Borhan Uddin - Academia.edu (original) (raw)

Papers by Borhan Uddin

Abstract: Several types of organophosphorous and carbamate pesticides have been used extensively ... more Abstract: Several types of organophosphorous and carbamate pesticides have been used extensively by the farmers in Bangladesh during the last few decades. Twenty seven water samples collected from both paddy and vegetable fields in the Savar and Dhamrai Upazilas in Bangladesh were analyzed to determine the occurrence and distribution of organophosphorus (chlorpyrifos, malathion and diazinon) and carbamate (carbaryl and carbofuran) pesticide residues. A high performance liquid chromatograph instrument equipped with a photodiode array detector was used to determine the concentrations of these pesticide residues. Diazinon and carbofuran were detected in water samples collected from Savar Upazila at 0.9 μg/L and 198.7 μg/L, respectively. Malathion was also detected in a single water sample at 105.2 μg/L from Dhamrai Upazila. Carbaryl was the most common pesticide detected in Dhamrai Upazila at 14.1 and 18.1 μg/L, while another water

Journal of Pharmacognosy and Phytochemistry, 2013

Oxidative stress is implicated in age-related deterioration of memory and learning ability. In th... more Oxidative stress is implicated in age-related deterioration of memory and learning ability. In this study, we evaluated whether oral administration of Syzygium cumini seed extract (SE) ameliorates the learning-related memory of old rats by eight-arm radial maze task. After 12-weeks oral administration of SE extract, learning-related memory was ameliorated, concurrently with decreases in the corticohippcampal levels of lipid peroxide (LPO) and increases in the catalase and AChE activities in the cortex. The levels of LPO were positively correlated with the RMEs. In carotid artery occlusion-induced hypoxia study, the SE-fed rats displayed significantly less microglial invasion, cell swelling and rupture in the cortico-hippocampal brain slices, thus suggesting an antioxidative defense of SE. Chemical analyses of SE revealed substantial amounts of polyphenols and free-radical scavenging activities. Finally, our results show that the S. cumini seed extract improves learning-related memor...

Journal of Medicinal Plants Studies, 2013

Mushroom, a new food item in Bangladesh, has remained largely obscure about its nutritional and m... more Mushroom, a new food item in Bangladesh, has remained largely obscure about its nutritional and medicinal values. Evaluation of antioxidant and antimicrobial activity of the Pleurotus florida ethanol extract was the purpose of the present study. Crude P. florida extract was qualitatively screened for the presence of phytochemicals while total polyphenol content was measured quantitatively. DPPH-free radical scavenging activity, total reducing power and ability of inhibiting in vitro Fenton’s reagent-induced oxidative stress were used to evaluate the antioxidant potentials of the P. florida extract. Minimum inhibitory concentration and antibiogram of the P. florida extract was assessed against six human pathogenic bacteria. Ethanol extract of P. florida possesses appreciable antioxidant activity, as indicated by the polyphenol contents, DPPH scavenging activity, reducing power and anti-lipid peroxide effect. The extract exhibited antimicrobial activity against all of the microorganis...

doi: 10.33472/AFJBS.3.1.2021.120-128 Article Info Abstract Smoking of cigarettes worsens morbidit... more doi: 10.33472/AFJBS.3.1.2021.120-128 Article Info Abstract Smoking of cigarettes worsens morbidity and mortality rates by prompting cancer, pulmonary, cardiovascular, and oral diseases. Despite having all these severe risks of smoking, the habit is unacceptably widespread, particularly among teenagers in many countries, including Bangladesh. In this investigation, the acute effect of cigarette smoking on oxidative stress and inflammation (Tumor Necrosis Factor-TNF-) has been analyzed in the cigarette smoke (CS)-exposed rats. Exposure of smoke in vivo significantly increased the levels of Lipid Peroxide (LPO) and TNF in the experimental rats, when compared to those of the control rats. Furthermore, washed erythrocytes isolated from control rats were exposed directly to CS in vitro. The time-dependent exposure of smoke to erythrocytes increased the oxidative stress in the erythrocytes, as indicated by increased levels of LPO in the erythrocytes. The toxic effect of acute cigaret...

The plant Paederia foetida Linn., locally known as “Gondhabadali”, has traditionally been used fo... more The plant Paederia foetida Linn., locally known as “Gondhabadali”, has traditionally been used for medicinal purposes, though its mechanisms of beneficial effects have remained largely unknown. We investigated antibacterial activity of the plant to justify the traditional claims that “Gondhabadali” plants are effective in killing a host of bacteria with a concurrent healing from various infectious diseases including shigellosis, diarrhea etc. The test microorganisms included two Gram-positive (Staphylococcus aureus, Enterococcus faecalis) and three Gram-negative (Escherichia coli, Salmonella typhimurium, Shigella flexneri) bacteria. The extract showed significant antibacterial activities against S. flexneri, S. aureus, E. coli and E. faecalis. The preliminary screening experiment revealed that the most susceptible bacterium was S. flexneri while the most resistant was S. typhimurium. The results of the present experiment clearly indicate that Paederia foetida plant could be used for...

13th ACM Web Science Conference 2021, 2021

The COVID-19 “infodemic” has resulted in the widespread dissemination of counterfeit medical advi... more The COVID-19 “infodemic” has resulted in the widespread dissemination of counterfeit medical advice, hoaxes, fake products, and phoney information about the virus and responses. As a result, computational methods for determining any information’s authenticity to improve trust in public health awareness and policy decisions are profoundly discussed in the scientific community. Even before the pandemic, mis- and disinformation, including fake news, have been observed in the online world in significant numbers for numerous business, political and personal reasons. Moreover, many of these fake news was published from sources believed to be reliable. In contrast, some other fake news was fabricated in a way that would be easily trusted and shared by the general people in social media. COVID-19 related fake news has enormous effects on both the offline and online community, and thus, it challenges government initiatives for proper health intervention. Therefore, interest in research in th...

The accident at a nuclear power plant that involved damage to fuel in the reactor core or in a sp... more The accident at a nuclear power plant that involved damage to fuel in the reactor core or in a spent fuel pool could cause deaths, severe health and psychological effects, and could also have economic and sociological consequences affecting the public. These consequences could be mitigated by implementing protective actions promptly in the emergency planning zone (EPZ). The EPZ included precautionary action zone (PAZ) to reduce substantially the risk of severe deterministic effects, urgent protective action planning zone (UPZ). The importance of EPZ has been demonstrated in Fukushima Accident as protective actions; evacuation of public within 20 km and sheltering within 20~30 km (later on advised to evacuate voluntarily) prevented radiological consequences effectively. The public could be exposed to direct radiation in the downwind direction and also to radioactivity deposited on the ground and vegetation resulting in exposure through different pathways. Computer codes could be used...

Journal of Armed Forces Medical College, Bangladesh, 2017

Crude preparations of the different parts of Hibiscus rosa-sinensis have been traditionally used ... more Crude preparations of the different parts of Hibiscus rosa-sinensis have been traditionally used in folk medicine for various purposes. In the present study, we have evaluated the antibacterial activity of the extracts of H. rosa-sinensis leaves and flowers against some clinical isolates of bacteria by simple agar-well diffusion and bacteriological enumeration method. In the preliminary screening experiment, all of the bacterial isolates showed varying degrees of sensitivity to the flower extracts excluding Klebsiella pneumoniae. We found Staphylococcus aureus, a Gram-positive bacterium as the most sensitive to the extracts of flowers at the applied doses of 50 and 100 mg/well. On the other hand, most of the tested bacterial isolates were resistant to the extracts of leaves excluding S. aureus and Salmonella typhimurium. In bacteriological enumeration study, all of the bacterial isolates showed substantial extent of sensitivity to the different extracts used. Our findings clearly de...

T he s t u d y p r e s e n t s a g e o g r a p h i c a l a n a l y s i s of c r o p l a n d p r o... more T he s t u d y p r e s e n t s a g e o g r a p h i c a l a n a l y s i s of c r o p l a n d p r o d u c t i v i t y i.n B a n g l a d e s h u s i n g t h a n a l e v e l d a t a . It i n v o l v e s the i n t e r p r e t a t i o n s of s p a t i a l p a t t e r n s t h a t e m e r g e d , a n d the e v a l u a t io n and i d e n t i f i c a t i o n of the i n f lu e n c e of c r o p p i n g i n t e n s i t y and the r e l a t i v e a c r e a g e and y i e l d s of v a r i o u s c r o p s on c r o p l a n d p r o d u c t i v i t y w i t h i n the p r e v a i l i n g s e t o f p h y s i c a l and s o c i o e c o n o m i c c o n d i t i o n s . T he c r o p l a n d p r o d u c t i v i t y i n d e x i s e x p r e s s e d in t o t a l v a lu e ( R u p e e s ) of p r o d u c t i o n p e r a c r e of n e t c r o p l a n d . T he s p a t i a l p a t t e r n s t h a t e m e r g e f r o m the c r o p l a n d p r o d u c t i v i t y i n d e x a r e a n a l y s e d u s i n g the t r e n...

Mitotic phosphatases play crucial roles in anaphase regulation and mitotic exit by annulling the ... more Mitotic phosphatases play crucial roles in anaphase regulation and mitotic exit by annulling the kinase-mediated protein phosphorylation. In budding yeast Saccharomyces cerevisiae, Cdc14 (cell division cycle 14) phosphatase antagonizes key Cdk1 (cyclin-dependent kinase 1) functions to drive cells out of mitosis. Despite the presence of highly conserved catalytic domains, human CDC14s are dispensable for cell cycle progression. Nevertheless, to decipher the molecular mechanisms of human CDC14s functions, we have investigated the knockout cellular models aided by various imaging and proteomics approaches. Phenotypic analyses of the generated hCDC14A knockout in human retinal pigment epithelium (hTERT-RPE1) cells have exhibited the occurrence of longer primary cilia upon serum starvation. The intermediate longer cilia in haploid-insufficient cells, as well as the extended cilia observed upon siRNA-mediated acute depletion of hCDC14A, have further confirmed the phenotype. Primary cilia ...

Summary: Fifty cases of hand trauma of different aetiology with soft tissue loss with exposed ten... more Summary: Fifty cases of hand trauma of different aetiology with soft tissue loss with exposed tendons and bones were treated in NITOR and DMCH, Dhaka between January ’97 and December ’02 with groin flap. Eighty three percent (83%) cases have good results with excellent flap adhesion and no flap loss. Seventeen percent (17%) cases have some degree of flap loss which were taken to be acceptable. Overall result in terms of restoring the hand function was encouraging which was approximately eighty eight percent (88%).

In vitro antioxidant activity of Centella asiatica (Linn.) and the impact of extraction solvent p... more In vitro antioxidant activity of Centella asiatica (Linn.) and the impact of extraction solvent polarity on the antioxidant potential were investigated in the present study. 100% ethanol, 50% ethanol and water were chosen as extraction solvent due to arithmetic progression of their polarity. Total polyphenol, flavonoid, β-carotene, tannin and vitamin C content of these three extracts were determined while their antioxidant potentials were assayed by total reducing power assay and 2, 2-diphenyl-1-picrylhydrazyl (DPPH)-scavenging activity. 50% ethanol extract of C. asiatica contained significantly higher amount of polyphenol, flavonoid while moderate amount of carotene and tannin but the lowest amount of vitamin C compared to 100% ethanol and water extract. All the phytochemicals showed solvent polarity specific extraction pattern. Total reducing power and DPPH-radical scavenging activity of 50% ethanol extract also were significantly higher when compared to those of the 100% ethanol ...

Budding yeast Cdc14 phosphatase has a central role in mitotic exit and cytokinesis. Puzzlingly, a... more Budding yeast Cdc14 phosphatase has a central role in mitotic exit and cytokinesis. Puzzlingly, a uniform picture for the three human CDC14 paralogues hCDC14A, B and C in cell cycle control has not emerged to date. Redundant functions between the three hCDC14 phosphatases could explain this unclear picture. To address the possibility of redundancy, we tested expression of hCDC14 and analysed cell cycle progression of cells with single- and double-deletion in hCDC14 genes. Our data suggest that hCDC14C is not expressed in human RPE1 cells excluding a function in this cell line. Single- and double-knockouts (KO) of hCDC14A and hCDC14B in RPE1 cells indicate that both phosphatases are not important for the timing of mitotic phases, cytokinesis and cell proliferation. However, cycling hCDC14A KO and hCDC14B KO cells show altered ciliogenesis compared to WT cells. The cilia of cycling hCDC14A KO cells are longer, whereas hCDC14B KO cilia are more frequent and disassemble faster. In concl...

Hypercholesterolemia is a clinical situation characterized by the elevated serum cholesterol and ... more Hypercholesterolemia is a clinical situation characterized by the elevated serum cholesterol and associated with the higher risk of cardiovascular disease, hypertension and stroke. Though current therapeutic strategies of hypercholesterolemia meet the present treatment demand but their efficacy is in question as well as the emergence of medicinal resistance. Demand of new therapeutic strategies is obvious while alternative therapeutic strategies are highly promising. Alternative therapeutic approaches are must in that respect but current experimental findings are still ambiguous and scarce. Several transcription factors playing vital role in cholesterol homeostasis and hypercholesterolemia change their expression profile in response to dietary polyphenols like PPARs, SREBPs, SHP, LXR, FXR etc. Function and expression of a number of proteins considered as therapeutically important regarding hypercholesterolemia like HMG-CoA reductase, CYP7A1, CETP, ABCA1 etc. are modulated by the die...

Advances in Traditional Medicine

2021 International Conference on System, Computation, Automation and Networking (ICSCAN)

Bangladesh, a developing country in the South Asia facing severe load shedding problem due to hig... more Bangladesh, a developing country in the South Asia facing severe load shedding problem due to high density of population and energy crisis. In comparison to all other energy sources, fossil fuels account for the majority of electricity production in this country. Due to lack of smart distribution of energy, the country unable to meets the demand of electricity. Therefore, this research has been taken virtual power plant (VPP) as a solution to develop smart energy distribution system in the country. Basically, VPP can be termed as a combination of distributed generators (DGs), energy storage systems, regulated loads etc., which operated by an energy management system (EMS) in order to control the distributed generation, and improve its exposure in the power markets. Right now, VPP has widely contributing in European and American energy markets, but Bangladesh has yet to introduce it as a new technology for more efficient energy delivery. Due to the shortage of resources, it requires a comprehensive study to investigate the implementation strategy of such kind of technology in perspective of Bangladesh. The main consideration of this work is cost reduction and reliability enhancement of energy delivery. For the case study of Bangladesh, a VPP model is designed for a university campus named IIUC campus, and the developed system is capable of sharing power to the grid. The whole system is controlled by control coordination center (CCC) which is developed by using a logic algorithm. The VPP design and simulations are carried out by using MATLAB –SIMULINK 2016a environment. Finally, the techno-economic analysis is done to compare its effectiveness with respective to the existing system. Results show that the designed VPP-based energy management system reduces about 53% cost with respect to the existing energy distribution system. The VPP technology can be an effective means for the energy management system of Bangladesh.