Brian Strickland - Academia.edu (original) (raw)

Papers by Brian Strickland

The American Journal of Emergency Medicine

Background: Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator and mild bronchodilat... more Background: Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator and mild bronchodilator that has been shown to improve systemic oxygenation, but has rarely been administered in the Emergency Department (ED). In addition to its favorable pulmonary vascular effects, in-vitro studies report that NO donors can inhibit replication of viruses, including SARS Coronavirus 2 (SARS-CoV-2). This study evaluated the administration of high-dose iNO by mask in spontaneously breathing emergency department (ED) patients with respiratory symptoms attributed to Coronavirus disease 2019 (COVID-19). Methods: We designed a randomized clinical trial to determine whether 30 min of high dose iNO (250 ppm) could be safely and practically administered by emergency physicians in the ED to spontaneously-breathing patients with respiratory symptoms attributed to COVID-19. Our secondary goal was to learn if iNO could prevent the progression of mild COVID-19 to a more severe state. Findings: We enrolled 47 ED patients with acute respiratory symptoms most likely due to COVID-19: 25 of 47 (53%) were randomized to the iNO treatment group; 22 of 47 (46%) to the control group (supportive care only). All patients tolerated the administration of high-dose iNO in the ED without significant complications or symptoms. Five patients receiving iNO (16%) experienced asymptomatic methemoglobinemia (MetHb) > 5%. Thirty-four of 47 (72%) subjects tested positive for SARS-CoV-2: 19 of 34 were randomized to the iNO treatment group and 15 of 34 subjects to the control group. Seven of 19 (38%) iNO patients returned to the ED, while 4 of 15 (27%) control patients did. One patient in each study arm was hospitalized: 5% in iNO treatment and 7% in controls. One patient was intubated in the iNO group. No patients in either group died. The differences between these groups were not significant. Conclusion: A single dose of iNO at 250 ppm was practical and not associated with any significant adverse effects when administered in the ED by emergency physicians. Local disease control led to early study closure and prevented complete testing of COVID-19 safety and treatment outcomes measures.

Wilderness & Environmental Medicine, 2019

IntroductiondEducational materials are important tools in the prevention of altitude illness amon... more IntroductiondEducational materials are important tools in the prevention of altitude illness among individuals traveling to high altitude destinations. Travelers obtain information about altitude illness from many different educational resources. Our objective was to determine which educational resources for altitude illness prevention were used by trekkers on the Everest Base Camp trek and Annapurna Circuit. We also sought to compare which resources were used by individuals from different geographic areas. MethodsdA survey was administered to trekkers attending an altitude illness information lecture at the Himalayan Rescue Association clinic. Trekkers provided their basic demographic information and educational resources they used while preparing for the trek. Comparisons were made between trekkers based on the resources they used, as well as their age and country of origin. ResultsdOf 1075 surveys administered, 906 were completed. Internet sources were most commonly used by trekkers (49%), followed by friends or family (22%), and healthcare providers (18%). The age of participants using Internet sources was 36 ± 12 y (mean ± SD), lower than those who did not use Internet sources (39 ± 14 y, P < 0.01). Participants came from 8 geographic areas; Europe (55%), North America (24%), and Oceania (11%) made up the vast majority. Compared to the overall cohort, participants from Oceania demonstrated more Internet reliance at 65% (c 2 (1, n ¼ 102)¼9.7, P< 0.01). ConclusionsdIn this group of trekkers in the Himalayas, the Internet was the most common source of information on altitude illness prevention and management. Trekkers using Internet sources were slightly younger than non-Internet users.

Composites Manufacturing, 1990

AIP Conference Proceedings, 1987

The paper gives a brief overview of the Strategic Defense Initiative Organization (SDIO) Neutral ... more The paper gives a brief overview of the Strategic Defense Initiative Organization (SDIO) Neutral Particle Beam (NPB) program giving the general goals and possible usages of a NPB system. The major program elements are given along with individual program objectives. The ion source and neutralizer technologies, which are most pertinent to the conference, are then outlined in more detail.

$Research paper thumbnail of Radar beam steering with remote reflectors/refractors$

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, Jan 16, 2015

(1) To describe the use of total ossicular prostheses (TOPs) in the setting of stapedectomy requi... more (1) To describe the use of total ossicular prostheses (TOPs) in the setting of stapedectomy requiring an incus bypass procedure. (2) To analyze the short- and long-term audiometric results of TOP utilization in the setting of stapedectomy for an incus bypass procedure. Case series with chart review. Tertiary neurotologic referral center. Seventeen cases of TOP reconstruction after stapedectomy were performed due to advanced incus erosion. The cases were assessed for pre- and postoperative bone conduction and air conduction pure-tone averages (PTAs; 0.5, 1, 2, 3 kHz), including high-tone bone conduction (1, 2, 4 kHz), air-bone gap, and speech discrimination scores. Hearing outcomes were measured: short-term (3 weeks) and long-term (average, 22 months). Among 17 ears undergoing revision stapedectomy managed with TOP reconstruction, the average number of previous revision attempts was 1.0 (SD, 1; range, 1-5). The preoperative bone conduction PTA was 30.7 dB preoperatively, while the preoperative air conduction PTA was 64.3 dB. The mean postoperative air-bone gap significantly decreased to 18.9 dB (SD, 12.7; range, 5-46.25; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .003) with a mean follow-up of 22.2 months (SD, 25.0; range, 0.75-78). No significant decrement in high-tone bone conduction PTA was observed (mean, 0 dB; SD, 12.8; range, -36.7 to 20; P = .427); however, 1 ear revealed a severe decrease in PTA and speech discrimination score postoperatively. No further revisions were noted in follow-up. TOP reconstruction in the setting of previous revision stapedectomy with limited incudovestibular reconstructive options may lead to favorable hearing outcomes, but it carries an increased risk of sensorineural hearing loss.

Conference Proceedings Southeastcon '81.

IEEE Global Telecommunications Conference, 2004. GLOBECOM '04.

As the cost of 802.11 hardware continues to fall, the appeal of inserting unauthorized wireless a... more As the cost of 802.11 hardware continues to fall, the appeal of inserting unauthorized wireless access into enterprise networks grows. These rogue access points (APs) expose the enterprise network to a barrage of security vulnerabilities in that they are typically connected to a network port behind the firewall. Most of the current approaches to detecting rogue APs are rudimentary and are easily evaded by hackers. We propose the use of temporal traffic characteristics to detect rogue APs at a central location. This detection is independent of the wireless technology (802.11a, 802.11b, or 802.11g), is scalable, does not posses the inefficiencies of the current solutions, and is independent of the signal range of the rogue APs.

SPIE Proceedings, 1998

Scintillation measurements performed during the limited-visibility lasercom experiment. [Proceedi... more Scintillation measurements performed during the limited-visibility lasercom experiment. [Proceedings of SPIE 3266, 209 (1998)]. Isaac I. Kim, Eric L. Woodbridge, Victor J. Chan, Brian R. Strickland. Abstract. The effects of scintillation ...

Defense and Space Programs Conference and Exhibit - Critical Defense and Space Programs for the Future, 1997

Submunitions carried aboard Ballistic Missiles pose a significant threat. These submunitions coul... more Submunitions carried aboard Ballistic Missiles pose a significant threat. These submunitions could carry either conventional, chemical, or biological payloads. Their potential effectiveness is based on the large number of submunitions that could be carried by a single Tactical Ballistic Missile (TBM), the dispersion of these submunitions, and the hit-to-kill mechanism employed by the current Theater Missile Defense (TMD) systems. SWARM (no acronym) is a midcourse multiple kill vehicle concept that may be a viable defense against this threat. Studies, tests, and analysis will be presented which demonstrate potential system feasibility.

A beam intensity monitor for monitoring high energy particle beams is described comprising: an el... more A beam intensity monitor for monitoring high energy particle beams is described comprising: an electromagnetic energy sensor disposed in a planar array for simultaneously intercepting small portions of energy across the face of the beam; optical energy detection means focused in the region of the planar array for detecting fluorescent action indicative of particle spatial distribution; voltage detection means coupled to the sensor for detecting changes in potential occurring on the array; and wherein the sensor is a planar array of thermal resistance wire having phosphor beads selectively attached thereto and uniformly disposed across the plane of the array for intercepting less than one percentage of a high energy particle beam directed through the plane of the sensor.

Otology & Neurotology, 2013

To determine whether partial tumor removal in large vestibular schwannoma improves facial nerve o... more To determine whether partial tumor removal in large vestibular schwannoma improves facial nerve outcomes while maintaining a low risk of tumor regrowth/recurrence. Study Design: Retrospective chart review and prospective database. Setting: Tertiary neurotologic referral center. Patients: Four hundred patients with a vestibular schwannoma of 2.5 cm or greater in maximum diameter undergoing translabyrinthine microsurgical resection from 2001 to 2011. There were 325 gross total resections (GTR), 44 near total resections (NTR), and 31 subtotal resections (STR), with an overall mean tumor size of 3.2 cm (standard deviation, 0.7). Intervention(s): Translabyrinthine surgical tumor resection. Main Outcome Measures: House-Brackmann (H-B) facial nerve grade postoperatively and at 1 year, tumor regrowth/ recurrence (Q2 mm), additional treatment, and complications. Results: Higher rates of H-B facial nerve Grades I and II were achieved at both the postoperative and 1-year follow-ups in the NTR (78%, 97%) and STR (71%, 96%) groups compared with GTR (53%, 77%) (p e 0.001). Eye treatment, medical or surgical, was required more often in GTR (28.0%) than NTR and STR (8% and 21%, respectively, p e 0.04), with no other differences in complications. The NTR and STR groups had a significantly higher rate of regrowth than GTR resection (21% and 22% versus 3%) (p e 0.001) at average follow-up times of 3.7, 3.7, and 5.1 years, respectively, and need for further treatment occurred at a higher rate, although infrequently, in NTR and STR (2% and 10% versus 0%) (p e 0.001). Conclusion: Near total and subtotal removal in large tumors are viable treatment options to maintain facial nerve function. During the follow-up period examined in this study, there was a low risk of need for further treatment. Longer-term follow-up is needed to better assess the need for retreatment in patients treated with NTR and STR.