Boran Uglešić - Academia.edu (original) (raw)

Papers by Boran Uglešić

Journal of psychoactive drugs, Jun 27, 2024

PubMed, Dec 1, 2023

Objective: The COVID-19 pandemic has imposed numerous challenges on the mental health of the popu... more Objective: The COVID-19 pandemic has imposed numerous challenges on the mental health of the population of each affected country. The mental health of patients hospitalized due to COVID-19 was particularly at risk. The goal of this research was to examine the occurrence of mental disorders in such patients and what were the risk factors for poorer mental health during hospital treatment for COVID-19. Method: We included 135 subjects treated for COVID-19 who were discharged during January 2022. We collected their sociodemographic data as well as data on somatic comorbidities and treatment during hospitalization. We monitored how many patients were hospitalized with a psychiatric diagnosis and therapy, and how many of them started using psychotropic drugs during hospitalization. Those data were recorded both at the time of discharge and again one year later. Results: Statistical analysis showed that the number of patients using psychotropic drugs increased 4x (n=11 (8.1%) at admission vs. n=44 (32.6%) in hospital) during hospital treatment due to COVID-19. There was an increase in the use of all psychotropic drugs except for antidepressants; specifically, there was a 3.3x increase in treatment with anxiolytics (5.2% at admission vs. 17.0% in hospital), a 3.4x increase in treatment with antipsychotics (5.2% vs. 17.8%), and an 8x increase in treatment with hypnotics (0.7% vs. 5.9%). Their use decreased close to baseline after discharge. Conclusions: Our research showed that hospitalization due to COVID-19 leads to deterioration of mental health. We assume that there is a fear of death in the background, which can be well explained by the "landscape of fear" theory.

European Psychiatry, 2013

Clinical neuropsychiatry, Dec 1, 2022

Objective: The superiority of long-acting injectable antipsychotics (LAIs) versus oral antipsycho... more Objective: The superiority of long-acting injectable antipsychotics (LAIs) versus oral antipsychotics is often emphasized, even in terms of adherence and rehospitaliza-tion rates. As such, LAIs are particularly recommended during the COVID-19 pandemic. The goal of our research was to determine whether there are differences in the number of rehospitalizations in patients treated for schizophrenia, schizophrenia-like disorders, and delusional states (psychotic disorders) with LAI antispychotics versus oral antispychotics. Method: Subjects with schizophrenia, schizophrenia-like disorders and delusional states participated in our retrospective study. 124 subjects were treated with oral anti-psychotics, while 72 received LAIs along with oral antipsychotics. We collected their sociodemographic data and psychiatric history data. Our main outcome measure was the number of rehospitalizations. Results: Statistical analysis showed that the studied groups did not differ according to sociodemographic parameters, except that in the group of patients with LAIs there was a significantly higher percentage of men (65 (52.4) vs 50 (69.4), p=0.029)). Also, the groups do not differ according to the psychiatric history data. There is no difference in the duration of the current hospitalization nor in the composition of the patients, considering the order of the current hospitalization. The difference in the number of rehospitalizations is not significant neither in the first year of follow-up (p=0.144), nor in the second (p=0.142), nor after two years of follow-up (p=0.083). Conclusions: Our research has shown that there is no difference in the number of rehospitalizations in patients with schizophrenia, schizophrenia-like disorders and delusional states, considering whether they take oral antipsychotics or they also take LAIs along with them. We can therefore conclude that it is particularly important to work on improving patient adherence. We must make psychiatrists aware that the pandemic, like other threats, can be our ally in improving adherence ("perceived threat as a health belief").

Sažeci 1. Hrvatski kongres Socijalne psihijatrije - psihijatrije u zajednici, Split 2004., 2004

U etiologiji psihijatrijskih bolesti i poremecaja sve veca uloga pripisuje se upalnim procesima i... more U etiologiji psihijatrijskih bolesti i poremecaja sve veca uloga pripisuje se upalnim procesima i medijatorima upale, a ne samo i iskljucivo poremecajima u funkciji razlicitih neurotransmitora i njihovih receptora. Danas je jasno da jedan neurotransmitor nije iskljucivo vezan za etiologiju pojedine bolesti, te dopamin nije ekskluzivno povezan s etiologijom shizofrenije. Na biokemijskoj razini gotovo da nema neurotransmitorskog sustava cija disregulacija nije povezivana s etiologijom shizofrenije. Upala nije specificna ni za jedan dusevni poremecaj premda se tragovi njezine prisutnosti srecu kod vecine dusevnih poremecaja: citokinski disbalans postoji i u shizofreniji i depresiji. Navedena opažanja utjecala su da se tijek i razvoj velikog dusevnog poremecaja promatra kao posljedica interreakcije nasljedne predispozicije i stanja intermitentne ili perzistirajuce upale. Citokini pospjesuju otpustanje serotonina i noradrenalina u mozgu i djeluju poticajno na aktivnost HHA osi koja je hi...

Psychiatria Danubina, 2021

Dissociative disorder is a partial or a complete loss of the normal integration between the sense... more Dissociative disorder is a partial or a complete loss of the normal integration between the sense of identity, memories of the past, sensory impression and control of voluntary movements. Diagnosis should be stated only after excluding active psychoactive substance use, neurological disorders and disorders associated with somatic conditions. We are describing a patient who had comorbidity of organic imperment while diagnosing dissociative disorder. A 36-year-old male was admitted to the Clinic for Psychiatry, University Hospital Centre (UHC) Split, Croatia, because of difficulty in walking and involuntary movements due to constant muscle contractions throughout whole body, with predominantly intense in diaphragm and upper extremities. Motoric symptoms began several months after a cerebellar tumor surgery in 2006. Despite organic impairment due to tumor incision, after extensive somatic diagnostic processing, the organic cause of his condition has not been detected. The patient was t...

Psychiatria Danubina, 2016

Psychiatria Danubina, 2011

Dermatological side effects of psychopharmacological drugs are fortunately not so often. They are... more Dermatological side effects of psychopharmacological drugs are fortunately not so often. They are mostly presented in the group of mood stabilizers and antiepileptic drugs, particularly the carbamazepine and lamotrigine, and can be manifested through the Stevens Johnson syndrome, Toxic Epidermal Necrolysis (TEN)/Lyell's syndrome with about 30% lethality. According to the literature the group of phenothiazines is the category of drugs with rare appearances of skin reactions. Promazine, aliphatic phenothiazines antipsychotic, including less frequent side effects in the leaflet states increased skin sensitivity to sun, skin rash-associated with contact dermatitis, allergic reactions, cholestatic icterus. The only reported dermatological side effect of promazine is its metabolites deposition in the cornea. Analyzing the e-data basis we have not found references connecting the Exanthema medicamentosum as a side effect of promazine. A forty-two years old female patient was admitted to...

Psychiatria Danubina, 2015

Psychiatria Danubina, 2014

The high prevalence of metabolic syndrome in patients with psychiatric disorders, almost double t... more The high prevalence of metabolic syndrome in patients with psychiatric disorders, almost double the prevalence reported for the general population, is worrying. The aim of this study is to investigate the presence of metabolic syndrome and inflammatory marker levels in patients with schizophrenia and recurrent depressive disorder in a Croatian psychiatric sample. This study included 62 inpatients with schizophrenia and 62 with recurrent depressive disorder treated at the Department of Psychiatry, University Hospital Centre Split, enrolled from November 2011 until May 2012. The cases were compared to 124 healthy subjects from the general population. The presence of metabolic syndrome was found in 56.5% of the patients with schizophrenia and 53.2% of the patients with depression, which was significantly more prevalent than in the control group (32.3%). The levels of inflammation markers (i.e., C-reactive protein and PAI-1) were significantly higher among patients with metabolic syndro...

Psychiatria Danubina, 2012