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Revista da Sociedade Brasileira de Medicina Tropical

Histoid leprosy is an uncommon form of lepromatous leprosy with distinct clinical, histopathologi... more Histoid leprosy is an uncommon form of lepromatous leprosy with distinct clinical, histopathological, immunological, and bacteriological features. This variant usually occurs in multibacillary patients who have irregular or inadequate treatment. Herein, we report a case of de novo histoid leprosy diagnosed in a patient from Cali, Colombia. In endemic areas, histoid leprosy should be in the differential diagnosis of any patient presenting with skin nodules. Early diagnosis and appropriate treatment are recommended for mitigating the impact of histoid leprosy cases, which are important reservoirs of Mycobacterium leprae.

A 40-year-old woman living in the countryside near Cali, Colombia, presented with exacerbation of... more A 40-year-old woman living in the countryside near Cali, Colombia, presented with exacerbation of papules located on her face and neck and an ulcer located on the left retroauricular area of 2 weeks' duration. She stated that her skin lesions appeared erratically, beginning at 13 years of age and that her father and daughter had similar skin lesions. Physical examination revealed multiple erythematous, hyperkeratotic papules, and yellowish brown crusts that coalesced to plaques located on symmetrical areas of the forehead, neck, and periauricular areas with excoriation and malodor (Figure 1a and 1b). There were flat-topped papules on the dorsal aspect of her hands. The fingernails exhibited subungual hyperkeratotic fragments, V-shaped notches at the free edges of some nails, distal onycholysis, and white longitudinal bands (Figure 1c). We also discovered a foul-smelling left retroauricular cavity, approximately 3 cm in length and 3 cm in depth, with multiple fly larvae inside of it (Figure 2). We made the diagnosis of retroauricular myiasis and obtained skin biopsy specimens from her forehead and scalp, to confirm the presumptive diagnosis of Darier disease.

No se reportan conflictos de intereses.

The eccrine poroma or Hidracanthoma Simplex is a rare benign adnexal tumor of ephitelial cells, w... more The eccrine poroma or Hidracanthoma Simplex is a rare benign adnexal tumor of ephitelial cells, with an incidence of 0.001 to 0.008%1. In two thirds of the patients it appears on the soles and lateral borders of the feet. We report the case of a patient with pigmented eccrine poroma in abdominal skin, of a rare entity presentation with a single report in the literature in that location.

REVISTA COLOMBIANA …, 2006

Paciente de sexo masculino de 23 años con síntomas de una semana de evolución de cambios en el co... more Paciente de sexo masculino de 23 años con síntomas de una semana de evolución de cambios en el comportamiento, y seis meses de pérdida de peso, eritema malar y palpebral, úlceras orales, se le detecta anticuerpos antinucleares (ANAS) positivos, planteándose como diagnóstico, lupus eritematoso sistémico (LES). El paciente permanece controlado durante tres años; al cabo de los cuales aparecen lesiones cutáneas ulceradas y necróticas en el tronco, acompañado de anticuerpos antifosfolípidos positivos, hallazgos que nos permiten diagnosticar síndrome antifosfolípido (SAF) secundario a LES. Se considera el caso interesante por su escasa ocurrencia en el sexo masculino y por su severidad probablemente relacionada con la asociación LES y SAF. Palabras clave: lupus eritematoso sistémico, síndrome antifosfolípido, anticoagulante lúpico. Summary A 23 years old man, with 1 week of changes in the behavior, and six months of lost of weight, erythema malar, palpebral, oral ulcers, with antinuclear antibodies positive, and complement low, with this is considered the diagnosis of systemic erythematosus lupus (SLE). The patient remains controlled during three years; when he begins necrotic cutaneous ulcers in the trunk, accompanied by antiphospholipid antibodies.

The HTLV-1 is a neurotropic and lymphotropic virus endemic in several countries, considered the e... more The HTLV-1 is a neurotropic and lymphotropic virus endemic in several countries, considered the etiological agent of tropical spastic paraparesis/HTLV-1 associated myelopathy (PET/MAH) and the adult T-cell leukemia/lymphoma (ATL). It is associated with various cutaneous and systemic manifestations such as polymyositis, pulmonary alveolitis, uveitis, Sjögren syndrome, arthropathy, strongyloidiasis, cryoglobulinemia, and monoclonal gammopathy among others that produce significant morbidity in infected.

Revista da Sociedade Brasileira de Medicina Tropical

2016 1 , which describes an unusual case of histoid leprosy in an adult male from Cali, Colombia,... more 2016 1 , which describes an unusual case of histoid leprosy in an adult male from Cali, Colombia, who did not exhibit previous clinical signs or treatment of the disease. While we appreciate and agree with their observations, we would like to provide some information about the management and diagnosis of leprosy in general and specifically in Colombia.

Palma en tripa en paciente con carcinoma pulmonar metastásico

Vitiligo en niños: Enfoque clínico , 2018

El vitíligo es una enfermedad despigmentante que afecta entre el 1 y el 2 % de la población mundi... more El vitíligo es una enfermedad despigmentante que afecta entre el 1 y el 2 % de la población mundial y cerca de la mitad de los casos se inician en la infancia. Los estudios de prevalencia en diferentes poblaciones de niños, adolescentes y adultos, muestran porcentajes similares en diferentes países del mundo.

Linfoma de células T del adulto asociado con HTLV-1 con infiltración en piel Resumen La leucemia/... more Linfoma de células T del adulto asociado con HTLV-1 con infiltración en piel Resumen La leucemia/linfoma de células T del adulto (ATLL por sus siglas en inglés) es una neoplasia de linfocitos T CD4 maduros causada por el virus linfotrópico de células T humanas (HTLV-1) con múltiples manifestaciones sistémicas y cutáneas. Se comunica el caso de una paciente con linfoma de células T por HTLV-1, pro-veniente de área endémica con afectación cutánea, confirmado por histología e inmunohistoquímica. PALABRAS CLAVE: Leucemia/linfoma de células T del adulto; ATLL; virus linfotrópico de células T humanas tipo 1; HTLV-1. Abstract Adult T-cell leukemia/lymphoma (ATLL) is a mature CD4 T lymphocyte neoplasm caused by human T-lymphotropic virus type-1 (HTLV-1) with multiple systemic and cutaneous manifestations. We present the case of a woman with HTLV-1 T-cell lym-phoma from an endemic area with cutaneous involvement confirmed by histology and immunohistochemistry.

Artículo de revisión RESUMEN El vitíligo es una enfermedad despigmentante que afecta entre el 1 y... more Artículo de revisión RESUMEN El vitíligo es una enfermedad despigmentante que afecta entre el 1 y el 2 % de la población mundial y cerca de la mitad de los casos se inician en la infancia. Los estudios de prevalencia en diferentes poblaciones de niños, adolescentes y adultos, muestran porcentajes similares en diferentes países del mundo. Hasta el momento, existen pocos estudios de seguimiento a largo plazo sobre el tratamiento en niños; la mayoría de las publicaciones se enfocan en conceptos preexistentes que son básicos en el estudio y la aproximación terapéutica del pa-ciente pediátrico con vitíligo. En esta revisión, se resumen la clasificación, las generalidades, las enfermedades asociadas al vitíligo segmentario y no segmentario, las alteraciones psicológicas que presentan los niños afectados por esta condición y sus padres, y el trata-miento, con énfasis en la 'evidencia' clínica sobre los medicamentos más usados. SUMMARY Vitiligo is a depigmenting disease that affects between 1 and 2% of the world population and about half of the cases begin in childhood. The prevalence studies in different populations in children, adolescents and adults show similar percentages in different countries of the world. So far, there are few long-term follow-up studies regarding treatment in children. Most of the publications focus on preexisting concepts that are basic in the study and in the therapeutic approach of the pediatric patient with vitiligo. In this review, we summarize its classification, generalities, diseases associated with segmental and non-segmental vitiligo, the psychological alterations presented by children affected by this condition and their parents, and the treatment emphasizing the clinical evidence of the most commonly used medications.

Revista da Sociedade Brasileira de Medicina Tropical

Histoid leprosy is an uncommon form of lepromatous leprosy with distinct clinical, histopathologi... more Histoid leprosy is an uncommon form of lepromatous leprosy with distinct clinical, histopathological, immunological, and bacteriological features. This variant usually occurs in multibacillary patients who have irregular or inadequate treatment. Herein, we report a case of de novo histoid leprosy diagnosed in a patient from Cali, Colombia. In endemic areas, histoid leprosy should be in the differential diagnosis of any patient presenting with skin nodules. Early diagnosis and appropriate treatment are recommended for mitigating the impact of histoid leprosy cases, which are important reservoirs of Mycobacterium leprae.

A 40-year-old woman living in the countryside near Cali, Colombia, presented with exacerbation of... more A 40-year-old woman living in the countryside near Cali, Colombia, presented with exacerbation of papules located on her face and neck and an ulcer located on the left retroauricular area of 2 weeks' duration. She stated that her skin lesions appeared erratically, beginning at 13 years of age and that her father and daughter had similar skin lesions. Physical examination revealed multiple erythematous, hyperkeratotic papules, and yellowish brown crusts that coalesced to plaques located on symmetrical areas of the forehead, neck, and periauricular areas with excoriation and malodor (Figure 1a and 1b). There were flat-topped papules on the dorsal aspect of her hands. The fingernails exhibited subungual hyperkeratotic fragments, V-shaped notches at the free edges of some nails, distal onycholysis, and white longitudinal bands (Figure 1c). We also discovered a foul-smelling left retroauricular cavity, approximately 3 cm in length and 3 cm in depth, with multiple fly larvae inside of it (Figure 2). We made the diagnosis of retroauricular myiasis and obtained skin biopsy specimens from her forehead and scalp, to confirm the presumptive diagnosis of Darier disease.

No se reportan conflictos de intereses.

The eccrine poroma or Hidracanthoma Simplex is a rare benign adnexal tumor of ephitelial cells, w... more The eccrine poroma or Hidracanthoma Simplex is a rare benign adnexal tumor of ephitelial cells, with an incidence of 0.001 to 0.008%1. In two thirds of the patients it appears on the soles and lateral borders of the feet. We report the case of a patient with pigmented eccrine poroma in abdominal skin, of a rare entity presentation with a single report in the literature in that location.

REVISTA COLOMBIANA …, 2006

Paciente de sexo masculino de 23 años con síntomas de una semana de evolución de cambios en el co... more Paciente de sexo masculino de 23 años con síntomas de una semana de evolución de cambios en el comportamiento, y seis meses de pérdida de peso, eritema malar y palpebral, úlceras orales, se le detecta anticuerpos antinucleares (ANAS) positivos, planteándose como diagnóstico, lupus eritematoso sistémico (LES). El paciente permanece controlado durante tres años; al cabo de los cuales aparecen lesiones cutáneas ulceradas y necróticas en el tronco, acompañado de anticuerpos antifosfolípidos positivos, hallazgos que nos permiten diagnosticar síndrome antifosfolípido (SAF) secundario a LES. Se considera el caso interesante por su escasa ocurrencia en el sexo masculino y por su severidad probablemente relacionada con la asociación LES y SAF. Palabras clave: lupus eritematoso sistémico, síndrome antifosfolípido, anticoagulante lúpico. Summary A 23 years old man, with 1 week of changes in the behavior, and six months of lost of weight, erythema malar, palpebral, oral ulcers, with antinuclear antibodies positive, and complement low, with this is considered the diagnosis of systemic erythematosus lupus (SLE). The patient remains controlled during three years; when he begins necrotic cutaneous ulcers in the trunk, accompanied by antiphospholipid antibodies.

The HTLV-1 is a neurotropic and lymphotropic virus endemic in several countries, considered the e... more The HTLV-1 is a neurotropic and lymphotropic virus endemic in several countries, considered the etiological agent of tropical spastic paraparesis/HTLV-1 associated myelopathy (PET/MAH) and the adult T-cell leukemia/lymphoma (ATL). It is associated with various cutaneous and systemic manifestations such as polymyositis, pulmonary alveolitis, uveitis, Sjögren syndrome, arthropathy, strongyloidiasis, cryoglobulinemia, and monoclonal gammopathy among others that produce significant morbidity in infected.

Revista da Sociedade Brasileira de Medicina Tropical

2016 1 , which describes an unusual case of histoid leprosy in an adult male from Cali, Colombia,... more 2016 1 , which describes an unusual case of histoid leprosy in an adult male from Cali, Colombia, who did not exhibit previous clinical signs or treatment of the disease. While we appreciate and agree with their observations, we would like to provide some information about the management and diagnosis of leprosy in general and specifically in Colombia.

Palma en tripa en paciente con carcinoma pulmonar metastásico

Vitiligo en niños: Enfoque clínico , 2018

El vitíligo es una enfermedad despigmentante que afecta entre el 1 y el 2 % de la población mundi... more El vitíligo es una enfermedad despigmentante que afecta entre el 1 y el 2 % de la población mundial y cerca de la mitad de los casos se inician en la infancia. Los estudios de prevalencia en diferentes poblaciones de niños, adolescentes y adultos, muestran porcentajes similares en diferentes países del mundo.

Linfoma de células T del adulto asociado con HTLV-1 con infiltración en piel Resumen La leucemia/... more Linfoma de células T del adulto asociado con HTLV-1 con infiltración en piel Resumen La leucemia/linfoma de células T del adulto (ATLL por sus siglas en inglés) es una neoplasia de linfocitos T CD4 maduros causada por el virus linfotrópico de células T humanas (HTLV-1) con múltiples manifestaciones sistémicas y cutáneas. Se comunica el caso de una paciente con linfoma de células T por HTLV-1, pro-veniente de área endémica con afectación cutánea, confirmado por histología e inmunohistoquímica. PALABRAS CLAVE: Leucemia/linfoma de células T del adulto; ATLL; virus linfotrópico de células T humanas tipo 1; HTLV-1. Abstract Adult T-cell leukemia/lymphoma (ATLL) is a mature CD4 T lymphocyte neoplasm caused by human T-lymphotropic virus type-1 (HTLV-1) with multiple systemic and cutaneous manifestations. We present the case of a woman with HTLV-1 T-cell lym-phoma from an endemic area with cutaneous involvement confirmed by histology and immunohistochemistry.

Artículo de revisión RESUMEN El vitíligo es una enfermedad despigmentante que afecta entre el 1 y... more Artículo de revisión RESUMEN El vitíligo es una enfermedad despigmentante que afecta entre el 1 y el 2 % de la población mundial y cerca de la mitad de los casos se inician en la infancia. Los estudios de prevalencia en diferentes poblaciones de niños, adolescentes y adultos, muestran porcentajes similares en diferentes países del mundo. Hasta el momento, existen pocos estudios de seguimiento a largo plazo sobre el tratamiento en niños; la mayoría de las publicaciones se enfocan en conceptos preexistentes que son básicos en el estudio y la aproximación terapéutica del pa-ciente pediátrico con vitíligo. En esta revisión, se resumen la clasificación, las generalidades, las enfermedades asociadas al vitíligo segmentario y no segmentario, las alteraciones psicológicas que presentan los niños afectados por esta condición y sus padres, y el trata-miento, con énfasis en la 'evidencia' clínica sobre los medicamentos más usados. SUMMARY Vitiligo is a depigmenting disease that affects between 1 and 2% of the world population and about half of the cases begin in childhood. The prevalence studies in different populations in children, adolescents and adults show similar percentages in different countries of the world. So far, there are few long-term follow-up studies regarding treatment in children. Most of the publications focus on preexisting concepts that are basic in the study and in the therapeutic approach of the pediatric patient with vitiligo. In this review, we summarize its classification, generalities, diseases associated with segmental and non-segmental vitiligo, the psychological alterations presented by children affected by this condition and their parents, and the treatment emphasizing the clinical evidence of the most commonly used medications.