Bjørn Søeberg - Academia.edu (original) (raw)

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Papers by Bjørn Søeberg

Advances in experimental medicine and biology, 1976

Since it is known that destruction of the afferent lymph pathway can prevent the induction of con... more Since it is known that destruction of the afferent lymph pathway can prevent the induction of contact sensitivity by skin painting the lymph must contain some essential element. In earlier experiments on pigs (McFarlin 1973) lymph was collected following skin painting with DNFB. Whole lymph was infused into an afferent lymphatic in a normal animal and shown to be capable of inducing contact sensitivity. In the experiments reported here pigs were painted with 50 microlitres of a 10% solution of DNFB in a mixture of equal parts of acetone and DMSO, a dose which was sufficient to sensitise the majority of animals.

Scandinavian journal of infectious diseases, 1989

In 1987, a total of 138 Danish patients (94 AIDS and 44 ARC) received treatment with zidovudine, ... more In 1987, a total of 138 Danish patients (94 AIDS and 44 ARC) received treatment with zidovudine, a total observation period of 572 treatment months. 15 AIDS and 1 ARC patient died after a median of 70 days (range 2-295). In the ARC group 4 patients developed AIDS (3 Pneumocystis carinii pneumonia, 1 Kaposi's sarcoma). Among the AIDS patients 38 new opportunistic infections were reported. 24 of these opportunistic infections occurred within 6 weeks after treatment initiation. 79 patients were observed for more than 3 months, 25 of these had their daily dose zidovudine reduced, usually from 1,200 mg to 600 mg, 9 others were temporarily off drug. HIV antigen was analyzed in serum samples from 93 patients. Of these, 28 (52%) of 54 initially HIV antigen-positive became antigen-negative, 7 (18%) of 39 initially HIV antigen-negative became antigen-positive within the first 8 weeks of zidovudine treatment. In 57 patients the total count of CD4+ cells were evaluated. A significant increa...

Acta medica Scandinavica, 1978

Human lymphokines can elicit several effects associated with inflammation, e.g. leucocyte migrati... more Human lymphokines can elicit several effects associated with inflammation, e.g. leucocyte migration inhibition and fibrinolysis. These effects can be assessed in vitro by the leucocyte migration agarose technique (LMAT) and the leucocyte migration fibrinolysis technique (LMFT). The present study shows that preincubation of normal leucocytes with aprotinin, tranexamic acid and phenyl-methyl-sulfonylfluoride (PMSF) reduces or abolishes their migration inhibition response to leucocyte migration inhibition factor. The compounds exert this effect at non-toxic concentrations, which do not otherwise interfere with migration or fibrinolysis, and are non-toxic as estimated by PHA stimulation of lymphocytes. The LMFT is more sensitive to the modifying effect than the LMAT. The effect of aprotinin and tranexamic acid is reversible, the effect of PMSF is irreversible.

Gut, 1972

Jejunal mucosal biopsies were obtained from 13 patients with acute enteritis. Ten patients were e... more Jejunal mucosal biopsies were obtained from 13 patients with acute enteritis. Ten patients were examined again after recovery. Quantitative analysis of the findings in immunofluorescence microscopy showed a significant increase of IgA- and IgM-containing cells during acute enteritis. After recovery the number of immunoglobulin-containing cells and their distribution within the different immunoglobulin classes were within normal limits.

Acta Medica Scandinavica, 1977