Subhasish Bose - Academia.edu (original) (raw)

Papers by Subhasish Bose

Research paper thumbnail of Abstract 1623: Quantification of Visceral Adipose Tissue Adds Value to BMI and Metabolic Syndrome in Prediction of Subclinical Atherosclerosis in Men With Type 2 Diabetes

Research paper thumbnail of Abstract 12258: Measurement of Waist Circumference Predicts Coronary Atherosclerosis Above Plasma Adipokines in Type 2 Diabetes

Circulation, Nov 23, 2010

Research paper thumbnail of Measurement of waist circumference predicts coronary atherosclerosis beyond plasma adipokines

Obesity, 2013

The association of plasma adipokines beyond waist circumference (WC) with coronary artery calcifi... more The association of plasma adipokines beyond waist circumference (WC) with coronary artery calcification (CAC), a measure of subclinical atherosclerosis, is unknown. Design and Methods: Asymptomatic Caucasian individuals from two community-based cross-sectional studies (n ¼ 1,285) were examined and multivariate analysis of traditional risk factors was performed, then WC and adipokines (adiponectin and leptin) were added. Incremental value of each was tested with likelihood ratio testing. Results: Beyond traditional risk factors, WC (Tobit regression ratio 1.69, P < 0.001) and plasma leptin (1.57, P < 0.001) but not plasma adiponectin (P ¼ 0.75) were independently associated with CAC. In nested models, neither adiponectin (v 2 ¼ 0.76, P ¼ 0.38) nor leptin (v 2 ¼ 1.32, P ¼ 0.25) added value to WC beyond traditional risk factors, whereas WC added incremental value to adiponectin (v 2 ¼ 28.02, P < 0.0001) and leptin (v 2 ¼ 13.58, P ¼ 0.0002). Conclusion: In the face of important biomarkers such as plasma adiponectin and leptin, WC remained a significant predictor of CAC beyond traditional risk factors underscoring the importance of WC measurement during cardiovascular risk assessment.

Research paper thumbnail of Dysglycemia but not lipids is associated with abnormal urinary albumin excretion in diabetic kidney disease: a report from the Kidney Early Evaluation Program (KEEP)

BMC Nephrology, 2012

Background: The relationship between glycemic control and lipid abnormalities with urinary albumi... more Background: The relationship between glycemic control and lipid abnormalities with urinary albumin-creatinine ratio (ACR) in chronic kidney disease (CKD) patients with diabetes mellitus (DM) is unknown. We sought to investigate the association of dyslipidemia and glycemic control with levels of albuminuria in the National Kidney Foundation (NKF) Kidney Early Evaluation Program (KEEP) participants with DM and CKD stage 3 or higher. Methods: We performed a cross-sectional study of 6639 eligible KEEP patients with DM and CKD Stage 3 to 5 from June 2008 to December 2009. Multivariate logistic regression was used to evaluate the association of lipid parameters (per 10 mg/dl change in serum level) and glycosylated hemoglobin (HbA1c) values with three degrees of albuminuria normo (<30 mg⁄g), micro (30 to 300 mg⁄g) and macro (>300 mg⁄g). Results: 2141 KEEP participants were included. HbA1c levels were strongly associated with micro-albuminuria (compared to normo-albuminuria) and macro-albuminuria (compared to normo-albuminuria and microalbuminuria). Each 1.0% increase in HbA1c increased the odds of micro-albuminuria by 32% (OR 1.32, 95% CI 1.23-1.42) and the odds of macro-albuminuria (vs. microalbuminuria) by 16% (OR 1.16, 95% CI 1.05-1.28). Only increases in serum HDL were associated with decreased odds of micro-albuminuria; otherwise, the association between other components of the serum lipid profile with urinary ACR did not reach statistical significance. Conclusion: In this cross-sectional study of 2141 KEEP participants with DM and CKD stages 3-5, overall glycemic control but not lipids were associated with abnormal urinary albumin excretion, a marker of increased risk for progressive disease.

Research paper thumbnail of 41 Poor Glycemic Control but not Dyslipidemia is Associated with Albuminuria in Patients with Chronic Kidney Disease (CKD) and Type 2 Diabetes Mellitus (T2DM): A Kidney Early Evaluation Program (KEEP) Report

American Journal of Kidney Diseases, 2011

Dyslipidemia and albuminuria have both been associated with unfavorable cardiovascular prognosis ... more Dyslipidemia and albuminuria have both been associated with unfavorable cardiovascular prognosis in patients with T2DM. However, the direct relation between lipid abnormalities and overall glycemic control with urinary albumin-creatinine ratio (ACR) in CKD patients with T2DM has not been elucidated. We sought to investigate the association of dyslipidemia and glycemic control with albuminuria in KEEP participants with T2DM and CKD stage ≤3. Our study included a total of 6639 eligible KEEP patients from June '08 to December '09 with glycosylated hemoglobin (HbA1c) values. After excluding nondiabetic, non-CKD and patients with missing values of urinary ACR, the total sample size was 2141. Baseline characteristics and health screening results based on quartiles of HbA1c were compared. We performed multivariate logistic regressions in estimating individual association of lipid parameters (per 10 mg/dl change in serum level) and HbA1c values with ACR, adjusting for age, gender and race. These associations were compared across different degrees of ACR groups: normo-albuminuria (<30 mg/g), micro-albuminuria (30 to 300 mg/g) and macro-albuminura (>300 mg/g). Association between components of serum lipid profile with ACR was not significant. HbA1c was associated with ACR when compared between normo-albuminuria and micro-albuminuria groups [OR=1.32, (95% CI: 1.23-1.41), p<0.001]. Association was attenuated in the micro-albuminuria versus macroalbuminuria groups [OR=1.15, (95% CI: 1.05-1.27), p<0.01]. In this cross-sectional study of 2141 KEEP participants with T2DM and CKD, overall glycemic control measured by HbA1C but not dyslipidemia was associated with urinary ACR.

Research paper thumbnail of An Uncommon Presentation of a Common Illness: Epstein-Barr Virus (EBV) Infection Case Report and Review of Literature

Cureus, 2011

Epstein-Barr Virus (EBV) infection has a diverse spectrum of clinical presentations. We encounter... more Epstein-Barr Virus (EBV) infection has a diverse spectrum of clinical presentations. We encountered a previously healthy young female adult with positive EBV Viral Capsid (VCA)-IgM serology and heterophile antibodies who presented with abdominal pain, mesenteric adenitis, and elevated liver enzymes without the more common manifestations of EBV infection. A review of the clinical and laboratory manifestations of EBV infection is provided, focusing on the association between EBV infection and elevated liver enzymes and abdominal pain.

Research paper thumbnail of Seizures, renal failure and acute respiratory failure: not your typical case of Henoch-Schonlein purpura

BMJ Case Reports

A 30-year-old Caucasian woman with no prior medical history presented with pedal oedema, arthralg... more A 30-year-old Caucasian woman with no prior medical history presented with pedal oedema, arthralgias and abdominal pain with diarrhoea, following a respiratory infection. She had mild abdominal tenderness along with a purpuric rash on the extremities and was anaemic. Following initial workup for anaemia and rash, her condition deteriorated with renal impairment, respiratory failure and seizures necessitating ventilatory support, dialysis and steroids. Serologies were negative, and skin biopsy showed leucocytoclastic vasculitis without vascular IgA deposition, and renal biopsy showed subendothelial, mesangial deposits of IgA with C3 indicative of Henoch-Schonlein purpura (HSP). She was treated with steroids, haemodialysis and on 6-month follow-up recovered renal function. We present the case to illustrate that HSP, though rare in adults, can present with multiorgan failure, with renal, pulmonary and central nervous system involvement, and the need for early diagnosis and prompt treat...

Research paper thumbnail of Abstract 1623: Quantification of Visceral Adipose Tissue Adds Value to BMI and Metabolic Syndrome in Prediction of Subclinical Atherosclerosis in Men With Type 2 Diabetes

Research paper thumbnail of Abstract 12258: Measurement of Waist Circumference Predicts Coronary Atherosclerosis Above Plasma Adipokines in Type 2 Diabetes

Circulation, Nov 23, 2010

Research paper thumbnail of Measurement of waist circumference predicts coronary atherosclerosis beyond plasma adipokines

Obesity, 2013

The association of plasma adipokines beyond waist circumference (WC) with coronary artery calcifi... more The association of plasma adipokines beyond waist circumference (WC) with coronary artery calcification (CAC), a measure of subclinical atherosclerosis, is unknown. Design and Methods: Asymptomatic Caucasian individuals from two community-based cross-sectional studies (n ¼ 1,285) were examined and multivariate analysis of traditional risk factors was performed, then WC and adipokines (adiponectin and leptin) were added. Incremental value of each was tested with likelihood ratio testing. Results: Beyond traditional risk factors, WC (Tobit regression ratio 1.69, P < 0.001) and plasma leptin (1.57, P < 0.001) but not plasma adiponectin (P ¼ 0.75) were independently associated with CAC. In nested models, neither adiponectin (v 2 ¼ 0.76, P ¼ 0.38) nor leptin (v 2 ¼ 1.32, P ¼ 0.25) added value to WC beyond traditional risk factors, whereas WC added incremental value to adiponectin (v 2 ¼ 28.02, P < 0.0001) and leptin (v 2 ¼ 13.58, P ¼ 0.0002). Conclusion: In the face of important biomarkers such as plasma adiponectin and leptin, WC remained a significant predictor of CAC beyond traditional risk factors underscoring the importance of WC measurement during cardiovascular risk assessment.

Research paper thumbnail of Dysglycemia but not lipids is associated with abnormal urinary albumin excretion in diabetic kidney disease: a report from the Kidney Early Evaluation Program (KEEP)

BMC Nephrology, 2012

Background: The relationship between glycemic control and lipid abnormalities with urinary albumi... more Background: The relationship between glycemic control and lipid abnormalities with urinary albumin-creatinine ratio (ACR) in chronic kidney disease (CKD) patients with diabetes mellitus (DM) is unknown. We sought to investigate the association of dyslipidemia and glycemic control with levels of albuminuria in the National Kidney Foundation (NKF) Kidney Early Evaluation Program (KEEP) participants with DM and CKD stage 3 or higher. Methods: We performed a cross-sectional study of 6639 eligible KEEP patients with DM and CKD Stage 3 to 5 from June 2008 to December 2009. Multivariate logistic regression was used to evaluate the association of lipid parameters (per 10 mg/dl change in serum level) and glycosylated hemoglobin (HbA1c) values with three degrees of albuminuria normo (<30 mg⁄g), micro (30 to 300 mg⁄g) and macro (>300 mg⁄g). Results: 2141 KEEP participants were included. HbA1c levels were strongly associated with micro-albuminuria (compared to normo-albuminuria) and macro-albuminuria (compared to normo-albuminuria and microalbuminuria). Each 1.0% increase in HbA1c increased the odds of micro-albuminuria by 32% (OR 1.32, 95% CI 1.23-1.42) and the odds of macro-albuminuria (vs. microalbuminuria) by 16% (OR 1.16, 95% CI 1.05-1.28). Only increases in serum HDL were associated with decreased odds of micro-albuminuria; otherwise, the association between other components of the serum lipid profile with urinary ACR did not reach statistical significance. Conclusion: In this cross-sectional study of 2141 KEEP participants with DM and CKD stages 3-5, overall glycemic control but not lipids were associated with abnormal urinary albumin excretion, a marker of increased risk for progressive disease.

Research paper thumbnail of 41 Poor Glycemic Control but not Dyslipidemia is Associated with Albuminuria in Patients with Chronic Kidney Disease (CKD) and Type 2 Diabetes Mellitus (T2DM): A Kidney Early Evaluation Program (KEEP) Report

American Journal of Kidney Diseases, 2011

Dyslipidemia and albuminuria have both been associated with unfavorable cardiovascular prognosis ... more Dyslipidemia and albuminuria have both been associated with unfavorable cardiovascular prognosis in patients with T2DM. However, the direct relation between lipid abnormalities and overall glycemic control with urinary albumin-creatinine ratio (ACR) in CKD patients with T2DM has not been elucidated. We sought to investigate the association of dyslipidemia and glycemic control with albuminuria in KEEP participants with T2DM and CKD stage ≤3. Our study included a total of 6639 eligible KEEP patients from June '08 to December '09 with glycosylated hemoglobin (HbA1c) values. After excluding nondiabetic, non-CKD and patients with missing values of urinary ACR, the total sample size was 2141. Baseline characteristics and health screening results based on quartiles of HbA1c were compared. We performed multivariate logistic regressions in estimating individual association of lipid parameters (per 10 mg/dl change in serum level) and HbA1c values with ACR, adjusting for age, gender and race. These associations were compared across different degrees of ACR groups: normo-albuminuria (<30 mg/g), micro-albuminuria (30 to 300 mg/g) and macro-albuminura (>300 mg/g). Association between components of serum lipid profile with ACR was not significant. HbA1c was associated with ACR when compared between normo-albuminuria and micro-albuminuria groups [OR=1.32, (95% CI: 1.23-1.41), p<0.001]. Association was attenuated in the micro-albuminuria versus macroalbuminuria groups [OR=1.15, (95% CI: 1.05-1.27), p<0.01]. In this cross-sectional study of 2141 KEEP participants with T2DM and CKD, overall glycemic control measured by HbA1C but not dyslipidemia was associated with urinary ACR.

Research paper thumbnail of An Uncommon Presentation of a Common Illness: Epstein-Barr Virus (EBV) Infection Case Report and Review of Literature

Cureus, 2011

Epstein-Barr Virus (EBV) infection has a diverse spectrum of clinical presentations. We encounter... more Epstein-Barr Virus (EBV) infection has a diverse spectrum of clinical presentations. We encountered a previously healthy young female adult with positive EBV Viral Capsid (VCA)-IgM serology and heterophile antibodies who presented with abdominal pain, mesenteric adenitis, and elevated liver enzymes without the more common manifestations of EBV infection. A review of the clinical and laboratory manifestations of EBV infection is provided, focusing on the association between EBV infection and elevated liver enzymes and abdominal pain.

Research paper thumbnail of Seizures, renal failure and acute respiratory failure: not your typical case of Henoch-Schonlein purpura

BMJ Case Reports

A 30-year-old Caucasian woman with no prior medical history presented with pedal oedema, arthralg... more A 30-year-old Caucasian woman with no prior medical history presented with pedal oedema, arthralgias and abdominal pain with diarrhoea, following a respiratory infection. She had mild abdominal tenderness along with a purpuric rash on the extremities and was anaemic. Following initial workup for anaemia and rash, her condition deteriorated with renal impairment, respiratory failure and seizures necessitating ventilatory support, dialysis and steroids. Serologies were negative, and skin biopsy showed leucocytoclastic vasculitis without vascular IgA deposition, and renal biopsy showed subendothelial, mesangial deposits of IgA with C3 indicative of Henoch-Schonlein purpura (HSP). She was treated with steroids, haemodialysis and on 6-month follow-up recovered renal function. We present the case to illustrate that HSP, though rare in adults, can present with multiorgan failure, with renal, pulmonary and central nervous system involvement, and the need for early diagnosis and prompt treat...