Claudia Weilg - Academia.edu (original) (raw)

Papers by Claudia Weilg

Asian Pacific Journal of Tropical Medicine, Dec 1, 2015

All in-text references underlined in blue are linked to publications on ResearchGate, letting you... more All in-text references underlined in blue are linked to publications on ResearchGate, letting you access and read them immediately.

Description and susceptibility of periodontopathic bacteria with severe chronic periodon... more Description and susceptibility of periodontopathic bacteria with severe chronic periodontitis among a group of Peruvian patients: A pilot study ABSTRACT Background: Severe periodontal disease is highly prevalent worldwide, affecting 20 % of the population between the ages of 35 and 44 years old. The etiological epidemiology in Peru is scarce, even though some studies describe a prevalence of 48.5 % of periodontal disease in the general population. Periodontitis is one of the most prevalent oral diseases associated with site-specific changes in the oral microbiota and it has been associated to socioeconomic state. This study aimed to determine the etiology and resistance profile of bacteria identified in a group of patients with chronic severe periodontitis. Methods: Six subgingival plaque samples were collected from eight patients with chronic severe periodontitis. Bacterial identification was carried out by an initial culture, PCR amplification and subsequently DNA sequencing. We evaluated the antibiotic susceptibility by disk diffusion method. Results: Variable diversity in oral microbiota was identified in each one the eight patients. The bacterial genus most frequently found was Streptococcus spp. (15/48, 31.3 %) followed by Rothia spp. (11/48, 22.9 %), Actinomyces spp. (9/48, 18.8 %), and Eikenella spp. (4/48, 8.3 %). The most common species found was Rothia dentocariosa (8/48, 16.7 %). The antimicrobial susceptibility assay varied according to the species tested, however, among all the isolates evaluated Actinomyces naeslundii was resistant to penicillin and tetracycline; Eikenella corrodens resistant to dicloxacillin; and Rothia dentocariosa was resistant to amoxicillin + clavulanic acid and metronidazole but also susceptible to trimethoprim-sulfamethoxazole. Conclusions: Bacterial species of importance medical were detected in patients with chronic severe periodontitis, especially Rothia dentocari [...]

First outbreak of Oropouche Fever reported in a non-endemic central-western region of th... more First outbreak of Oropouche Fever reported in a non-endemic central-western region of the Peruvian Amazon. Molecular diagnosis and clinical characteristics. Introduction: Oropouche virus (OROV) is an underreported and emerging infectious disease. Its incidence is underestimated mainly due to clinical similarities with other diseases that are also caused by arboviruses present in endemic areas. We report the first outbreak of OROV in the western region of the Peruvian Amazon in the department of Huanuco, Peru. Methods: This outbreak occurred in the region of Huanuco, Peru during July of 2016. Blood samples were taken from 268 patients who presented acute febrile syndrome to be later analyzed for Oropouche Virus via Polymerase Chain Reaction.Results: Of all 268 patients, 46 (17%) cases tested were positive for OROV. the most common symptom reported was headaches with a frequency of 87% (n=40) followed by myalgias with 76% (n=35), arthralgias with 65.2% (n=30), retro-ocular pain 60.8% (n=28) and hyporexia with 50% (n=23). Concerning signs and symptoms that may suggest severe OROV infection, 4.3% (n=2) had low platelet count, 8.6% (n=4) had intense abdominal pain, and only 2.1% (n=1) had a presentation with thoracic pain

Background: Human Metapneumovirus (hMPV) is a negative single-stranded RNA virus. Infection by hM... more Background: Human Metapneumovirus (hMPV) is a negative single-stranded RNA virus. Infection by hMPV mainly affects the pediatric population and can cause upper or lower respiratory tract pathologies which can develop life threating complications. This study was carried out between 2009 and 2010 in a high complexity national hospital in Lima, Peru. The time frame corresponds to the pandemic of influenza A H1N1. Methods: RT-PCR was utilized to attain the amplification and identification of the virus.Results: A total of 539 samples were analized from patients with a clinical context suggestive of an acute respiratory tract infection. Of these samples 73 (13.54%) were positive for hMPV. Out of the positive cases, 63% were under 1 year old, and increased to nearly 80% when considering children younger than 2 years old. Cough was the most frequent symptom presented by our population with a number of 62 cases (84.93%). Viral seasonality was also established, noting its predominance during ...

Background Severe periodontal disease is highly prevalent worldwide, affecting 20% of the populat... more Background Severe periodontal disease is highly prevalent worldwide, affecting 20% of the population between the ages of 35 and 44 years. The etiological epidemiology in Peru is scarce, even though some studies describe a prevalence of 48.5% of periodontal disease in the general population. Periodontitis is one of the most prevalent oral diseases associated with site-specific changes in the oral microbiota and it has been associated with a socioeconomic state. This study aimed to determine the etiology and resistance profile of bacteria identified in a group of Peruvian patients with periodontal disease. Methods Six subgingival plaque samples were collected from eight patients with severe periodontitis. Bacterial identification was carried out by an initial culture, PCR amplification, and subsequently DNA sequencing. We evaluated the antibiotic susceptibility by the disk diffusion method. Results Variable diversity in oral microbiota was identified in each one of the eight patients....

PeerJ, 2019

Background Human Metapneumovirus (hMPV) is a negative single-stranded RNA virus. Infection by hMP... more Background Human Metapneumovirus (hMPV) is a negative single-stranded RNA virus. Infection by hMPV mainly affects the pediatric population and can cause upper or lower respiratory tract pathologies which can develop life threating complications. This study was carried out between 2009 and 2010 in a high complexity national hospital in Lima, Peru. The time frame corresponds to the pandemic of influenza A H1N1. Methods A prospective study was performed between September 2009 and September 2010. Patients with a clinical diagnosis suggestive of an acute respiratory infection were included. RT-PCR was utilized to attain the amplification and identification of the hMPV. Results A total of 539 samples were analyzed from patients with a clinical context suggestive of an acute respiratory tract infection. Of these samples 73, (13.54%) were positive for hMPV. Out of the positive cases, 63% were under one year old, and increased to nearly 80% when considering children younger than two years ol...

International Journal of Infectious Diseases, 2019

Background: Huánuco is a central eastern region of Peru whose geography includes high forest and ... more Background: Huánuco is a central eastern region of Peru whose geography includes high forest and low jungle, as well as a mountain range that constitutes the inter-Andean valleys. It is considered a region endemic for dengue due to the many favorable conditions that facilitate transmission of the virus. Methods: A total of 268 serum samples from patients in Huánuco, Peru with an acute febrile illness were assessed for the presence of dengue virus (DENV) via RT-PCR and NS1, IgM, and IgG ELISA during December 2015 and March 2016. Results: DENV was detected in 25% of samples via RT-PCR, 19% of samples by NS1 antigen ELISA, and 10.5% of samples by IgM ELISA. DENV IgG was detected in 15.7% of samples by ELISA. The most frequent symptoms associated with fever across all groups were headache, myalgia, and arthralgia, with no significant difference between the four test methods Conclusions: In this study, DENV was identified in up to 25% of the samples using the standard laboratory method. In addition, a correlation was established between the frequency of positive results and the serological tests that determine NS1, IgM, and IgG. There is an increasing need for point-of-care tests to strengthen epidemiological surveillance in Peru.

BMC research notes, 2017

This study investigated an outbreak of Bartonellosis in a coastal region in Peru. A total of 70 (... more This study investigated an outbreak of Bartonellosis in a coastal region in Peru. A total of 70 (n = 70) samples with clinical criteria for the acute phase of Bartonellosis and a positive peripheral blood smear were included. 22.85% (n = 16) cases of the samples were positive for Bartonella bacilliformis by PCR and automatic sequencing. Of those positive samples, 62.5% (n = 10) cases were positive only for B. bacilliformis and 37.5% (n = 6) cases were positive to both Mycobacterium spp. and B. bacilliformis. The symptom frequencies were similar in patients diagnosed with Carrion's disease and those co-infected with Mycobacterium spp. The most common symptoms were headaches, followed by malaise and arthralgia.

Asian Pacific Journal of Tropical Medicine, 2016

European Journal of Applied Physiology, 2011

An 11 year old, hispanic girl with a history of B-cell acute lymphoblastic leukemia was admitted ... more An 11 year old, hispanic girl with a history of B-cell acute lymphoblastic leukemia was admitted to the hospital for symptoms compatible with Bartonella henselae infection. The first molecularly diagnosed case of disseminated Bartonella henselae infection was reported in an immunocompromised patient in Lima, Peru. The analysis was confirmed by Polymerase Chain Reaction and automated sequencing of a liver biopsy sample, even though the serologic tests were negative. In conclusion, Bartonella spp. infection should have a particular diagnostic consideration in immunocompromised patients with fever of unknown origin and further investigation regarding the patient's past exposures with cats should also be elicited.

Asian Pacific Journal of Tropical Medicine, Dec 1, 2015

PeerJ, 2019

International Journal of Infectious Diseases, 2019

BMC research notes, 2017

Asian Pacific Journal of Tropical Medicine, 2016

European Journal of Applied Physiology, 2011