Bishnu Hari Paudel - Academia.edu (original) (raw)

Papers by Bishnu Hari Paudel

Kathmandu University Medical Journal, 2010

Background: Heart rate variability is actually a misnomer for R to R variability in cardiac cycle... more Background: Heart rate variability is actually a misnomer for R to R variability in cardiac cycle. Variation in successive cycle length is called the heart rate variability (HRV). Head-up tilt is a model of studying cardiovascular haemodynamics, which reflects in heart rate variability (HRV). Objectives: To study the effect of 10° and 70° head-up tilt on HRV. Materials and methods: The study was done in the Department of Physiology using graded head up tilt (passive orthostatism). HRV measurement was done at 10° and 70° tilt and compared with supine using standardised methods on 30 consenting healthy males (age 25.37±3.89 years). The HRV variables across postures were compared by ANOVA and Bonferroni test. Results: The heart rate increased at 70° compared to 10° and supine (70.48±8.17 Vs 70.22±8.67 and 88.51±12.84 bpm, p<0.001). The 70° tilt decreased vagal HRV indicators compared to 10° and supine: SDNN (31.13±8.12 Vs 38.07±11.29 and 38.13±10.89 ms, p<0.05), RMSSD (20.06 ±8.4...

<b>Copyright information:</b>Taken from "Sphincter saving anorectoplasty (SSARP)... more <b>Copyright information:</b>Taken from "Sphincter saving anorectoplasty (SSARP) for the reconstruction of Anorectal malformations"http://www.biomedcentral.com/1471-2482/7/20BMC Surgery 2007;7():20-20.Published online 24 Sep 2007PMCID:PMC2093923. Note the complete sparing of the posterior midline skin and excellent cosmetic appearance.

Journal of Physiological Society of Nepal, 2020

Wstep. Powszechnie wiadomo o wystepowaniu neuropatii u chorych na cukrzyce typu 2 (T2DM). Mniej u... more Wstep. Powszechnie wiadomo o wystepowaniu neuropatii u chorych na cukrzyce typu 2 (T2DM). Mniej uwagi poświeca sie jednak wystepującym u tych chorych zmianom elektrofizjologicznym w nerwach obwodowych, zwlaszcza przed rozwojem jawnej neuropatii obwodowej. W związku z tym autorzy przeprowadzili badanie mające na celu ocene parametrow elektrofizjologicznych nerwow lydkowych obu konczyn dolnych u chorych na T2DM bez objawow neuropatii obwodowej. Material i metody. Do badania wlączono 35 mezczyzn z T2DM oraz 35-osobową grupe kontrolną zlozoną z dopasowanych pod wzgledem wieku i plci osob bez jakichkolwiek objawow neuropatii obwodowej ani chorob zakaźnych, ogolnoustrojowych, metabolicznych czy neuropsychiatrycznych. Od wszystkich uczestnikow przed rozpoczeciem badania uzyskano pisemną zgode na udzial w nim. Obustronne badanie przewodnictwa nerwowego (NCS) w nerwach lydkowych w obu grupach wykonano w pracowni elektrofizjologicznej, w temperaturze 26 ± 2oC, z zastosowaniem standardowej ant...

Journal of Nepal Health Research Council, 2021

Background: Female hormones fluctuate with the phases of menstrual cycle. Estrogen, which has att... more Background: Female hormones fluctuate with the phases of menstrual cycle. Estrogen, which has attributes in cardio-protection, is secreted less during luteal phase. In post-ovulatory phase, days 1-2 before menstruation has minimal female hormone influence due to less secretion. Mental stress subjected at this phase might enhance sympathetic activation which in long run may precipitate cardiovascular diseases. Hence, to explore the autonomic activity to mental stress during this phase of menstrual cycle the study was undertaken.Methods: Thirty apparently healthy young postovulatory female medical students of B. P. Koirala Institute of Health Sciences, Nepal of age 19.93 (± 0.91) years with BMI of 20.70 kg/m2 (± 2.49) kg/m2 were recruited for the present study. Their short term heart rate variability (HRV) of 5 min was recorded during rest at sitting position. Then each subject was given a mental stress (nine questions selected from MENSA workout questionnaire) for 5 min. During the s...

Journal of Biomedical Sciences, 2020

Background: Medical students experience immense mental stress while understanding and retaining n... more Background: Medical students experience immense mental stress while understanding and retaining new terms, drug names and mechanisms and eventually generating a concept. Such stress, in long run, may affect their cardiovascular health. This can be assessed by heart rate variability, a reliable non-penetrating tool to determine the cardiac autonomic tone. Material and methods: Thirty healthy young male medical students of BPKIHS, Nepal of age 21.03 ± 1.73 years, and BMI 20.83 ± 2.07 kg/m2 were recruited for the present study. Their resting BP, HR, RR, and short-term heart rate variability (HRV) were recorded in sitting position. Each subject was given a mental stress for 5 min. Their BP, HR, and RR were recorded at 5th min of mental stress. HRV of 5 min was also recorded simultaneously during mental stress. Results: Mental stress increased SBP (p=0.001), DBP (p= 0.001), PR (p= 0.005) and RR (p= 0.042) in young male medical students. Time domain measures of HRV viz; RMSSD (p= 0.001), ...

Journal of Nepal Medical Association, 2003

This is a "meta-analytical" study of publications in Journal of Nepal Medical Association (JNMA).... more This is a "meta-analytical" study of publications in Journal of Nepal Medical Association (JNMA). The study aimed at investigating the quantitative status of publications in JNMA during 1991-2000, which could possibly be used as a feedback for improvement of journal quality. A total of 469 articles were classified according to their headings. They were sub-grouped into yearly, two

Journal of Nepal Medical Association, 2004

Peer review - a process of assessing the quality of manuscripts submitted to a journal – is an es... more Peer review - a process of assessing the quality of manuscripts submitted to a journal – is an establishednorm in biomedical publications. It is viewed as an extension of scientific process. The peer-reviewed researcharticles are considered trustworthy because they are believed to be unbiased and independent. The processof reviewing is a privilege and prestige. It is highly responsible, intellectually honest, and difficult job.Being expert in certain area of biomedical science is a prerequisite for reviewers. Young peer reviewerstrained in epidemiology or statistics produce high-quality review. The International Congresses on PeerReview in Biomedical Publication have shown many unresolved issues related to preparation or handling ofmanuscripts by a journal. Therefore, it is vital to identify authentic peer reviewers to ensure qualitypublication, thus, a set of peer review criteria is proposed for peer reviewing original articles. It is useful inquantifying (scoring) the manuscript q...

Journal of Nepal Medical Association, 2003

ABSTRACTWater and electrolyte balance is a vital homeostatic function. Their excretion depends on... more ABSTRACTWater and electrolyte balance is a vital homeostatic function. Their excretion depends on various factors –state of hydration, plasma osmolarity etc. There are rare reports on effect of hypertonic solution on urinaryoutput. Therefore, the study aimed at investigating the effect of water or saline (especially the hypertonic)load on urinary output (UO) in healthy undergraduate male medical students (17-20 years). They (n=20)were randomised into 4 equal groups: control, water, normal and hypertonic saline (1.8%). The study wasa part of undergraduate practical conducted under controlled conditions in the Physiology Department,BPKIHS. The day before the experiment, all of them were given same instructions. Next day, the experimentalgroups drank water/saline solution 12 ml/kg. Then the UO was measured ½-hourly. A non-parametric –Friedman test was used for intra- and inter-group differences in UO and specific gravity. The data arepresented as median (range). In water group the 60-m...

Journal of neurodegenerative diseases, 2017

Visual evoked potentials (VEPs) assess the integrity of the visual pathways from the optic nerve ... more Visual evoked potentials (VEPs) assess the integrity of the visual pathways from the optic nerve to the occipital cortex. Optic disc cupping and visual field loss have been associated with prolongation of latency of VEP in primary open angle glaucoma (POAG). Pattern reversal and flash VEP tests were done in consenting 20 primary open angle glaucoma eyes and 40 normal control eyes. In POAG cases, the refractive error [3.51 ± 1.88 versus 1.88 ± 1.11, D, p = 0.001], cup-disc ratio in percent [66.00 ± 16.98 versus 28.50 ± 5.80, p = 0.001], intraocular pressure [19.55 ± 2.08 versus 11.65 ± 1.64, mmHg, p = 0.001], and automated visual field pattern standard deviation [4.13 ± 6.96 versus 1.64 ± 0.45, dB, p = 0.001] were significantly more than in control. The visual acuity [0.41 ± 0.29 versus 1.00 ± 0.00, p = 0.001], foveal visual sensitivity [25.92 ± 6.88 versus 33.48 ± 1.75, dB, p = 0.001], and automated visual field mean deviation [-9.63 ± 10.58 versus 0.07 ± 1.54, dB, p = 0.001] were s...

Nepal Medical College journal : NMCJ, 2012

Heart rate variability (HRV) refers to the beat-to-beat alteration in cardiac cycle length. The o... more Heart rate variability (HRV) refers to the beat-to-beat alteration in cardiac cycle length. The objective is to study effect of posture on HRV. Five minutes ECG of children (12 females and 20 males) with mean height 138.88 +/- 11.88 cm, weight 27.66 +/- 5.87 kg and BMI 16.11 +/- 1.38 kg/m(2) were recorded in supine, sitting and standing position. HRV parameters were compared by one-way ANOVA and Bonferroni test. Standing decreases Mean interval between successive RR waves (622.69 +/- 83.24 ms versus 721.66 +/- 89.30 ms versus 750.28 +/- 107.917, p < 0.001), the square root of the mean squared differences of successive interval (25.37 +/- 17.52 ms versus 50.16 +/- 25.03 ms, p < 0.001), numbered of RR interval differences 50ms (40.59 +/- 61.58 versus 115.72 +/- 75.408 versus 134.16 +/- 76.57, p < 0.001), percentage NN50 (9.65 +/- 15.32 versus 29.85 +/- 20.52, versus 36.18 +/- 22.33, p < 0.001), High frequency (HF) peak (152.63 +/- 254.41 versus 427.84 +/- 369.62, 540.84 +/...

Nepal Medical College journal : NMCJ, 2007

Effective teaching is a concern of all teachers. Therefore, regular teachers' training is emp... more Effective teaching is a concern of all teachers. Therefore, regular teachers' training is emphasized globally. B. P. Koirala Institute of Health Sciences (BPKIHS), a health science deemed university situated in eastern region of Nepal has an established Medical Education unit which attempts to improve teaching-learning skills by training faculty members through organizing regular medical education training programs. The aim of the present study was to assess the effectiveness of 3-day training workshop on "Teaching-learning methodology and Evaluation" held in four different medical colleges of Nepal. The workshop was targeted at middle and entry level of health profession teachers who had not been previously exposed to any teacher's training program. The various components, such as teaching-learning principles, writing educational objectives, organizing and sequencing education materials, teaching-learning methods, microteaching and assessment techniques, were inco...

Indian journal of physiology and pharmacology, 1996

Thirteen healthy subjects were tested for parasympathetic reactivity during head-up tilt and reve... more Thirteen healthy subjects were tested for parasympathetic reactivity during head-up tilt and reversal of the tilt. Head-up tilt (70 degrees) resulted in significant increase in baseline heart rate and diastolic blood pressure. Head-up tilt also led to increased parasympathetic reactivity as measured by Valsalva manoeuvre and hand grip test. Heart rate response to deep breathing test did not change. The reversal of the tilt led to returning of heart responses to original values. Responses indicate towards enhanced parasympathetic reactivity during head-up tilt position.

International Journal of Diabetes in Developing Countries, 2013

ABSTRACT

Kathmandu University Medical Journal, 2010

Journal of Physiological Society of Nepal, 2020

Journal of Nepal Health Research Council, 2021

Journal of Biomedical Sciences, 2020

Journal of Nepal Medical Association, 2003

Journal of Nepal Medical Association, 2004

Journal of Nepal Medical Association, 2003

Journal of neurodegenerative diseases, 2017

Nepal Medical College journal : NMCJ, 2012

Nepal Medical College journal : NMCJ, 2007

Indian journal of physiology and pharmacology, 1996

International Journal of Diabetes in Developing Countries, 2013

ABSTRACT