Carine Vieira - Academia.edu (original) (raw)
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Papers by Carine Vieira
Toxicon, 2011
Pha1b is a potent toxin obtained from the spider Phoneutria nigriventer that blocks neuronal volt... more Pha1b is a potent toxin obtained from the spider Phoneutria nigriventer that blocks neuronal voltage-sensitive Ca 2þ channels. This study compared the antiallodynic effects of Pha1b, u-conotoxin MVIIA and morphine in mice and their side effects in rats. Mechanical allodynia was measured in mice receiving single intrathecal administration of Pha1b, u-conotoxin MVIIA or morphine before or after the incisional plantar procedure. The effect of the treatments on cardiovascular profile and global neurological were evaluated in rats. The expression of pro or anti-inflammatory cytokines of human polymorph mononuclear cells was also evaluated.
Toxicon, 2011
Pha1b is a potent toxin obtained from the spider Phoneutria nigriventer that blocks neuronal volt... more Pha1b is a potent toxin obtained from the spider Phoneutria nigriventer that blocks neuronal voltage-sensitive Ca 2þ channels. This study compared the antiallodynic effects of Pha1b, u-conotoxin MVIIA and morphine in mice and their side effects in rats. Mechanical allodynia was measured in mice receiving single intrathecal administration of Pha1b, u-conotoxin MVIIA or morphine before or after the incisional plantar procedure. The effect of the treatments on cardiovascular profile and global neurological were evaluated in rats. The expression of pro or anti-inflammatory cytokines of human polymorph mononuclear cells was also evaluated.