Calin Andritoiu - Academia.edu (original) (raw)
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Papers by Calin Andritoiu
Annals of the Romanian Society for Cell Biology
The composition of the immune infiltrate in breast tumors can be associated with improved prognos... more The composition of the immune infiltrate in breast tumors can be associated with improved prognosis and leading to the enhanced survival of cancer patients, but there are studies where inflammatory cells have been described to assist the tumor’s capabilities to progress, proliferate, and metastasize. In breast cancer’s immune infiltrate, all inflammatory cells can be found. We have identified subsets of lymphocytes, which are able to control the local immunity. The determination of lymphocytary populations and histopathology of the tumor is able to define some particularities of the tumor. Our experiments were performed using the flow-cytometer from Department of Immunology Iasi. Flow-cytometry on cellular suspensions shows the presence of lymphocytic infiltrate and a considerable concentration of helper T cells and cytotoxic T cells. Lymphocytes B have an uncertain role in tumor’s evolution. The levels of T cells were increased in the tumor areas where a high grade of morphological...
European Journal of Internal Medicine, 2011
International Journal of Biological Macromolecules, 2015
ABSTRACT Flaxseed lignans are a natural source of useful biologically active components that show... more ABSTRACT Flaxseed lignans are a natural source of useful biologically active components that show a diverse spectrum of health-promoting properties. The valuable effects of the phenolic molecules are mainly due to their antioxidant activity by preventing oxidative stress and stimulate collagen synthesis, therefore, providing benefits to the skin. The present work highlights the development of flaxseed extract formulation as novel wound healing agent. The recognition of key structural features within flaxseed extract was crucial for the design and development of the therapeutic cream. Chromatographic analyses were employed for bioactive compounds identification and quantification. Folin-Ciocalteu method determined the total phenolic content and the antioxidant properties were evaluated by DPPH assay. The storage and loss modulus and tan δ were calculated for cream rheological properties evaluation. In vitro diffusion capacity and in vivo wound healing activity of phenolic cream were evaluated on Wistar rats. The collective properties and healing effect of the flaxseed suggested wound healing capacity.
Annals of the Romanian Society for Cell Biology
The composition of the immune infiltrate in breast tumors can be associated with improved prognos... more The composition of the immune infiltrate in breast tumors can be associated with improved prognosis and leading to the enhanced survival of cancer patients, but there are studies where inflammatory cells have been described to assist the tumor’s capabilities to progress, proliferate, and metastasize. In breast cancer’s immune infiltrate, all inflammatory cells can be found. We have identified subsets of lymphocytes, which are able to control the local immunity. The determination of lymphocytary populations and histopathology of the tumor is able to define some particularities of the tumor. Our experiments were performed using the flow-cytometer from Department of Immunology Iasi. Flow-cytometry on cellular suspensions shows the presence of lymphocytic infiltrate and a considerable concentration of helper T cells and cytotoxic T cells. Lymphocytes B have an uncertain role in tumor’s evolution. The levels of T cells were increased in the tumor areas where a high grade of morphological...
European Journal of Internal Medicine, 2011
International Journal of Biological Macromolecules, 2015
ABSTRACT Flaxseed lignans are a natural source of useful biologically active components that show... more ABSTRACT Flaxseed lignans are a natural source of useful biologically active components that show a diverse spectrum of health-promoting properties. The valuable effects of the phenolic molecules are mainly due to their antioxidant activity by preventing oxidative stress and stimulate collagen synthesis, therefore, providing benefits to the skin. The present work highlights the development of flaxseed extract formulation as novel wound healing agent. The recognition of key structural features within flaxseed extract was crucial for the design and development of the therapeutic cream. Chromatographic analyses were employed for bioactive compounds identification and quantification. Folin-Ciocalteu method determined the total phenolic content and the antioxidant properties were evaluated by DPPH assay. The storage and loss modulus and tan δ were calculated for cream rheological properties evaluation. In vitro diffusion capacity and in vivo wound healing activity of phenolic cream were evaluated on Wistar rats. The collective properties and healing effect of the flaxseed suggested wound healing capacity.