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Papers by Brigita Smolovic

Research paper thumbnail of Non-Steroidal Anti-Inflammatory Drug-Induced Colopathy as Possible Rare Cause of a Positive Immunochemical Faecal Occult Blood Test: A Case Report: 1563

The American Journal of Gastroenterology, 2017

Research paper thumbnail of Diabetic ketoacidosis, hypertriglyceridemia and acute pancreatitis- a case report

Research paper thumbnail of Non-Steroidal Anti-Inflammatory Drug-Induced Colopathy as Possible Rare Cause of a Positive Immunochemical Faecal Occult Blood Test: A Case Report

American Journal of Gastroenterology

Research paper thumbnail of The Impact of Pro-hemorrhagic Drugs on Predictability of the Glasgow-Blatchford, Rockall and Full Rockall Risk Scoring Systems

American Journal of Gastroenterology

Research paper thumbnail of Misdiagnosis of Caroliʼs Disease: A Case Report

American Journal of Gastroenterology

Research paper thumbnail of Pregnancy-Induced Sweet’s Syndrome Treated with Infliximab

Medical Principles and Practice

Significance of the Study • Sweet's syndrome may be triggered by pregnancy. In cases of pregnant ... more Significance of the Study • Sweet's syndrome may be triggered by pregnancy. In cases of pregnant women with Sweet's syndrome and onset or relapse of Crohn's disease, the pregnancy might be a simultaneous trigger for both diseases. Sweet's syndrome can be treated with "off-label" use of infliximab.

Research paper thumbnail of Nonsteroidal Anti-Inflammatory Drug-Induced Colopathy in a Colorectal Cancer Screening Program

Medical Principles and Practice

Significance of the Study • Nonsteroidal anti-inflammatory drug (NSAID)-induced colopathy should ... more Significance of the Study • Nonsteroidal anti-inflammatory drug (NSAID)-induced colopathy should be taken into consideration as a possible differential diagnosis in patients with a positive immunochemical faecal occult blood test (iFOBT) performed in a colorectal cancer screening program. There is no need to stop NSAIDs before iFOBT.

Research paper thumbnail of Nonsteroidal anti-inflammatory drug-induced colopathy: An uncommon cause of positive immunochemical faecal occult blood test in program for screening of colorectal cancer

Research paper thumbnail of Renal aspergillosis in a liver transplant patient: A case report and review of literature

World Journal of Clinical Cases

BACKGROUND Aspergillosis is a frequent invasive fungal infection in liver recipients (affecting 1... more BACKGROUND Aspergillosis is a frequent invasive fungal infection in liver recipients (affecting 1%-9.2% of all patients), second only to candidiasis. Significant risk factors for invasive aspergillosis in liver recipients include corticosteroid therapy, neutropenia, T-cell dysfunction, renal failure and requirement for renal replacement therapy. Aspergillus infection usually affects the lungs of liver recipients, with hematogenous dissemination occurring in 50%-60% of cases. Renal involvement is rare and is considered to occur in 0.4% of all cases of invasive aspergillosis. CASE SUMMARY This paper describes a case of a liver recipient presenting with a newly formed renal mass a year after liver transplantation. The patient underwent liver transplantation due to alcoholic liver cirrhosis, with preoperative corticosteroid therapy and postoperative immunosuppressants (tacrolimus and mycophenolate mofetil). His 1-year follow-up was uneventful, with a satisfying graft function and lack of any symptoms. During a routine follow-up abdominal ultrasound, he was diagnosed with a renal tumor. The renal ima

Research paper thumbnail of Preoperative misdiagnosed gist surgical "tranferred" into gastric duplication cyst

Vojnosanitetski pregled, 2016

Introduction. Gastrointestinal duplications are rare congenital anomalies, especially in the adul... more Introduction. Gastrointestinal duplications are rare congenital anomalies, especially in the adult population which can occur along the entire gastrointestinal tract. The rarest among them are gastric duplications, making up 2-8% of all gastrointestinal duplications. Unusual embryonic malformations can be found even in the adult population and should always be considered in the differential diagnosis of thoraco-abdominal tumors. Unclear findings during preoperative diagnostic procedures are the reason for presenting the case. Case report. We present a 33 years old female, with tumorous lesion in the stomach wall, which had the endoscopic ultrasound features of gastrointestinal stromal tumor. During surgery, it was determined that the lesion was actually a cystic formation with gelatin content and histological examination confirmed the diagnosis of gastric duplication cyst. Conclusion. Preoperative diagnosis of gastric duplication cyst has always been a challenge for clinicians, since its morphological appearance may vary. That is the reason why these anomalies are often misdiagnosed as solid tumorous lesions by imaging methods and even by the most superior ones, and set up the surgery as a part of diagnostic algorithm.

Research paper thumbnail of Mo1188 High-Risk Group Targeting Colorectal Cancer Screening May Be More Adequate for Countries With Lower Incidence Compared With Average-Risk Population Screening: The Montenegro Experience

Research paper thumbnail of Colorectal cancer screening in a low-incidence area

European Journal of Gastroenterology & Hepatology, 2015

Colorectal cancer (CRC) is one of the most common malignancies worldwide. The aim of this study w... more Colorectal cancer (CRC) is one of the most common malignancies worldwide. The aim of this study was to compare the outcomes of two different screening approaches in a small country (Montenegro, 650 000 inhabitants) with a CRC incidence lower than the European average. Two structured invitation programs were compared with respect to compliance and neoplasia yield: (i) program A focused on first-degree relatives of CRC patients diagnosed in two hospitals (n=206), inviting them for colonoscopy; (ii) program B was an invitation program for fecal occult blood testing, followed by colonoscopy if positive, conducted in University Hospital, Podgorica, Montenegro, on 2760 randomly selected average-risk persons, age 50-74 years, living in a single municipality. Of 710 first-degree relatives of 206 CRC patients approached, 540 presented for colonoscopy (76.05% uptake). Overall, 31 were diagnosed with a cancer, 58 with advanced adenoma, and 151 with adenoma in general. In the general screening program, of 2760 individuals invited, 920 underwent fecal immunochemical test (33.3% uptake) and colonoscopy was performed in all 95 positive cases (10.3%); six cancers was found in five patients (one patient had two cancers), 19 patients were diagnosed with advanced adenoma, and 26 with any adenomas. The risk-targeted screening program had a significantly higher yield for cancers in both per invited (31/710 vs. 5/2760, P<0.001) and per eligible person analysis (31/540 vs. 5/920, P<0.001). In a low-incidence country with limited resources, it may be advisable to start with CRC screening targeted to risk groups.

Research paper thumbnail of Bleeding gastroduodenal ulcers in patients without Helicobacter pylori infection and without exposure to non-steroidal anti-inflammatory drugs

Vojnosanitetski pregled, 2014

Background/Aim. A high risk of bleeding in Helicobacter pylori (H.pylori)-negative, non-steroidal... more Background/Aim. A high risk of bleeding in Helicobacter pylori (H.pylori)-negative, non-steroidal anti-inflammatory drugs (NSAID)-negative ulcers highlights the clinical importance of analysis of the changing trends of peptic ulcer disease. The aim of the study was to investigate the risk factors for ulcer bleeding in patients with non-H. pylori infection, and with no NSAIDs use. Methods. A prospective study included patients with endoscopically diagnosed ulcer disease. The patients were without H. pylori infection (verified by pathohistology and serology) and without exposure to NSAIDs and proton pump inhibitors (PPI) within 4 weeks before endoscopy. After endoscopy the patients were divided into 2 groups: the study group of 48 patients with bleeding ulcer and the control group of 47 patients with ulcer, but with no bleeding. Prior to endoscopy they had completed a questionnaire about demographics, risk factors and habits. The platelet function, von Willebrand factor (vWF) and bloo...

Research paper thumbnail of Role of Helicobacter pylori Infection in Gastroduodenal Damage in Patients Starting NSAID Therapy: 4 Months Follow-Up Study

Digestive Diseases and Sciences, 2010

Research paper thumbnail of Complications related to Meckel's diverticulum (MD): Perforation due to enteroscopy and bleeding

Acta chirurgica iugoslavica, 2014

Complications of Meckels diverticulum (MD) are rare and occur in about 4-6% of cases, more freque... more Complications of Meckels diverticulum (MD) are rare and occur in about 4-6% of cases, more frequently in younger men. Most common complication is bleeding; less frequent are intussusception, perforation and intestinal obstruction. Detection of MD and its complications can be challenging, but the combination of video capsule endoscopy (VCE) and double - balloon endoscopy (DBE) allow more precise diagnosis and present a challenge for clinicians. We described two patients with complicated MD: one with perforated diverticulum after enteroscopy, and one with bleeding. Both patients were previously examined for obscure bleeding. Due to the limitation of conventional endoscopy, highly suspected MD is diagnosed with new and innovative methods, VCE and DBE. In the first case the diverticulum was with ectopic gastric tissue, in second case diverticulum was bleeding without ectopic mucosa. Surgical approach required resection method. We need to think about MD if we wish to diagnose and treat i...

Research paper thumbnail of Non-Steroidal Anti-Inflammatory Drug-Induced Colopathy as Possible Rare Cause of a Positive Immunochemical Faecal Occult Blood Test: A Case Report: 1563

The American Journal of Gastroenterology, 2017

Research paper thumbnail of Diabetic ketoacidosis, hypertriglyceridemia and acute pancreatitis- a case report

Research paper thumbnail of Non-Steroidal Anti-Inflammatory Drug-Induced Colopathy as Possible Rare Cause of a Positive Immunochemical Faecal Occult Blood Test: A Case Report

American Journal of Gastroenterology

Research paper thumbnail of The Impact of Pro-hemorrhagic Drugs on Predictability of the Glasgow-Blatchford, Rockall and Full Rockall Risk Scoring Systems

American Journal of Gastroenterology

Research paper thumbnail of Misdiagnosis of Caroliʼs Disease: A Case Report

American Journal of Gastroenterology

Research paper thumbnail of Pregnancy-Induced Sweet’s Syndrome Treated with Infliximab

Medical Principles and Practice

Significance of the Study • Sweet's syndrome may be triggered by pregnancy. In cases of pregnant ... more Significance of the Study • Sweet's syndrome may be triggered by pregnancy. In cases of pregnant women with Sweet's syndrome and onset or relapse of Crohn's disease, the pregnancy might be a simultaneous trigger for both diseases. Sweet's syndrome can be treated with "off-label" use of infliximab.

Research paper thumbnail of Nonsteroidal Anti-Inflammatory Drug-Induced Colopathy in a Colorectal Cancer Screening Program

Medical Principles and Practice

Significance of the Study • Nonsteroidal anti-inflammatory drug (NSAID)-induced colopathy should ... more Significance of the Study • Nonsteroidal anti-inflammatory drug (NSAID)-induced colopathy should be taken into consideration as a possible differential diagnosis in patients with a positive immunochemical faecal occult blood test (iFOBT) performed in a colorectal cancer screening program. There is no need to stop NSAIDs before iFOBT.

Research paper thumbnail of Nonsteroidal anti-inflammatory drug-induced colopathy: An uncommon cause of positive immunochemical faecal occult blood test in program for screening of colorectal cancer

Research paper thumbnail of Renal aspergillosis in a liver transplant patient: A case report and review of literature

World Journal of Clinical Cases

BACKGROUND Aspergillosis is a frequent invasive fungal infection in liver recipients (affecting 1... more BACKGROUND Aspergillosis is a frequent invasive fungal infection in liver recipients (affecting 1%-9.2% of all patients), second only to candidiasis. Significant risk factors for invasive aspergillosis in liver recipients include corticosteroid therapy, neutropenia, T-cell dysfunction, renal failure and requirement for renal replacement therapy. Aspergillus infection usually affects the lungs of liver recipients, with hematogenous dissemination occurring in 50%-60% of cases. Renal involvement is rare and is considered to occur in 0.4% of all cases of invasive aspergillosis. CASE SUMMARY This paper describes a case of a liver recipient presenting with a newly formed renal mass a year after liver transplantation. The patient underwent liver transplantation due to alcoholic liver cirrhosis, with preoperative corticosteroid therapy and postoperative immunosuppressants (tacrolimus and mycophenolate mofetil). His 1-year follow-up was uneventful, with a satisfying graft function and lack of any symptoms. During a routine follow-up abdominal ultrasound, he was diagnosed with a renal tumor. The renal ima

Research paper thumbnail of Preoperative misdiagnosed gist surgical "tranferred" into gastric duplication cyst

Vojnosanitetski pregled, 2016

Introduction. Gastrointestinal duplications are rare congenital anomalies, especially in the adul... more Introduction. Gastrointestinal duplications are rare congenital anomalies, especially in the adult population which can occur along the entire gastrointestinal tract. The rarest among them are gastric duplications, making up 2-8% of all gastrointestinal duplications. Unusual embryonic malformations can be found even in the adult population and should always be considered in the differential diagnosis of thoraco-abdominal tumors. Unclear findings during preoperative diagnostic procedures are the reason for presenting the case. Case report. We present a 33 years old female, with tumorous lesion in the stomach wall, which had the endoscopic ultrasound features of gastrointestinal stromal tumor. During surgery, it was determined that the lesion was actually a cystic formation with gelatin content and histological examination confirmed the diagnosis of gastric duplication cyst. Conclusion. Preoperative diagnosis of gastric duplication cyst has always been a challenge for clinicians, since its morphological appearance may vary. That is the reason why these anomalies are often misdiagnosed as solid tumorous lesions by imaging methods and even by the most superior ones, and set up the surgery as a part of diagnostic algorithm.

Research paper thumbnail of Mo1188 High-Risk Group Targeting Colorectal Cancer Screening May Be More Adequate for Countries With Lower Incidence Compared With Average-Risk Population Screening: The Montenegro Experience

Research paper thumbnail of Colorectal cancer screening in a low-incidence area

European Journal of Gastroenterology & Hepatology, 2015

Colorectal cancer (CRC) is one of the most common malignancies worldwide. The aim of this study w... more Colorectal cancer (CRC) is one of the most common malignancies worldwide. The aim of this study was to compare the outcomes of two different screening approaches in a small country (Montenegro, 650 000 inhabitants) with a CRC incidence lower than the European average. Two structured invitation programs were compared with respect to compliance and neoplasia yield: (i) program A focused on first-degree relatives of CRC patients diagnosed in two hospitals (n=206), inviting them for colonoscopy; (ii) program B was an invitation program for fecal occult blood testing, followed by colonoscopy if positive, conducted in University Hospital, Podgorica, Montenegro, on 2760 randomly selected average-risk persons, age 50-74 years, living in a single municipality. Of 710 first-degree relatives of 206 CRC patients approached, 540 presented for colonoscopy (76.05% uptake). Overall, 31 were diagnosed with a cancer, 58 with advanced adenoma, and 151 with adenoma in general. In the general screening program, of 2760 individuals invited, 920 underwent fecal immunochemical test (33.3% uptake) and colonoscopy was performed in all 95 positive cases (10.3%); six cancers was found in five patients (one patient had two cancers), 19 patients were diagnosed with advanced adenoma, and 26 with any adenomas. The risk-targeted screening program had a significantly higher yield for cancers in both per invited (31/710 vs. 5/2760, P<0.001) and per eligible person analysis (31/540 vs. 5/920, P<0.001). In a low-incidence country with limited resources, it may be advisable to start with CRC screening targeted to risk groups.

Research paper thumbnail of Bleeding gastroduodenal ulcers in patients without Helicobacter pylori infection and without exposure to non-steroidal anti-inflammatory drugs

Vojnosanitetski pregled, 2014

Background/Aim. A high risk of bleeding in Helicobacter pylori (H.pylori)-negative, non-steroidal... more Background/Aim. A high risk of bleeding in Helicobacter pylori (H.pylori)-negative, non-steroidal anti-inflammatory drugs (NSAID)-negative ulcers highlights the clinical importance of analysis of the changing trends of peptic ulcer disease. The aim of the study was to investigate the risk factors for ulcer bleeding in patients with non-H. pylori infection, and with no NSAIDs use. Methods. A prospective study included patients with endoscopically diagnosed ulcer disease. The patients were without H. pylori infection (verified by pathohistology and serology) and without exposure to NSAIDs and proton pump inhibitors (PPI) within 4 weeks before endoscopy. After endoscopy the patients were divided into 2 groups: the study group of 48 patients with bleeding ulcer and the control group of 47 patients with ulcer, but with no bleeding. Prior to endoscopy they had completed a questionnaire about demographics, risk factors and habits. The platelet function, von Willebrand factor (vWF) and bloo...

Research paper thumbnail of Role of Helicobacter pylori Infection in Gastroduodenal Damage in Patients Starting NSAID Therapy: 4 Months Follow-Up Study

Digestive Diseases and Sciences, 2010

Research paper thumbnail of Complications related to Meckel's diverticulum (MD): Perforation due to enteroscopy and bleeding

Acta chirurgica iugoslavica, 2014

Complications of Meckels diverticulum (MD) are rare and occur in about 4-6% of cases, more freque... more Complications of Meckels diverticulum (MD) are rare and occur in about 4-6% of cases, more frequently in younger men. Most common complication is bleeding; less frequent are intussusception, perforation and intestinal obstruction. Detection of MD and its complications can be challenging, but the combination of video capsule endoscopy (VCE) and double - balloon endoscopy (DBE) allow more precise diagnosis and present a challenge for clinicians. We described two patients with complicated MD: one with perforated diverticulum after enteroscopy, and one with bleeding. Both patients were previously examined for obscure bleeding. Due to the limitation of conventional endoscopy, highly suspected MD is diagnosed with new and innovative methods, VCE and DBE. In the first case the diverticulum was with ectopic gastric tissue, in second case diverticulum was bleeding without ectopic mucosa. Surgical approach required resection method. We need to think about MD if we wish to diagnose and treat i...