Carlos Lorenzo - Academia.edu (original) (raw)

Papers by Carlos Lorenzo

Research paper thumbnail of Statin Use as a Moderator of Metformin Effect on Risk for Prostate Cancer Among Type 2 Diabetic Patients

Diabetes Care, 2012

OBJECTIVE Metformin and statins have shown promise for cancer prevention. This study assessed whe... more OBJECTIVE Metformin and statins have shown promise for cancer prevention. This study assessed whether the effect of metformin on prostate cancer (PCa) incidence varied by statin use among type 2 diabetic patients. RESEARCH DESIGN AND METHODS The study cohort consisted of 5,042 type 2 diabetic male patients seen in the Veteran Administration Health Care System who were without prior cancer and were prescribed with metformin or sulfonylurea as the exclusive hypoglycemic medication between fiscal years 1999 and 2005. Cox proportional hazards analyses were conducted to assess the differential hazard ratio (HR) of PCa due to metformin by statin use versus sulfonylurea use, where propensity scores of metformin and statin use were adjusted to account for imbalances in baseline covariates across medication groups. RESULTS Mean follow-up was ∼5 years, and 7.5% had a PCa diagnosis. Statin use modified the effect of metformin on PCa incidence (P < 0.0001). Metformin was associated with a si...

Research paper thumbnail of Origin of gas retention and symptoms in patients with bloating

Gastroenterology, 2005

Background & Aims: Patients reporting abdominal bloating exhibit impaired tolerance to intestinal... more Background & Aims: Patients reporting abdominal bloating exhibit impaired tolerance to intestinal gas loads. The aim of this study was to identify the gut compartment responsible for gas retention. Methods: In 30 patients predominantly reporting abdominal bloating (24 with irritable bowel syndrome and 6 with functional bloating) and 22 healthy subjects, gas (nitrogen, carbon dioxide, and oxygen) was infused into the intestine for 2 hours while measuring rectal gas outflow. First, in 12 patients and 10 healthy subjects, gas transit (24 mL/min jejunal infusion labeled with 74 MBq bolus of 133Xe) was measured by scintigraphy. Second, in groups of patients and healthy subjects, the effects of gas infusion (12 mL/min) in the jejunum versus ileum, jejunum versus cecum, and jejunum versus sham infusion (n = 6 each) were compared by paired tests. Results: In patients, total gut transit of gas was delayed (50% clearance time, 33 ± 4 min vs 23 ± 4 min in healthy subjects; P < .05) owing to impaired small bowel transit (50% clearance time, 20 ± 2 min vs 12 ± 3 min in healthy subjects; P < .05), whereas colonic transit was normal (50% clearance time, 13 ± 2 min vs 11 ± 2 min in healthy subjects; not significant). Furthermore, jejunal gas infusion in patients was associated with gas retention (329 ± 81 mL vs 88 ± 79 mL in healthy subjects; P < .05), whereas direct ileal or colonic infusion was not (61 ± 103 mL and −143 ± 87 mL retention, respectively). Conclusions:: In patients reporting bloating, the small bowel is the gut region responsible for ineffective gas propulsion.

Research paper thumbnail of The Metabolic Syndrome as Predictor of Type 2 Diabetes

OBJECTIVE -The oral glucose tolerance test identifies high-risk subjects for diabetes, but it is ... more OBJECTIVE -The oral glucose tolerance test identifies high-risk subjects for diabetes, but it is costly and inconvenient. To find better predictors of type 2 diabetes, we evaluated two different definitions of the metabolic syndrome because insulin resistance, which is commonly associated with this clustering of metabolic factors, frequently precedes the onset of type 2 diabetes.

Research paper thumbnail of Central Adiposity Determines Prevalence Differences of the Metabolic Syndrome

Obesity, 2003

LORENZO, CARLOS, MANUEL SERRANO-RÍOS, MARÍA T. MARTÍNEZ-LARRAD, RAFAEL GABRIEL, KEN WILLIAMS, JUA... more LORENZO, CARLOS, MANUEL SERRANO-RÍOS, MARÍA T. MARTÍNEZ-LARRAD, RAFAEL GABRIEL, KEN WILLIAMS, JUAN A. GÓ MEZ-GERIQUE, MICHAEL P. STERN, AND STEVEN M. HAFFNER.

Research paper thumbnail of Gadamer Jauss crucefilosofico

En el siguiente texto nos propondremos trazar un dialogo entre dos filósofos contemporáneos entre... more En el siguiente texto nos propondremos trazar un dialogo entre dos filósofos contemporáneos entre sí, que desarrollaron sus trabajos en el siglo XX. Por un lado teneos a Georg Gadamer fundador de la Escuela Hermenéutica, en su proyecto filosófico, fue elaborado en relación directa con la hermenéutica filosófica. El logro de Gadamer reside en descubrir y mostrar la naturaleza de la comprensión humana a nivel teórico-metodológico: la verdad está íntimamente ligada al método y no puede considerarse una sin la otra. Gadamer fue muy crítico con los dos enfoques metodológicos que se emplean en el estudio de las ciencias humanas (Geisteswissenschaften).

Research paper thumbnail of Statin Use as a Moderator of Metformin Effect on Risk for Prostate Cancer Among Type 2 Diabetic Patients

Diabetes Care, 2012

OBJECTIVE Metformin and statins have shown promise for cancer prevention. This study assessed whe... more OBJECTIVE Metformin and statins have shown promise for cancer prevention. This study assessed whether the effect of metformin on prostate cancer (PCa) incidence varied by statin use among type 2 diabetic patients. RESEARCH DESIGN AND METHODS The study cohort consisted of 5,042 type 2 diabetic male patients seen in the Veteran Administration Health Care System who were without prior cancer and were prescribed with metformin or sulfonylurea as the exclusive hypoglycemic medication between fiscal years 1999 and 2005. Cox proportional hazards analyses were conducted to assess the differential hazard ratio (HR) of PCa due to metformin by statin use versus sulfonylurea use, where propensity scores of metformin and statin use were adjusted to account for imbalances in baseline covariates across medication groups. RESULTS Mean follow-up was ∼5 years, and 7.5% had a PCa diagnosis. Statin use modified the effect of metformin on PCa incidence (P < 0.0001). Metformin was associated with a si...

Research paper thumbnail of Origin of gas retention and symptoms in patients with bloating

Gastroenterology, 2005

Background & Aims: Patients reporting abdominal bloating exhibit impaired tolerance to intestinal... more Background & Aims: Patients reporting abdominal bloating exhibit impaired tolerance to intestinal gas loads. The aim of this study was to identify the gut compartment responsible for gas retention. Methods: In 30 patients predominantly reporting abdominal bloating (24 with irritable bowel syndrome and 6 with functional bloating) and 22 healthy subjects, gas (nitrogen, carbon dioxide, and oxygen) was infused into the intestine for 2 hours while measuring rectal gas outflow. First, in 12 patients and 10 healthy subjects, gas transit (24 mL/min jejunal infusion labeled with 74 MBq bolus of 133Xe) was measured by scintigraphy. Second, in groups of patients and healthy subjects, the effects of gas infusion (12 mL/min) in the jejunum versus ileum, jejunum versus cecum, and jejunum versus sham infusion (n = 6 each) were compared by paired tests. Results: In patients, total gut transit of gas was delayed (50% clearance time, 33 ± 4 min vs 23 ± 4 min in healthy subjects; P < .05) owing to impaired small bowel transit (50% clearance time, 20 ± 2 min vs 12 ± 3 min in healthy subjects; P < .05), whereas colonic transit was normal (50% clearance time, 13 ± 2 min vs 11 ± 2 min in healthy subjects; not significant). Furthermore, jejunal gas infusion in patients was associated with gas retention (329 ± 81 mL vs 88 ± 79 mL in healthy subjects; P < .05), whereas direct ileal or colonic infusion was not (61 ± 103 mL and −143 ± 87 mL retention, respectively). Conclusions:: In patients reporting bloating, the small bowel is the gut region responsible for ineffective gas propulsion.

Research paper thumbnail of The Metabolic Syndrome as Predictor of Type 2 Diabetes

OBJECTIVE -The oral glucose tolerance test identifies high-risk subjects for diabetes, but it is ... more OBJECTIVE -The oral glucose tolerance test identifies high-risk subjects for diabetes, but it is costly and inconvenient. To find better predictors of type 2 diabetes, we evaluated two different definitions of the metabolic syndrome because insulin resistance, which is commonly associated with this clustering of metabolic factors, frequently precedes the onset of type 2 diabetes.

Research paper thumbnail of Central Adiposity Determines Prevalence Differences of the Metabolic Syndrome

Obesity, 2003

LORENZO, CARLOS, MANUEL SERRANO-RÍOS, MARÍA T. MARTÍNEZ-LARRAD, RAFAEL GABRIEL, KEN WILLIAMS, JUA... more LORENZO, CARLOS, MANUEL SERRANO-RÍOS, MARÍA T. MARTÍNEZ-LARRAD, RAFAEL GABRIEL, KEN WILLIAMS, JUAN A. GÓ MEZ-GERIQUE, MICHAEL P. STERN, AND STEVEN M. HAFFNER.

Research paper thumbnail of Gadamer Jauss crucefilosofico

En el siguiente texto nos propondremos trazar un dialogo entre dos filósofos contemporáneos entre... more En el siguiente texto nos propondremos trazar un dialogo entre dos filósofos contemporáneos entre sí, que desarrollaron sus trabajos en el siglo XX. Por un lado teneos a Georg Gadamer fundador de la Escuela Hermenéutica, en su proyecto filosófico, fue elaborado en relación directa con la hermenéutica filosófica. El logro de Gadamer reside en descubrir y mostrar la naturaleza de la comprensión humana a nivel teórico-metodológico: la verdad está íntimamente ligada al método y no puede considerarse una sin la otra. Gadamer fue muy crítico con los dos enfoques metodológicos que se emplean en el estudio de las ciencias humanas (Geisteswissenschaften).