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Papers by Caroline O'Sullivan
Journal of Biomedical Materials Research Part B, Aug 24, 2010
A series of doped apatites have been deposited onto titanium (V) substrates using a novel ambient... more A series of doped apatites have been deposited onto titanium (V) substrates using a novel ambient temperature blasting process. The potential of these deposited doped apatites as non-colonizing osteoconductive coatings has been evaluated in vitro. XPS, EDX, and gravimetric analysis demonstrated that a high degree of coating incorporation was observed for each material. The modified surfaces were found to produce osteoblast proliferation comparable to, or better than, a hydroxyapatite finish. Promising levels of initial microbial inhibition were observed from the Sr- and Ag-doped surfaces, with the strontium showing prolonged ability to reduce bacteria numbers over a 30-day period. Ion elution profiles have been characterized and linked to the microbial response and based on the results obtained, mechanisms of kill have been suggested. In this study, the direct contact of coated substrate surfaces with microbes was observed to be a significant contributing factor to the antimicrobial performance and the anticolonizing activity. The silver substituted apatite was observed to out-perform both the SrA and ZnA in terms of biofilm inhibition.
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Procedia Manufacturing
Abstract Microneedles (MN) skin patches are novel medical devices in micron scale with a needle a... more Abstract Microneedles (MN) skin patches are novel medical devices in micron scale with a needle array which offers an alternative drug delivery system to conventional methods. MN patches are applied onto the skin reaching the dermal layer where the drug molecules are released at a specific rate. There is a lack of knowledge surrounding some determinant factors required to define an efficient MN application into the user skin. The aim of the project is to determine the optimum application parameters to fabricate a polymeric MN patch and to design a disposable single-use MN applicator with enhanced usability.
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Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs, 2017
Abstract By integrating nanoscience, engineering, and technology, nanoparticles have found an inc... more Abstract By integrating nanoscience, engineering, and technology, nanoparticles have found an increasing number of applications in the field of drug delivery, offering promising possibilities to significantly improve medical diagnosis and therapy. Particularly focus has been directed toward the development of a wide spectrum of novel biomedical nanomaterials for their utilization in formulating carriers for controlled drug delivery as well as in diagnostic applications. Special attention has been paid to synthetic polymers due to their biodegradability and biocompatibility. Numerous studies have demonstrated that incorporating polymeric nanocarriers in topical products enhances the percutaneous penetration of the therapeutic agents and offers increased efficacy, controlled drug release, reduced enzymatic degradation, improved drug stability, and reduced skin irritation. This chapter focuses on the preparation and characterization of ketoprofen-loaded biodegradable polymer nanoparticles, as well as on the different aspects of their percutaneous absorption. The physicochemical properties of polymer-based nanosystems responsible for successful drug delivery following topical application are highlighted in the following discussion.
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Organic Letters, 2007
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Coatings, 2011
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Surface and Coatings Technology, 2009
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Surface and Coatings Technology, 2008
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Macromolecular Bioscience, 2002
Nanoparticles have been prepared by dispersion polymerisation of n-butyl cyanoacrylate in acidifi... more Nanoparticles have been prepared by dispersion polymerisation of n-butyl cyanoacrylate in acidified water, with and without the inclusion of insulin. The molecular weight of the polymerising material increases by a stepwise process, in which chains are initiated, terminated, and reinitiated, ...
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Chemical Vapor Deposition, 2009
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Chemical Communications, 2005
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Journal of the American Chemical Society, 2006
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Polymer Degradation and Stability, 2002
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Procedia Manufacturing, 2017
Abstract The paper presents the application of the factorial Design of Experiments (DoE) to evalu... more Abstract The paper presents the application of the factorial Design of Experiments (DoE) to evaluate the influence of process parameters on the physical characteristics of ceramic microneedles (CMN). In this study, an understanding of the fabrication process was achieved by performing a DoE based on varying two levels of five parameters. Statistical analyses were performed on the data to investigate whether the process parameters have a significant effect on the production of a patch of 25 microneedles (MN) with sharp tips. The study showed that four out of five main effects as well as an interaction between two parameters were significant.
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Journal of Biomedical Materials Research Part B, Aug 24, 2010
A series of doped apatites have been deposited onto titanium (V) substrates using a novel ambient... more A series of doped apatites have been deposited onto titanium (V) substrates using a novel ambient temperature blasting process. The potential of these deposited doped apatites as non-colonizing osteoconductive coatings has been evaluated in vitro. XPS, EDX, and gravimetric analysis demonstrated that a high degree of coating incorporation was observed for each material. The modified surfaces were found to produce osteoblast proliferation comparable to, or better than, a hydroxyapatite finish. Promising levels of initial microbial inhibition were observed from the Sr- and Ag-doped surfaces, with the strontium showing prolonged ability to reduce bacteria numbers over a 30-day period. Ion elution profiles have been characterized and linked to the microbial response and based on the results obtained, mechanisms of kill have been suggested. In this study, the direct contact of coated substrate surfaces with microbes was observed to be a significant contributing factor to the antimicrobial performance and the anticolonizing activity. The silver substituted apatite was observed to out-perform both the SrA and ZnA in terms of biofilm inhibition.
Bookmarks Related papers MentionsView impact
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Procedia Manufacturing
Abstract Microneedles (MN) skin patches are novel medical devices in micron scale with a needle a... more Abstract Microneedles (MN) skin patches are novel medical devices in micron scale with a needle array which offers an alternative drug delivery system to conventional methods. MN patches are applied onto the skin reaching the dermal layer where the drug molecules are released at a specific rate. There is a lack of knowledge surrounding some determinant factors required to define an efficient MN application into the user skin. The aim of the project is to determine the optimum application parameters to fabricate a polymeric MN patch and to design a disposable single-use MN applicator with enhanced usability.
Bookmarks Related papers MentionsView impact
Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs, 2017
Abstract By integrating nanoscience, engineering, and technology, nanoparticles have found an inc... more Abstract By integrating nanoscience, engineering, and technology, nanoparticles have found an increasing number of applications in the field of drug delivery, offering promising possibilities to significantly improve medical diagnosis and therapy. Particularly focus has been directed toward the development of a wide spectrum of novel biomedical nanomaterials for their utilization in formulating carriers for controlled drug delivery as well as in diagnostic applications. Special attention has been paid to synthetic polymers due to their biodegradability and biocompatibility. Numerous studies have demonstrated that incorporating polymeric nanocarriers in topical products enhances the percutaneous penetration of the therapeutic agents and offers increased efficacy, controlled drug release, reduced enzymatic degradation, improved drug stability, and reduced skin irritation. This chapter focuses on the preparation and characterization of ketoprofen-loaded biodegradable polymer nanoparticles, as well as on the different aspects of their percutaneous absorption. The physicochemical properties of polymer-based nanosystems responsible for successful drug delivery following topical application are highlighted in the following discussion.
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Organic Letters, 2007
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Coatings, 2011
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Surface and Coatings Technology, 2009
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Surface and Coatings Technology, 2008
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Macromolecular Bioscience, 2002
Nanoparticles have been prepared by dispersion polymerisation of n-butyl cyanoacrylate in acidifi... more Nanoparticles have been prepared by dispersion polymerisation of n-butyl cyanoacrylate in acidified water, with and without the inclusion of insulin. The molecular weight of the polymerising material increases by a stepwise process, in which chains are initiated, terminated, and reinitiated, ...
Bookmarks Related papers MentionsView impact
Chemical Vapor Deposition, 2009
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Chemical Communications, 2005
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Journal of the American Chemical Society, 2006
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Polymer Degradation and Stability, 2002
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Procedia Manufacturing, 2017
Abstract The paper presents the application of the factorial Design of Experiments (DoE) to evalu... more Abstract The paper presents the application of the factorial Design of Experiments (DoE) to evaluate the influence of process parameters on the physical characteristics of ceramic microneedles (CMN). In this study, an understanding of the fabrication process was achieved by performing a DoE based on varying two levels of five parameters. Statistical analyses were performed on the data to investigate whether the process parameters have a significant effect on the production of a patch of 25 microneedles (MN) with sharp tips. The study showed that four out of five main effects as well as an interaction between two parameters were significant.
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