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Papers by Boyd Knosp

Research paper thumbnail of Research data warehouse best practices: catalyzing national data sharing through informatics innovation

Journal of the American Medical Informatics Association, Mar 8, 2022

Research paper thumbnail of Need for Improved Collection and Harmonization of Rural Maternal Healthcare Data

Clinical Obstetrics & Gynecology

Research paper thumbnail of Maturity in Enterprise Data Warehouses for Research Operations: Analysis of a Pilot Study

Journal of Clinical and Translational Science

This version may be subject to change during the production process.

Research paper thumbnail of Development and Utility of a Novel Intergenerational Health Knowledgebase

Research paper thumbnail of Stereotactic Technique with Visualization of the Intracerebral Landmarks

Stereotactic Atlas of the Macaca mulatta Thalamus and Adjacent Basal Ganglia Nuclei, 2002

Details of the stereotactic technique on experimental animals (cats and monkeys) with the use of ... more Details of the stereotactic technique on experimental animals (cats and monkeys) with the use of ventriculographic landmarks and the intracerebral coordinate system have been described in detail earlier (Ilinsky et al., 1978; 1980; Ilinsky and KultasIlinsky, 1982). Below is a brief summary of the method that consists of three stages.

Research paper thumbnail of SkipMard: a multi-attribute peer-to-peer resource discovery approach

Second International Multi-Symposiums on Computer and Computational Sciences (IMSCCS 2007), 2007

Page 1. SkipMard: A Multi-attribute Peer-to-Peer Resource Discovery Approach Tao He1,2, Jun Ni1,2... more Page 1. SkipMard: A Multi-attribute Peer-to-Peer Resource Discovery Approach Tao He1,2, Jun Ni1,2, Alberto M Segre1, Shaowen Wang2, Boyd M Knosp2 1Department of Computer Science, The University of Iowa, Iowa City ...

Research paper thumbnail of Nuclear Outlines and Nomenclature

Stereotactic Atlas of the Macaca mulatta Thalamus and Adjacent Basal Ganglia Nuclei, 2002

The identification of thalamic nuclei was based on the cytoarchitecture and the available data on... more The identification of thalamic nuclei was based on the cytoarchitecture and the available data on the topography of their subcortical connections. The outlines of the nuclei outside the ventral tier, for example the midline nuclei, were based solely on the cytoarchitecture as described by Olszewski (1952) and also by Ilinsky and KultasIlinsky (1987). The ventral tier nuclei include the regions that receive motor-related and somatosensory afferents. The topographic relationships of the subcortical afferents in the ventral tier are more obvious in the sagittal section plane as the major afferent-receiving zones are arranged back to front from the anterior to the posterior pole of the thalamus with a limited co-presence in the coronal plane (Asanuma et al., 1983a,b; Ilinsky and Kultas-Ilinsky, 1987; Ilinsky et al., 1993). At the same time the adjacent afferent zones interdigitize profusely. This interdigitation is difficult to detect in the coronal plane but is quite obvious in the sagittal plane (Ilinsky et al., 1993). In the process of the atlas preparation the initial outlines of the ventral tier nuclei were very detailed and closely followed these extremely wavy boundaries. However, this amount of the detail became an impediment in 3D computer reconstructions and, therefore, the original outlines were edited to smooth out the contours. Nonetheless, the degree of the interdigitation retained in the atlas is still significant and is expressed by intrusions of the colors of the adjacent nuclei into one other. This is especially impressive in the coronal section plane.

Research paper thumbnail of Opioids Bind to the Amino Acids 84 to 118 of UDP-Glucuronosyltransferase UGT2B7

Molecular Pharmacology, 2003

The UDP-glucuronosyltransferase UGT2B7 is an important human UGT isoform that catalyzes the conju... more The UDP-glucuronosyltransferase UGT2B7 is an important human UGT isoform that catalyzes the conjugation of many endogenous and exogenous compounds, among them opioids, resulting in the formation of D-glucuronides. The binding site of the aglycone is located in the N-terminal half of the protein. Using NMR analysis, we demonstrate that the opioid binding site in UGT2B7 is within the 84 to 118 N-terminal amino acids. Three maltose binding protein-UGT2B7 fusion proteins, 2B7F3 and 2B7F4 incorporating the amino acids 24 to 118 and 24 to 96 of UGT2B7, respectively, and 2B7F5 incorporating amino acids 84 to 118 of UGT2B7 were expressed in Escherichia coli and purified by affinity chromatography. NMR analysis showed that morphine was bound to the fusion protein 2B7F3 with a K D value similar to the K D values obtained for the previously produced fusion proteins, which included amino acids 24 to 180. Morphine did not bind to 2B7F4, but it did bind to 2B7F5. Both NMR 1-D spectra and NOESY experiments indicated that the 2B7F5 protein was mediating magnetization transfer within the morphine. These results allowed us to predict and model a binding site within the amino acids 96 to 101 of UGT2B7. A mutant fusion protein 2B7F3 with the substitution D99A was produced, and the NMR spectroscopy analysis of the protein supported the model. A marked reduction of morphine binding was observed when the charged aspartate was substituted with alanine. Of the more than 30 mammalian isoforms of UDP-glucuronosyltransferase that have been identified, the human UGT2B7 isoenzyme is one of the most important. It is expressed in liver, kidney, intestine, colon, testis, and brain (King et al., 2000), and it catalyzes the glucuronidation of opioids, androsterone, catechol estrogens, hyodeoxycholic acid, nonsteroidal anti-inflammatory drugs, 3Ј-azido-3Јdideoxythymidine, and retinoic acid with high efficiency (Rit

Research paper thumbnail of Understanding enterprise data warehouses to support clinical and translational research

Journal of the American Medical Informatics Association, 2020

Objective Among National Institutes of Health Clinical and Translational Science Award (CTSA) hub... more Objective Among National Institutes of Health Clinical and Translational Science Award (CTSA) hubs, adoption of electronic data warehouses for research (EDW4R) containing data from electronic health record systems is nearly ubiquitous. Although benefits of EDW4R include more effective, efficient support of scientists, little is known about how CTSA hubs have implemented EDW4R services. The goal of this qualitative study was to understand the ways in which CTSA hubs have operationalized EDW4R to support clinical and translational researchers. Materials and Methods After conducting semistructured interviews with informatics leaders from 20 CTSA hubs, we performed a directed content analysis of interview notes informed by naturalistic inquiry. Results We identified 12 themes: organization and data; oversight and governance; data access request process; data access modalities; data access for users with different skill sets; engagement, communication, and literacy; service management co...

Research paper thumbnail of Understanding enterprise data warehouses to support clinical and translational research: enterprise information technology relationships, data governance, workforce, and cloud computing

Journal of the American Medical Informatics Association, Mar 15, 2022

Objective: Among National Institutes of Health Clinical and Translational Science Award (CTSA) hu... more Objective: Among National Institutes of Health Clinical and Translational Science Award (CTSA) hubs, effective approaches for enterprise data warehouses for research (EDW4R) development, maintenance, and sustainability remain unclear. The goal of this qualitative study was to understand CTSA EDW4R operations within the broader contexts of academic medical centers and technology. Materials and methods: We performed a directed content analysis of transcripts generated from semistructured interviews with informatics leaders from 20 CTSA hubs. Results: Respondents referred to services provided by health system, university, and medical school information technology (IT) organizations as "enterprise information technology (IT)." Seventy-five percent of respondents stated that the team providing EDW4R service at their hub was separate from enterprise IT; strong relationships between EDW4R teams and enterprise IT were critical for success. Managing challenges of EDW4R staffing was made easier by executive leadership support. Data governance appeared to be a work in progress, as most hubs reported complex and incomplete processes, especially for commercial data sharing. Although nearly all hubs (n = 16) described use of cloud computing for specific projects, only 2 hubs reported using a cloud-based EDW4R. Respondents described EDW4R cloud migration facilitators, barriers, and opportunities. Discussion: Descriptions of approaches to how EDW4R teams at CTSA hubs work with enterprise IT organizations, manage workforces, make decisions about data, and approach cloud computing provide insights for institutions seeking to leverage patient data for research. Conclusion: Identification of EDW4R best practices is challenging, and this study helps identify a breadth of viable options for CTSA hubs to consider when implementing EDW4R services.

Research paper thumbnail of Barriers and Solutions to Developing and Maintaining Research Networks during a Pandemic: An example from the iELEVATE Perinatal Network

Research paper thumbnail of Material and Methods

Research paper thumbnail of Content Alerts

This article cites 49 articles, 24 of which can be accessed free

Research paper thumbnail of Maturity Models for Research IT and Informatics - Reports from the Field

Research paper thumbnail of Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative

Research paper thumbnail of Dissemination and Continuous Improvement of a CTSA-based Software Platform, SPARCRequest©, Using an Open Source Governance Model

Journal of Clinical and Translational Science, 2019

SPARCRequest© (Services, Pricing, & Application for Research Centers) is a web-based research man... more SPARCRequest© (Services, Pricing, & Application for Research Centers) is a web-based research management system that provides a modular and adaptable "electronic storefront" for research-related services. Developed by the South Carolina Clinical & Translational Research Institute at the Medical University of South Carolina, it was released as open source (OS) code in 2014. The adoption of SPARCRequest© accelerated in 2016, when, to ensure responsiveness to the needs of partners, its governance also became open. This governance model enables OS partners to suggest and prioritize features for new releases. As a result, the software code has become more modularized and can be easily customized to meet the diverse needs of adopting hubs. This article describes innovative aspects of the OS governance model, including a multi-institutional committee structure to set strategic vision, make operational decisions, and develop technical solutions; a virtual roadmap that ensures transparency and aligns adopters with release-based goals; and a business process model that provides a robust voting mechanism for prioritizing new features while also enabling fast-paced bug fixes. OS software evolves best in open governance environments. OS governance has made SPARCRequest© more responsive to user needs, attracted more adopters, and increased the proportion of code contributed by adopters.

Research paper thumbnail of Corrigendum: Research IT maturity models for academic health centers: Early development and initial evaluation

Journal of Clinical and Translational Science, 2019

This paper proposes the creation and application of maturity models to guide institutional strate... more This paper proposes the creation and application of maturity models to guide institutional strategic investment in research informatics and information technology (research IT) and to provide the ability to measure readiness for clinical and research infrastructure as well as sustainability of expertise. Conducting effective and efficient research in health science increasingly relies upon robust research IT systems and capabilities. Academic health centers are increasing investments in health IT systems to address operational pressures, including rapidly growing data, technological advances, and increasing security and regulatory challenges associated with data access requirements. Current approaches for planning and investment in research IT infrastructure vary across institutions and lack comparable guidance for evaluating investments, resulting in inconsistent approaches to research IT implementation across peer academic health centers as well as uncertainty in linking research IT investments to institutional goals. Maturity models address these issues through coupling the assessment of current organizational state with readiness for deployment of potential research IT investment, which can inform leadership strategy. Pilot work in maturity model development has ranged from using them as a catalyst for engaging medical school IT leaders in planning at a single institution to developing initial maturity indices that have been applied and refined across peer medical schools.

Research paper thumbnail of Research IT maturity models for academic health centers: Early development and initial evaluation

Journal of Clinical and Translational Science, 2018

This paper proposes the creation and application of maturity models to guide institutional strate... more This paper proposes the creation and application of maturity models to guide institutional strategic investment in research informatics and information technology (research IT) and to provide the ability to measure readiness for clinical and research infrastructure as well as sustainability of expertise. Conducting effective and efficient research in health science increasingly relies upon robust research IT systems and capabilities. Academic health centers are increasing investments in health IT systems to address operational pressures, including rapidly growing data, technological advances, and increasing security and regulatory challenges associated with data access requirements. Current approaches for planning and investment in research IT infrastructure vary across institutions and lack comparable guidance for evaluating investments, resulting in inconsistent approaches to research IT implementation across peer academic health centers as well as uncertainty in linking research ...

Research paper thumbnail of Sustainability considerations for clinical and translational research informatics infrastructure

Journal of Clinical and Translational Science, 2018

A robust biomedical informatics infrastructure is essential for academic health centers engaged i... more A robust biomedical informatics infrastructure is essential for academic health centers engaged in translational research. There are no templates for what such an infrastructure encompasses or how it is funded. An informatics workgroup within the Clinical and Translational Science Awards network conducted an analysis to identify the scope, governance, and funding of this infrastructure. After we identified the essential components of an informatics infrastructure, we surveyed informatics leaders at network institutions about the governance and sustainability of the different components. Results from 42 survey respondents showed significant variations in governance and sustainability; however, some trends also emerged. Core informatics components such as electronic data capture systems, electronic health records data repositories, and related tools had mixed models of funding including, fee-for-service, extramural grants, and institutional support. Several key components such as regu...

Research paper thumbnail of Parallel Numerical Integration on a P2P/Grid Computing Environment

Gca, 2005

Abstract This paper presents a preliminary study of using MCMS-powered P2P technology to conduct ... more Abstract This paper presents a preliminary study of using MCMS-powered P2P technology to conduct parallel integrations which has been widely used in applied mathematics, sciences and engineering. In this study, we designed a system which allow migrate ...

Research paper thumbnail of Research data warehouse best practices: catalyzing national data sharing through informatics innovation

Journal of the American Medical Informatics Association, Mar 8, 2022

Research paper thumbnail of Need for Improved Collection and Harmonization of Rural Maternal Healthcare Data

Clinical Obstetrics & Gynecology

Research paper thumbnail of Maturity in Enterprise Data Warehouses for Research Operations: Analysis of a Pilot Study

Journal of Clinical and Translational Science

This version may be subject to change during the production process.

Research paper thumbnail of Development and Utility of a Novel Intergenerational Health Knowledgebase

Research paper thumbnail of Stereotactic Technique with Visualization of the Intracerebral Landmarks

Stereotactic Atlas of the Macaca mulatta Thalamus and Adjacent Basal Ganglia Nuclei, 2002

Details of the stereotactic technique on experimental animals (cats and monkeys) with the use of ... more Details of the stereotactic technique on experimental animals (cats and monkeys) with the use of ventriculographic landmarks and the intracerebral coordinate system have been described in detail earlier (Ilinsky et al., 1978; 1980; Ilinsky and KultasIlinsky, 1982). Below is a brief summary of the method that consists of three stages.

Research paper thumbnail of SkipMard: a multi-attribute peer-to-peer resource discovery approach

Second International Multi-Symposiums on Computer and Computational Sciences (IMSCCS 2007), 2007

Page 1. SkipMard: A Multi-attribute Peer-to-Peer Resource Discovery Approach Tao He1,2, Jun Ni1,2... more Page 1. SkipMard: A Multi-attribute Peer-to-Peer Resource Discovery Approach Tao He1,2, Jun Ni1,2, Alberto M Segre1, Shaowen Wang2, Boyd M Knosp2 1Department of Computer Science, The University of Iowa, Iowa City ...

Research paper thumbnail of Nuclear Outlines and Nomenclature

Stereotactic Atlas of the Macaca mulatta Thalamus and Adjacent Basal Ganglia Nuclei, 2002

The identification of thalamic nuclei was based on the cytoarchitecture and the available data on... more The identification of thalamic nuclei was based on the cytoarchitecture and the available data on the topography of their subcortical connections. The outlines of the nuclei outside the ventral tier, for example the midline nuclei, were based solely on the cytoarchitecture as described by Olszewski (1952) and also by Ilinsky and KultasIlinsky (1987). The ventral tier nuclei include the regions that receive motor-related and somatosensory afferents. The topographic relationships of the subcortical afferents in the ventral tier are more obvious in the sagittal section plane as the major afferent-receiving zones are arranged back to front from the anterior to the posterior pole of the thalamus with a limited co-presence in the coronal plane (Asanuma et al., 1983a,b; Ilinsky and Kultas-Ilinsky, 1987; Ilinsky et al., 1993). At the same time the adjacent afferent zones interdigitize profusely. This interdigitation is difficult to detect in the coronal plane but is quite obvious in the sagittal plane (Ilinsky et al., 1993). In the process of the atlas preparation the initial outlines of the ventral tier nuclei were very detailed and closely followed these extremely wavy boundaries. However, this amount of the detail became an impediment in 3D computer reconstructions and, therefore, the original outlines were edited to smooth out the contours. Nonetheless, the degree of the interdigitation retained in the atlas is still significant and is expressed by intrusions of the colors of the adjacent nuclei into one other. This is especially impressive in the coronal section plane.

Research paper thumbnail of Opioids Bind to the Amino Acids 84 to 118 of UDP-Glucuronosyltransferase UGT2B7

Molecular Pharmacology, 2003

The UDP-glucuronosyltransferase UGT2B7 is an important human UGT isoform that catalyzes the conju... more The UDP-glucuronosyltransferase UGT2B7 is an important human UGT isoform that catalyzes the conjugation of many endogenous and exogenous compounds, among them opioids, resulting in the formation of D-glucuronides. The binding site of the aglycone is located in the N-terminal half of the protein. Using NMR analysis, we demonstrate that the opioid binding site in UGT2B7 is within the 84 to 118 N-terminal amino acids. Three maltose binding protein-UGT2B7 fusion proteins, 2B7F3 and 2B7F4 incorporating the amino acids 24 to 118 and 24 to 96 of UGT2B7, respectively, and 2B7F5 incorporating amino acids 84 to 118 of UGT2B7 were expressed in Escherichia coli and purified by affinity chromatography. NMR analysis showed that morphine was bound to the fusion protein 2B7F3 with a K D value similar to the K D values obtained for the previously produced fusion proteins, which included amino acids 24 to 180. Morphine did not bind to 2B7F4, but it did bind to 2B7F5. Both NMR 1-D spectra and NOESY experiments indicated that the 2B7F5 protein was mediating magnetization transfer within the morphine. These results allowed us to predict and model a binding site within the amino acids 96 to 101 of UGT2B7. A mutant fusion protein 2B7F3 with the substitution D99A was produced, and the NMR spectroscopy analysis of the protein supported the model. A marked reduction of morphine binding was observed when the charged aspartate was substituted with alanine. Of the more than 30 mammalian isoforms of UDP-glucuronosyltransferase that have been identified, the human UGT2B7 isoenzyme is one of the most important. It is expressed in liver, kidney, intestine, colon, testis, and brain (King et al., 2000), and it catalyzes the glucuronidation of opioids, androsterone, catechol estrogens, hyodeoxycholic acid, nonsteroidal anti-inflammatory drugs, 3Ј-azido-3Јdideoxythymidine, and retinoic acid with high efficiency (Rit

Research paper thumbnail of Understanding enterprise data warehouses to support clinical and translational research

Journal of the American Medical Informatics Association, 2020

Objective Among National Institutes of Health Clinical and Translational Science Award (CTSA) hub... more Objective Among National Institutes of Health Clinical and Translational Science Award (CTSA) hubs, adoption of electronic data warehouses for research (EDW4R) containing data from electronic health record systems is nearly ubiquitous. Although benefits of EDW4R include more effective, efficient support of scientists, little is known about how CTSA hubs have implemented EDW4R services. The goal of this qualitative study was to understand the ways in which CTSA hubs have operationalized EDW4R to support clinical and translational researchers. Materials and Methods After conducting semistructured interviews with informatics leaders from 20 CTSA hubs, we performed a directed content analysis of interview notes informed by naturalistic inquiry. Results We identified 12 themes: organization and data; oversight and governance; data access request process; data access modalities; data access for users with different skill sets; engagement, communication, and literacy; service management co...

Research paper thumbnail of Understanding enterprise data warehouses to support clinical and translational research: enterprise information technology relationships, data governance, workforce, and cloud computing

Journal of the American Medical Informatics Association, Mar 15, 2022

Objective: Among National Institutes of Health Clinical and Translational Science Award (CTSA) hu... more Objective: Among National Institutes of Health Clinical and Translational Science Award (CTSA) hubs, effective approaches for enterprise data warehouses for research (EDW4R) development, maintenance, and sustainability remain unclear. The goal of this qualitative study was to understand CTSA EDW4R operations within the broader contexts of academic medical centers and technology. Materials and methods: We performed a directed content analysis of transcripts generated from semistructured interviews with informatics leaders from 20 CTSA hubs. Results: Respondents referred to services provided by health system, university, and medical school information technology (IT) organizations as "enterprise information technology (IT)." Seventy-five percent of respondents stated that the team providing EDW4R service at their hub was separate from enterprise IT; strong relationships between EDW4R teams and enterprise IT were critical for success. Managing challenges of EDW4R staffing was made easier by executive leadership support. Data governance appeared to be a work in progress, as most hubs reported complex and incomplete processes, especially for commercial data sharing. Although nearly all hubs (n = 16) described use of cloud computing for specific projects, only 2 hubs reported using a cloud-based EDW4R. Respondents described EDW4R cloud migration facilitators, barriers, and opportunities. Discussion: Descriptions of approaches to how EDW4R teams at CTSA hubs work with enterprise IT organizations, manage workforces, make decisions about data, and approach cloud computing provide insights for institutions seeking to leverage patient data for research. Conclusion: Identification of EDW4R best practices is challenging, and this study helps identify a breadth of viable options for CTSA hubs to consider when implementing EDW4R services.

Research paper thumbnail of Barriers and Solutions to Developing and Maintaining Research Networks during a Pandemic: An example from the iELEVATE Perinatal Network

Research paper thumbnail of Material and Methods

Research paper thumbnail of Content Alerts

This article cites 49 articles, 24 of which can be accessed free

Research paper thumbnail of Maturity Models for Research IT and Informatics - Reports from the Field

Research paper thumbnail of Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative

Research paper thumbnail of Dissemination and Continuous Improvement of a CTSA-based Software Platform, SPARCRequest©, Using an Open Source Governance Model

Journal of Clinical and Translational Science, 2019

SPARCRequest© (Services, Pricing, & Application for Research Centers) is a web-based research man... more SPARCRequest© (Services, Pricing, & Application for Research Centers) is a web-based research management system that provides a modular and adaptable "electronic storefront" for research-related services. Developed by the South Carolina Clinical & Translational Research Institute at the Medical University of South Carolina, it was released as open source (OS) code in 2014. The adoption of SPARCRequest© accelerated in 2016, when, to ensure responsiveness to the needs of partners, its governance also became open. This governance model enables OS partners to suggest and prioritize features for new releases. As a result, the software code has become more modularized and can be easily customized to meet the diverse needs of adopting hubs. This article describes innovative aspects of the OS governance model, including a multi-institutional committee structure to set strategic vision, make operational decisions, and develop technical solutions; a virtual roadmap that ensures transparency and aligns adopters with release-based goals; and a business process model that provides a robust voting mechanism for prioritizing new features while also enabling fast-paced bug fixes. OS software evolves best in open governance environments. OS governance has made SPARCRequest© more responsive to user needs, attracted more adopters, and increased the proportion of code contributed by adopters.

Research paper thumbnail of Corrigendum: Research IT maturity models for academic health centers: Early development and initial evaluation

Journal of Clinical and Translational Science, 2019

This paper proposes the creation and application of maturity models to guide institutional strate... more This paper proposes the creation and application of maturity models to guide institutional strategic investment in research informatics and information technology (research IT) and to provide the ability to measure readiness for clinical and research infrastructure as well as sustainability of expertise. Conducting effective and efficient research in health science increasingly relies upon robust research IT systems and capabilities. Academic health centers are increasing investments in health IT systems to address operational pressures, including rapidly growing data, technological advances, and increasing security and regulatory challenges associated with data access requirements. Current approaches for planning and investment in research IT infrastructure vary across institutions and lack comparable guidance for evaluating investments, resulting in inconsistent approaches to research IT implementation across peer academic health centers as well as uncertainty in linking research IT investments to institutional goals. Maturity models address these issues through coupling the assessment of current organizational state with readiness for deployment of potential research IT investment, which can inform leadership strategy. Pilot work in maturity model development has ranged from using them as a catalyst for engaging medical school IT leaders in planning at a single institution to developing initial maturity indices that have been applied and refined across peer medical schools.

Research paper thumbnail of Research IT maturity models for academic health centers: Early development and initial evaluation

Journal of Clinical and Translational Science, 2018

This paper proposes the creation and application of maturity models to guide institutional strate... more This paper proposes the creation and application of maturity models to guide institutional strategic investment in research informatics and information technology (research IT) and to provide the ability to measure readiness for clinical and research infrastructure as well as sustainability of expertise. Conducting effective and efficient research in health science increasingly relies upon robust research IT systems and capabilities. Academic health centers are increasing investments in health IT systems to address operational pressures, including rapidly growing data, technological advances, and increasing security and regulatory challenges associated with data access requirements. Current approaches for planning and investment in research IT infrastructure vary across institutions and lack comparable guidance for evaluating investments, resulting in inconsistent approaches to research IT implementation across peer academic health centers as well as uncertainty in linking research ...

Research paper thumbnail of Sustainability considerations for clinical and translational research informatics infrastructure

Journal of Clinical and Translational Science, 2018

A robust biomedical informatics infrastructure is essential for academic health centers engaged i... more A robust biomedical informatics infrastructure is essential for academic health centers engaged in translational research. There are no templates for what such an infrastructure encompasses or how it is funded. An informatics workgroup within the Clinical and Translational Science Awards network conducted an analysis to identify the scope, governance, and funding of this infrastructure. After we identified the essential components of an informatics infrastructure, we surveyed informatics leaders at network institutions about the governance and sustainability of the different components. Results from 42 survey respondents showed significant variations in governance and sustainability; however, some trends also emerged. Core informatics components such as electronic data capture systems, electronic health records data repositories, and related tools had mixed models of funding including, fee-for-service, extramural grants, and institutional support. Several key components such as regu...

Research paper thumbnail of Parallel Numerical Integration on a P2P/Grid Computing Environment

Gca, 2005

Abstract This paper presents a preliminary study of using MCMS-powered P2P technology to conduct ... more Abstract This paper presents a preliminary study of using MCMS-powered P2P technology to conduct parallel integrations which has been widely used in applied mathematics, sciences and engineering. In this study, we designed a system which allow migrate ...