Dra. Carla Castillo Magariños, MD (original) (raw)
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Papers by Dra. Carla Castillo Magariños, MD
Con-ciencia, Aug 16, 2021
Introduction. Obesity is a chronic disease that leads to the onset of cardiovascular diseases and... more Introduction. Obesity is a chronic disease that leads to the onset of cardiovascular diseases and type 2 diabetes mellitus (T2DM). Overweight, obese or T2DM patients generally have a lipid profile with high blood levels of cholesterol, triglycerides, LDL (low-density lipoprotein) and VLDL-c (very low-density lipoprotein) and low levels of HDL-c (high-density lipoprotein of cholesterol). Pseudocereals such as Amaranthus caudatus (Amaranth), Chenopodium quinoa (Quinoa) and Lupinus mutabilis (Tarwi) present in the Andean region of Bolivia, have potentially nutraceutical properties, with a high content of macronutrients and various phytochemicals with biological activity such as quinolizidine alkaloids, saponins, triterpenes and γ-conglutin.
Facultad de Ciencias Farmacéuticas y Bioquímicas, Nov 1, 2018
Global strategy for infant and young child feeding: steps to successful breastfeeding Resumen Una... more Global strategy for infant and young child feeding: steps to successful breastfeeding Resumen Una buena alimentación resulta fundamental para la salud de los niños, especialmente en la etapa comprendida entre el nacimiento y los dos años de vida. Estudios biológicos y epide-miológicos muestran que la decisión de no ama-mantar tiene importantes efectos negativos so-bre la nutrición, desarrollo y salud general del niño y de la madre. La lactancia materna es la intervención sanitaria que, con menores costes económicos, consigue mayores beneficios sobre la salud del individuo. Es por ello que la Orga-nización Mundial de la Salud (OMS) y el Fondo Internacional de Emergencia de las Naciones Unidas para la Infancia (UNICEF) adoptaron la "Estrategia Mundial para la alimentación ópti-ma del lactante y del niño pequeño" que inclu-yen los diez pasos hacia una lactancia materna Abstract Good nutrition is essential for the health of children, especially in the stage between birth and two years of life. Biological and epidemiological studies show that the decision not to breastfeed has important negative effects on the nutrition, development and general health of the child and the mother. Breastfeeding is the health intervention that, with lower economic costs, achieves greater benefits on the health of the individual. Thus, the World Health Organization (WHO) and the United Nations International Emergency Fund for Children (UNICEF) adopted the "Global Strategy for Optimal Feeding of Infants and Young Children" that includes the ten steps towards a successful breastfeeding that recommends starting breastfeeding in the first hour of life and continuing with exclusive 7
Revista Con-Ciencia, 2018
Una buena alimentación resulta fundamental para la salud de los niños, especialmente en la etapa ... more Una buena alimentación resulta fundamental para la salud de los niños, especialmente en la etapa comprendida entre el nacimiento y los dos años de vida. Estudios biológicos y epidemiológicos muestran que la decisión de no amamantar tiene importantes efectos negativos sobre
la nutrición, desarrollo y salud general del niño y de la madre.
La lactancia materna es la intervención sanitaria que, con menores costes económicos, consigue mayores beneficios sobre la salud del individuo. Es por ello que la Organización Mundial de la Salud (OMS) y el Fondo Internacional de Emergencia de las Naciones Unidas para la Infancia (UNICEF) adoptaron la "Estrategia Mundial para la alimentación óptima del lactante y del niño pequeño" que incluyen los diez pasos hacia una lactancia materna exitosa, que recomienda iniciar la lactancia en la primera hora de vida y continuar con lactancia materna exclusiva (LME) durante los primeros seis meses de vida. En dicha guía se anima a las madres primerizas a amamantar a sus bebés, se dan pautas a los profesionales sanitarios para poder apoyar la lactancia materna y que las mujeres no abandonen precozmente la lactancia.
The seeds of Phaseolus vulgaris are known as common beans or kidney beans. The dry seeds are eate... more The seeds of Phaseolus vulgaris are known as common beans or kidney beans. The dry seeds are eaten as pulse and are enriched with protein, fiber, starch, B vitamins (B1, B6, B9), iron, potassium and selenium. Beans also contain about 1-2 % of fixed oil. Phaseolus vulgaris is linked with anticancer, antihyperlipidemic, hypoglycemic and antioxidant actions. The fixed oil of Phaseolus vulgaris (PVFO) seeds is extracted with hexane and used in this study to assess acute oral toxicity, analgesic (by acetic acid induced writhing, hot plate and tail flick tests in mice) and antiinflammatory (by carrageenan induced paw edema in rats) actions. Four groups were made (n=6): Group-I: Normal Saline Control (2ml/kg), Group-II: PVFO (2ml/kg), Group-III: PVFO (4ml/kg) and Group-IV: Standard Acetyl salicylic acid (ASA 300 mg/kg). PVFO in 2ml/kg and 4ml/kg dose demonstrated analgesic and anti-inflammatory activities but in hot plate results were unreliable as here significant activity started after 90 minutes. For toxicity test 5ml/kg dose was administered orally in mice and no toxicity symptoms were observed. It is therefore concluded that PVFO is safe for oral use up to 5ml/kg and may possess analgesic and anti-inflammatory actions.
Con-ciencia, Aug 16, 2021
Introduction. Obesity is a chronic disease that leads to the onset of cardiovascular diseases and... more Introduction. Obesity is a chronic disease that leads to the onset of cardiovascular diseases and type 2 diabetes mellitus (T2DM). Overweight, obese or T2DM patients generally have a lipid profile with high blood levels of cholesterol, triglycerides, LDL (low-density lipoprotein) and VLDL-c (very low-density lipoprotein) and low levels of HDL-c (high-density lipoprotein of cholesterol). Pseudocereals such as Amaranthus caudatus (Amaranth), Chenopodium quinoa (Quinoa) and Lupinus mutabilis (Tarwi) present in the Andean region of Bolivia, have potentially nutraceutical properties, with a high content of macronutrients and various phytochemicals with biological activity such as quinolizidine alkaloids, saponins, triterpenes and γ-conglutin.
Facultad de Ciencias Farmacéuticas y Bioquímicas, Nov 1, 2018
Global strategy for infant and young child feeding: steps to successful breastfeeding Resumen Una... more Global strategy for infant and young child feeding: steps to successful breastfeeding Resumen Una buena alimentación resulta fundamental para la salud de los niños, especialmente en la etapa comprendida entre el nacimiento y los dos años de vida. Estudios biológicos y epide-miológicos muestran que la decisión de no ama-mantar tiene importantes efectos negativos so-bre la nutrición, desarrollo y salud general del niño y de la madre. La lactancia materna es la intervención sanitaria que, con menores costes económicos, consigue mayores beneficios sobre la salud del individuo. Es por ello que la Orga-nización Mundial de la Salud (OMS) y el Fondo Internacional de Emergencia de las Naciones Unidas para la Infancia (UNICEF) adoptaron la "Estrategia Mundial para la alimentación ópti-ma del lactante y del niño pequeño" que inclu-yen los diez pasos hacia una lactancia materna Abstract Good nutrition is essential for the health of children, especially in the stage between birth and two years of life. Biological and epidemiological studies show that the decision not to breastfeed has important negative effects on the nutrition, development and general health of the child and the mother. Breastfeeding is the health intervention that, with lower economic costs, achieves greater benefits on the health of the individual. Thus, the World Health Organization (WHO) and the United Nations International Emergency Fund for Children (UNICEF) adopted the "Global Strategy for Optimal Feeding of Infants and Young Children" that includes the ten steps towards a successful breastfeeding that recommends starting breastfeeding in the first hour of life and continuing with exclusive 7
Revista Con-Ciencia, 2018
Una buena alimentación resulta fundamental para la salud de los niños, especialmente en la etapa ... more Una buena alimentación resulta fundamental para la salud de los niños, especialmente en la etapa comprendida entre el nacimiento y los dos años de vida. Estudios biológicos y epidemiológicos muestran que la decisión de no amamantar tiene importantes efectos negativos sobre
la nutrición, desarrollo y salud general del niño y de la madre.
La lactancia materna es la intervención sanitaria que, con menores costes económicos, consigue mayores beneficios sobre la salud del individuo. Es por ello que la Organización Mundial de la Salud (OMS) y el Fondo Internacional de Emergencia de las Naciones Unidas para la Infancia (UNICEF) adoptaron la "Estrategia Mundial para la alimentación óptima del lactante y del niño pequeño" que incluyen los diez pasos hacia una lactancia materna exitosa, que recomienda iniciar la lactancia en la primera hora de vida y continuar con lactancia materna exclusiva (LME) durante los primeros seis meses de vida. En dicha guía se anima a las madres primerizas a amamantar a sus bebés, se dan pautas a los profesionales sanitarios para poder apoyar la lactancia materna y que las mujeres no abandonen precozmente la lactancia.
The seeds of Phaseolus vulgaris are known as common beans or kidney beans. The dry seeds are eate... more The seeds of Phaseolus vulgaris are known as common beans or kidney beans. The dry seeds are eaten as pulse and are enriched with protein, fiber, starch, B vitamins (B1, B6, B9), iron, potassium and selenium. Beans also contain about 1-2 % of fixed oil. Phaseolus vulgaris is linked with anticancer, antihyperlipidemic, hypoglycemic and antioxidant actions. The fixed oil of Phaseolus vulgaris (PVFO) seeds is extracted with hexane and used in this study to assess acute oral toxicity, analgesic (by acetic acid induced writhing, hot plate and tail flick tests in mice) and antiinflammatory (by carrageenan induced paw edema in rats) actions. Four groups were made (n=6): Group-I: Normal Saline Control (2ml/kg), Group-II: PVFO (2ml/kg), Group-III: PVFO (4ml/kg) and Group-IV: Standard Acetyl salicylic acid (ASA 300 mg/kg). PVFO in 2ml/kg and 4ml/kg dose demonstrated analgesic and anti-inflammatory activities but in hot plate results were unreliable as here significant activity started after 90 minutes. For toxicity test 5ml/kg dose was administered orally in mice and no toxicity symptoms were observed. It is therefore concluded that PVFO is safe for oral use up to 5ml/kg and may possess analgesic and anti-inflammatory actions.