Bruna Pereira - Academia.edu (original) (raw)

Papers by Bruna Pereira

Research paper thumbnail of How Can the Use of Participatory and Co-Creation Approaches Enhance Young People´s Civic Participation for Climate Change Adaptation?

Research paper thumbnail of Internal Translation of p53 Oncoproteins During Integrated Stress Response Confers Survival Advantage on Cancer Cells

p53is the most known and studied tumour suppressor gene. Yet we have recently shown thatp53is als... more p53is the most known and studied tumour suppressor gene. Yet we have recently shown thatp53is also a proto-oncogene, as it encodes the Δ160p53 oncoprotein. Integrated stress response (ISR) is a survival pathway frequently activated in cancers, marked by the phosphorylation of eukaryotic initiation factor 2alpha (eIF2α) and a defined reprogramming in mRNA translation. Here we identified ISR as a powerful trigger of p53 oncogene, leading to the induction of not only Δ160p53 but also Δ133p53, another protein variant of thep53gene. Upon ISR the two isoforms were translated internally from p53 full-length (FL) transcript through an internal regulator of expression site (IRES) located in the vicinity of codon 160. Frameshift mutations upstream of codons 133 and 160 demonstrated that FLp53 protein synthesis is not required for making Δ133p53 and Δ160p53. Instead, targeting IRES(160) with an antisense oligo was sufficient to efficiently and specifically impair the expression of these isofor...

Research paper thumbnail of A Social Study of the Importance of Diabetes Mellitus Screening

International Journal of Health Science

All content in this magazine is licensed under a Creative Commons Attribution License. Attributio... more All content in this magazine is licensed under a Creative Commons Attribution License. Attribution-Non-Commercial-Non-Derivatives 4.0 International (CC BY-NC-ND 4.0).

Research paper thumbnail of The Role of Assisted Natural Regeneration in Accelerating Forest and Landscape Restoration: Practical Experiences from the Field

World Resources Institute, 2022

Practice notes provide a quick review of experiences related to a specific project. Analysis and ... more Practice notes provide a quick review of experiences related to a specific project. Analysis and recommendations are limited to the specific context presented in the note and should not be interpreted for wider application.

Research paper thumbnail of Sobre O Desperdício De Alimentos: Relação Entre as Causas De Condenação Post Mortem De Frangos e O Bem-Estar Animal

Dinamismo e Clareza no Planejamento em Ciências da Saúde 5, 2021

Research paper thumbnail of As redes sociais, estilos e qualidade de vida em séniores: estudo de caso

Nota de edição: Respeitou-se a norma ortográfica seguida pelos Autores. © CDA, Universidade da Ma... more Nota de edição: Respeitou-se a norma ortográfica seguida pelos Autores. © CDA, Universidade da Madeira O conteúdo desta obra está protegido por Lei. Qualquer forma de reprodução, distribuição, comunicação pública ou transformação da totalidade ou de parte desta obra carece de expressa autorização dos editores e dos seus autores. Os capítulos, bem como a autorização de publicação das imagens, são da exclusiva responsabilidade dos autores.

Research paper thumbnail of Influence of tomato and lycopene supplementation on the cardiac remodeling after acute myocardial infarction (LB337)

The FASEB Journal, 2014

Due to its antioxidant properties, tomato (Lycopersicon esculentum) and one of its primary consti... more Due to its antioxidant properties, tomato (Lycopersicon esculentum) and one of its primary constituents, lycopene have been evaluated in clinical and experimental studies. Our objective was to evaluate the influence of tomato and lycopene supplementation on the cardiac remodeling after acute myocardial infarction. Wistar rats were assigned to 6 groups: SHAM group, in which animals were submitted to simulated surgery (SHAM group; n=15); SHAM group that received lycopene 1mg/kg of body weight/day in the chow (SHAM-L group, n=9); SHAM group that received tomato in the chow (SHAM-T group, n=10); myocardial infarction (MI) group, in which animals were submitted to coronary artery ligation (MI group, n=16); MI group that received lycopene 1mg/kg of body weight/day in the chow (MI-L group, n=12); and MI group that received tomato in the chow (MI-T group, n=15). The amount of tomato supplemented had the same quantity of lycopene that was given for the groups supplemented only with this carotenoid. The rats were o...

Research paper thumbnail of Additional file 1: Table S1. of A betabaculovirus encoding a gp64 homolog

Gene content. (DOC 313 kb)

Research paper thumbnail of Effect of resveratrol on the erectile machinery is due to the underlying mechanisms of the alpha 1‐adrenoceptor activation (1097.2)

The FASEB Journal, 2014

The anococcygeus muscle is part of the erectile machinery in male rodents whose innervation is ma... more The anococcygeus muscle is part of the erectile machinery in male rodents whose innervation is mainly due the autonomic system. Activation of alpha1-adreneceptor triggers the production of reactive...

Research paper thumbnail of Petróleo como tema gerador de ensino para alunos surdos

Segundo Godoy (2000) 1 a política de inclusão de alunos que apresentam necessidades educativas es... more Segundo Godoy (2000) 1 a política de inclusão de alunos que apresentam necessidades educativas especiais na rede regular de ensino não consiste apenas na permanência física dos alunos junto com os demais educandos, mas sim, em desenvolver o potencial dessas pessoas, respeitando suas diferenças e atendendo às suas necessidades. Considerando limitações como: vocabulário restrito e a dificuldade de entendimento de conceitos abstratos por parte dos surdos, é possível inferir que esses alunos tenham dificuldade na compreensão de alguns conceitos científicos 2 . Dessa forma, este trabalho teve como objetivo facilitar o processo de ensino-aprendizagem de um aluno surdo, por meio da prática de monitorias para o ensino de química, utilizando materiais de apoio tais como: Apostila ilustrada com fluxogramas, vídeos e imagens representativas. O material foi desenvolvido pelos bolsistas do PIBID (Programa Institucional de Bolsa de Iniciação à Docência) e aplicado a um aluno surdo da terceira sér...

Research paper thumbnail of The Practice of Playful Groups as Tool for Education in Health in a Strategy of the Family Health: An Experience Report 1

The practice of health groups is necessary for the actions of health education and establishment ... more The practice of health groups is necessary for the actions of health education and establishment of prevention, control and treatment of some chronic diseases. The objective of this study was to report the experience of an undergraduate student of Nursing course of Universidade Federal de Santa Maria (UFSM) in a Estrategia de Saude da Familia (ESF) of the Santa Maria-RS. This is the description of a health group where appropriate concepts and behaviors to users with SAH were worked out. The main problems found were about the life habits of the users, mostly involving food consumption and sedentary lifestyle. Besides, according to the participants, stress and anxiety interfere with blood pressure levels. It was possible to realize that health group is one of the relevant strategies of health education, and that it should be carried out by Nursing staff in order to promote prevention and recovery of health, providing greater visibility to the professional.

Research paper thumbnail of Gestão estratégica para o desenvolvimento sustentável de florestas plantadas - estudo aplicado em Dois Vizinhos, Paraná, Brasil

Disciplinarum Scientia - Ciências Naturais e Tecnológicas, 2021

O propósito do trabalho foi avaliar variáveis quantitativas relacionadas às áreas plantadas e com... more O propósito do trabalho foi avaliar variáveis quantitativas relacionadas às áreas plantadas e com potencial para novos plantios florestais, visando a criação de estratégias para o crescimento da cadeia produtiva de base florestal no município de Dois Vizinhos-Paraná. Com base em análise de imagem de satélite e avaliações in loco, foram estudadas todas as áreas e suas variáveis associadas. O município apresenta uma proporção maior de Área Potencial (AP), com 1.407,4 ha, sendo 0,98% maior do que a área de Floresta Plantada (FP) com 996,4 ha, em relação à área total do município. A classe FP-Eucalipto apresenta maior extensão de área, com 879,9 ha, seguido de FP-Pinus (80,4 ha) e FP-Erva-mate (36,1 ha). Na Classe AP, a que mais se destacou foi pastagem degradada (811,7 ha), seguida de AP-Capoeira (552,1 ha) e AP-Lavoura degradada (42,8 ha). Os produtores vêm investindo no setor florestal nos últimos anos, com grande foco em eucalipto, movido principalmente pelas agroindústrias regionais que demandam aporte de biomassa energética. Há um déficit de matéria prima para usos com maior valor agregado, sendo imprescindível a ampliação do potencial de fornecimento de madeira para estes e outros setores nos próximos anos.

Research paper thumbnail of ‘Nenhum passo atrás’ (Not a step back): Brazilian Black women’s resistance in the era of Bolsonaro’s far-right government

Gender & Development, 2021

ABSTRACT Since 2010, the far-right in Brazil has led the backlash to feminism, sexual and gender ... more ABSTRACT Since 2010, the far-right in Brazil has led the backlash to feminism, sexual and gender diversity, racial equality, and other human rights agendas. In this article, we shed light on the devastating impact of the comeback of conservatism and Jair Bolsonaro’s presidency on the lives of Black women. Next, we draw from the interviews conducted with a wide range of activists to unveil how Black women have been energised to resist the backlash. We argue that the Black women’s movement has employed grassroots organising, institutional politics, counter narratives, and the Black culture, in complementary and interconnected ways, to resist the resurgence of the far-right. Moreover, we suggest that the ability to engage with different forms of activism and strategies of resistance is a key strength of the Black women’s movement in Brazil and has placed it at the forefront of the resistance against the far-right.

Research paper thumbnail of Perfil De População Quanto À Presença De Litíase Do Trato Urinário: Dados Preliminares – Clínicos e Bioquímicos

Research paper thumbnail of Comissão Nacional da Verdade e Relações Civis - Militares no Brasil

In this article, we work the concept of civil military relations Alfred Stepan from the political... more In this article, we work the concept of civil military relations Alfred Stepan from the political transition to democracy in Brazil, after 21 years in force during the military dictatorship in Brazil (1964-1985). Through a documentary of the final report analyzing the National Truth Commission seek to understand how agreements between civil and military members occurred in 1985 during the political transition influenced the current political and social situation of the country in order to limit and obscure the gains brought by this Commission. From this material, the main objective of this article was to analyze how the configuration of military civil relations during the work of CNV is directly related to the permanence of the dictatorial legacy in our current democracy.

Research paper thumbnail of O Teatro Como Ferramenta De Educação Humanitária Nas Escolas Rurais De Realeza

O Grupo Cinco Liberdades levou o projeto as escolas rurais, a fim de oportunizar as criancas de a... more O Grupo Cinco Liberdades levou o projeto as escolas rurais, a fim de oportunizar as criancas de areas distantes da cidade, a experiencia da arte teatral. O teatro nao consiste apenas em uma acao de transformacao cultural, mas tambem e principalmente social. Os meios rurais acabam por nao participar ativamente nos processos de producao e criacao cultural, ficando excluidos de propostas que comumente sao desenvolvidas nas cidades. Assim, as atividades artisticas e culturais em comunidades rurais tem que lutar contra muitas dificuldades, como os escassos recursos financeiros e humanos. O objetivo desta proposta cultural foi apresentar atraves do teatro como ferramenta de educacao humanitaria, os conceitos de bem-estar animal (BEA), especialmente das cinco liberdades, aos alunos do ensino fundamental de escolas rurais de Realeza. A relacao entre homem e animais tem como norteamento o conceito das cinco liberdades: todos os animais devem ser livres de medo e estresse; livres de fome e se...

Research paper thumbnail of Um "Olhar Oposicional" Sobre o Amor: Afetividade e Sexualidade Pelo Olhar de Intelectuais Negras

WSQ: Women's Studies Quarterly, 2021

Research paper thumbnail of Neonatal Death Related to Giant Placental Chorioangioma: Case Report

Revista Brasileira de Ultrassonografia, 2020

RBUS-REVISTA BRASILEIRA DE ULTRASSONOGRAFIA | 4 REGRAS PARA PUBLICAÇÃO A revista aceitará materia... more RBUS-REVISTA BRASILEIRA DE ULTRASSONOGRAFIA | 4 REGRAS PARA PUBLICAÇÃO A revista aceitará material original para publicação no campo relacionado à ultrassonografia. A revista publicará: In press: Wyon DP. Thermal comfort during surgical operations. J Hyg Camb 20-;in press (colocar o ano atual).

Research paper thumbnail of Translational switch during integrated stress response: the examples of p53 and UPF1

The scanning model for eukaryotic mRNA translation initiation states that the small ribosomal sub... more The scanning model for eukaryotic mRNA translation initiation states that the small ribosomal subunit, along with initiation factors, binds to the cap structure at the 5’ end of the mRNA and scans the 5’ untranslated region (5’UTR) until an initiation codon is found. However, when cells are exposed to stress stimuli, cap-dependent translation is inhibited, while the synthesis of some proteins is maintained by alternative mechanisms of translation initiation, which are vital for cell survival and stress recovery. Here we show two examples in which a translational switch occurs during integrated stress response (ISR). In the first case, tumor suppressor p53, we show that the ISR leads to the specific induction of a shorter p53 isoform (Δ160p53 isoform). This induction is dependent on translation elongation but does not require the eIF4E-eIF4G interaction. Studies using bicistronic constructs with wild-type Δ160p53 or reporter genes confirmed the presence of an Internal Ribosome Entry Site (IRES) in p53 mRNA, being eIF2α phosphorylation a key event leading to cap-independent expression of Δ160p53 during ISR. Interestingly, cancer-specific mutations in p53 also enhance cap-independent translation of Δ160p53 via Δ160p53IRES. Our data support a model in which an IRES structure in the coding region of p53, and the cancer-specific mutations that affect this structure, control p53 oncogenic functions by regulating Δ160p53 protein expression. A better understanding of Δ160p53IRES structure and function may be advantageous for a more efficient therapeutic targeting of p53. Human up-frameshift 1 (UPF1) is a key-protein involved in nonsense-mediated mRNA decay, telomere replication and homeostasis, and cell cycle progression. These crucial UPF1 functions suggest its tight gene expression regulation. Indeed, our results show that UPF1 5’UTR is able to mediate cap-independent translation in a bicistronic luciferase vector expressed in cervical and colorectal cancer cell lines. Such activity is maintained under endoplasmic reticulum stress. Interestingly, we found that the UPF1 5’UTR IRES function is inhibited when the first 100 nucleotides, or the last 125, are absent or altered. Understanding these IRESs mechanism of function and their biological relevance might provide tools for developing new therapies for human diseases such as cancer.This work was supported by grants PTDC/MED-ONC/32048/2017 and PTDC/BIM-ONC/4890/2014 from the Fundação para a Ciência e a Tecnologia (FCT), by Grants-in-Aid 16K21111 and 18K07229 from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan, by Takeda Foundation and Astellas Grant, by Instituto Nacional de Saúde Doutor Ricardo Jorge, and by UIDB/04046/2020 and UIDP/04046/2020 Centre grants from FCT, Portugal (to BioISI).info:eu-repo/semantics/publishedVersio

Research paper thumbnail of Solid γ-Cyclodextrin Inclusion Compound with Gingerols, a Multi-Component Guest: Preparation, Properties and Application in Yogurt

Biomolecules, 2020

Gingerols from the rhizome of fresh ginger (Zingiber officinale) were obtained by a simple extrac... more Gingerols from the rhizome of fresh ginger (Zingiber officinale) were obtained by a simple extraction, followed by purification. The gingerols extract was composed of 6-gingerol (54%), 8-gingerol (20%), and 10-gingerol (26%). It was included into γ-cyclodextrin by classic co-dissolution procedures. Solid-state characterisation of γ-cyclodextrin·gingerols shows that this inclusion compound features 1:1 host-to-guest stoichiometry and that it is a microcrystalline powder with a crystalline cell that belongs to the tetragonal space group 4212, having the host molecules stacked in infinite channels where the gingerols are accommodated. In chimico studies with ABTS•+ scavenging, NO• scavenging, β-carotene peroxidation, and 5-LOX inhibition show that γ-cyclodextrin is a suitable carrier for gingerols, because it does not alter their reactivity towards these substances. Yogurt was tested as a matrix for the incorporation of gingerols and γ-cyclodextrin·gingerols into foodstuff. The colour ...

Research paper thumbnail of How Can the Use of Participatory and Co-Creation Approaches Enhance Young People´s Civic Participation for Climate Change Adaptation?

Research paper thumbnail of Internal Translation of p53 Oncoproteins During Integrated Stress Response Confers Survival Advantage on Cancer Cells

p53is the most known and studied tumour suppressor gene. Yet we have recently shown thatp53is als... more p53is the most known and studied tumour suppressor gene. Yet we have recently shown thatp53is also a proto-oncogene, as it encodes the Δ160p53 oncoprotein. Integrated stress response (ISR) is a survival pathway frequently activated in cancers, marked by the phosphorylation of eukaryotic initiation factor 2alpha (eIF2α) and a defined reprogramming in mRNA translation. Here we identified ISR as a powerful trigger of p53 oncogene, leading to the induction of not only Δ160p53 but also Δ133p53, another protein variant of thep53gene. Upon ISR the two isoforms were translated internally from p53 full-length (FL) transcript through an internal regulator of expression site (IRES) located in the vicinity of codon 160. Frameshift mutations upstream of codons 133 and 160 demonstrated that FLp53 protein synthesis is not required for making Δ133p53 and Δ160p53. Instead, targeting IRES(160) with an antisense oligo was sufficient to efficiently and specifically impair the expression of these isofor...

Research paper thumbnail of A Social Study of the Importance of Diabetes Mellitus Screening

International Journal of Health Science

All content in this magazine is licensed under a Creative Commons Attribution License. Attributio... more All content in this magazine is licensed under a Creative Commons Attribution License. Attribution-Non-Commercial-Non-Derivatives 4.0 International (CC BY-NC-ND 4.0).

Research paper thumbnail of The Role of Assisted Natural Regeneration in Accelerating Forest and Landscape Restoration: Practical Experiences from the Field

World Resources Institute, 2022

Practice notes provide a quick review of experiences related to a specific project. Analysis and ... more Practice notes provide a quick review of experiences related to a specific project. Analysis and recommendations are limited to the specific context presented in the note and should not be interpreted for wider application.

Research paper thumbnail of Sobre O Desperdício De Alimentos: Relação Entre as Causas De Condenação Post Mortem De Frangos e O Bem-Estar Animal

Dinamismo e Clareza no Planejamento em Ciências da Saúde 5, 2021

Research paper thumbnail of As redes sociais, estilos e qualidade de vida em séniores: estudo de caso

Nota de edição: Respeitou-se a norma ortográfica seguida pelos Autores. © CDA, Universidade da Ma... more Nota de edição: Respeitou-se a norma ortográfica seguida pelos Autores. © CDA, Universidade da Madeira O conteúdo desta obra está protegido por Lei. Qualquer forma de reprodução, distribuição, comunicação pública ou transformação da totalidade ou de parte desta obra carece de expressa autorização dos editores e dos seus autores. Os capítulos, bem como a autorização de publicação das imagens, são da exclusiva responsabilidade dos autores.

Research paper thumbnail of Influence of tomato and lycopene supplementation on the cardiac remodeling after acute myocardial infarction (LB337)

The FASEB Journal, 2014

Due to its antioxidant properties, tomato (Lycopersicon esculentum) and one of its primary consti... more Due to its antioxidant properties, tomato (Lycopersicon esculentum) and one of its primary constituents, lycopene have been evaluated in clinical and experimental studies. Our objective was to evaluate the influence of tomato and lycopene supplementation on the cardiac remodeling after acute myocardial infarction. Wistar rats were assigned to 6 groups: SHAM group, in which animals were submitted to simulated surgery (SHAM group; n=15); SHAM group that received lycopene 1mg/kg of body weight/day in the chow (SHAM-L group, n=9); SHAM group that received tomato in the chow (SHAM-T group, n=10); myocardial infarction (MI) group, in which animals were submitted to coronary artery ligation (MI group, n=16); MI group that received lycopene 1mg/kg of body weight/day in the chow (MI-L group, n=12); and MI group that received tomato in the chow (MI-T group, n=15). The amount of tomato supplemented had the same quantity of lycopene that was given for the groups supplemented only with this carotenoid. The rats were o...

Research paper thumbnail of Additional file 1: Table S1. of A betabaculovirus encoding a gp64 homolog

Gene content. (DOC 313 kb)

Research paper thumbnail of Effect of resveratrol on the erectile machinery is due to the underlying mechanisms of the alpha 1‐adrenoceptor activation (1097.2)

The FASEB Journal, 2014

The anococcygeus muscle is part of the erectile machinery in male rodents whose innervation is ma... more The anococcygeus muscle is part of the erectile machinery in male rodents whose innervation is mainly due the autonomic system. Activation of alpha1-adreneceptor triggers the production of reactive...

Research paper thumbnail of Petróleo como tema gerador de ensino para alunos surdos

Segundo Godoy (2000) 1 a política de inclusão de alunos que apresentam necessidades educativas es... more Segundo Godoy (2000) 1 a política de inclusão de alunos que apresentam necessidades educativas especiais na rede regular de ensino não consiste apenas na permanência física dos alunos junto com os demais educandos, mas sim, em desenvolver o potencial dessas pessoas, respeitando suas diferenças e atendendo às suas necessidades. Considerando limitações como: vocabulário restrito e a dificuldade de entendimento de conceitos abstratos por parte dos surdos, é possível inferir que esses alunos tenham dificuldade na compreensão de alguns conceitos científicos 2 . Dessa forma, este trabalho teve como objetivo facilitar o processo de ensino-aprendizagem de um aluno surdo, por meio da prática de monitorias para o ensino de química, utilizando materiais de apoio tais como: Apostila ilustrada com fluxogramas, vídeos e imagens representativas. O material foi desenvolvido pelos bolsistas do PIBID (Programa Institucional de Bolsa de Iniciação à Docência) e aplicado a um aluno surdo da terceira sér...

Research paper thumbnail of The Practice of Playful Groups as Tool for Education in Health in a Strategy of the Family Health: An Experience Report 1

The practice of health groups is necessary for the actions of health education and establishment ... more The practice of health groups is necessary for the actions of health education and establishment of prevention, control and treatment of some chronic diseases. The objective of this study was to report the experience of an undergraduate student of Nursing course of Universidade Federal de Santa Maria (UFSM) in a Estrategia de Saude da Familia (ESF) of the Santa Maria-RS. This is the description of a health group where appropriate concepts and behaviors to users with SAH were worked out. The main problems found were about the life habits of the users, mostly involving food consumption and sedentary lifestyle. Besides, according to the participants, stress and anxiety interfere with blood pressure levels. It was possible to realize that health group is one of the relevant strategies of health education, and that it should be carried out by Nursing staff in order to promote prevention and recovery of health, providing greater visibility to the professional.

Research paper thumbnail of Gestão estratégica para o desenvolvimento sustentável de florestas plantadas - estudo aplicado em Dois Vizinhos, Paraná, Brasil

Disciplinarum Scientia - Ciências Naturais e Tecnológicas, 2021

O propósito do trabalho foi avaliar variáveis quantitativas relacionadas às áreas plantadas e com... more O propósito do trabalho foi avaliar variáveis quantitativas relacionadas às áreas plantadas e com potencial para novos plantios florestais, visando a criação de estratégias para o crescimento da cadeia produtiva de base florestal no município de Dois Vizinhos-Paraná. Com base em análise de imagem de satélite e avaliações in loco, foram estudadas todas as áreas e suas variáveis associadas. O município apresenta uma proporção maior de Área Potencial (AP), com 1.407,4 ha, sendo 0,98% maior do que a área de Floresta Plantada (FP) com 996,4 ha, em relação à área total do município. A classe FP-Eucalipto apresenta maior extensão de área, com 879,9 ha, seguido de FP-Pinus (80,4 ha) e FP-Erva-mate (36,1 ha). Na Classe AP, a que mais se destacou foi pastagem degradada (811,7 ha), seguida de AP-Capoeira (552,1 ha) e AP-Lavoura degradada (42,8 ha). Os produtores vêm investindo no setor florestal nos últimos anos, com grande foco em eucalipto, movido principalmente pelas agroindústrias regionais que demandam aporte de biomassa energética. Há um déficit de matéria prima para usos com maior valor agregado, sendo imprescindível a ampliação do potencial de fornecimento de madeira para estes e outros setores nos próximos anos.

Research paper thumbnail of ‘Nenhum passo atrás’ (Not a step back): Brazilian Black women’s resistance in the era of Bolsonaro’s far-right government

Gender & Development, 2021

ABSTRACT Since 2010, the far-right in Brazil has led the backlash to feminism, sexual and gender ... more ABSTRACT Since 2010, the far-right in Brazil has led the backlash to feminism, sexual and gender diversity, racial equality, and other human rights agendas. In this article, we shed light on the devastating impact of the comeback of conservatism and Jair Bolsonaro’s presidency on the lives of Black women. Next, we draw from the interviews conducted with a wide range of activists to unveil how Black women have been energised to resist the backlash. We argue that the Black women’s movement has employed grassroots organising, institutional politics, counter narratives, and the Black culture, in complementary and interconnected ways, to resist the resurgence of the far-right. Moreover, we suggest that the ability to engage with different forms of activism and strategies of resistance is a key strength of the Black women’s movement in Brazil and has placed it at the forefront of the resistance against the far-right.

Research paper thumbnail of Perfil De População Quanto À Presença De Litíase Do Trato Urinário: Dados Preliminares – Clínicos e Bioquímicos

Research paper thumbnail of Comissão Nacional da Verdade e Relações Civis - Militares no Brasil

In this article, we work the concept of civil military relations Alfred Stepan from the political... more In this article, we work the concept of civil military relations Alfred Stepan from the political transition to democracy in Brazil, after 21 years in force during the military dictatorship in Brazil (1964-1985). Through a documentary of the final report analyzing the National Truth Commission seek to understand how agreements between civil and military members occurred in 1985 during the political transition influenced the current political and social situation of the country in order to limit and obscure the gains brought by this Commission. From this material, the main objective of this article was to analyze how the configuration of military civil relations during the work of CNV is directly related to the permanence of the dictatorial legacy in our current democracy.

Research paper thumbnail of O Teatro Como Ferramenta De Educação Humanitária Nas Escolas Rurais De Realeza

O Grupo Cinco Liberdades levou o projeto as escolas rurais, a fim de oportunizar as criancas de a... more O Grupo Cinco Liberdades levou o projeto as escolas rurais, a fim de oportunizar as criancas de areas distantes da cidade, a experiencia da arte teatral. O teatro nao consiste apenas em uma acao de transformacao cultural, mas tambem e principalmente social. Os meios rurais acabam por nao participar ativamente nos processos de producao e criacao cultural, ficando excluidos de propostas que comumente sao desenvolvidas nas cidades. Assim, as atividades artisticas e culturais em comunidades rurais tem que lutar contra muitas dificuldades, como os escassos recursos financeiros e humanos. O objetivo desta proposta cultural foi apresentar atraves do teatro como ferramenta de educacao humanitaria, os conceitos de bem-estar animal (BEA), especialmente das cinco liberdades, aos alunos do ensino fundamental de escolas rurais de Realeza. A relacao entre homem e animais tem como norteamento o conceito das cinco liberdades: todos os animais devem ser livres de medo e estresse; livres de fome e se...

Research paper thumbnail of Um "Olhar Oposicional" Sobre o Amor: Afetividade e Sexualidade Pelo Olhar de Intelectuais Negras

WSQ: Women's Studies Quarterly, 2021

Research paper thumbnail of Neonatal Death Related to Giant Placental Chorioangioma: Case Report

Revista Brasileira de Ultrassonografia, 2020

RBUS-REVISTA BRASILEIRA DE ULTRASSONOGRAFIA | 4 REGRAS PARA PUBLICAÇÃO A revista aceitará materia... more RBUS-REVISTA BRASILEIRA DE ULTRASSONOGRAFIA | 4 REGRAS PARA PUBLICAÇÃO A revista aceitará material original para publicação no campo relacionado à ultrassonografia. A revista publicará: In press: Wyon DP. Thermal comfort during surgical operations. J Hyg Camb 20-;in press (colocar o ano atual).

Research paper thumbnail of Translational switch during integrated stress response: the examples of p53 and UPF1

The scanning model for eukaryotic mRNA translation initiation states that the small ribosomal sub... more The scanning model for eukaryotic mRNA translation initiation states that the small ribosomal subunit, along with initiation factors, binds to the cap structure at the 5’ end of the mRNA and scans the 5’ untranslated region (5’UTR) until an initiation codon is found. However, when cells are exposed to stress stimuli, cap-dependent translation is inhibited, while the synthesis of some proteins is maintained by alternative mechanisms of translation initiation, which are vital for cell survival and stress recovery. Here we show two examples in which a translational switch occurs during integrated stress response (ISR). In the first case, tumor suppressor p53, we show that the ISR leads to the specific induction of a shorter p53 isoform (Δ160p53 isoform). This induction is dependent on translation elongation but does not require the eIF4E-eIF4G interaction. Studies using bicistronic constructs with wild-type Δ160p53 or reporter genes confirmed the presence of an Internal Ribosome Entry Site (IRES) in p53 mRNA, being eIF2α phosphorylation a key event leading to cap-independent expression of Δ160p53 during ISR. Interestingly, cancer-specific mutations in p53 also enhance cap-independent translation of Δ160p53 via Δ160p53IRES. Our data support a model in which an IRES structure in the coding region of p53, and the cancer-specific mutations that affect this structure, control p53 oncogenic functions by regulating Δ160p53 protein expression. A better understanding of Δ160p53IRES structure and function may be advantageous for a more efficient therapeutic targeting of p53. Human up-frameshift 1 (UPF1) is a key-protein involved in nonsense-mediated mRNA decay, telomere replication and homeostasis, and cell cycle progression. These crucial UPF1 functions suggest its tight gene expression regulation. Indeed, our results show that UPF1 5’UTR is able to mediate cap-independent translation in a bicistronic luciferase vector expressed in cervical and colorectal cancer cell lines. Such activity is maintained under endoplasmic reticulum stress. Interestingly, we found that the UPF1 5’UTR IRES function is inhibited when the first 100 nucleotides, or the last 125, are absent or altered. Understanding these IRESs mechanism of function and their biological relevance might provide tools for developing new therapies for human diseases such as cancer.This work was supported by grants PTDC/MED-ONC/32048/2017 and PTDC/BIM-ONC/4890/2014 from the Fundação para a Ciência e a Tecnologia (FCT), by Grants-in-Aid 16K21111 and 18K07229 from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan, by Takeda Foundation and Astellas Grant, by Instituto Nacional de Saúde Doutor Ricardo Jorge, and by UIDB/04046/2020 and UIDP/04046/2020 Centre grants from FCT, Portugal (to BioISI).info:eu-repo/semantics/publishedVersio

Research paper thumbnail of Solid γ-Cyclodextrin Inclusion Compound with Gingerols, a Multi-Component Guest: Preparation, Properties and Application in Yogurt

Biomolecules, 2020

Gingerols from the rhizome of fresh ginger (Zingiber officinale) were obtained by a simple extrac... more Gingerols from the rhizome of fresh ginger (Zingiber officinale) were obtained by a simple extraction, followed by purification. The gingerols extract was composed of 6-gingerol (54%), 8-gingerol (20%), and 10-gingerol (26%). It was included into γ-cyclodextrin by classic co-dissolution procedures. Solid-state characterisation of γ-cyclodextrin·gingerols shows that this inclusion compound features 1:1 host-to-guest stoichiometry and that it is a microcrystalline powder with a crystalline cell that belongs to the tetragonal space group 4212, having the host molecules stacked in infinite channels where the gingerols are accommodated. In chimico studies with ABTS•+ scavenging, NO• scavenging, β-carotene peroxidation, and 5-LOX inhibition show that γ-cyclodextrin is a suitable carrier for gingerols, because it does not alter their reactivity towards these substances. Yogurt was tested as a matrix for the incorporation of gingerols and γ-cyclodextrin·gingerols into foodstuff. The colour ...