Bryar Nuradeen - Academia.edu (original) (raw)

Papers by Bryar Nuradeen

Cerebrospinal Fluid Research, Dec 1, 2007

International journal of clinical medicine, 2014

Background: Helicobacter pylori (H. pylori) infection has been suggested to be associated with at... more Background: Helicobacter pylori (H. pylori) infection has been suggested to be associated with atherosclerosis. The issue is still controversial. It is well known that abnormal lipid profile is related to atherosclerosis and measurement of carotid intima-media thickness. Aim of the study: to investigate carotid intima-media thickness and lipid parameters in H. pylori-positive and-negative subjects. Materials & Methods: This study was conducted in Kurdistan Teaching center of Gastroenterology and Hepatology (KCGH) in Sulaimani city during the period of December 2012 to March 2014. One hundred dyspeptic patients with H. pylori infection and 74 apparently healthy asymptomatic volunteers with H. pylori-negative tests were enrolled in this study. Both groups were comparable in age distribution and gender. H. pylori infection (IgG & IgA) were assessed by ELISA tests, Triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) concentrations were measured by routine enzymatic methods using commercial kits. Carotid intima-media thickness was assessed by high-resolution ultrasound. Results: The mean and maximum values of internal and common carotid intima-media thickness in H. pylori-positive subjects were significantly thicker than in H. pylori-negative subjects (p < 0.05). HDL-C level was lower in patients (H. pylori seropositive) than in controls (seronegative subjects), total cholesterol, LDL-C and triglyceride level were found to be higher in patients than in controls (p < 0.01). Conclusions: Carotid intima-media thickness as well as all lipid values apart from HDL-C was increased in H. pylori-positive subjects. These data indicated that H.

Journal of Biomedical Materials Research Part A, Jun 1, 2007

Propionibacterium acnes is found increasingly as a cause of delayed infection, usually involving ... more Propionibacterium acnes is found increasingly as a cause of delayed infection, usually involving implanted biomaterials. Despite susceptibility to common antibiotics, such infections are very difficult to treat and usually require surgical removal of the device. Three clinical isolates of P. acnes were assessed for ability to adhere to titanium, surgical steel and silicone, with and without a plasma conditioning film. After adherence, the biomaterials were then incubated for a further 6 days and examined for biofilm development. All three isolates adhered to all three biomaterials similarly. Importantly, we were able to demonstrate biofilm formation, including production of exopolymer similar in appearance to the polysaccharide intercellular adhesin of Staphylococcus epidermidis. A case summary also demonstrated failure to eradicate P. acnes infection in a hydrocephalus shunt after prolonged treatment. The removed shunt showed obvious biofilm formation, initially obscured by exopolymer when viewed by environmental scanning electron microscopy. Biofilm development by P. acnes explains the difficulties encountered in clinical management of such infections. 2006 Wiley Periodicals, Inc.

F. hepatica were positive for five, borderline for one, and negative for two patients. These eigh... more F. hepatica were positive for five, borderline for one, and negative for two patients. These eight patients were

$Research paper thumbnail of Severe refractory COVID-19 patients responding to convalescent plasma; A case series$

Annals of Medicine and Surgery, 2020

Introduction: Although some medicines are under research, currently, no specific antiviral drug h... more Introduction: Although some medicines are under research, currently, no specific antiviral drug has been approved to target 2019 novel coronavirus. In this report two severe cases of 2019 novel coronavirus disease (COVID-19) patients have been described who received convalescent plasma (CP). Case report: Two male cases (a 46-year-old and a 56-year-old) after being diagnosed with severe COVID-19, they deteriorated despite supportive care and antiviral therapy. They started to improve with CP infusion both clinically and radiologically. Finally they were discharged in a very well condition with negative virology tests. Conclusion: CP might be an effective therapy for severe COVID-19 patients.

Journal of Sulaimani Medical College, 2018

Journal of Zankoy Sulaimani - Part A, 2015

Nephrology Dialysis Transplantation, 1999

Key words: gastrin; haemodialysis; helicobacter pylori Background. Helicobacter pylori infection ... more Key words: gastrin; haemodialysis; helicobacter pylori Background. Helicobacter pylori infection is associated with increased gastrin release in patients with normal renal function. Hypergastrinaemia is a common finding

Clinical Microbiology and Infection, 2009

Propionibacterium acnes is a common and probably underestimated cause of delayed joint prosthesis... more Propionibacterium acnes is a common and probably underestimated cause of delayed joint prosthesis infection. Bacterial biofilm formation is central in the pathogenesis of infections related to foreign material, and P. acnes has been shown to form biofilm both in vitro and in vivo. Here, biofilm formation by 93 P. acnes isolates, either from invasive infections (n = 45) or from the skin of healthy people (n = 48), was analysed. The majority of isolates from deep infections produced biofilm in a microtitre model of biofilm formation, whereas the skin isolates were poor biofilm producers (p <0.001 for a difference). This indicates a role for biofilm formation in P. acnes virulence. The type distribution, as determined by sequencing of recA, was similar among isolates isolated from skin and from deep infections, demonstrating that P. acnes isolates with different genetic backgrounds have pathogenic potential. The biofilm formed on plastic and on bone cement was analysed by scanning electron microscopy (EM) and by transmission EM. The biofilm was seen as a 10-lm-thick layer covering the bacteria and was composed of filamentous as well as more amorphous structures. Interestingly, the presence of human plasma in solution or at the plastic surface inhibits biofilm formation, which could explain why P. acnes primarily infect plasma-poor environments of, for example, joint prostheses and cerebrospinal shunts. This work underlines the importance of biofilm formation in P. acnes pathogenesis, and shows that biofilm formation should be considered in the diagnosis and treatment of invasive P. acnes infections.

BMC Infectious Diseases, 2013

Background Deep eosinophilic granulomatous abscesses, as distinguished from eosinophilic subcutan... more Background Deep eosinophilic granulomatous abscesses, as distinguished from eosinophilic subcutaneous abscesses, are rare. Most reports are from the Far-East and India where the most commonly attributed cause is Toxocara. Sulaimaniyah in Northeastern Iraq has experienced an outbreak of eosinophilic granulomatous liver and gastrointestinal (GI) abscesses beginning in 2009. The purpose of this study was to determine the etiology and guide treatment. Methods The study was an ongoing investigation of patients having a histopathologic diagnosis of eosinophilic granulomatous abdominal abscesses in Sulaimaniyah hospitals from May 2009 to August 2012. Tissues were examined for organisms, and Enzyme Linked Immunoabsorbent Assays (ELISA) were performed for serum antibodies to Fasciola hepatica, Toxocara, and Echinococcus granulosus. Results Fourteen patients had granulomatous inflammation surrounding a central necrotizing eosinophilic exudate identified in surgical pathology specimens from ab...

Journal of Antimicrobial Chemotherapy, 2007

Propionibacterium acnes is increasingly recognized as a cause of delayed infection after spinal i... more Propionibacterium acnes is increasingly recognized as a cause of delayed infection after spinal instrumentation or shunting for hydrocephalus. Biofilm development by this organism has recently been demonstrated. We therefore investigated the effect of two different courses of three antibiotics (penicillin, rifampicin and linezolid) on mature P. acnes biofilms in vitro. Outcomes were eradication or regrowth after withdrawal of antibiotics, simulating successful treatment and relapse. Methods: P. acnes biofilms were grown on titanium discs for 6 days until mature, then exposed to the antibiotics for either 7 or 14 days before sonication and culture. Further, discs were similarly exposed, but after each course, they were reincubated for a further 9 days to check for regrowth. Results: Penicillin, linezolid and linezolid plus rifampicin eradicated P. acnes biofilms after 14 days, but only penicillin had this effect after 7 days. 'Relapse' was prevented only by 14 day courses of penicillin or linezolid plus rifampicin, but not by linezolid alone. Conclusions: For P. acnes spinal instrumentation infections, either penicillin or linezolid plus rifampicin might be equally effective. For shunt infections, as penicillin does not give therapeutic cerebrospinal fluid concentrations, rifampicin plus linezolid might be the treatment of choice. Linezolid alone appears not to be as effective as penicillin against P. acnes biofilms.