Paul Brain - Academia.edu (original) (raw)
Papers by Paul Brain
The Journal of endocrinology, 1978
Aggressive Behavior, 1985
Veterinary Research Communications, 2004
Aggressive Behavior, 1982
Harwood Academic Publishers eBooks, 1990
Journal of Substance Abuse, 1989
The history of cocaine is charted with specific reference to its usefulness as a medicine and loc... more The history of cocaine is charted with specific reference to its usefulness as a medicine and local anesthetic. It is common knowledge that coca leaves were used as a panacea and local anesthetic throughout the history of the Incan Empire of Peru. In Europe, however, its medical usefulness was not fully recognized until Carl Koller used it to anesthetize the cornea of the eye. Over the next 20 years, cocaine became a popular medicine and tonic in Europe and America, where it was credited with curing a wide variety of diseases and illnesses. However, reports soon started to appear claiming that cocaine was a drug with a high social abuse potential and in America it seemed to underpin growing crime figures. As a result, cocaine was misclassified as a narcotic and its use was restricted to specific surgical procedures and medicinal preparations. Today, cocaine and its derivatives are still popular local anesthetics in operations of the ear, nose and throat and it is also used in a preparation given to alleviate the pain (physical and mental) of terminal diseases. Although cocaine has a high public profile as a drug of addictive potential, this drug has also had a long and distinguished history as a medicine and local anesthetic. The legitimate uses of cocaine exacerbate the problems of controlling this substance of abuse and should provide a stimulus for generating local anesthetics that lack addictive potential.
Progress in Brain Research, 1974
ABSTRACT
Biochemical Society Transactions, Aug 1, 1995
Topics in the neurosciences, 1987
The utility of ethological assessments of murine agonistic interactions in behavioural teratology... more The utility of ethological assessments of murine agonistic interactions in behavioural teratology: The foetal alcohol syndrome. PF Brain, JS Ajarem, VV Petkov TOPICS NEUROSCI. 1987., 1987. Y 25817 Mammals(excluding ...
General Pharmacology-the Vascular System, 1991
1. The present experiment examined, using a battery of tests, the effects of in utero exposure to... more 1. The present experiment examined, using a battery of tests, the effects of in utero exposure to the benzodiazepine inverse agonists DMCM and FG 7142 upon the early development and adult behaviour of Swiss Mice. 2. Early development was respectively retarded and augmented by treatments with the higher and lower doses of DMCM. FG 7142 suppressed later development. DMCM retarded righting reflex on certain days. FG 7142 had a significant, biphasic effect on eye opening. 3. Adult social behaviour was examined using the resident-intruder paradigm, by determining the time spent in broad behavioural categories. Male offspring of dams treated with DMCM showed increased threat. FG 7142 had no significant effects.
General Pharmacology-the Vascular System, 1991
1. The present experiment examined, using a battery of tests, the effects of in utero exposure to... more 1. The present experiment examined, using a battery of tests, the effects of in utero exposure to the benzodiazepine inverse agonists DMCM and FG 7142 upon the early development and adult behaviour of Swiss Mice. 2. Early development was respectively retarded and augmented by treatments with the higher and lower doses of DMCM. FG 7142 suppressed later development. DMCM retarded righting reflex on certain days. FG 7142 had a significant, biphasic effect on eye opening. 3. Adult social behaviour was examined using the resident-intruder paradigm, by determining the time spent in broad behavioural categories. Male offspring of dams treated with DMCM showed increased threat. FG 7142 had no significant effects.
General Pharmacology-the Vascular System, 1991
1. The present experiment examined, using a battery of tests, the effects of in utero exposure to... more 1. The present experiment examined, using a battery of tests, the effects of in utero exposure to the benzodiazepine inverse agonists DMCM and FG 7142 upon the early development and adult behaviour of Swiss Mice. 2. Early development was respectively retarded and augmented by treatments with the higher and lower doses of DMCM. FG 7142 suppressed later development. DMCM retarded righting reflex on certain days. FG 7142 had a significant, biphasic effect on eye opening. 3. Adult social behaviour was examined using the resident-intruder paradigm, by determining the time spent in broad behavioural categories. Male offspring of dams treated with DMCM showed increased threat. FG 7142 had no significant effects.
The Journal of endocrinology, 1978
Aggressive Behavior, 1985
Veterinary Research Communications, 2004
Aggressive Behavior, 1982
Harwood Academic Publishers eBooks, 1990
Journal of Substance Abuse, 1989
The history of cocaine is charted with specific reference to its usefulness as a medicine and loc... more The history of cocaine is charted with specific reference to its usefulness as a medicine and local anesthetic. It is common knowledge that coca leaves were used as a panacea and local anesthetic throughout the history of the Incan Empire of Peru. In Europe, however, its medical usefulness was not fully recognized until Carl Koller used it to anesthetize the cornea of the eye. Over the next 20 years, cocaine became a popular medicine and tonic in Europe and America, where it was credited with curing a wide variety of diseases and illnesses. However, reports soon started to appear claiming that cocaine was a drug with a high social abuse potential and in America it seemed to underpin growing crime figures. As a result, cocaine was misclassified as a narcotic and its use was restricted to specific surgical procedures and medicinal preparations. Today, cocaine and its derivatives are still popular local anesthetics in operations of the ear, nose and throat and it is also used in a preparation given to alleviate the pain (physical and mental) of terminal diseases. Although cocaine has a high public profile as a drug of addictive potential, this drug has also had a long and distinguished history as a medicine and local anesthetic. The legitimate uses of cocaine exacerbate the problems of controlling this substance of abuse and should provide a stimulus for generating local anesthetics that lack addictive potential.
Progress in Brain Research, 1974
ABSTRACT
Biochemical Society Transactions, Aug 1, 1995
Topics in the neurosciences, 1987
The utility of ethological assessments of murine agonistic interactions in behavioural teratology... more The utility of ethological assessments of murine agonistic interactions in behavioural teratology: The foetal alcohol syndrome. PF Brain, JS Ajarem, VV Petkov TOPICS NEUROSCI. 1987., 1987. Y 25817 Mammals(excluding ...
General Pharmacology-the Vascular System, 1991
1. The present experiment examined, using a battery of tests, the effects of in utero exposure to... more 1. The present experiment examined, using a battery of tests, the effects of in utero exposure to the benzodiazepine inverse agonists DMCM and FG 7142 upon the early development and adult behaviour of Swiss Mice. 2. Early development was respectively retarded and augmented by treatments with the higher and lower doses of DMCM. FG 7142 suppressed later development. DMCM retarded righting reflex on certain days. FG 7142 had a significant, biphasic effect on eye opening. 3. Adult social behaviour was examined using the resident-intruder paradigm, by determining the time spent in broad behavioural categories. Male offspring of dams treated with DMCM showed increased threat. FG 7142 had no significant effects.
General Pharmacology-the Vascular System, 1991
1. The present experiment examined, using a battery of tests, the effects of in utero exposure to... more 1. The present experiment examined, using a battery of tests, the effects of in utero exposure to the benzodiazepine inverse agonists DMCM and FG 7142 upon the early development and adult behaviour of Swiss Mice. 2. Early development was respectively retarded and augmented by treatments with the higher and lower doses of DMCM. FG 7142 suppressed later development. DMCM retarded righting reflex on certain days. FG 7142 had a significant, biphasic effect on eye opening. 3. Adult social behaviour was examined using the resident-intruder paradigm, by determining the time spent in broad behavioural categories. Male offspring of dams treated with DMCM showed increased threat. FG 7142 had no significant effects.
General Pharmacology-the Vascular System, 1991
1. The present experiment examined, using a battery of tests, the effects of in utero exposure to... more 1. The present experiment examined, using a battery of tests, the effects of in utero exposure to the benzodiazepine inverse agonists DMCM and FG 7142 upon the early development and adult behaviour of Swiss Mice. 2. Early development was respectively retarded and augmented by treatments with the higher and lower doses of DMCM. FG 7142 suppressed later development. DMCM retarded righting reflex on certain days. FG 7142 had a significant, biphasic effect on eye opening. 3. Adult social behaviour was examined using the resident-intruder paradigm, by determining the time spent in broad behavioural categories. Male offspring of dams treated with DMCM showed increased threat. FG 7142 had no significant effects.