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Papers by Diana Bruno

Introducción: Existen reportes de que la disfunción cognitiva es altamente prevalente en paciente... more Introducción: Existen reportes de que la disfunción cognitiva es altamente prevalente en pacientes con Enfermedad Renal Crónica, generando mayor compromiso en lo que respecta a las funciones ejecutivas, memoria y lenguaje. Objetivo: Comparar el rendimiento cognitivo en cuatro pacientes que acceden a trasplante renal, para describir el perfil cognitivo asociado a la enfermedad renal. Método: Estudio exploratorio descriptivo. Se aplicó una Batería Neuropsicológica integrada por nueve pruebas, la cual fue confeccionada para evaluar diversos dominios cognitivos. La muestra estuvo conformada por 4 personas con diagnóstico de ERC en Estadio 5 (de 18, 40, 62 y 75 años) que acceden a trasplante renal. Resultados: Los sujetos evaluados presentaron un déficit significativo en aquellas pruebas que evalúan, atención, velocidad motora, fluencia verbal semántica, memoria episódica verbal, memoria semántica, memoria operativa en comparación con los valores normativos reportados para su grupo de re...

REVISTA CUADERNOS Nueva Serie, Dec 9, 2020

European Journal of Neurology, 2021

Sensory abilities decline with age, in the world there are approximately 360 million people with ... more Sensory abilities decline with age, in the world there are approximately 360 million people with hearing loss. In adults, hearing disability is associated with numerous health issues, including accelerated cognitive decline, depression, poor balance, falls, hospitalizations, and early mortality (Davis et. al., 2016). Accordingly, age-related hearing impairment is a highly frequent disorder in the elderly and, at the same time, a risk factor for dementia in older adults (Deal et. al., 2017).

Applied Neuropsychology: Adult

REVISTA CUADERNOS Nueva Serie, Dec 10, 2020

Juan, organizó un ciclo de charlas junto con profesionales de distintas áreas, destinadas a la po... more Juan, organizó un ciclo de charlas junto con profesionales de distintas áreas, destinadas a la población en general a fin de brindar información precisa sobre determinadas temáticas, con un sustento teórico suficiente para reducir el impacto que la pandemia y el aislamiento social han tenido y tienen en la población. La situación actual de pandemia, con el consecuente distanciamiento social como medida primordial para detener el contagio, ha cambiado el mundo de manera rotunda. Gran parte de la población mundial se encuentra en cuarentena o en aislamiento obligatorio, mientras las cifras de contagios y muertes en el mundo aumentan a pesar del alto porcentaje de recuperados. Si bien las medidas de distanciamiento social parecen ser las más efectivas, conllevan costos no solo a nivel económico sino también a nivel de salud mental en los distintos grupos sociales. Numerosos estudios han reportado efectos psicológicos negativos, como síntomas de ansiedad, estrés, depresión e incluso cambios cognitivos.

Anuario Digital de Investigación Educativa, 2010

Introduction: Executive Functions (EF) and social cognition (SC) have been shown to be impaired i... more Introduction: Executive Functions (EF) and social cognition (SC) have been shown to be impaired in MS. Previous morphometry studies evidenced atrophy of cortical sites in MS including the insular cortex (IC) and primary somatosensorial cortex (S1) which are crucial hubs of the salience network for bodily sensation and social cognition domains. Objective: Here we evaluate the atrophy of specific nodes of the salience network in MS and relate them to EF and SC deficits. Methods: 20 RRME patients (mean age=40.3; mean EDSS=2) were assessed with neuropsychology tests of EF (Phonological Fluency, Hayling test, INECO-Frontal-screening [IFS] and PASAT) and SC (reading the mind in the eyes, Faux Pas test) and voxel-based morphometry of white matter (WM) and gray matter (GM) of structural magnetic resonance imaging. Results: GM and WM atrophy in patients with MS involved a pattern of frontal, parietal and occipital atrophy. Phonological fluency correlated with atrophy of bilateral S1-IC (r=0....

Neurología Argentina, 2020

Resumen Introduccion El uso de cuestionarios para indagar sintomas cognitivos es frecuente, pero ... more Resumen Introduccion El uso de cuestionarios para indagar sintomas cognitivos es frecuente, pero la mayoria se circunscriben al dominio mnesico. Objetivos Explorar quejas cognitivas generales (y no solo mnesicas) en mayores de 60 anos alfabetizados que asisten a consulta medica (clinica, neurologica, psiquiatrica o neuropsicologica). El Cuestionario de Quejas Cognitivas (CQC) explora los principales sintomas por dominios cognitivos, consta de 24 items, 4 por dominio, con un formato de respuesta en escala Likert de 5 opciones. Es breve y autoadministrable. Este estudio pretende evaluar la validez y confiabilidad del CQC por medio del juicio de expertos y la evaluacion con otras medidas objetivas. Metodologia Se envio el CQC a 10 expertos en el area, que debian evaluar la relevancia, la suficiencia y la pertinencia de los items y la prueba en general, asi como su utilidad en la evaluacion de la poblacion diana. El instrumento modificado, junto con el ACE-III , se administraron a 54 personas antes del inicio de un taller de estimulacion. Resultados De los 10 expertos convocados, 7 contestaron. La consigna general obtuvo puntajes altos en suficiencia, claridad, coherencia y relevancia. La totalidad de los items obtuvieron puntuaciones altas, aunque se recomendo que se incorporen ejemplos en 3 de los items. Las puntuaciones de las evaluaciones cognitivas de las personas mayores de la muestra mostraron una matriz de dispersion analoga entre ACE-III y CQC. El CQC mostro muy buena consistencia interna. Discusion El CQC mostro buena validez y confiabilidad. Como limitacion del presente trabajo, hay que considerar que se ha realizado sobre una muestra poblacional sesgada. Futuros estudios deberan correlacionar con pruebas neuropsicologicas y proporcionar valores normativos.

Neurology, 2012

Several studies have reported that about 65 % of patients with relapsing-remitting multiple scler... more Several studies have reported that about 65 % of patients with relapsing-remitting multiple sclerosis (RRMS) suffer from cognitive impairment, with executive dysfunction being the most frequently described. Even if several executive screening tests have been designed to specifically detect executive deficits, few studies have investigated their ability to tackle such dysfunction particularly in multiple sclerosis (MS). The aim of the present study was to evaluate the sensitivity and specificity of the INECO frontal screening (IFS) in the detection of executive dysfunction in patients with relapsing-remitting MS (RRMS). 54 patients with RRMS were included in the study. 34 presented executive dysfunction while 20 did not. 32 control subjects matched for age, sex, and educational level were also included. All were evaluated with the IFS and with a battery of classical executive tests. A patient was considered to have executive dysfunction if he/she scored a one and a half standard deviation below the control mean in at least one of the classical executive tests. Sensitivity and specificity of the IFS in its ability to detect executive dysfunction in MS was analyzed. Using a cutoff of 25.5 points, sensitivity of the IFS was 73.53 %, and specificity 78.13 % in differentiating controls from MS patients with executive dysfunction. The IFS showed excellent concurrent validity with executive tasks. The IFS can be considered a brief, easy-to-administer, cost-less tool for the detection of executive dysfunction in patients with RRMS.

Supplemental material, MSJ888881_supplemental_material for Fatigue in multiple sclerosis is assoc... more Supplemental material, MSJ888881_supplemental_material for Fatigue in multiple sclerosis is associated with multimodal interoceptive abnormalities by Cecilia Gonzalez Campo, Paula C Salamone, Nicolás Rodríguez-Arriagada, Fabian Richter, Eduar Herrera, Diana Bruno, Fátima Pagani Cassara, Vladimiro Sinay, Adolfo M García, Agustín Ibáñez and Lucas Sedeño in Multiple Sclerosis Journal

The relationship between executive functions and fluid

Neurology, 2016

Introduction and Objectives: In recent years, research has reported that at least 65[percnt] of M... more Introduction and Objectives: In recent years, research has reported that at least 65[percnt] of MS patients have cognitive deficits, the most prominent being those associated with frontal lobe. Within these deficits is the ability to infer feelings and thoughts of others (theory of mind). In other research, some authors have suggested that such capacity requires a basic skill that would be the ability to change perspective (a relationship analogous to the relationship between attention and memory). The aim of this study is to evaluate the ability to change perspective in patients with relapsing-remitting multiple sclerosis and determine whether there is any relationship between this and the theory of mind. Methodology: 34 RRMS patients and 39 controls matched for age, sex and educational level were included. Both groups were administered a test designed to assess the ability to change perspective in three domains: personal, temporal and visual. They were also assessed with a battery...

Objective: To evaluate the heartbeat evoked potential (HEP) in patients with multiple sclerosis (... more Objective: To evaluate the heartbeat evoked potential (HEP) in patients with multiple sclerosis (MS) and controls. Background: The HEP is a negative modulation between 200 and 400 ms and is associated with the perception of the heartbeat (cardiac interoception). The insular cortex is one of the main areas involved in the processing of bodily signal information and of emotional awareness. Regarding MS, several studies have described atrophy of this area; however, there are no reports about whether interoceptive processing is affected or not in these patients. Methods: Thirty three patients with MS and 40 controls were evaluated with a heartbeat detection (HBD) task during which a high density electroencephalogram (hd-EEG) was registered. The HBD task consisted of one condition where subjects paid attention to an external stimulus (control condition) and a second where they followed their own heartbeats without external help (interoceptive condition). Each condition lasted five minute...

Executive dysfunction (EF) is a common feature of adult traumatic brain injury (TBI), especially ... more Executive dysfunction (EF) is a common feature of adult traumatic brain injury (TBI), especially in moderate to severe cases. Assessing EF usually requires the administration of an extensive neuropsychological battery, which is time consuming and expensive. The INECO frontal screening (IFS) is a brief, easy-to-administer screening test which has previously shown to be useful in the detection of executive deficits in different psychiatric and neurological populations. The aim of the present study was to assess the usefulness of the IFS in the detection of executive dysfunction in TBI patients. Twenty-eight TBI patients and thirty-two healthy controls were assessed with a battery that included classical executive tests and the IFS. Our results indicated that with a cutoff score of 26.25 points, the IFS showed good sensitivity and specificity in the detection of executive impairments in TBI patients. It also showed good positive and negative predicted values. Our results suggest that t...

Neuropsychiatric Disease and Treatment, 2019