Bronwyn Laycock - Academia.edu (original) (raw)

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Papers by Bronwyn Laycock

Research paper thumbnail of Biorefineries as sources of fuels and chemicals

At present, the value of biofuels is such that only large biorefineries are likely to be economic... more At present, the value of biofuels is such that only large biorefineries are likely to be economic except in special circumstances. Large biorefineries require a large capital investment and thus represent a large commercial risk.

Research paper thumbnail of Allylsilanes from allylchlorides and silylcuprates

Tetrahedron Letters, 1983

Research paper thumbnail of Hydrogel Lens Monomer Constituents Modulate Protein Sorption

To examine the effect of hydrogel lens monomer constituents on protein sorption.

Research paper thumbnail of Silylcuprate Routes to Cyclohex-2-enylsilanes

Australian Journal of Chemistry, 1988

... Bronwyn ~ a ~ cock , ~ Ian A4aynardA Geoffrey W7ckhamA and William Kitchine ... In recent yea... more ... Bronwyn ~ a ~ cock , ~ Ian A4aynardA Geoffrey W7ckhamA and William Kitchine ... In recent years a number of attractive approaches based on copper(1) mediation of organosilyllithium reactions have been developed, particularly by Fleming and his group.14 Our studies of ...

Research paper thumbnail of Stereochemistry of acidolysis of cyclohept-2-enyl-silanes and -stannanes

Journal of The Chemical Society, Chemical Communications, 1986

... William Kitching," Bronwyn Laycock, Ian Maynard, and Kerry Penman Chemistry Department, ... more ... William Kitching," Bronwyn Laycock, Ian Maynard, and Kerry Penman Chemistry Department, University of Queensland, St. 1 ucia, Queensland, Australia 4067 ... References 1 (a) TH Chan and I. Fleming, Synthesis, 1979, 761; (b) 1. Fleming and N. K. Terrett, Pure Appl. ...

Research paper thumbnail of Cell interactions with perfluoropolyether-based network copolymers

Journal of Biomaterials Science-polymer Edition, 1999

We have investigated the potential of several polymers based on perfluoropolyether (PFPE) macromo... more We have investigated the potential of several polymers based on perfluoropolyether (PFPE) macromonomers for use in biomaterial applications. Polymer networks were synthesised from the PFPE macromonomers of increasing chain length and the adhesion and proliferation of corneal, vascular and bone cells was evaluated on these polymers. The polymer surfaces were quite hydrophobic, having sessile air-water contact angles ranging between 96 and 125 degrees. However, these polymers supported the attachment and growth of bovine corneal epithelial and endothelial cells and fibroblasts at 60-100% of the rate of cell growth on the culture substratum, TCPS. Furthermore, the PFPE polymers supported the attachment and growth of vascular endothelial cells (from human umbilical artery) and human bone-derived cells over a 7 day period at an equal level to TCPS. The relationship between the macromonomer chain length (n = 1 to 4) and the ability of the resulting PFPE homopolymer to support the overgrowth of corneal epithelial tissue was also evaluated. The PFPE-containing polymers supported corneal epithelial tissue overgrowth, with the most effective having a performance equivalent to that of TCPS. In addition to these homopolymers, copolymers comprising of PFPE and N,N-dimethylaminoethyl methacrylate (DMAEMA) were also synthesised. Surprisingly, the addition of DMAEMA to the PFPE polymer network lead to a reduction in the growth and attachment of corneal epithelial cells and fibroblasts. These results indicate that PFPE-based materials show a potential for use in the development of biomaterials in the ocular, vascular and orthopaedic areas.

Research paper thumbnail of Biorefineries as sources of fuels and chemicals

At present, the value of biofuels is such that only large biorefineries are likely to be economic... more At present, the value of biofuels is such that only large biorefineries are likely to be economic except in special circumstances. Large biorefineries require a large capital investment and thus represent a large commercial risk.

Research paper thumbnail of Allylsilanes from allylchlorides and silylcuprates

Tetrahedron Letters, 1983

Research paper thumbnail of Hydrogel Lens Monomer Constituents Modulate Protein Sorption

To examine the effect of hydrogel lens monomer constituents on protein sorption.

Research paper thumbnail of Silylcuprate Routes to Cyclohex-2-enylsilanes

Australian Journal of Chemistry, 1988

... Bronwyn ~ a ~ cock , ~ Ian A4aynardA Geoffrey W7ckhamA and William Kitchine ... In recent yea... more ... Bronwyn ~ a ~ cock , ~ Ian A4aynardA Geoffrey W7ckhamA and William Kitchine ... In recent years a number of attractive approaches based on copper(1) mediation of organosilyllithium reactions have been developed, particularly by Fleming and his group.14 Our studies of ...

Research paper thumbnail of Stereochemistry of acidolysis of cyclohept-2-enyl-silanes and -stannanes

Journal of The Chemical Society, Chemical Communications, 1986

... William Kitching," Bronwyn Laycock, Ian Maynard, and Kerry Penman Chemistry Department, ... more ... William Kitching," Bronwyn Laycock, Ian Maynard, and Kerry Penman Chemistry Department, University of Queensland, St. 1 ucia, Queensland, Australia 4067 ... References 1 (a) TH Chan and I. Fleming, Synthesis, 1979, 761; (b) 1. Fleming and N. K. Terrett, Pure Appl. ...

Research paper thumbnail of Cell interactions with perfluoropolyether-based network copolymers

Journal of Biomaterials Science-polymer Edition, 1999

We have investigated the potential of several polymers based on perfluoropolyether (PFPE) macromo... more We have investigated the potential of several polymers based on perfluoropolyether (PFPE) macromonomers for use in biomaterial applications. Polymer networks were synthesised from the PFPE macromonomers of increasing chain length and the adhesion and proliferation of corneal, vascular and bone cells was evaluated on these polymers. The polymer surfaces were quite hydrophobic, having sessile air-water contact angles ranging between 96 and 125 degrees. However, these polymers supported the attachment and growth of bovine corneal epithelial and endothelial cells and fibroblasts at 60-100% of the rate of cell growth on the culture substratum, TCPS. Furthermore, the PFPE polymers supported the attachment and growth of vascular endothelial cells (from human umbilical artery) and human bone-derived cells over a 7 day period at an equal level to TCPS. The relationship between the macromonomer chain length (n = 1 to 4) and the ability of the resulting PFPE homopolymer to support the overgrowth of corneal epithelial tissue was also evaluated. The PFPE-containing polymers supported corneal epithelial tissue overgrowth, with the most effective having a performance equivalent to that of TCPS. In addition to these homopolymers, copolymers comprising of PFPE and N,N-dimethylaminoethyl methacrylate (DMAEMA) were also synthesised. Surprisingly, the addition of DMAEMA to the PFPE polymer network lead to a reduction in the growth and attachment of corneal epithelial cells and fibroblasts. These results indicate that PFPE-based materials show a potential for use in the development of biomaterials in the ocular, vascular and orthopaedic areas.