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Papers by Carlos Esteban Builes-Montaño

Hepatología

La enfermedad hepática grasa no alcohólica (EHGNA) es una condición altamente prevalente y usualm... more La enfermedad hepática grasa no alcohólica (EHGNA) es una condición altamente prevalente y usualmente relacionada con el sobrepeso y la obesidad, pero afecta al 10% de la población no obesa en el mundo, con tendencia al aumento. Mecanismos diferentes a los tradicionalmente relacionados con el exceso de grasa corporal, como algunos polimorfismos genéticos y la exposición a ciertos factores ambientales, se han asociado con el desarrollo de esta entidad. Comparados con individuos sanos, las personas con EHGNA tienen con mayor frecuencia desarreglos metabólicos, como resistencia a la insulina y síndrome metabólico. El curso de la enfermedad hepática pareciera ser más benigno en los individuos no obesos en comparación con las personas obesas, pero el riesgo de desarrollar enfermedades como la diabetes mellitus pareciera ser mayor. En Latinoamérica se ha reportado una de las prevalencias más altas de EHGNA, sin embargo, el fenómeno en personas no obesas se ha estudiado principalmente en A...

Medicina y Laboratorio, 2017

El hiperparatiroidismo primario es uno de los trastornos endocrinos más frecuentes, caracterizado... more El hiperparatiroidismo primario es uno de los trastornos endocrinos más frecuentes, caracterizado por la producción no controlada de la paratohormona. Esta condición clínica puede ser completamente asintomática o mostrarse con manifestaciones que ponen en peligro la vida de quien la padece. La gran variedad en las formas de presentación y algunos errores frecuentes en la interpretación de los resultados de las pruebas disponibles para su diagnóstico hacen de esta alteración un reto para el médico. Un hiperparatiroidismo no diagnosticado, y en consecuencia no tratado, puede tener consecuencias nefastas para los pacientes como deterioro en la función renal, que puede llevar a requerir una terapia de reemplazo renal, osteoporosis, que se puede acompañar de fracturas por fragilidad y cambios neurocognitivos que pueden socavar la calidad de vida de las personas. Por lo anterior, es fundamental conocer y comprender este trastorno, así como reconocer e interpretar adecuadamente las ayudas ...

IX Latin American Robotics Symposium and IEEE Colombian Conference on Automatic Control, 2011 IEEE, 2011

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

The Pediatric Infectious Disease Journal, 2000

To study the incidence, clinical presentation, management, complications and outcome of tuberculo... more To study the incidence, clinical presentation, management, complications and outcome of tuberculosis in pediatric liver transplant recipients. Methods. A retrospective review of the medical records of children who underwent liver transplantation between 1991 and 1998. Results. Mycobacterium tuberculosis infection occurred in 6 of 254 (2.4%) children undergoing liver transplantation between 1991 and 1998. Cough, pyrexia and poor appetite were common presentations; one-half had normal chest radiographs. The median time to confirmation of diagnosis was 8 months (range, 1 to 17 months). Tests contributing to diagnosis included: Ziehl-Neelsen (ZN) stain (2 patients), M. tuberculosis polymerase chain reaction (1 patient), Mantoux test (1 patient) and histopathology (4 patients). Family health screening was productive for 4 patients. Duration of treatment varied from 9 to 18 months. Isoniazid-induced hepatitis was observed in 2 patients but resolved with dose reduction. Two patients died while receiving treatment, one of Klebsiella spp. septicemia and the other of pulmonary hemorrhage. Conclusions. Tuberculosis after liver transplantation has a significant morbidity and mortality. Pretransplantation a personal and family history of tuberculosis must be sought, and screening of patients and their families should be considered. Standard regimens incorporating isoniazid and rifampin are effective, but regular monitoring of liver function is essential to detect drug-induced hepatotoxicity.

Growth hormone has other functions besides those that are implied by its name. During adulthood, ... more Growth hormone has other functions besides those that are implied by its name. During adulthood, it is iportant for lipid and carbohydrate metabolism, it has vital function in non-fasting states and it has a pivotal role in maintaining the energy balance of the body. Growth hormone deficiency is a well-known disease in childhood, with established and easily recognizable manifestations. In contrast, adult growth hormone deficiency is more difficult to establish and it can result from either genetic or acquired causes during childhood, or acquired causes during adulthood. In recent years, the isolation and synthesis of recombinant human growth hormone was achieved, and this made it possible to treat affected patients. However, many questions remain regarding adult growth hormone deficiency, including questions about the criteria for an adequate diagnosis, and questions with regards to the real benefits and safety of treatment with human growth hormone. This article reviews the current...

IntroductionVitiligo is a chronic skin condition with no cure. Clinical assessment and treatment ... more IntroductionVitiligo is a chronic skin condition with no cure. Clinical assessment and treatment evaluation relays heavily on clinometry tools and expert knowledge. The Vitiligo Extent Score has been proposed as one of the most reliable and easy-to-use clinometry tools for vitiligo.Methods and analysisWe proposed a scoping review to identify all the available evidence on the clinical research availability around the Vitiligo Extent Score. This review will follow the approach proposed in the Joanna Briggs Institute Reviewer’s Manual Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews.Ethics and disseminationWe intend to publish the results in a specialized peer-reviewed journal and local, national, and international conference presentations. It will also be incorporated as educational material in our institution’s postgraduate program in dermatology.Article summaryStrengths and limitations of this studyThis scoping review will be the first...

Case Reports in Medicine

The association of type B insulin resistance syndrome (TBIRS) due to autoimmune diseases such as ... more The association of type B insulin resistance syndrome (TBIRS) due to autoimmune diseases such as systemic lupus erythematosus (SLE) is uncommon. This is partly due to the lack of established criteria for the diagnosis of this resistance. However, some clinical aspects may suggest that the diagnosis does not necessarily have to be positive insulin receptor antibodies as such patients could respond to immunosuppressive treatment. Methods. We describe a case and have performed a literature review on PubMed/MEDLINE, EMBASE, and Google Scholar bibliographic databases to identify all case reports. All available studies from January 1975 through December 2020 were included. Data collected were tabulated, and outcomes were analyzed cumulatively. Results. Thirty-one cases of TBIRS associated with SLE have been described. These patients presented with catabolic symptoms and hyperglycemia in most cases, with an average time from the onset of symptoms of four months. In addition to that clinica...

Journal of Clinical Apheresis, 2021

Thyroid storm and severe thyrotoxicosis remain among the most frequent endocrine emergencies, and... more Thyroid storm and severe thyrotoxicosis remain among the most frequent endocrine emergencies, and first‐line hyperthyroidism treatment is not always an option. Since the first report in 1970, plasmapheresis is a second‐line treatment for severe or otherwise untreatable thyrotoxicosis when rapid euthyroidism is desired.

Infectio, 2014

Khorama score as a predictive tool for thromboembolic events in high risk patients Background: Th... more Khorama score as a predictive tool for thromboembolic events in high risk patients Background: There is an established relation between cancer and the development of thromboembolic venous disease. Khorana et al developed a predictive score using clinical characteristics and laboratory values to stratify patients according to their risk. Aim: To characterize using Khorana score, patients with active cancer and a diagnosis of thromboembolic disease during hospitalization in an oncology hospital. Material and Methods: Review of records of the pharmacy of the hospital, selecting patients who received heparin in therapeutic doses during their hospitalization. Using laboratory values available in the medical records, the Khorama score was calculated. Results: Twenty seven patients with thromboembolic events, aged 60 ± 2 years (56% males) were selected for the study. Eighty percent of them were catalogued in the intermediate and high risk group according to Khorana score. Conclusions: Khorana score is a simple scale that might be useful to establish early prophylactic measures in patients with high risk for thromboembolic events, especially those with cancer.

Revista Colombiana de Reumatología, 2012

Los autores declaran no presentar ningún conflicto de interés al momento de la redacción del manu... more Los autores declaran no presentar ningún conflicto de interés al momento de la redacción del manuscrito.

Revista Colombiana de Endocrinología, Diabetes & Metabolismo

Introducción: La deficiencia de 17?-hidroxilasa / 17,20-liasa es causada por un defecto en el gen... more Introducción: La deficiencia de 17?-hidroxilasa / 17,20-liasa es causada por un defecto en el gen CYP17A1 que codifica una enzima que expresa tanto actividad 17?-hidroxilasa como 17,20-liasa en las glándulas suprarrenales y las gónadas. El fenotipo de esta condición es muy característico, pero lo pueden compartir otros defectos enzimáticos. La adecuada relación genotipo-fenotipo es importante para el correcto diagnóstico, enfocar el tratamiento y la consejería a los pacientes. Objetivo del caso: Reportar por primera vez una variante genética potencialmente relacionada con una hiperplasia adrenal congénita en una paciente con un fenotipo compatible con una deficiencia de 17?-hidroxilasa y la 17,20-liasa. Presentación del caso: Se presenta el caso de una mujer que consultó por infantilismo sexual y amenorrea primaria en presencia de cariotipo 46XX. Durante su evolución cursó con hipertensión e hipokalemia que condujo a la sospecha diagnóstica de una hiperplasia adrenal congénita (HA...

BMJ Open

Introduction Vitiligo is a chronic skin condition with no cure. Clinical assessment and treatment... more Introduction Vitiligo is a chronic skin condition with no cure. Clinical assessment and treatment evaluation relies heavily on clinometry tools and expert knowledge. The Vitiligo Extent Score has been proposed as one of the most reliable and easy-to-use clinometry tools for vitiligo. Methods and analysis We proposed a scoping review to identify all the available evidence on the clinical research availability around the Vitiligo Extent Score. The following databases will be searched: MEDLINE (PubMed), Embase, Open Grey, Lens and Directory of Open Access Journals. In addition, the approach proposed in the Joanna Briggs Institute Reviewer’s Manual will be followed. Finally, this review will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. Ethics and dissemination Ethics approval for this review is not required. We intend to publish the results in a specialised peer-reviewed journal and local, national and int...

Revista Colombiana de Endocrinología, Diabetes & Metabolismo

Contexto: El conteo de carbohidratos se ha considerado la forma ideal de calcular la insulina pra... more Contexto: El conteo de carbohidratos se ha considerado la forma ideal de calcular la insulina prandial, por ende se han propuesto varias formas de mejorarlo. Objetivo: Proponemos refinar el conteo de carbohidratos utilizando una simulación, la cual se presenta en una aplicación móvil, STUDIA, que simula en tiempo real la glucosa postprandial.Métodos: Utilizamos un fenomenológico del tracto gastrointestinal, acoplado al modelo mínimo para la glucosa postprandial en personas con diabetes mellitus tipo 1 (DM1). Las funciones y requisitos técnicos se definieron mediante un sistema de adquisición de requerimientos. Para la caracterización de usuarios, utilizamos una aproximación basada en el individuo. El ecosistema de datos se evaluó mediante el criterio UX/UI, la curva de aprendizaje, flexibilidad y la posibilidad de ejecutar modelos matemáticos. Utilizamos datos de un paciente con DM1 para ejemplificar el uso de la aplicación y los datos del monitoreo continuo de glucosa para comparac...

Journal of Diabetes Science and Technology

Background: This work evaluates the accuracy and agreement between the FreeStyle Libre sensor (FS... more Background: This work evaluates the accuracy and agreement between the FreeStyle Libre sensor (FSL) and an off-label converted real-time continuous glucose monitor (c-rtCGM) device consisting of the MiaoMiao transmitter and the xDrip+ application which can be coupled to the FSL. Methods: Four weeks of glucose data were collected from 21 participants with type 1 diabetes using the c-rtCGM and FSL: two weeks with a single initial calibration (uncalibrated) and two weeks with a daily calibration (calibrated). Accuracy and agreement evaluation included mean absolute relative difference (MARD), the %20/20 rule, Bland-Altman plots, and the Consensus Error Grid analysis. Results: Values reported by the c-rtCGM system compared with the FSL resulted in an overall MARD of 12.06% and 84.71% of the results falling within Consensus Error Grid Zone A when the device is calibrated. For uncalibrated devices, an overall MARD of 17.49% was obtained. Decreased accuracy was shown in the hypoglycemic ra...

Gazzetta medica italiana. Archivio per le scienze mediche, Jun 1, 2017

BACKGROUND: Atherosclerotic disease and its complications are the leading causes of death in peop... more BACKGROUND: Atherosclerotic disease and its complications are the leading causes of death in people over 45 years in Colombia and LDL cholesterol levels have an exponentially relation with the risk of acute myocardial infarction. It is generally recommended to calculate the value of LDL cholesterol using the Friedewald formula. The aim of this study was to estimate in a population of the city of Medellin the correlation between the value of LDL cholesterol by direct measurement with the LDL cholesterol calculated by the Friedewald formula. In an exploratory manner estimate the correlation with the formula proposed by Cordova and Cordova. METHODS: This is a descriptive study of the correlation between LDL cholesterol value measured and calculated by the Friedewald formula in persons between 18 and 75 years with triglyceride levels below 400 mg. RESULTS: Data from 454 persons were obtain, 61% were women, mean age was 50.7 years (SD±16.2), the mean measured LDL cholesterol was 123mg/dL (SD±36) and the calculated by the Friedewald formula was 119 mg/dL (SD±36), the correlation maintain between the different groups. CONCLUSIONS: In a population of Medellín both formulas show a very good correlation with the measured cholesterol and this is maintained regardless of the value of triglycerides, age and sex.

Medicina y Laboratorio

La enfermedad por coronavirus SARS-CoV-2 que surgió en el año 2019 (COVID-19), ha obligado al ráp... more La enfermedad por coronavirus SARS-CoV-2 que surgió en el año 2019 (COVID-19), ha obligado al rápido desarrollo de vacunas para prevenir su propagación e intentar controlar la pandemia. Dentro de las vacunas desarrolladas, las primeras en ser aprobadas con una tecnología nueva en el campo de la vacunación, fueron las vacunas basadas en ARNm (ácido ribonucleico mensajero), que lograron tasas de efectividad cercanas al 95 % para la prevención de la enfermedad COVID-19 grave. Los eventos adversos comunes son reacciones locales leves, pero ha habido varios informes de pacientes que desarrollaron tiroiditis subaguda y disfunción tiroidea después de recibir la vacuna contra SARS-CoV-2. Este artículo presenta dos casos de tiroiditis subaguda poco después de recibir la vacuna contra COVID-19.

European Journal of Case Reports in Internal Medicine

We present the case of a patient with a history of symptomatic hypoglycaemic episodes and a negat... more We present the case of a patient with a history of symptomatic hypoglycaemic episodes and a negative 72-hour fasting test with histological confirmation of insulinoma. A literature review of hyperinsulinaemic hypoglycaemia with a negative fasting test was performed.

Hepatología

La enfermedad hepática grasa no alcohólica (EHGNA) es una condición altamente prevalente y usualm... more La enfermedad hepática grasa no alcohólica (EHGNA) es una condición altamente prevalente y usualmente relacionada con el sobrepeso y la obesidad, pero afecta al 10% de la población no obesa en el mundo, con tendencia al aumento. Mecanismos diferentes a los tradicionalmente relacionados con el exceso de grasa corporal, como algunos polimorfismos genéticos y la exposición a ciertos factores ambientales, se han asociado con el desarrollo de esta entidad. Comparados con individuos sanos, las personas con EHGNA tienen con mayor frecuencia desarreglos metabólicos, como resistencia a la insulina y síndrome metabólico. El curso de la enfermedad hepática pareciera ser más benigno en los individuos no obesos en comparación con las personas obesas, pero el riesgo de desarrollar enfermedades como la diabetes mellitus pareciera ser mayor. En Latinoamérica se ha reportado una de las prevalencias más altas de EHGNA, sin embargo, el fenómeno en personas no obesas se ha estudiado principalmente en A...

Medicina y Laboratorio, 2017

El hiperparatiroidismo primario es uno de los trastornos endocrinos más frecuentes, caracterizado... more El hiperparatiroidismo primario es uno de los trastornos endocrinos más frecuentes, caracterizado por la producción no controlada de la paratohormona. Esta condición clínica puede ser completamente asintomática o mostrarse con manifestaciones que ponen en peligro la vida de quien la padece. La gran variedad en las formas de presentación y algunos errores frecuentes en la interpretación de los resultados de las pruebas disponibles para su diagnóstico hacen de esta alteración un reto para el médico. Un hiperparatiroidismo no diagnosticado, y en consecuencia no tratado, puede tener consecuencias nefastas para los pacientes como deterioro en la función renal, que puede llevar a requerir una terapia de reemplazo renal, osteoporosis, que se puede acompañar de fracturas por fragilidad y cambios neurocognitivos que pueden socavar la calidad de vida de las personas. Por lo anterior, es fundamental conocer y comprender este trastorno, así como reconocer e interpretar adecuadamente las ayudas ...

IX Latin American Robotics Symposium and IEEE Colombian Conference on Automatic Control, 2011 IEEE, 2011

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

The Pediatric Infectious Disease Journal, 2000

To study the incidence, clinical presentation, management, complications and outcome of tuberculo... more To study the incidence, clinical presentation, management, complications and outcome of tuberculosis in pediatric liver transplant recipients. Methods. A retrospective review of the medical records of children who underwent liver transplantation between 1991 and 1998. Results. Mycobacterium tuberculosis infection occurred in 6 of 254 (2.4%) children undergoing liver transplantation between 1991 and 1998. Cough, pyrexia and poor appetite were common presentations; one-half had normal chest radiographs. The median time to confirmation of diagnosis was 8 months (range, 1 to 17 months). Tests contributing to diagnosis included: Ziehl-Neelsen (ZN) stain (2 patients), M. tuberculosis polymerase chain reaction (1 patient), Mantoux test (1 patient) and histopathology (4 patients). Family health screening was productive for 4 patients. Duration of treatment varied from 9 to 18 months. Isoniazid-induced hepatitis was observed in 2 patients but resolved with dose reduction. Two patients died while receiving treatment, one of Klebsiella spp. septicemia and the other of pulmonary hemorrhage. Conclusions. Tuberculosis after liver transplantation has a significant morbidity and mortality. Pretransplantation a personal and family history of tuberculosis must be sought, and screening of patients and their families should be considered. Standard regimens incorporating isoniazid and rifampin are effective, but regular monitoring of liver function is essential to detect drug-induced hepatotoxicity.

Growth hormone has other functions besides those that are implied by its name. During adulthood, ... more Growth hormone has other functions besides those that are implied by its name. During adulthood, it is iportant for lipid and carbohydrate metabolism, it has vital function in non-fasting states and it has a pivotal role in maintaining the energy balance of the body. Growth hormone deficiency is a well-known disease in childhood, with established and easily recognizable manifestations. In contrast, adult growth hormone deficiency is more difficult to establish and it can result from either genetic or acquired causes during childhood, or acquired causes during adulthood. In recent years, the isolation and synthesis of recombinant human growth hormone was achieved, and this made it possible to treat affected patients. However, many questions remain regarding adult growth hormone deficiency, including questions about the criteria for an adequate diagnosis, and questions with regards to the real benefits and safety of treatment with human growth hormone. This article reviews the current...

IntroductionVitiligo is a chronic skin condition with no cure. Clinical assessment and treatment ... more IntroductionVitiligo is a chronic skin condition with no cure. Clinical assessment and treatment evaluation relays heavily on clinometry tools and expert knowledge. The Vitiligo Extent Score has been proposed as one of the most reliable and easy-to-use clinometry tools for vitiligo.Methods and analysisWe proposed a scoping review to identify all the available evidence on the clinical research availability around the Vitiligo Extent Score. This review will follow the approach proposed in the Joanna Briggs Institute Reviewer’s Manual Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews.Ethics and disseminationWe intend to publish the results in a specialized peer-reviewed journal and local, national, and international conference presentations. It will also be incorporated as educational material in our institution’s postgraduate program in dermatology.Article summaryStrengths and limitations of this studyThis scoping review will be the first...

Case Reports in Medicine

The association of type B insulin resistance syndrome (TBIRS) due to autoimmune diseases such as ... more The association of type B insulin resistance syndrome (TBIRS) due to autoimmune diseases such as systemic lupus erythematosus (SLE) is uncommon. This is partly due to the lack of established criteria for the diagnosis of this resistance. However, some clinical aspects may suggest that the diagnosis does not necessarily have to be positive insulin receptor antibodies as such patients could respond to immunosuppressive treatment. Methods. We describe a case and have performed a literature review on PubMed/MEDLINE, EMBASE, and Google Scholar bibliographic databases to identify all case reports. All available studies from January 1975 through December 2020 were included. Data collected were tabulated, and outcomes were analyzed cumulatively. Results. Thirty-one cases of TBIRS associated with SLE have been described. These patients presented with catabolic symptoms and hyperglycemia in most cases, with an average time from the onset of symptoms of four months. In addition to that clinica...

Journal of Clinical Apheresis, 2021

Thyroid storm and severe thyrotoxicosis remain among the most frequent endocrine emergencies, and... more Thyroid storm and severe thyrotoxicosis remain among the most frequent endocrine emergencies, and first‐line hyperthyroidism treatment is not always an option. Since the first report in 1970, plasmapheresis is a second‐line treatment for severe or otherwise untreatable thyrotoxicosis when rapid euthyroidism is desired.

Infectio, 2014

Khorama score as a predictive tool for thromboembolic events in high risk patients Background: Th... more Khorama score as a predictive tool for thromboembolic events in high risk patients Background: There is an established relation between cancer and the development of thromboembolic venous disease. Khorana et al developed a predictive score using clinical characteristics and laboratory values to stratify patients according to their risk. Aim: To characterize using Khorana score, patients with active cancer and a diagnosis of thromboembolic disease during hospitalization in an oncology hospital. Material and Methods: Review of records of the pharmacy of the hospital, selecting patients who received heparin in therapeutic doses during their hospitalization. Using laboratory values available in the medical records, the Khorama score was calculated. Results: Twenty seven patients with thromboembolic events, aged 60 ± 2 years (56% males) were selected for the study. Eighty percent of them were catalogued in the intermediate and high risk group according to Khorana score. Conclusions: Khorana score is a simple scale that might be useful to establish early prophylactic measures in patients with high risk for thromboembolic events, especially those with cancer.

Revista Colombiana de Reumatología, 2012

Los autores declaran no presentar ningún conflicto de interés al momento de la redacción del manu... more Los autores declaran no presentar ningún conflicto de interés al momento de la redacción del manuscrito.

Revista Colombiana de Endocrinología, Diabetes & Metabolismo

Introducción: La deficiencia de 17?-hidroxilasa / 17,20-liasa es causada por un defecto en el gen... more Introducción: La deficiencia de 17?-hidroxilasa / 17,20-liasa es causada por un defecto en el gen CYP17A1 que codifica una enzima que expresa tanto actividad 17?-hidroxilasa como 17,20-liasa en las glándulas suprarrenales y las gónadas. El fenotipo de esta condición es muy característico, pero lo pueden compartir otros defectos enzimáticos. La adecuada relación genotipo-fenotipo es importante para el correcto diagnóstico, enfocar el tratamiento y la consejería a los pacientes. Objetivo del caso: Reportar por primera vez una variante genética potencialmente relacionada con una hiperplasia adrenal congénita en una paciente con un fenotipo compatible con una deficiencia de 17?-hidroxilasa y la 17,20-liasa. Presentación del caso: Se presenta el caso de una mujer que consultó por infantilismo sexual y amenorrea primaria en presencia de cariotipo 46XX. Durante su evolución cursó con hipertensión e hipokalemia que condujo a la sospecha diagnóstica de una hiperplasia adrenal congénita (HA...

BMJ Open

Introduction Vitiligo is a chronic skin condition with no cure. Clinical assessment and treatment... more Introduction Vitiligo is a chronic skin condition with no cure. Clinical assessment and treatment evaluation relies heavily on clinometry tools and expert knowledge. The Vitiligo Extent Score has been proposed as one of the most reliable and easy-to-use clinometry tools for vitiligo. Methods and analysis We proposed a scoping review to identify all the available evidence on the clinical research availability around the Vitiligo Extent Score. The following databases will be searched: MEDLINE (PubMed), Embase, Open Grey, Lens and Directory of Open Access Journals. In addition, the approach proposed in the Joanna Briggs Institute Reviewer’s Manual will be followed. Finally, this review will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. Ethics and dissemination Ethics approval for this review is not required. We intend to publish the results in a specialised peer-reviewed journal and local, national and int...

Revista Colombiana de Endocrinología, Diabetes & Metabolismo

Contexto: El conteo de carbohidratos se ha considerado la forma ideal de calcular la insulina pra... more Contexto: El conteo de carbohidratos se ha considerado la forma ideal de calcular la insulina prandial, por ende se han propuesto varias formas de mejorarlo. Objetivo: Proponemos refinar el conteo de carbohidratos utilizando una simulación, la cual se presenta en una aplicación móvil, STUDIA, que simula en tiempo real la glucosa postprandial.Métodos: Utilizamos un fenomenológico del tracto gastrointestinal, acoplado al modelo mínimo para la glucosa postprandial en personas con diabetes mellitus tipo 1 (DM1). Las funciones y requisitos técnicos se definieron mediante un sistema de adquisición de requerimientos. Para la caracterización de usuarios, utilizamos una aproximación basada en el individuo. El ecosistema de datos se evaluó mediante el criterio UX/UI, la curva de aprendizaje, flexibilidad y la posibilidad de ejecutar modelos matemáticos. Utilizamos datos de un paciente con DM1 para ejemplificar el uso de la aplicación y los datos del monitoreo continuo de glucosa para comparac...

Journal of Diabetes Science and Technology

Background: This work evaluates the accuracy and agreement between the FreeStyle Libre sensor (FS... more Background: This work evaluates the accuracy and agreement between the FreeStyle Libre sensor (FSL) and an off-label converted real-time continuous glucose monitor (c-rtCGM) device consisting of the MiaoMiao transmitter and the xDrip+ application which can be coupled to the FSL. Methods: Four weeks of glucose data were collected from 21 participants with type 1 diabetes using the c-rtCGM and FSL: two weeks with a single initial calibration (uncalibrated) and two weeks with a daily calibration (calibrated). Accuracy and agreement evaluation included mean absolute relative difference (MARD), the %20/20 rule, Bland-Altman plots, and the Consensus Error Grid analysis. Results: Values reported by the c-rtCGM system compared with the FSL resulted in an overall MARD of 12.06% and 84.71% of the results falling within Consensus Error Grid Zone A when the device is calibrated. For uncalibrated devices, an overall MARD of 17.49% was obtained. Decreased accuracy was shown in the hypoglycemic ra...

Gazzetta medica italiana. Archivio per le scienze mediche, Jun 1, 2017

BACKGROUND: Atherosclerotic disease and its complications are the leading causes of death in peop... more BACKGROUND: Atherosclerotic disease and its complications are the leading causes of death in people over 45 years in Colombia and LDL cholesterol levels have an exponentially relation with the risk of acute myocardial infarction. It is generally recommended to calculate the value of LDL cholesterol using the Friedewald formula. The aim of this study was to estimate in a population of the city of Medellin the correlation between the value of LDL cholesterol by direct measurement with the LDL cholesterol calculated by the Friedewald formula. In an exploratory manner estimate the correlation with the formula proposed by Cordova and Cordova. METHODS: This is a descriptive study of the correlation between LDL cholesterol value measured and calculated by the Friedewald formula in persons between 18 and 75 years with triglyceride levels below 400 mg. RESULTS: Data from 454 persons were obtain, 61% were women, mean age was 50.7 years (SD±16.2), the mean measured LDL cholesterol was 123mg/dL (SD±36) and the calculated by the Friedewald formula was 119 mg/dL (SD±36), the correlation maintain between the different groups. CONCLUSIONS: In a population of Medellín both formulas show a very good correlation with the measured cholesterol and this is maintained regardless of the value of triglycerides, age and sex.

Medicina y Laboratorio

La enfermedad por coronavirus SARS-CoV-2 que surgió en el año 2019 (COVID-19), ha obligado al ráp... more La enfermedad por coronavirus SARS-CoV-2 que surgió en el año 2019 (COVID-19), ha obligado al rápido desarrollo de vacunas para prevenir su propagación e intentar controlar la pandemia. Dentro de las vacunas desarrolladas, las primeras en ser aprobadas con una tecnología nueva en el campo de la vacunación, fueron las vacunas basadas en ARNm (ácido ribonucleico mensajero), que lograron tasas de efectividad cercanas al 95 % para la prevención de la enfermedad COVID-19 grave. Los eventos adversos comunes son reacciones locales leves, pero ha habido varios informes de pacientes que desarrollaron tiroiditis subaguda y disfunción tiroidea después de recibir la vacuna contra SARS-CoV-2. Este artículo presenta dos casos de tiroiditis subaguda poco después de recibir la vacuna contra COVID-19.

European Journal of Case Reports in Internal Medicine

We present the case of a patient with a history of symptomatic hypoglycaemic episodes and a negat... more We present the case of a patient with a history of symptomatic hypoglycaemic episodes and a negative 72-hour fasting test with histological confirmation of insulinoma. A literature review of hyperinsulinaemic hypoglycaemia with a negative fasting test was performed.