular. After decalcifying and clearing of the specimen, they were graded for transparency and haziness criteria. Results: The results of the present study indicated that methyl salicylate when used as a clearing agent showed better transparency, lower level of haziness and good root canal morphology. On th...

Journal of Cancer Research and Therapeutics, 2012

The micronuclei assay (MA) in exfoliated buccal cells is an innovative genotoxicity technique, wh... more The micronuclei assay (MA) in exfoliated buccal cells is an innovative genotoxicity technique, which holds promise for the study of epithelial carcinogens. Micronuclei are suitable internal dosimeters for revealing tissue-specific genotoxic damage in individuals exposed to carcinogenic mixtures. This article reviews the MN assay with respect to oral buccal mucosa, which has been used since the 1980s to demonstrate cytogenetic effects of environmental and occupational exposures, lifestyle factors, dietary deficiencies, and different diseases along with the characteristics of micronuclei and other nuclear abnormalities.

Contemporary Clinical Dentistry, 2012

Aim: Reactive lesions of the oral cavity are associated with injuries of soft tissue and have hig... more Aim: Reactive lesions of the oral cavity are associated with injuries of soft tissue and have high prevalence rates and different involvement patterns in different parts of the world. This study reviews the pathogenesis and analyzes demographic data, histopathological features and compares the clinico-pathologic profiles of the diseases to those previously reported. Materials and Methods: Patient records of the Department of Oral Pathology during one and half year period were reviewed for diagnosis of oral connective tissue reactive hyperplastic lesion. Data including the area involved and the type of lesion were collected and analyzed using descriptive statistical methods and ANOVA test. Results: 100 cases (mean age 36 years, male:female ratio 1:2) matched study criterion. The most common affected site was mandibular anterior region and buccal mucosa and the most common lesion was pyogenic granuloma and focal fibrous hyperplasia. All the lesions were more common in the mandible than in the maxilla. PGCG was seen to be equally distributed in males and females. Conclusion: Reactive hyperplastic lesions of the oral connective tissue are more common in females and the majority of the lesions occur in gingiva. This study supports previous assertions that PG and FFH may occur on any oral mucosal site with special preference for the mandibular anterior gingiva and buccal mucosa while PGCG and POF occur exclusively on the mandibular gingiva.

Contemporary Clinical Dentistry, 2013

Background: Transition of the normal oral epithelium to dysplasia and to malignancy is featured b... more Background: Transition of the normal oral epithelium to dysplasia and to malignancy is featured by increased cell proliferation. To evaluate the hypothesis of distributional disturbances in proliferating and stem cells in oral epithelial dysplasia and oral squamous cell carcinoma (OSCC). Aim: To evaluate layer wise expression of Ki-67 in oral epithelial dysplasia and in OSCC. Materials and Methods: Thirty histologically confirmed cases of oral epithelial dysplasia, fifteen cases of OSCC and five cases of normal buccal mucosa were immunohistochemically examined and nuclear expression of Ki-67 was counted according to basal, parabasal, and suprabasal layers in epithelial dysplasia and number of positive cells per 100 cells in OSCC as labeling index (LI). Results: Suprabasal expression of Ki-67 increased according to the severity of epithelial dysplasia and the difference was statistically significant (P < 0.001). The mean Ki-67LI was 12.78 for low risk lesions, 28.68 for high risk lesions, 39.45 for OSCC and 13.6 for normal buccal mucosa. Conclusion: The results of the present study demonstrate the use of proliferative marker Ki-67 in assessing the severity of epithelial dysplasia. Suprabasal expression of Ki-67 provides an objective criteria for determining the severity of epithelial dysplasia and histological grading of OSCC.

Annals of Tropical Medicine and Public Health, 2012

Rhinosporidiosis is a chronic infestation by the fungus Rhinosporidium seeberi, which predominant... more Rhinosporidiosis is a chronic infestation by the fungus Rhinosporidium seeberi, which predominantly affects the mucus membranes of the nose and nasopharynx. We report a case of rhinosporidiosis with presentation as a mass extending up to the oropharynx. Functional endoscopic sinus surgery was performed.

Annals of Nigerian Medicine, 2011

... Nasal rhinosporidiosis with oropharyngeal extension Suresh Babu 1 , A Anuradha 2 , Sathish Ch... more ... Nasal rhinosporidiosis with oropharyngeal extension Suresh Babu 1 , A Anuradha 2 , Sathish Chandra 1 , Bina Kashyap 2 1 Department ... lips, palate, uvula, maxillary antrum, conjunctiva, lacrimal sac, epiglottis, larynx, trachea, bronchus, ear, scalp, skin, penis, vulva, and vagina. ...

International Journal of Trichology, 2013

Aim: The aim of the present study was to determine whether hair could be used as biomarker of flu... more Aim: The aim of the present study was to determine whether hair could be used as biomarker of fluoride exposure. Materials and Methods: The study was carried out on 30 people living in an endemically fluoridated area and a low fluoridated area. Samples of hair from the occipital were taken and subjected to fluoride analysis by a fluoride ion electrode. Results: Lower fluoride levels in water supplies correlated with lower levels of fluoride in hair and more over higher fluoride levels in water correlated with higher levels of fluoride in hair. A direct relationship was evident between fluoride levels in water supplies and concentration of fluoride in hair (P < 0.01). Conclusions: The results of the present study indicate hair can be used as an indicator of fluoride exposure.

International Journal of Radiation Biology

International Journal of ADVANCED AND APPLIED SCIENCES, Aug 1, 2016

This study employed to explore the outcome and benefits of role play as a teaching methodology fo... more This study employed to explore the outcome and benefits of role play as a teaching methodology for teaching dental subjects to the dental students. The experimental study group included 40 students (Group A and Group B) of the same level in Buraydah Private Dental College, Saudi Arabia. Students in the group A were taught through didactic lectures, while those in group B were taught using role play method. At the end of the course, we compared the outcome of theoretical knowledge before, after and one month after teaching. All the data were statistically evaluated using Graph Pad Prism software. The result obtained in pretest, posttest and surprise test were statistically significant. The role play method showed significantly better results compared to the didactic lectures (p<0.05). The role play showed 75% of result compared to didactic lectures (60%). Retention of knowledge was also statistically significant among the groups. Role Play is an important and alternative method of teaching dental students. In addition, when the course is discussion based and asynchronous, it leaves time for student's to be reflective, which is a particular benefit of this role playing teaching method.