Bruna Del Vechio Koike - Academia.edu (original) (raw)

Papers by Bruna Del Vechio Koike

Frontiers in neurology, 2018

The interaction of Mesial Temporal Lobe Epilepsy (mTLE) with the circadian system control is appa... more The interaction of Mesial Temporal Lobe Epilepsy (mTLE) with the circadian system control is apparent from an oscillatory pattern of limbic seizures, daytime's effect on seizure onset and the efficacy of antiepileptic drugs. Moreover, seizures can interfere with the biological rhythm output, including circadian oscillation of body temperature, locomotor activity, EEG pattern as well as the transcriptome. However, the molecular mechanisms underlying this cross-talk remain unclear. In this study, we systematically evaluated the temporal expression of seven core circadian transcripts (, and ) and the spontaneous locomotor activity (SLA) in post- (SE) model of mTLE. Twenty-four hour oscillating SLA remained intact in post-SE groups although the circadian phase and the amount and intensity of activity were changed in early post-SE and epileptic phases. The acrophase of the SLA rhythm was delayed during epileptogenesis, a fragmented 24 h rhythmicity and extended active phase length ap...

Brazilian Journal of Health Review, Apr 10, 2024

Efficiency of daily kombucha consumption in reducing glycemic levels and hypercholesterolemia Efi... more Efficiency of daily kombucha consumption in reducing glycemic levels and hypercholesterolemia Eficiência do consumo diário de kombucha na redução dos níveis glicêmicos e da hipercolesterolemia Eficiencia del consumo diario de kombucha para reducir los niveles de glucemia y la hipercolesterolemia

Sao Paulo Medical Journal, 2024

BACKGROUND: There is a lack of studies evaluating the oral health of traditional indigenous commu... more BACKGROUND: There is a lack of studies evaluating the oral health of traditional indigenous communities in Brazil. OBJECTIVES: Thus, the objective of this study was to describe the oral health characteristics of the indigenous Fulni-ô ethnic group in Northeast Brazil. DESIGN AND SETTING: A cross-sectional observational investigation was conducted within the Project on Atherosclerosis among Indigenous Populations. METHODS: This study included participants of both sexes from the Fulni-ô ethnic group. The participants included in this investigation underwent a comprehensive oral health evaluation by a registered and experienced dentist to assess oral health and identify potentially malignant oral lesions. Participants with suspicious lesions were referred for biopsy. Shapiro-Wilk, Mann-Whitney, and Student's t-tests were used, and measures of central tendency and dispersion were described. Statistical significance was 5%. RESULTS: A total of 104 individuals were included in this study. The prevalence of the use of tobacco derivatives was 94.0%, with similarities between sexes. The prevalence of oral changes in this study population was 84.4%. Fifty-one individuals who underwent oral reassessment were referred for oral lesion biopsy. CONCLUSIONS: This study demonstrated a high prevalence of oral alterations in the Fulni-ô population. Histopathological analyses indicated the presence of mild oral epithelial dysplasia in five cases.

Sleep Science

Shift work can cause circadian cycles disturbances and misaligns the endogenous rhythms. The phys... more Shift work can cause circadian cycles disturbances and misaligns the endogenous rhythms. The physiological variables are driven by the circadian system and, its misalignment, can impair the metabolic functions. Thus, the main objective of this study was to evaluate the metabolic alterations as a result of shift work and night work reported in articles published in the last 5 years, using the eligibility criteria both gender and indexed articles in English language. In order to execute this work, we perform a systematic review according to PRISMA guidelines and searched about Chronobiology Disorders and Night Work, both related to metabolism, in Medline, Lilacs, ScienceDirect and Cochrane. Cross-sectional, cohort and experimental studies with low risk of bias were included. We found a total of 132 articles, and, after the selection process, 16 articles remained to be analyzed. It was observed that shift work can cause circadian misalignment and, consequently, some metabolic parameter...

Revista de Ensino, Ciência e Inovação em Saúde

We aimed to evaluate the association of hypertension and diabetes with the severity prognosis of ... more We aimed to evaluate the association of hypertension and diabetes with the severity prognosis of COVID-19 in ICU hospitalization by analyzing significant differences in epidemiological, clinical and laboratory aspects when compared with non-diabetic and non-hypertensive patients. This review was conducted according to PRISMA, registered on PROSPERO, guided for 4 independent researchers, we used 5 different database and Newcastle-Ottawa scale was the bias analysis applied. A total of 26 articles were included in this review. Diabetics patients admitted to the ICU were older than non-diabetics, about 10 years. Males were associated with a higher chance of death compared to females. Patients with newly diagnosed diabetes and poorly controlled HBA1C had a higher risk of death compared to long-term and controlled patients. Diabetic patients presented evidence that this population tends to have more symptoms in the lower respiratory tract than upper respiratory tract. Procalcitonin levels...

SCIENTEX/UNIVASF - Semana de Ensino, Pesquisa e Extensão da Universidade Federal do Vale do São Francisco, 2022

Anais do(a) Anais da Semana de Ensino, Pesquisa e Extensão da UNIVASF, 2021

SCIENTEX/UNIVASF - Semana de Ensino, Pesquisa e Extensão da Universidade Federal do Vale do São Francisco, 2022

SCIENTEX/UNIVASF - Semana de Ensino, Pesquisa e Extensão da Universidade Federal do Vale do São Francisco

Revista Estudos Culturais, 2021

Nos ultimos meses, acompanhou-se a emersao de um novo coronavirus humano (SARS-CoV-2) e das compl... more Nos ultimos meses, acompanhou-se a emersao de um novo coronavirus humano (SARS-CoV-2) e das complexas manifestacoes apresentadas pelos individuos infectados por esse virus. Tendo em vista os diferentes processos que permeiam o desenvolvimento da COVID-19 e as diversas incognitas existentes em relacao a infeccao pelo SARS-CoV-2, esta revisao apresenta aspectos relacionados a imunopatogenese da COVID-19, abordando a acao da imunidade inata e adquirida, o papel dos interferons I e III, bem como a influencia da tempestade de citocinas no decorrer da infeccao pelo SARS-CoV-2. Desta forma, pretende-se aqui expor um breve panorama a respeito do que vem sendo debatido nos trabalhos cientificos sobre o assunto. Foi feito um levantamento bibliografico em tres base de dados: Science Direct, PubMed e BVS. A partir da analise dos artigos encontrados foi possivel concluir que as manifestacoes imunologicas, apesar da grande importância para o controle e eliminacao do patogeno causador da COVID-19 ...

Handbook of Behavioral Neuroscience, 2018

Abstract The investigation of the sleep-dependent mechanisms of memory processing and consolidati... more Abstract The investigation of the sleep-dependent mechanisms of memory processing and consolidation is largely based on the electrophysiological recording of action potentials (spikes), local field potentials (LFPs), and muscle activity from freely behaving rodents. The ability to record continuously for extended periods of time and across all the behavioral states that comprise the sleep–wake cycle is of utmost importance for this field. This chapter will review the main methods involved in the general technique, including the customized assemblage of multielectrode arrays composed of single wires or tetrodes, the reasons to choose either, the combination of arrays with cannulas for pharmacological injections or optic fibers for light stimulation, the surgical stereotaxic implantation of arrays, important aspects of pre- and postoperative care, chronic recordings and experimental manipulations, and data analyses able to effectively integrate information from spikes, LFP, acceleration, muscle activity, and overall behavior. Troubleshooting for a series of frequent problems will be addressed, including the choice of materials, difficulties with anesthesia, surgery and animal care, pitfalls of recordings and experimental manipulations, and important considerations regarding data storage and processing. Future perspectives of the field will be discussed, with a focus on the need to develop methods to dynamically track the spatiotemporal transformation of memories over time.

Sleep Medicine: X, 2022

Arterial hypertension is a cardiovascular disease defined as a sustained high blood pressure, con... more Arterial hypertension is a cardiovascular disease defined as a sustained high blood pressure, constituting an important risk factor for the development of heart diseases, such as coronary heart disease and heart failure. At the same time, pathophysiological pathways underlying sleeping deprivation provides biological plausibility for a causation connection between sleep deprivation and acute or chronic blood pressure elevation, such as the mechanism behind blood pressure dipping at night, which strongly relies on reduced sympathetic activity provided by sleep, besides empirical and clinical evidence suggesting that sleep disorders incidence is correlate with posterior development of arterial hypertension. The aim of this study was to systematically review published studies analyzing the possible relationship between sleep deprivation and variations in blood pressure during nighttime and daytime. The research was carried out in the second semester of 2020 following the PRISMA model and using the LILACS, MEDLINE and COCHRANE (CENTRAL) databases. The keywords used were associated using the Boolean method. Only trials and studies in humans unrelated to sleep apnea were included, in an attempt to answer the question proposed. Duplications and articles outside the topic were excluded. After the selection processes, fourteen studies were left, which were classified, depending on the findings, in four categories: 1) blood pressure differences only in sleep deprivation's night; 2) blood pressure differences only in the following day after sleep deprivation's night; 3) blood pressure differences in both nights and 4) those that found no blood pressure differences. It was found an increase in blood pressure on the night of sleep deprivation, suggesting a possible causality with an acute increase in blood pressure depending on the population studied. In general, sleep deprivation is acutely associated with blood pressure elevation or acute elevation of markers that suggest the role of compensatory mechanisms, such as increased natriuresis and increased parasympathetic activity.

COVID-19 has been a widespread disease; reaching the global pandemic scale. Its distribution was ... more COVID-19 has been a widespread disease; reaching the global pandemic scale. Its distribution was non-uniform and was modulated by several factors. In Petrolina - PE, the virus has arrived in March 2020 and showed an increasing evolution. The objective of this work is to observe how the geographical distribution of the confirmed cases of COVID-19 in Petrolina took place - period from March 23th to July18th, 2020. Daily monitoring analysis was done based on municipality's health department information and the Ministry of Health. We observed that this virus was introduced by people who arrived abroad in the central region of Petrolina, in March, followed by a gradual increase in confirmed cases of the disease, spreading to the most populous neighborhoods. With that, we observed the propagation is faster in populated areas and with few precautionary measures. Numerous challenges need to be overcome in the face of the new coronavirus. So far, it is known that social distance and pers...

Arylalkylamine N-Acetyltransferase (AANAT) is a rate-limiting enzyme of the melatonin synthesis p... more Arylalkylamine N-Acetyltransferase (AANAT) is a rate-limiting enzyme of the melatonin synthesis pathway. Polymorphisms in the AANAT gene are likely to alter the rate of melatonin synthesis and thus lead particular variations on the circadian rhythms of individuals. The purpose of this study was to perform a screening of the AANAT gene in order to identify the polymorphisms presents in a Brazilian sample and seek associations with diurnal preferences. Individuals that scored extreme diurnal preference according to the Horne-Ostberg questionnaire were selected. The search for SNPs was done using Denaturing High Performance Liquid Chromatography (DHPLC). Segregated association tests were performed for each SNP and for the haplotype blocks. A total of six polymorphisms were found, including two that are still not reported in DNA data banks or in the literature. All polymorphisms in the AANAT gene found in this sample, except for one, appeared with very low frequencies, of which the rare...

Segundo dados da Organizacao Mundial da Saude, o disturbio do sono esta presente em aproximadamen... more Segundo dados da Organizacao Mundial da Saude, o disturbio do sono esta presente em aproximadamente 40% dos brasileiros e cerca de 45% da populacao mundial. Devido a essa necessidade social, o estudo consistiu em analisar a qualidade do sono de profissionais do Hospital Universitario da Universidade Federal do Vale do Sao Francisco, tomando como base a escala de Pittsburgh, bem como associa-la ao estilo de vida. Pretende-se, portanto, estabelecer uma conexao entre o estilo de vida e o sono, a fim de que seja possivel estudar a dessincronizacao do sistema circadiano, a despeito de tumores, com a falta de um sono regular, propondo uma intervencao cronoterapeutica em futuros estudos. O estudo em questao pretende estabelecer uma associacao entre o estilo de vida e o sono, levando em consideracao fatores como o “Shift Work”, “Jet Lag Social(JLS)”, “Escala de Sonolencia de Epworth(ESE)”², “Indice de Qualidade de Sono de Pittsburgh(IQSP)”, “Questionario de Cronotipo de Munique(MCTQ)”, &qu...

Sleep Science, Aug 8, 2013

HIOMT is a gene that encodes hydroxyindole-O-methyltransferase, the final enzyme in the melatonin... more HIOMT is a gene that encodes hydroxyindole-O-methyltransferase, the final enzyme in the melatonin synthesis pathway. As the timing of melatonin synthesis is different for morning and evening people, it is possible that polymorphisms in genes coding for the enzymes which participate in melatonin synthesis can influence this hormone synthesis and release patterns that may result in different circadian outputs. The aim of this study was to search for polymorphisms in the HIOMT gene and to verify possible associations between genetic variations in this gene and circadian phenotypes in a Brazilian population sample. Among the 44 extreme morning and the 48 extreme evening people, ten polymorphisms were found, being two of them not described so far. Haploview analyses showed linkage disequilibrium between pairs of polymorphisms in the promoter B region. Also, the haplotype AG (rs4446909, rs5989681) is associated with evening preference. The analysis of these data indicates that polymorphis...

Frontiers in neurology, 2018

The interaction of Mesial Temporal Lobe Epilepsy (mTLE) with the circadian system control is appa... more The interaction of Mesial Temporal Lobe Epilepsy (mTLE) with the circadian system control is apparent from an oscillatory pattern of limbic seizures, daytime's effect on seizure onset and the efficacy of antiepileptic drugs. Moreover, seizures can interfere with the biological rhythm output, including circadian oscillation of body temperature, locomotor activity, EEG pattern as well as the transcriptome. However, the molecular mechanisms underlying this cross-talk remain unclear. In this study, we systematically evaluated the temporal expression of seven core circadian transcripts (, and ) and the spontaneous locomotor activity (SLA) in post- (SE) model of mTLE. Twenty-four hour oscillating SLA remained intact in post-SE groups although the circadian phase and the amount and intensity of activity were changed in early post-SE and epileptic phases. The acrophase of the SLA rhythm was delayed during epileptogenesis, a fragmented 24 h rhythmicity and extended active phase length ap...

Brazilian Journal of Health Review, Apr 10, 2024

Efficiency of daily kombucha consumption in reducing glycemic levels and hypercholesterolemia Efi... more Efficiency of daily kombucha consumption in reducing glycemic levels and hypercholesterolemia Eficiência do consumo diário de kombucha na redução dos níveis glicêmicos e da hipercolesterolemia Eficiencia del consumo diario de kombucha para reducir los niveles de glucemia y la hipercolesterolemia

Sao Paulo Medical Journal, 2024

BACKGROUND: There is a lack of studies evaluating the oral health of traditional indigenous commu... more BACKGROUND: There is a lack of studies evaluating the oral health of traditional indigenous communities in Brazil. OBJECTIVES: Thus, the objective of this study was to describe the oral health characteristics of the indigenous Fulni-ô ethnic group in Northeast Brazil. DESIGN AND SETTING: A cross-sectional observational investigation was conducted within the Project on Atherosclerosis among Indigenous Populations. METHODS: This study included participants of both sexes from the Fulni-ô ethnic group. The participants included in this investigation underwent a comprehensive oral health evaluation by a registered and experienced dentist to assess oral health and identify potentially malignant oral lesions. Participants with suspicious lesions were referred for biopsy. Shapiro-Wilk, Mann-Whitney, and Student's t-tests were used, and measures of central tendency and dispersion were described. Statistical significance was 5%. RESULTS: A total of 104 individuals were included in this study. The prevalence of the use of tobacco derivatives was 94.0%, with similarities between sexes. The prevalence of oral changes in this study population was 84.4%. Fifty-one individuals who underwent oral reassessment were referred for oral lesion biopsy. CONCLUSIONS: This study demonstrated a high prevalence of oral alterations in the Fulni-ô population. Histopathological analyses indicated the presence of mild oral epithelial dysplasia in five cases.

Sleep Science

Shift work can cause circadian cycles disturbances and misaligns the endogenous rhythms. The phys... more Shift work can cause circadian cycles disturbances and misaligns the endogenous rhythms. The physiological variables are driven by the circadian system and, its misalignment, can impair the metabolic functions. Thus, the main objective of this study was to evaluate the metabolic alterations as a result of shift work and night work reported in articles published in the last 5 years, using the eligibility criteria both gender and indexed articles in English language. In order to execute this work, we perform a systematic review according to PRISMA guidelines and searched about Chronobiology Disorders and Night Work, both related to metabolism, in Medline, Lilacs, ScienceDirect and Cochrane. Cross-sectional, cohort and experimental studies with low risk of bias were included. We found a total of 132 articles, and, after the selection process, 16 articles remained to be analyzed. It was observed that shift work can cause circadian misalignment and, consequently, some metabolic parameter...

Revista de Ensino, Ciência e Inovação em Saúde

We aimed to evaluate the association of hypertension and diabetes with the severity prognosis of ... more We aimed to evaluate the association of hypertension and diabetes with the severity prognosis of COVID-19 in ICU hospitalization by analyzing significant differences in epidemiological, clinical and laboratory aspects when compared with non-diabetic and non-hypertensive patients. This review was conducted according to PRISMA, registered on PROSPERO, guided for 4 independent researchers, we used 5 different database and Newcastle-Ottawa scale was the bias analysis applied. A total of 26 articles were included in this review. Diabetics patients admitted to the ICU were older than non-diabetics, about 10 years. Males were associated with a higher chance of death compared to females. Patients with newly diagnosed diabetes and poorly controlled HBA1C had a higher risk of death compared to long-term and controlled patients. Diabetic patients presented evidence that this population tends to have more symptoms in the lower respiratory tract than upper respiratory tract. Procalcitonin levels...

SCIENTEX/UNIVASF - Semana de Ensino, Pesquisa e Extensão da Universidade Federal do Vale do São Francisco, 2022

Anais do(a) Anais da Semana de Ensino, Pesquisa e Extensão da UNIVASF, 2021

SCIENTEX/UNIVASF - Semana de Ensino, Pesquisa e Extensão da Universidade Federal do Vale do São Francisco, 2022

SCIENTEX/UNIVASF - Semana de Ensino, Pesquisa e Extensão da Universidade Federal do Vale do São Francisco

Revista Estudos Culturais, 2021

Nos ultimos meses, acompanhou-se a emersao de um novo coronavirus humano (SARS-CoV-2) e das compl... more Nos ultimos meses, acompanhou-se a emersao de um novo coronavirus humano (SARS-CoV-2) e das complexas manifestacoes apresentadas pelos individuos infectados por esse virus. Tendo em vista os diferentes processos que permeiam o desenvolvimento da COVID-19 e as diversas incognitas existentes em relacao a infeccao pelo SARS-CoV-2, esta revisao apresenta aspectos relacionados a imunopatogenese da COVID-19, abordando a acao da imunidade inata e adquirida, o papel dos interferons I e III, bem como a influencia da tempestade de citocinas no decorrer da infeccao pelo SARS-CoV-2. Desta forma, pretende-se aqui expor um breve panorama a respeito do que vem sendo debatido nos trabalhos cientificos sobre o assunto. Foi feito um levantamento bibliografico em tres base de dados: Science Direct, PubMed e BVS. A partir da analise dos artigos encontrados foi possivel concluir que as manifestacoes imunologicas, apesar da grande importância para o controle e eliminacao do patogeno causador da COVID-19 ...

Handbook of Behavioral Neuroscience, 2018

Abstract The investigation of the sleep-dependent mechanisms of memory processing and consolidati... more Abstract The investigation of the sleep-dependent mechanisms of memory processing and consolidation is largely based on the electrophysiological recording of action potentials (spikes), local field potentials (LFPs), and muscle activity from freely behaving rodents. The ability to record continuously for extended periods of time and across all the behavioral states that comprise the sleep–wake cycle is of utmost importance for this field. This chapter will review the main methods involved in the general technique, including the customized assemblage of multielectrode arrays composed of single wires or tetrodes, the reasons to choose either, the combination of arrays with cannulas for pharmacological injections or optic fibers for light stimulation, the surgical stereotaxic implantation of arrays, important aspects of pre- and postoperative care, chronic recordings and experimental manipulations, and data analyses able to effectively integrate information from spikes, LFP, acceleration, muscle activity, and overall behavior. Troubleshooting for a series of frequent problems will be addressed, including the choice of materials, difficulties with anesthesia, surgery and animal care, pitfalls of recordings and experimental manipulations, and important considerations regarding data storage and processing. Future perspectives of the field will be discussed, with a focus on the need to develop methods to dynamically track the spatiotemporal transformation of memories over time.

Sleep Medicine: X, 2022

Arterial hypertension is a cardiovascular disease defined as a sustained high blood pressure, con... more Arterial hypertension is a cardiovascular disease defined as a sustained high blood pressure, constituting an important risk factor for the development of heart diseases, such as coronary heart disease and heart failure. At the same time, pathophysiological pathways underlying sleeping deprivation provides biological plausibility for a causation connection between sleep deprivation and acute or chronic blood pressure elevation, such as the mechanism behind blood pressure dipping at night, which strongly relies on reduced sympathetic activity provided by sleep, besides empirical and clinical evidence suggesting that sleep disorders incidence is correlate with posterior development of arterial hypertension. The aim of this study was to systematically review published studies analyzing the possible relationship between sleep deprivation and variations in blood pressure during nighttime and daytime. The research was carried out in the second semester of 2020 following the PRISMA model and using the LILACS, MEDLINE and COCHRANE (CENTRAL) databases. The keywords used were associated using the Boolean method. Only trials and studies in humans unrelated to sleep apnea were included, in an attempt to answer the question proposed. Duplications and articles outside the topic were excluded. After the selection processes, fourteen studies were left, which were classified, depending on the findings, in four categories: 1) blood pressure differences only in sleep deprivation's night; 2) blood pressure differences only in the following day after sleep deprivation's night; 3) blood pressure differences in both nights and 4) those that found no blood pressure differences. It was found an increase in blood pressure on the night of sleep deprivation, suggesting a possible causality with an acute increase in blood pressure depending on the population studied. In general, sleep deprivation is acutely associated with blood pressure elevation or acute elevation of markers that suggest the role of compensatory mechanisms, such as increased natriuresis and increased parasympathetic activity.

COVID-19 has been a widespread disease; reaching the global pandemic scale. Its distribution was ... more COVID-19 has been a widespread disease; reaching the global pandemic scale. Its distribution was non-uniform and was modulated by several factors. In Petrolina - PE, the virus has arrived in March 2020 and showed an increasing evolution. The objective of this work is to observe how the geographical distribution of the confirmed cases of COVID-19 in Petrolina took place - period from March 23th to July18th, 2020. Daily monitoring analysis was done based on municipality's health department information and the Ministry of Health. We observed that this virus was introduced by people who arrived abroad in the central region of Petrolina, in March, followed by a gradual increase in confirmed cases of the disease, spreading to the most populous neighborhoods. With that, we observed the propagation is faster in populated areas and with few precautionary measures. Numerous challenges need to be overcome in the face of the new coronavirus. So far, it is known that social distance and pers...

Arylalkylamine N-Acetyltransferase (AANAT) is a rate-limiting enzyme of the melatonin synthesis p... more Arylalkylamine N-Acetyltransferase (AANAT) is a rate-limiting enzyme of the melatonin synthesis pathway. Polymorphisms in the AANAT gene are likely to alter the rate of melatonin synthesis and thus lead particular variations on the circadian rhythms of individuals. The purpose of this study was to perform a screening of the AANAT gene in order to identify the polymorphisms presents in a Brazilian sample and seek associations with diurnal preferences. Individuals that scored extreme diurnal preference according to the Horne-Ostberg questionnaire were selected. The search for SNPs was done using Denaturing High Performance Liquid Chromatography (DHPLC). Segregated association tests were performed for each SNP and for the haplotype blocks. A total of six polymorphisms were found, including two that are still not reported in DNA data banks or in the literature. All polymorphisms in the AANAT gene found in this sample, except for one, appeared with very low frequencies, of which the rare...

Segundo dados da Organizacao Mundial da Saude, o disturbio do sono esta presente em aproximadamen... more Segundo dados da Organizacao Mundial da Saude, o disturbio do sono esta presente em aproximadamente 40% dos brasileiros e cerca de 45% da populacao mundial. Devido a essa necessidade social, o estudo consistiu em analisar a qualidade do sono de profissionais do Hospital Universitario da Universidade Federal do Vale do Sao Francisco, tomando como base a escala de Pittsburgh, bem como associa-la ao estilo de vida. Pretende-se, portanto, estabelecer uma conexao entre o estilo de vida e o sono, a fim de que seja possivel estudar a dessincronizacao do sistema circadiano, a despeito de tumores, com a falta de um sono regular, propondo uma intervencao cronoterapeutica em futuros estudos. O estudo em questao pretende estabelecer uma associacao entre o estilo de vida e o sono, levando em consideracao fatores como o “Shift Work”, “Jet Lag Social(JLS)”, “Escala de Sonolencia de Epworth(ESE)”², “Indice de Qualidade de Sono de Pittsburgh(IQSP)”, “Questionario de Cronotipo de Munique(MCTQ)”, &qu...

Sleep Science, Aug 8, 2013

HIOMT is a gene that encodes hydroxyindole-O-methyltransferase, the final enzyme in the melatonin... more HIOMT is a gene that encodes hydroxyindole-O-methyltransferase, the final enzyme in the melatonin synthesis pathway. As the timing of melatonin synthesis is different for morning and evening people, it is possible that polymorphisms in genes coding for the enzymes which participate in melatonin synthesis can influence this hormone synthesis and release patterns that may result in different circadian outputs. The aim of this study was to search for polymorphisms in the HIOMT gene and to verify possible associations between genetic variations in this gene and circadian phenotypes in a Brazilian population sample. Among the 44 extreme morning and the 48 extreme evening people, ten polymorphisms were found, being two of them not described so far. Haploview analyses showed linkage disequilibrium between pairs of polymorphisms in the promoter B region. Also, the haplotype AG (rs4446909, rs5989681) is associated with evening preference. The analysis of these data indicates that polymorphis...