Bojan Pajic - Academia.edu (original) (raw)

Papers by Bojan Pajic

Vojnosanitetski pregled, 2017

Background/Aim. Keratoconus is a disorder of the eye which results in progressive thinning of the... more Background/Aim. Keratoconus is a disorder of the eye which results in progressive thinning of the cornea. The cross-linking procedure (CXL) is applied in the treatment of initial progredient forms of keratoconus. It is aiming at increasing biomechanical stability of corneal stromal tissue to slow down or stop progressing the ectatic disorder. The aim of the study was to examine the effect of CXL procedure on values of steep keratometry (K2) and central pachymetry (CCT) six months after the intervention in keratoconusaffected patients. Methods. Clinical prospective cohort study included 30 eyes of 29 patients suffering from keratoconus. All patients were examined on Allegro-Oculyzer in order to diagnose and follow up keratoconus, thus obtaining corneal topography parameters and parameters important for this study: K2 and CCT, preoperatively and six months postoperatively. The CXL procedure was carried out by following the modified Dresden Protocol. Results. K2 mean value was 49.01 ? ...

Applied Sciences, 2020

A study to compare femto-presbyLASIK to standard myopia femto-LASIK refractive surgical correctio... more A study to compare femto-presbyLASIK to standard myopia femto-LASIK refractive surgical correction with a total of 45 candidates was performed. The goal was to identify a more specific set of indications for presbyopia LASIK treatments. The results showed thoroughly good uncorrected visual acuity for myopia (decimal: 1.01 ± 0.15) as well as for presbyLASIK (decimal: 0.78 ± 0.17) corrections. Astigmatism was comparable in both groups and did not change significantly from preoperative (0.98D ± 0.53 SD) to postoperative (1.01D ± 0.50 SD). Our study results suggest, that presbyLASIK treatment is as safe and effective as regular LASIK myopia correction and can hence be recommended to treat presbyopia.

Vojnosanitetski pregled, 2021

Background/Aim. Corneal cross-linking (CXL) treatment shows the best results in stabilizing the c... more Background/Aim. Corneal cross-linking (CXL) treatment shows the best results in stabilizing the cornea and stopping the progress of the ectatic process. The aim of the study was to assess the impact of CXL on the keratoconus regarding higher-order aberrations (HOAs) and potential improvement of visual function. Methods. In 19 patients, a standard epithelium-off CXL was performed with an energy density of three mW/cm2 for half an hour. The cornea was examined by Pentacam topography before CXL and one and six months after CXL. Best-corrected visual acuity (BCVA), topographic data, and aberrations were collected. Results. A significant reduction in vertical coma was observed from preoperative -1.03 ? 1.89 to -0.74 ? 1.73 (p = 0.004) six months after CXL, and in spherical aberration from preoperative -0.22 ? 1.05 to -0.08 ? 1.13 (p = 0.002) six months after CXL. Root mean square (RMS) HOAs six months after CXL also significantly reduced from 2.31 ? 1.82 to 2.26 ? 1.84 six months after C...

Journal of Clinical Medicine, 2021

Background: Presbyopia treatment in pseudophakic patients with a monofocal IOL is challenging. Th... more Background: Presbyopia treatment in pseudophakic patients with a monofocal IOL is challenging. This study investigates the refractive results of femto-PresbyLASIK and analyzes presbyopia treatment in pseudophakic eyes. Methods: 14 patients with 28 pseudophakic eyes were treated with femto-PresbyLASIK. The dominant eye was targeted at a distance and the non-dominant eye at −0.5 D. The presbyopic algorithm creates a steepness in the cornea center by using an excimer laser that leads to corneal multifocality. Results: 6 months after surgery a refraction of −0.11 ± 0.13 D (p = 0.001), an uncorrected distance visual acuity of 0.05 ± 1.0 logMAR (p < 0.001) and an uncorrected near visual acuity of 0.15 ± 0.89 logMAR (p = 0.001) were achieved in the dominant eye. For the non-dominant eye, the refraction was −0.28 ± 0.22 D (p = 0.002), the uncorrected distance of visual acuity was 0.1 ± 1.49 logMAR, and the uncorrected near visual acuity was 0.11 ± 0.80 logMAR (p < 0.001). Spherical ab...

Medicina

The power density of femtosecond lasers and exposure time to the tissue are crucial for a success... more The power density of femtosecond lasers and exposure time to the tissue are crucial for a successful procedure in terms of safety and precision. The reduction of the pulse duration allows reducing the quantity of the energy to be delivered to the tissue for disruption with strongly diminished mechanical and thermal collateral damage. The cutting effect of ultra-short pulses is very precise, minimally traumatic, safe, and predictable. Future developments will lead to further energy reductions to achieve optical breakdowns. However, the pulse length cannot be shortened arbitrarily because below 100 fs nonlinear effects can change the process in an unfavorable way. Compared to manual-conventional cataract surgery, femtosecond laser-assisted cataract surgery (FLACS) shows many advantages in clinical application, especially with regard to precision and tissue protection. The femtosecond laser has become particularly important and has made the overall procedure safer when we deal with com...

Sensors

Pterygium is a vascularized, invasive transformation on the anterior corneal surface that can be ... more Pterygium is a vascularized, invasive transformation on the anterior corneal surface that can be treated by Strontium-/Yttrium90 beta irradiation. Finite element modeling was used to analyze the biomechanical effects governing the treatment, and to help understand clinically observed changes in corneal astigmatism. Results suggested that irradiation-induced pulling forces on the anterior corneal surface can cause astigmatism, as well as central corneal flattening. Finite element modeling of corneal biomechanics closely predicted the postoperative corneal surface (astigmatism error −0.01D; central curvature error −0.16D), and can help in understanding beta irradiation treatment. Numerical simulations have the potential to preoperatively predict corneal shape and function changes, and help to improve corneal treatments.

Journal of Cataract & Refractive Surgery, 2011

Surgical Techniques in Ophthalmology Refractive Surgery, 2010

Mastering the Techniques of Glaucoma Diagnosis and Management, 2006

Surgical Techniques in Ophthalmology (Glaucoma Surgery), 2010

Step by Step Minimally Invasive Glaucoma Surgery, 2006

A Textbook of Practical Physiology, 2007

Retina, 2006

To report a complex mutation in the peripherin/RDS gene found in a family in whom retinal pattern... more To report a complex mutation in the peripherin/RDS gene found in a family in whom retinal pattern dystrophy is segregating as an autosomal dominant trait. Clinical data were collected from family members of a large Swiss family affected by autosomal dominant retinal pattern dystrophy. Single strand conformation polymorphism (SSCP) analysis of the candidate gene peripherin/RDS and subsequent sequencing of the first exon were performed. Pattern dystrophy of the retina was suspected in 18 family members aged 30 years or older. Assuming a homogeneous phenotype, the candidate locus peripherin/RDS was investigated. SSCP analysis of the first exon of the peripherin/RDS gene showed an aberrant pattern in 18 affected individuals. Direct sequencing of polymerase chain reaction products detected a complex mutation, del265-268GCCA ins AGGGCC, leading to a stop codon at amino acid position 99. To our knowledge, we report the first complex mutation in the peripherin/RDS gene as the cause of a mild macular phenotype, supporting the importance of molecular diagnosis in genetic counseling.

Klinische Monatsblätter für Augenheilkunde, 2000

Journal of Glaucoma, 2011

The goal of this study is to show the efficacy and safety of an innovative surgical procedure reg... more The goal of this study is to show the efficacy and safety of an innovative surgical procedure regarding the treatment of open-angle and juvenile glaucoma known as sclerothalamotomy ab interno (STT ab interno). Between February and July 2002 surgery was performed in 58 eyes of 58 consecutive patients, of which 53 were diagnosed with open-angle and 5 with juvenile glaucoma. The procedure was performed with the assistance of a custom-made high-frequency dissection probe (19 gauge with a tip of 0.3 × 1 mm), which applies a bipolar current of 500 kHz frequency. The probe penetrates approximately 1 mm into the nasal sclera (ab interno) and through the trabecular meshwork and Schlemm&amp;amp;amp;amp;amp;amp;amp;#39;s canal, thus forming a deep sclerotomy or &amp;amp;amp;amp;amp;amp;amp;quot;thalami&amp;amp;amp;amp;amp;amp;amp;quot; of 0.3 mm height and 0.6 mm width. The average baseline intraocular pressure (IOP) was 25.6 ± 2.3 mm Hg (range: 18-48 mm Hg) for the open-angle glaucoma group and 39.6 ± 2.3 mm Hg (range: 34-46 mm Hg) for the juvenile glaucoma group. All patients had a minimum follow-up of 72 months. The mean IOP for the stated period was 14.7 ± 1.8 mm Hg for the open-angle glaucoma group and 13.2 ± 1.3 mm Hg for the juvenile group. The IOP after surgery was statistically significantly lower than the baseline IOP at all measured intervals (P &amp;amp;amp;amp;amp;amp;amp;lt; 0.001). After 72 months only 11 eyes accounted for a 20.8% continuous antiglaucoma therapy. With regard to the procedure no serious complication was documented. Sclerothalamotomy ab interno is a minimally invasive, safe, and efficient surgical technique for lowering the IOP in open-angle and juvenile glaucoma.

Journal Français d'Ophtalmologie, 2008