Bruce Silver - Academia.edu (original) (raw)

Papers by Bruce Silver

Midwest Studies in Philosophy

Philosophy and Literature

2009 IEEE Conference on Commerce and Enterprise Computing, 2009

Mathias Weske, Hasso-Plattner-Institute, University of Potsdam, Germany ... Wil van der Aalst, TU... more Mathias Weske, Hasso-Plattner-Institute, University of Potsdam, Germany ... Wil van der Aalst, TU Eindhoven, The Netherlands Alistair Barros, SAP Research Brisbane, Australia Gero Decker, Hasso-Plattner-Institute, University of Potsdam, Germany Remco Dijkman, TU Eindhoven, The Netherlands Marlon Dumas, University of Tartu, Estonia Jakob Freund, Camunda, Germany Felix Garcia, University of Castilla-La Mancha, Spain Luciano García-Bañuelos, Universidad Autónoma de Tlaxcala, Mexico Ismael Ghalimi, Intalio, ...

Thesis Massachusetts Institute of Technology 1977 Source American Doctoral Dissertations Source Code X1977, Jun 1, 1977

Annals of Internal Medicine, Mar 1, 1979

Skip to main content. CERN Logo CERN Document Server. Related links. CDS; Indico; Library; Bullet... more Skip to main content. CERN Logo CERN Document Server. Related links. CDS; Indico; Library; Bulletin; EDMS. Main navigation links: Search; Submit; Help; Your CDS: Your alerts; Your baskets; Your searches. login. Home > BPMN method and style. ...

Archives of Internal Medicine, Dec 1, 1986

The interaction between the histamine H-2 receptor antagonist, cimetidine, and warfarin sodium wa... more The interaction between the histamine H-2 receptor antagonist, cimetidine, and warfarin sodium was prospectively studied in 14 patients who were previously anticoagulated for five years. The patients received warfarin and cimetidine concomitantly for a minimum of ten days. Seven of the patients experienced increases in plasma warfarin concentrations. This correspondingly resulted in abnormal prolongation of their prothrombin times. In these patients the elevation in the steady-state warfarin concentration demonstrates that coadministration of cimetidine significantly reduces the plasma clearance rate of warfarin. The serum and urine metabolite levels of warfarin were not qualitatively different in the absence in contrast to the presence of cimetidine. It is apparent that cimetidine can act as an inhibitory influence on the catabolic degradation of warfarin.

Cancer Research

We have conducted a clinical trial utilizing anti-thymocyte globulin (ATG) for the treatment of p... more We have conducted a clinical trial utilizing anti-thymocyte globulin (ATG) for the treatment of patients with non-Hodgkin's lymphomas. Six patients were treated; 50% reductions in tumor mass of short duration were observed in one patient with a Tcell lymphoma and two patients with B-cell lymphomas. In vitro assays have been performed in an attempt to study the reac tivity and potential mechanism of antitumor action of the ATG. The ATG bound to essentially all normal blood mononuclear leukocytes as well as tumor cells from patients with T-, B-, or null cell lymphomas demonstrating its lack of specificity. Fur thermore, complement-mediated lysis of normal mononuclear leukocytes, normal T-or B-cells, and tumor cells from two unresponsive patients were all comparable; moreover, since this lysis occurred only at concentrations of ATG that are not attainable in vivo, it is unlikely that complement-mediated cytotoxicity accounts for the responses observed. Peripheral blood lymphocyte counts and total erythrocyte rosettes did decrease during ATG treatment. Thus, objective tumor re sponses in both B-and T-cell non-Hodgkin's lymphomas can be achieved with a very nonspecific antiserum although sig nificant toxicity resulted. Whether the magnitude or duration of response can be increased with monoclonal antibodies remains to be determined. Future success with serotherapy might re quire use of either a battery of different monoclonal antibodies or a single monoclonal antibody that can deliver radioisotopes, chemotherapy, or toxins to the tumor cells.

Philosophy as Frustration, 2013