Carla Boga - Academia.edu (original) (raw)

Papers by Carla Boga

RSC Advances, 2020

The first attempt to compare Boulton–Katritzky rearrangement with N-1/N-3-oxide tautomerism: form... more The first attempt to compare Boulton–Katritzky rearrangement with N-1/N-3-oxide tautomerism: formation of isomeric products in the reaction between 2-aminothiazoles and 7-chloro-4,6-dinitrobenzofuroxan.

Environmental Engineering and Management Journal, 2018

The bioremediation represents an ongoing challenge, especially in the case of organochlorinated c... more The bioremediation represents an ongoing challenge, especially in the case of organochlorinated compounds, due to the difficulties in their degradation that causes persistence in the environment. Herein we report a study on the ability of a mixture of microorganisms (MOM) to interact with organochlorinated compounds belonging to different chemical classes, i.e. DDT, PCB, tetrachlorobenzene, and lindane. Experiments in vitro showed the disappearance, partially reversible of these compounds in mixtures containing microorganisms, with a trend dependent on the kind of used pollutant. Unexpected 'complexation' by some components of molasses used as growth nutrient for microorganisms was found. Experiments carried out in the presence of soil showed that also in this case the participation of MOM to hide pollutants cannot be excluded. The obtained results may be an interesting starting point for further investigations on the bioremediation of organic pollutants using biological and not expensive method.

Langmuir : the ACS journal of surfaces and colloids, Jan 8, 2015

The possibility to functionalize calcium phosphates with bioactive agents is a promising strategy... more The possibility to functionalize calcium phosphates with bioactive agents is a promising strategy to design innovative biomaterials for bone repair able to couple the bioactive properties of the inorganic compounds with the therapeutic effect of the functionalizing agent. The R enantiomer of the 9-hydroxystearic acid, (9R)-9-HSA, produced from Dimorphotheca sinuata L. seeds, has proven to act as a natural negative regulator of tumor cell proliferation. On this basis, hydroxyapatite was synthesized with increasing contents of (9R)-9-hydroxystearate, up to about 8.6 wt%. The incorporation of HSA in the composite nanocrystals induces a reduction of the crystal mean dimensions and of the length of the coherently scattering crystalline domains, which suggest a preferential adsorption onto the hydroxyapatite crystal faces parallel to the c-axis direction. The composite nanocrystals were designed so that their cytostatic and cytotoxic effects towards osteosarcoma cells are modulated by hyd...

European Journal of Medicinal Chemistry, 2015

Novel Clinked imidazole derivatives have been synthesized in good to excellent yields and charact... more Novel Clinked imidazole derivatives have been synthesized in good to excellent yields and characterized by analytical and spectral analysis. Four of the newly synthesized compounds exhibited moderate antibacterial activity.

Journal of Molecular Catalysis, 1991

Abstract Two Michael-type addition reactions of nitromethane to chalcone, reaction (1a), and of m... more Abstract Two Michael-type addition reactions of nitromethane to chalcone, reaction (1a), and of methyl 1-oxo-2-indanecarboxylate to methyl vinyl ketone (reaction (1b)) have been tested for catalytic asymmetric induction when carried out in the presence of Ni(II) or Co(II) and homochiral ligands. Proline-derived ligands in conjunction with Ni(II) are found to be moderately effective asymmetric inductors in the former addition (up to 59% e.e.). For this addition the absolute configuration of the adduct ( 2 ) has been established via correlation with ( S )-(+)-1-(dimethylamino)-2,4-diphenylbutan-4-one ( 21 ). For reaction (1b), Co(II) complexes appear to be the more effective catalysts; the highest e.e. (38%) was obtained with a tetradentate ligand, a diaminodiol ( 16 ). Although the e.e.s so far obtained are not much better than those previously obtained, the method appears to allow further improvement.

Journal of the Chemical Society-Perkin Transactions 1, 1996

The sense of asymmetric induction and the degree of diastereoselectivity in the addition of allyl... more The sense of asymmetric induction and the degree of diastereoselectivity in the addition of allylmetal compounds to imines derived from aldehydes and (27)-l-phenylethanamine is affected by the nature of the imine and of the metal. Allyl-BBN,-MgX,-ZnBr,-Cu, and ...

Tetrahedron: Asymmetry, 1990

The reactions of methylcopper-and dimethylcuprate-boron trlfluorlde reagents with aldlmlnes deriv... more The reactions of methylcopper-and dimethylcuprate-boron trlfluorlde reagents with aldlmlnes derived from (S)-1-phenylethylamlne afford with good dlastereoselectlvlty (S,S)-amlnes from aromatlc Imines, but

Tetrahedron, 1994

The reductive amination of 2, 5-hexanedione and 2, 6-heptanedione with ammonia and primary amines... more The reductive amination of 2, 5-hexanedione and 2, 6-heptanedione with ammonia and primary amines in the presence of hydride regents afforded 2, 5-dimethylpyrrolidines and 2, 6-dimethylpiperidines with variable diastercoselectivity, as the cis/trans ratio was affected ...

Synthesis, 1986

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Synthesis, 1983

Relatively few examples of polymer-supported reducing agents have been reported '). In this conte... more Relatively few examples of polymer-supported reducing agents have been reported '). In this context, carbonyl groups, except a,gunsaturated ketones, have been efficiently reduced by a poly(2-~inylpyridine)-borane complex exclusively in benzene in the presence of equimolar amounts of BF30Et,. In the course of our investigation on polymer-supported reagents3), we used weak anion-exchangers as suitable supports for bonding Lewis acids such as phosphorus(II1, V) halides 4). Now we refer that also aluminium hydride, a Lewis acid which is known to form adducts with tertiary amines5), can be attached to Amberlite IRA 93 (Rohm and Haas), a macroporous styrene-divinylbenzene copolymer functionalized with tertiary amino groups. General part Aluminium hydride, by which a number of organic functional groups can be reduced6), is conveniently prepared6) by addition of 0,5 mol of 100% sulfuric acid to 1 mol of lithium aluminium hydride in THF solution. Hydrogen is evolved, and lithium sulfate precipitates quantitatively following the equation: 2LiAIH, + H,SO, Li2S0, 1 + 2A1H3 + 2H2 Amberlite IRA 93 is treated with the obtained THF solution of AIH, under argon. This resin reduces aldehydes, ketones and esters in good yields and, stored in a desiccator, is stable for almost a month. The capacity of the polymeric reagent has been evaluated by treating a weighed amount of the resin with an excess of acetic acid and backtitrating with aqueous 0,l M sodium hydroxide: a mean value of 5 3 mmol of aluminium hydride per gram of dry resin is obtained. Reactions are performed in batch, at room temperature under an inert atmosphere, by stirring the substrate, dissolved in a dry solvent, usually diethyl ether (hexane, THF and methylene chloride are also suitable), with a twofold molar excess of resin:

Rapid Communications in Mass Spectrometry, 2000

Langmuir, 2005

Hydroxystearic acid (HSA) molecules at the air-water interface present an interesting bicompetiti... more Hydroxystearic acid (HSA) molecules at the air-water interface present an interesting bicompetitive adsorption between primary and secondary hydrophilic groups on either end of an alkyl chain, which, depending on the position of the second hydrophilic group, may lead to a sharp transition from an expanded phase to a crystalline condensed morphology as surface pressure is increased. Here we report a set of measurements on a series of hydroxystearic acids in which the position of the secondary competing hydrophilic group position is varied along the whole extent of the alkyl chain from position 2 (i.e., close to the primary hydrophilic group) to positions 7, 9 and 12, the latter being the compounds mostly studied in the literature. We show here direct microscopic evidence, obtained by synchrotron radiation reflectometry and grazing incidence diffraction, that the position of the secondary hydrophilic group not only strongly influences the phase diagram as determined by compression isotherms and ellipsometry but also induces different crystallization patterns in the 2D system of the Langmuir monolayer. In particular, we report for the first time the existence of a turning point in the effects of the hydroxyl position on the monolayers structure at 7-HSA.

Journal of Organometallic Chemistry, 1988

Abstract The reaction of dillyltin dibromide, readily prepared from allyl bromide and tin powder,... more Abstract The reaction of dillyltin dibromide, readily prepared from allyl bromide and tin powder, with aldehydes in the presence of monosodium-(+)-diethyl tartrate affords the corresponding homoallylic alcohols in good yields with enantiomeric excesses in the ...

$Research paper thumbnail of The first isolation of a Wheland complex in azo-coupling reaction, X-ray diffraction analysis and products from its evolution$

Arkivoc, 2014

The reaction between tris(N-piperidinyl)benzene and 4-methoxybenzenediazonium tetrafluoroborate a... more The reaction between tris(N-piperidinyl)benzene and 4-methoxybenzenediazonium tetrafluoroborate afforded a Wheland intermediate (W) that was isolated and crystallized at low temperature. This permitted to obtain, for the first time, the X-ray structure analysis of a σcomplex in the diazo coupling reaction. In solution, W slowly evolves to the rearomatized product PH + (as salt). The single crystal X-ray diffraction determination of the neutral azo compound P is also reported.

Angewandte Chemie International Edition, 2004

Organo-phosphorus compounds S 0080 Efficient One-Pot Synthesis of Secondary Cyclic Phosphanes wit... more Organo-phosphorus compounds S 0080 Efficient One-Pot Synthesis of Secondary Cyclic Phosphanes with Easy Regeneration of the Phosphorus-Donor Reagent Used.-An unusual phosphane obtained by reaction of p-methylthioanisole and PCl3 and AlCl3 is used as phosphorus-donor for the reaction with a Grignard reagent followed by treatment with aqueous acid to afford secondary cyclic phosphanes. The reagent can be easily regenerated by treatment of by-product (III) with PCl 3 .-(BACCOLINI*, G.; BOGA, C.; GALEOTTI, M.;

Journal of Chemical Research-s, 2001

Page 1. J. CHEM. RESEARCH (S), 2001 43 Recently, the Betti reaction2 has received renewed interes... more Page 1. J. CHEM. RESEARCH (S), 2001 43 Recently, the Betti reaction2 has received renewed interest3 and literature reports new investigations4 for synthetic chiral purposes.5 The original Betti reaction2 was performed using ...

Journal of …, 1988

The reaction of dillyltin dibromide, readily prepared from allyl bromide and tin powder, with ald... more The reaction of dillyltin dibromide, readily prepared from allyl bromide and tin powder, with aldehydes in the presence of monosodium-(+)-diethyl tartrate affords the corresponding homoallylic alcohols in good yields with enantiomeric excesses in the ...