Boja Poojary - Academia.edu (original) (raw)
Papers by Boja Poojary
Journal of the Iranian Chemical Society, 2020
In view of discovering novel bioactive molecules, 1-phenyl-1H-2-(1-aryl-5-methyl-1H-1,2,3-triazol... more In view of discovering novel bioactive molecules, 1-phenyl-1H-2-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)-3-(N-arylcarbamoylmethylthio)-1,2,4-triazoles (8a-n) were designed and synthesized in good yield. Preliminary antibacterial activity was tested against Chromobacterium violaceum and Xanthomonas campestris pv. Campestris (Xcc). Out of 14 derivatives, compound 8g selectively possessed antibacterial activity against C. violaceum. Further derivatives that possessed an electronwithdrawing group and halogen atoms in N-phenylacetamide moiety were moderately active against Xcc (plant pathogen). After observing the reduction of violacein production through plate assay, compounds 8a, 8c, 8h, 8i and 8m were subjected to quantification of quorum sensing inhibition. Compounds with the electron-withdrawing group in N-phenylacetamide moiety showed admirable activity with > 80% inhibition of violacein. Mainly compound 8c which was inactive against the growth of bacteria were identified as excellent QSI which could be a lead compound for further development.
Zeitschrift für Naturforschung B, 2010
The key precursor rac-2-(4-isobutylphenyl)ethyl-1,2,4-triazole-5-thione (3) was synthesized in go... more The key precursor rac-2-(4-isobutylphenyl)ethyl-1,2,4-triazole-5-thione (3) was synthesized in good yield from Ibuprofen (1). One-pot three-component reactions of 3 with 5-aryl-furan-2-carboxaldehydes/ substituted aromatic aldehydes and monochloroacetic acid in acetic acid in the presence of acetic anhydride and anhydrous sodium acetate afforded substituted thiazolo[3,2-b][1,2,4]triazole derivatives 4 and 5. The structures of the newly synthesized compounds were elucidated by elemental analyses and spectral data. The compounds were tested for their in-vitro antimicrobial activities.
Биоорганическая химия, 2020
![Research paper thumbnail of Hantzsch and Schiff’s reaction: synthesis, in vitro cytotoxic and antimicrobial activity of [1,3,4]oxadiazoline and [1,3]thiazole derivatives](https://attachments.academia-assets.com/96050042/thumbnails/1.jpg)
](Medicinal Chemistry Research, 2014
Two new series of compounds namely, 1-chloro-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalene incorp... more Two new series of compounds namely, 1-chloro-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalene incorporated [1,3,4]oxadiazoline 4a-j and [1,3]thiazole 6a-j derivatives, were prepared. The precursor 1-chloro-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalene-2-carboxaldehyde 2 has been synthesized by Vilsmeier-Haack reaction, and X-ray crystallographic data were recorded. The Schiff's bases 3a-j subjected to dehydration followed by cyclization afford [1,3,4]oxadiazoline derivatives 4aj. The [1,3]thiazole derivatives 6a-j were prepared through Hantzsch thiazole synthesis by the reaction of intermediate 5 with different substituted a-halo ketones. The structures of the synthesized compounds were deduced according to FTIR, 1 H NMR, 13 C NMR, and mass spectral along with micro-analytical data. The newly synthesized compounds have been tested for their cytotoxicity bioassays, antibacterial, and anti-fungal activities. Some of the tested compounds showed significant cytotoxicity activity against HeLa cells. The majority of the synthesized compounds showed moderate to good anti-bacterial and anti-fungal activities.
Zeitschrift für Naturforschung. B, A journal of chemical sciences, Dec 1, 2010
The key precursor rac-2-(4-isobutylphenyl)ethyl-1,2,4-triazole-5-thione (3) was synthesized in go... more The key precursor rac-2-(4-isobutylphenyl)ethyl-1,2,4-triazole-5-thione (3) was synthesized in good yield from Ibuprofen (1). One-pot three-component reactions of 3 with 5-aryl-furan-2-carboxaldehydes/substituted aromatic aldehydes and monochloroacetic acid in acetic acid in the presence of acetic anhydride and anhydrous sodium acetate afforded substituted thiazolo[3,2-b][1,2,4]triazole derivatives 4 and 5. The structures of the newly synthesized compounds were elucidated by elemental analyses and spectral data. The compounds were tested for their in-vitro antimicrobial activities.
Journal of the Iranian Chemical Society, 2021
The synthesis of novel benzimidazole derivatives with varied carbon chain length was achieved via... more The synthesis of novel benzimidazole derivatives with varied carbon chain length was achieved via “one-pot” nitro reductive cyclization ( 6a–o ). In each case, compounds were determined by the elemental analyses, FT-IR, mass, 1 H and 13 C NMR spectroscopy. Further, these derivatives were screened for their in vitro anticancer, in vitro and in vivo anti-inflammatory activities. The results revealed that the length of the carbon chain greatly affects the activity. Among the 15 derivatives, compound 6d induced maximum cell death in HeLa and A549 cell lines and compound 6a emerged as a potent anti-inflammatory agent. Also, the physicochemical properties of potent compounds were studied.
Zeitschrift für Naturforschung. B, A journal of chemical sciences, Mar 1, 2006
Chloropyridin-3-yl methyl)-4-phenyl-1,2,4-triazole-3-thiol (2) and 5-substituted-4-phenyl-1,2,4-t... more Chloropyridin-3-yl methyl)-4-phenyl-1,2,4-triazole-3-thiol (2) and 5-substituted-4-phenyl-1,2,4-triazole-3-thiols (3) were synthesized. Alkylation and aminomethylation reactions of these triazoles were also carried out. Some of the newly synthesized compounds were screened for their antibacterial activities.
European journal of medicinal chemistry, 2012
On account of the reported anticancer activity of triazolothiadiazines, we have synthesized a nov... more On account of the reported anticancer activity of triazolothiadiazines, we have synthesized a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl)propan-2-yl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and tested for in-vitro cytotoxicity by trypan blue exclusion and MTT assay. These compounds were also evaluated for their in-vivo anthelmintic activity, as well as in-vitro antimicrobial studies. Amongst the tested compounds, the compound 7j was the most promising cytotoxic agent with IC(50) value of 10.54μM in MCF-7 cells. The compounds 7l and 7q exhibited excellent anthelmintic activity. The compounds 7d, 7f, 7j, 7l, 7o, 7p and 7r showed good antibacterial activity, whereas compounds 7e and 7k exhibited excellent antifungal activity. The structures of newly synthesized compounds were characterized by IR, (1)H NMR, (13)C NMR and LCMS analysis.
RSC Advances, 2016
In the present study, we describe the design and expeditious synthesis of novel 2-aryl-5-(3-aryl-... more In the present study, we describe the design and expeditious synthesis of novel 2-aryl-5-(3-aryl-[1,2,4]-oxadiazol-5-yl)-1-methyl-1H-benzo[d]imidazole hybrid molecules as promising antimicrobial agents.
![Research paper thumbnail of Synthesis and evaluation of biological and nonlinear optical properties of some novel 2,4-disubstituted [1,3]-thiazoles carrying 2-(aryloxymethyl)-phenyl moiety](https://attachments.academia-assets.com/89626273/thumbnails/1.jpg)
](Medicinal Chemistry Research, 2012
A series of 2,4-disubstituted-[1,3]-thiazoles (4a-p and 6a-l) was synthesized from 2-(aryloxymeth... more A series of 2,4-disubstituted-[1,3]-thiazoles (4a-p and 6a-l) was synthesized from 2-(aryloxymethyl)benzoic acids (1a-d) through a multistep reaction sequence in good yield. The structures of the new compounds were established on the basis of their elemental analyses, IR, 1 H-NMR, 13 C-NMR and mass spectral data. All the synthesized compounds were screened for their antimicrobial and anti-inflammatory activities. Preliminary results indicated that some of them exhibit promising activities and they deserve more consideration as potential antimicrobial and anti-inflammatory agents. The nonlinear optical (NLO) property of 4a-p was also studied. The compound 4n with 2-(3-methylphenoxymethyl)phenyl and 4-nitrophenyl substituents showed very good NLO property compared to other compounds and also the reference compound, urea. Keywords 2-(Aryloxymethyl)benzothioamides Á 2,4-Disubstituted thiazoles Á Antimicrobial activity Á Anti-inflammatory activity
European Journal of Medicinal Chemistry, 2010
The acid hydrazides (2) derived from ibuprofen and 4-methylthiophenyl acetic acids have been subj... more The acid hydrazides (2) derived from ibuprofen and 4-methylthiophenyl acetic acids have been subjected to cyclization with carbon disulphide under basic conditions to yield 1,3,4-oxadiazol-2-thiones (3) which on aminomethylation with formaldehyde and secondary amines afforded a series of Mannich bases (4 and 5). Purity of the compounds has been confirmed by TLC. Structures of these compounds were established on the basis of elemental analyses and spectral studies. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and antimicrobial activities.
![Research paper thumbnail of Synthesis of some 7-arylidene-3-(4-(Methylthio) bezyl)-7H-thiazolo [2, 3-c][1, 2, 4] triazine-4, 6-diones and their anticonvulsant and antimicrobial activity](https://attachments.academia-assets.com/89626265/thumbnails/1.jpg)
](In the present study two series of novel 4-(4-methylthiobenzyl)-5-oxo-7-(5-aryl-2-furfurylidene/a... more In the present study two series of novel 4-(4-methylthiobenzyl)-5-oxo-7-(5-aryl-2-furfurylidene/arylidene)-1,2,4triazino[3,4-b]-thiazole-6-ones were synthesized by the multi component reaction of 6-(4-methylthiobenzyl)-3mercapto-1,2,4-triazin-5(4H)-one with chloroacetic acid and 5-aryl furfurals/aromatic aldehydes in presence of acetic anhydride and sodium acetate in acetic acid media. The structures of the newly synthesized compounds were characterized by spectral studies. New compounds were screened for their anticonvulsant(Pentylenetetrazole animal model) and antimicrobial activity. Compound 4c and 4d exhibited considerable anticonvulsant effect on animals by protecting them for a longer duration.
![Research paper thumbnail of Synthesis and evaluation of 4-aryl-2-[(2E)-2-substituted hydrazinyl]-1,3-thiazoles for possible antioxidant and antimicrobial activities](https://attachments.academia-assets.com/89626211/thumbnails/1.jpg)
](In the present work 4-aryl-2-[(2E)-2-(3,4,5-trimethoxybenzylidene)hydrazinyl]-1,3-thiazoles and 4... more In the present work 4-aryl-2-[(2E)-2-(3,4,5-trimethoxybenzylidene)hydrazinyl]-1,3-thiazoles and 4-aryl-2-{(2E)-2- [5-phenylfuran-2-yl)methylidene}hydrazinyl}-1,3-thiazoles were synthesized in good yield by cyclisation of the corresponding thiosemicarbazones with substituted phenacyl bromides in alcohol media. The thiosemicarbazones were in turn prepared by treating aryl aldehydes /arylfurfuraldehydes with thiosemicarbazide in the presence of few drops of sulphuric acid in alcohol media. The structures of newly synthesized compounds were characterized by the spectral studies. The newly synthesized compounds were evaluated for their anti-microbial and antioxidant activity. From the biological studies, it was possible to observe that some of the substituents on the phenyl ring influenced the activity. Among synthesized compound 2b, 4a and 4f have shown very good antioxidant activity when compared the reference drug. Compounds showed moderate to good antimicrobial activity at low concen...
R factor = 0.055; wR factor = 0.190; data-to-parameter ratio = 38.5. In the title compound, C20H2... more R factor = 0.055; wR factor = 0.190; data-to-parameter ratio = 38.5. In the title compound, C20H23N3S, the central 1,2,4-triazole ring makes dihedral angles of 69.76 (9) and 81.69 (8), respectively, with the phenyl and benzene rings. In the crystal, molecules are linked into a centrosymmetric dimer by a pair of intermolecular N—H S hydrogen bonds, generating an R2 2 (8) ring motif. Related literature For general background to and applications of 1,2,4-triazole
R factor = 0.026; wR factor = 0.074; data-to-parameter ratio = 35.1. In the title compound, C15H1... more R factor = 0.026; wR factor = 0.074; data-to-parameter ratio = 35.1. In the title compound, C15H14Cl2N2OS, the piperidine ring adopts a chair conformation. The dihedral angle between the thiazolidine ring and the dichlorobenzene ring is 9.30 (4) ; this near coplanar conformation is stabilized by the formation of an intramolecular C—H S hydrogen bond, which generates an S(6) ring. In the crystal, molecules are linked by C—H O hydrogen bonds, forming [001] chains. Weak – interactions [centroid–centroid separation = 3.5460 (5) A ˚ ] consolidate the structure. Related literature For details and properties of the 4-thiazolidinone ring system, see: Lesyk & Zimenkovsky (2004); Lesyk et al. (2007); Havrylyuk et al. (2009); Ahn et al. (2006); Park et al. (2008); Geronikaki et al. (2008); Zimenkovsky et al. (2005). For ring puckering, see: Cremer & Pople (1975). For hydrogen-bond motifs, see: Bernstein et al. (1995). For the stability of the temperature controller used in the data collection,...
A series of 2-(6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b]-2-aryloxymethyl-1,2,4-triazol-5-yl)-Narylace... more A series of 2-(6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b]-2-aryloxymethyl-1,2,4-triazol-5-yl)-Narylacetamides 6 were synthesized in good yield by condensing 5-aryloxymethyl-4H-1,2,4-triazole3-thiol 5 with various substituted N-phenyl-maleimides in acetic acid media. The newly synthesized compounds were characterized by spectral data and tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.
Journal of the Iranian Chemical Society, 2020
In view of discovering novel bioactive molecules, 1-phenyl-1H-2-(1-aryl-5-methyl-1H-1,2,3-triazol... more In view of discovering novel bioactive molecules, 1-phenyl-1H-2-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)-3-(N-arylcarbamoylmethylthio)-1,2,4-triazoles (8a-n) were designed and synthesized in good yield. Preliminary antibacterial activity was tested against Chromobacterium violaceum and Xanthomonas campestris pv. Campestris (Xcc). Out of 14 derivatives, compound 8g selectively possessed antibacterial activity against C. violaceum. Further derivatives that possessed an electronwithdrawing group and halogen atoms in N-phenylacetamide moiety were moderately active against Xcc (plant pathogen). After observing the reduction of violacein production through plate assay, compounds 8a, 8c, 8h, 8i and 8m were subjected to quantification of quorum sensing inhibition. Compounds with the electron-withdrawing group in N-phenylacetamide moiety showed admirable activity with > 80% inhibition of violacein. Mainly compound 8c which was inactive against the growth of bacteria were identified as excellent QSI which could be a lead compound for further development.
Zeitschrift für Naturforschung B, 2010
The key precursor rac-2-(4-isobutylphenyl)ethyl-1,2,4-triazole-5-thione (3) was synthesized in go... more The key precursor rac-2-(4-isobutylphenyl)ethyl-1,2,4-triazole-5-thione (3) was synthesized in good yield from Ibuprofen (1). One-pot three-component reactions of 3 with 5-aryl-furan-2-carboxaldehydes/ substituted aromatic aldehydes and monochloroacetic acid in acetic acid in the presence of acetic anhydride and anhydrous sodium acetate afforded substituted thiazolo[3,2-b][1,2,4]triazole derivatives 4 and 5. The structures of the newly synthesized compounds were elucidated by elemental analyses and spectral data. The compounds were tested for their in-vitro antimicrobial activities.
Биоорганическая химия, 2020
Medicinal Chemistry Research, 2014
Two new series of compounds namely, 1-chloro-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalene incorp... more Two new series of compounds namely, 1-chloro-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalene incorporated [1,3,4]oxadiazoline 4a-j and [1,3]thiazole 6a-j derivatives, were prepared. The precursor 1-chloro-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalene-2-carboxaldehyde 2 has been synthesized by Vilsmeier-Haack reaction, and X-ray crystallographic data were recorded. The Schiff's bases 3a-j subjected to dehydration followed by cyclization afford [1,3,4]oxadiazoline derivatives 4aj. The [1,3]thiazole derivatives 6a-j were prepared through Hantzsch thiazole synthesis by the reaction of intermediate 5 with different substituted a-halo ketones. The structures of the synthesized compounds were deduced according to FTIR, 1 H NMR, 13 C NMR, and mass spectral along with micro-analytical data. The newly synthesized compounds have been tested for their cytotoxicity bioassays, antibacterial, and anti-fungal activities. Some of the tested compounds showed significant cytotoxicity activity against HeLa cells. The majority of the synthesized compounds showed moderate to good anti-bacterial and anti-fungal activities.
Zeitschrift für Naturforschung. B, A journal of chemical sciences, Dec 1, 2010
The key precursor rac-2-(4-isobutylphenyl)ethyl-1,2,4-triazole-5-thione (3) was synthesized in go... more The key precursor rac-2-(4-isobutylphenyl)ethyl-1,2,4-triazole-5-thione (3) was synthesized in good yield from Ibuprofen (1). One-pot three-component reactions of 3 with 5-aryl-furan-2-carboxaldehydes/substituted aromatic aldehydes and monochloroacetic acid in acetic acid in the presence of acetic anhydride and anhydrous sodium acetate afforded substituted thiazolo[3,2-b][1,2,4]triazole derivatives 4 and 5. The structures of the newly synthesized compounds were elucidated by elemental analyses and spectral data. The compounds were tested for their in-vitro antimicrobial activities.
Journal of the Iranian Chemical Society, 2021
The synthesis of novel benzimidazole derivatives with varied carbon chain length was achieved via... more The synthesis of novel benzimidazole derivatives with varied carbon chain length was achieved via “one-pot” nitro reductive cyclization ( 6a–o ). In each case, compounds were determined by the elemental analyses, FT-IR, mass, 1 H and 13 C NMR spectroscopy. Further, these derivatives were screened for their in vitro anticancer, in vitro and in vivo anti-inflammatory activities. The results revealed that the length of the carbon chain greatly affects the activity. Among the 15 derivatives, compound 6d induced maximum cell death in HeLa and A549 cell lines and compound 6a emerged as a potent anti-inflammatory agent. Also, the physicochemical properties of potent compounds were studied.
Zeitschrift für Naturforschung. B, A journal of chemical sciences, Mar 1, 2006
Chloropyridin-3-yl methyl)-4-phenyl-1,2,4-triazole-3-thiol (2) and 5-substituted-4-phenyl-1,2,4-t... more Chloropyridin-3-yl methyl)-4-phenyl-1,2,4-triazole-3-thiol (2) and 5-substituted-4-phenyl-1,2,4-triazole-3-thiols (3) were synthesized. Alkylation and aminomethylation reactions of these triazoles were also carried out. Some of the newly synthesized compounds were screened for their antibacterial activities.
European journal of medicinal chemistry, 2012
On account of the reported anticancer activity of triazolothiadiazines, we have synthesized a nov... more On account of the reported anticancer activity of triazolothiadiazines, we have synthesized a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl)propan-2-yl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and tested for in-vitro cytotoxicity by trypan blue exclusion and MTT assay. These compounds were also evaluated for their in-vivo anthelmintic activity, as well as in-vitro antimicrobial studies. Amongst the tested compounds, the compound 7j was the most promising cytotoxic agent with IC(50) value of 10.54μM in MCF-7 cells. The compounds 7l and 7q exhibited excellent anthelmintic activity. The compounds 7d, 7f, 7j, 7l, 7o, 7p and 7r showed good antibacterial activity, whereas compounds 7e and 7k exhibited excellent antifungal activity. The structures of newly synthesized compounds were characterized by IR, (1)H NMR, (13)C NMR and LCMS analysis.
RSC Advances, 2016
In the present study, we describe the design and expeditious synthesis of novel 2-aryl-5-(3-aryl-... more In the present study, we describe the design and expeditious synthesis of novel 2-aryl-5-(3-aryl-[1,2,4]-oxadiazol-5-yl)-1-methyl-1H-benzo[d]imidazole hybrid molecules as promising antimicrobial agents.
Medicinal Chemistry Research, 2012
A series of 2,4-disubstituted-[1,3]-thiazoles (4a-p and 6a-l) was synthesized from 2-(aryloxymeth... more A series of 2,4-disubstituted-[1,3]-thiazoles (4a-p and 6a-l) was synthesized from 2-(aryloxymethyl)benzoic acids (1a-d) through a multistep reaction sequence in good yield. The structures of the new compounds were established on the basis of their elemental analyses, IR, 1 H-NMR, 13 C-NMR and mass spectral data. All the synthesized compounds were screened for their antimicrobial and anti-inflammatory activities. Preliminary results indicated that some of them exhibit promising activities and they deserve more consideration as potential antimicrobial and anti-inflammatory agents. The nonlinear optical (NLO) property of 4a-p was also studied. The compound 4n with 2-(3-methylphenoxymethyl)phenyl and 4-nitrophenyl substituents showed very good NLO property compared to other compounds and also the reference compound, urea. Keywords 2-(Aryloxymethyl)benzothioamides Á 2,4-Disubstituted thiazoles Á Antimicrobial activity Á Anti-inflammatory activity
European Journal of Medicinal Chemistry, 2010
The acid hydrazides (2) derived from ibuprofen and 4-methylthiophenyl acetic acids have been subj... more The acid hydrazides (2) derived from ibuprofen and 4-methylthiophenyl acetic acids have been subjected to cyclization with carbon disulphide under basic conditions to yield 1,3,4-oxadiazol-2-thiones (3) which on aminomethylation with formaldehyde and secondary amines afforded a series of Mannich bases (4 and 5). Purity of the compounds has been confirmed by TLC. Structures of these compounds were established on the basis of elemental analyses and spectral studies. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and antimicrobial activities.
In the present study two series of novel 4-(4-methylthiobenzyl)-5-oxo-7-(5-aryl-2-furfurylidene/a... more In the present study two series of novel 4-(4-methylthiobenzyl)-5-oxo-7-(5-aryl-2-furfurylidene/arylidene)-1,2,4triazino[3,4-b]-thiazole-6-ones were synthesized by the multi component reaction of 6-(4-methylthiobenzyl)-3mercapto-1,2,4-triazin-5(4H)-one with chloroacetic acid and 5-aryl furfurals/aromatic aldehydes in presence of acetic anhydride and sodium acetate in acetic acid media. The structures of the newly synthesized compounds were characterized by spectral studies. New compounds were screened for their anticonvulsant(Pentylenetetrazole animal model) and antimicrobial activity. Compound 4c and 4d exhibited considerable anticonvulsant effect on animals by protecting them for a longer duration.
In the present work 4-aryl-2-[(2E)-2-(3,4,5-trimethoxybenzylidene)hydrazinyl]-1,3-thiazoles and 4... more In the present work 4-aryl-2-[(2E)-2-(3,4,5-trimethoxybenzylidene)hydrazinyl]-1,3-thiazoles and 4-aryl-2-{(2E)-2- [5-phenylfuran-2-yl)methylidene}hydrazinyl}-1,3-thiazoles were synthesized in good yield by cyclisation of the corresponding thiosemicarbazones with substituted phenacyl bromides in alcohol media. The thiosemicarbazones were in turn prepared by treating aryl aldehydes /arylfurfuraldehydes with thiosemicarbazide in the presence of few drops of sulphuric acid in alcohol media. The structures of newly synthesized compounds were characterized by the spectral studies. The newly synthesized compounds were evaluated for their anti-microbial and antioxidant activity. From the biological studies, it was possible to observe that some of the substituents on the phenyl ring influenced the activity. Among synthesized compound 2b, 4a and 4f have shown very good antioxidant activity when compared the reference drug. Compounds showed moderate to good antimicrobial activity at low concen...
R factor = 0.055; wR factor = 0.190; data-to-parameter ratio = 38.5. In the title compound, C20H2... more R factor = 0.055; wR factor = 0.190; data-to-parameter ratio = 38.5. In the title compound, C20H23N3S, the central 1,2,4-triazole ring makes dihedral angles of 69.76 (9) and 81.69 (8), respectively, with the phenyl and benzene rings. In the crystal, molecules are linked into a centrosymmetric dimer by a pair of intermolecular N—H S hydrogen bonds, generating an R2 2 (8) ring motif. Related literature For general background to and applications of 1,2,4-triazole
R factor = 0.026; wR factor = 0.074; data-to-parameter ratio = 35.1. In the title compound, C15H1... more R factor = 0.026; wR factor = 0.074; data-to-parameter ratio = 35.1. In the title compound, C15H14Cl2N2OS, the piperidine ring adopts a chair conformation. The dihedral angle between the thiazolidine ring and the dichlorobenzene ring is 9.30 (4) ; this near coplanar conformation is stabilized by the formation of an intramolecular C—H S hydrogen bond, which generates an S(6) ring. In the crystal, molecules are linked by C—H O hydrogen bonds, forming [001] chains. Weak – interactions [centroid–centroid separation = 3.5460 (5) A ˚ ] consolidate the structure. Related literature For details and properties of the 4-thiazolidinone ring system, see: Lesyk & Zimenkovsky (2004); Lesyk et al. (2007); Havrylyuk et al. (2009); Ahn et al. (2006); Park et al. (2008); Geronikaki et al. (2008); Zimenkovsky et al. (2005). For ring puckering, see: Cremer & Pople (1975). For hydrogen-bond motifs, see: Bernstein et al. (1995). For the stability of the temperature controller used in the data collection,...
A series of 2-(6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b]-2-aryloxymethyl-1,2,4-triazol-5-yl)-Narylace... more A series of 2-(6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b]-2-aryloxymethyl-1,2,4-triazol-5-yl)-Narylacetamides 6 were synthesized in good yield by condensing 5-aryloxymethyl-4H-1,2,4-triazole3-thiol 5 with various substituted N-phenyl-maleimides in acetic acid media. The newly synthesized compounds were characterized by spectral data and tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.