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Papers by Bipin kumar Verma
Key Engineering Materials, 2021
In present investigation, an attempt was made to optimise the peak stress for paper laminate comp... more In present investigation, an attempt was made to optimise the peak stress for paper laminate composite using FRANC2D software. It was observed that the laminate having the triangular geometry supposed to be most appropriate as it has the lowest value of peak stress contour compared to other models like parallel strip, up-down tapered and down-up tapered. The minimum peak stress was observed for the samples having triangular geometry while the maximum was observed for down-up tapered samples. Therefore, the hypothesis adopted to use in-built materials with variables reinforcement area and strip geometry and length in the FRANC2D software to optimize the sample geometry and then apply it to the paper laminate by considering its mechanical properties might be use to optimize the peak stress of paper laminate composite in tensile loading conditions. It was also observed a length of one-quarter of the length of the plane strip, might be the optimum length of the paper laminate samples. H...
International Journal of Research and Development in Pharmacy and Life Sciences, 2014
Diabetes mellitus is a dreadful disease found in all parts of the world and is becoming a serious... more Diabetes mellitus is a dreadful disease found in all parts of the world and is becoming a serious threat to mankind health.Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels thatresult from defects in insulin secretion, or action, or both. The World Health Organization (WHO) has listed 21,000 plants, which are used for medicinal purposes around the world. Herbal medicines have been highly esteemed sourceof medicine throughout the human history. Alternative to synthetic agents, plants provide a potential source of hypoglycemic drugs and are widely used to prevent diabetes. In the present review, an attempt has been made to summarize some of the herbal plants having anti-diabetic activity which are beneficial for the mankind.
Universal Journal of Pharmaceutical Research, 2017
Plants have been one of the important sources of medicines for human being and animals since the ... more Plants have been one of the important sources of medicines for human being and animals since the ancient time. At present scenario there is an increasing demand for herbal medicines, health products and pharmaceuticals products. Herbal medicines have attained popularity at global level to replace the synthetic chemicals as they have shown less adverse reactions. Glycyrrhiza glabra Linn is a commonly used herb for different diseases. Present review article deals with chemical constituents present in various parts of Glycyrrhiza glabra and pharmacological activities. Present article aim to comply all the updated information on its phytochemical and pharmacological activities, which were performed by widely different methods. Glycyrrhiza glabra Linn possesses antibacterial, antioxidant, antimalarial, antispasmodic, anti-inflammatory and anti-hyper glycemic properties. Various other effects like antiulcer, antiviral, antifungal have also been discussed. This article may be useful for many researchers in discovering potential therapeutic effects and developing new formulations.
Indian Journal of Pharmaceutical and Biological Research, 2017
In the present work, some new imidazole derivatives (3i-xii) were synthesized as per design synth... more In the present work, some new imidazole derivatives (3i-xii) were synthesized as per design synthetic protocol scheme. The structures of newly prepared compounds were confirmed by modern analytical technique (IR, 1H-NMR, Mass spectral data) and elemental analysis, results found in full agreement with their assigned structures. All the synthetic compounds were screened for their antimicrobial activity against bacterial strains viz. Escherichia coli (E. coli, MTCC 2961), Staphylococcus aureus (S. aureus, MTCC 3160), Bacillus subtilis (B. subtilis, MTCC 121), Klebsiella pneumoniae (K. pneumoniae, MTCC 3040) and Micrococcus luteus (M. luteus, MTCC 7527)) and fungal strains viz. Candida albicans (C. albicans, MTCC 227), Aspergillus niger (A. niger, MTCC 277) and Aspergillus flavus (A. flavus, MTCC 418) ; results showed good to remarkable activity. The MIC (minimum inhibitory concentration) values were determined by comparison to ciprofloxacin (anti-bacterial) and fluconazole (anti-fungal...
Universal Journal of Pharmaceutical Research, Mar 15, 2017
Some new imidazole derivatives (3i-xii) were synthesized as per design synthetic protocol scheme.... more Some new imidazole derivatives (3i-xii) were synthesized as per design synthetic protocol scheme. The structures of newly prepared compounds were confirmed by modern analytical technique and elemental analysis. All the synthetic compounds were screened for their antimicrobial activity against bacterial results showed good to remarkable activity. The MIC (minimum inhibitory concentration) values were determined by comparison to ciprofloxacin (anti-bacterial) and fluconazole (anti-fungal) as standard drug. Among them, compound 3iv and 3x exhibited notable antimicrobial activity. These compounds may be used as new template for the searching of potential antimicrobial agents.
Granulation is a size enlargement process, in fine or coarse particles converted into physically ... more Granulation is a size enlargement process, in fine or coarse particles converted into physically stronger and larger agglomerates having good flow property, better compression characteristics and uniformity, prevent segregation of the blend components, improve content uniformity, and eliminate excessive amounts of fine particles. Size of granules has a size range of 0.2 to 4.0 mm, depending on their subsequent use. Size of the granules depends on the quantity and feeding rate of granulating liquid. The selection of process to prepare granules requires thorough knowledge of physicochemical properties of the drug, excipients, required flow and release properties, to name a few. At current scenario available technologies includes, spray drying, roller compaction, high shear mixing, and fluid bed granulation etc. The objective of present work is to focus on the commonly used and novel granulation technologies like such as pneumatic dry granulation, steam granulation, moisture-activated ...
Key Engineering Materials, 2021
In present investigation, an attempt was made to optimise the peak stress for paper laminate comp... more In present investigation, an attempt was made to optimise the peak stress for paper laminate composite using FRANC2D software. It was observed that the laminate having the triangular geometry supposed to be most appropriate as it has the lowest value of peak stress contour compared to other models like parallel strip, up-down tapered and down-up tapered. The minimum peak stress was observed for the samples having triangular geometry while the maximum was observed for down-up tapered samples. Therefore, the hypothesis adopted to use in-built materials with variables reinforcement area and strip geometry and length in the FRANC2D software to optimize the sample geometry and then apply it to the paper laminate by considering its mechanical properties might be use to optimize the peak stress of paper laminate composite in tensile loading conditions. It was also observed a length of one-quarter of the length of the plane strip, might be the optimum length of the paper laminate samples. H...
International Journal of Research and Development in Pharmacy and Life Sciences, 2014
Diabetes mellitus is a dreadful disease found in all parts of the world and is becoming a serious... more Diabetes mellitus is a dreadful disease found in all parts of the world and is becoming a serious threat to mankind health.Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels thatresult from defects in insulin secretion, or action, or both. The World Health Organization (WHO) has listed 21,000 plants, which are used for medicinal purposes around the world. Herbal medicines have been highly esteemed sourceof medicine throughout the human history. Alternative to synthetic agents, plants provide a potential source of hypoglycemic drugs and are widely used to prevent diabetes. In the present review, an attempt has been made to summarize some of the herbal plants having anti-diabetic activity which are beneficial for the mankind.
Universal Journal of Pharmaceutical Research, 2017
Plants have been one of the important sources of medicines for human being and animals since the ... more Plants have been one of the important sources of medicines for human being and animals since the ancient time. At present scenario there is an increasing demand for herbal medicines, health products and pharmaceuticals products. Herbal medicines have attained popularity at global level to replace the synthetic chemicals as they have shown less adverse reactions. Glycyrrhiza glabra Linn is a commonly used herb for different diseases. Present review article deals with chemical constituents present in various parts of Glycyrrhiza glabra and pharmacological activities. Present article aim to comply all the updated information on its phytochemical and pharmacological activities, which were performed by widely different methods. Glycyrrhiza glabra Linn possesses antibacterial, antioxidant, antimalarial, antispasmodic, anti-inflammatory and anti-hyper glycemic properties. Various other effects like antiulcer, antiviral, antifungal have also been discussed. This article may be useful for many researchers in discovering potential therapeutic effects and developing new formulations.
Indian Journal of Pharmaceutical and Biological Research, 2017
In the present work, some new imidazole derivatives (3i-xii) were synthesized as per design synth... more In the present work, some new imidazole derivatives (3i-xii) were synthesized as per design synthetic protocol scheme. The structures of newly prepared compounds were confirmed by modern analytical technique (IR, 1H-NMR, Mass spectral data) and elemental analysis, results found in full agreement with their assigned structures. All the synthetic compounds were screened for their antimicrobial activity against bacterial strains viz. Escherichia coli (E. coli, MTCC 2961), Staphylococcus aureus (S. aureus, MTCC 3160), Bacillus subtilis (B. subtilis, MTCC 121), Klebsiella pneumoniae (K. pneumoniae, MTCC 3040) and Micrococcus luteus (M. luteus, MTCC 7527)) and fungal strains viz. Candida albicans (C. albicans, MTCC 227), Aspergillus niger (A. niger, MTCC 277) and Aspergillus flavus (A. flavus, MTCC 418) ; results showed good to remarkable activity. The MIC (minimum inhibitory concentration) values were determined by comparison to ciprofloxacin (anti-bacterial) and fluconazole (anti-fungal...
Universal Journal of Pharmaceutical Research, Mar 15, 2017
Some new imidazole derivatives (3i-xii) were synthesized as per design synthetic protocol scheme.... more Some new imidazole derivatives (3i-xii) were synthesized as per design synthetic protocol scheme. The structures of newly prepared compounds were confirmed by modern analytical technique and elemental analysis. All the synthetic compounds were screened for their antimicrobial activity against bacterial results showed good to remarkable activity. The MIC (minimum inhibitory concentration) values were determined by comparison to ciprofloxacin (anti-bacterial) and fluconazole (anti-fungal) as standard drug. Among them, compound 3iv and 3x exhibited notable antimicrobial activity. These compounds may be used as new template for the searching of potential antimicrobial agents.
Granulation is a size enlargement process, in fine or coarse particles converted into physically ... more Granulation is a size enlargement process, in fine or coarse particles converted into physically stronger and larger agglomerates having good flow property, better compression characteristics and uniformity, prevent segregation of the blend components, improve content uniformity, and eliminate excessive amounts of fine particles. Size of granules has a size range of 0.2 to 4.0 mm, depending on their subsequent use. Size of the granules depends on the quantity and feeding rate of granulating liquid. The selection of process to prepare granules requires thorough knowledge of physicochemical properties of the drug, excipients, required flow and release properties, to name a few. At current scenario available technologies includes, spray drying, roller compaction, high shear mixing, and fluid bed granulation etc. The objective of present work is to focus on the commonly used and novel granulation technologies like such as pneumatic dry granulation, steam granulation, moisture-activated ...