Cassandra Kelleher - Academia.edu (original) (raw)

Papers by Cassandra Kelleher

Research paper thumbnail of Workforce Attrition Among Male and Female Physicians Working in US Academic Hospitals, 2014-2019

JAMA network open, Jul 17, 2023

Research paper thumbnail of Identification of CIS-acting DNA elements in the FGF-5 gene promoter in proliferating and differentiated human rpe cells

Investigative Ophthalmology & Visual Science, 1997

Research paper thumbnail of Equal Work for Equal Pay

Annals of Surgery, Oct 20, 2022

Research paper thumbnail of Functional identification in human RPE cells of cis-acting sequences in the FGF-5 gene promoter

Investigative Ophthalmology & Visual Science, Feb 15, 1996

Research paper thumbnail of The Leaky Pipeline: Female Physician Attrition from Academic Medicine Across the US

Journal of The American College of Surgeons, Oct 17, 2022

Research paper thumbnail of Mesenchymal Cell Fate is Influenced by Elastin Signaling During Lung Alveolarization

Journal of Surgical Research, Feb 1, 2014

Research paper thumbnail of Standardizing the Evaluation and Management of Necrotizing Enterocolitis in a Level IV NICU

Research paper thumbnail of Case 10-2012

The New England Journal of Medicine, Mar 29, 2012

Dr. Jennifer C. Hensley (Pediatrics): A 16-year-old boy was admitted to this hospital because of ... more Dr. Jennifer C. Hensley (Pediatrics): A 16-year-old boy was admitted to this hospital because of abdominal pain and a mediastinal mass. The patient had been well until 4 days before admission, when he began to feel vaguely ill. The next day, nonbloody emesis occurred. Two days before admission, epigastric pain, nausea, decreased appetite, and constipation developed. On the morning of admission, he took laxatives and acetaminophen, without relief. He saw his pediatrician; a tentative diagnosis of pancreatitis was made, and the patient was sent to the emergency department at an affiliated hospital. On arrival, he rated the pain at 10 on a scale of 0 to 10 (with 10 indicating the most severe pain). He had not had fever, additional episodes of vomiting, or diarrhea. On examination, the weight was 138.5 kg, the temperature 36.7°C, the blood pressure 155/75 mm Hg, the pulse 88 beats per minute, the respiratory rate 36 breaths per minute, and the oxygen saturation 100% while he was breathing ambient air. The abdomen was soft, with moderate tenderness in the epigastrium and right upper quadrant; the remainder of the examination was normal. Levels of platelets, electrolytes, albumin, alkaline phosphatase, calcium, creatine kinase isoenzymes, and troponin I were normal, as were tests of renal function; other test results are shown in Table 1. An electrocardiogram was normal. Computed tomography (CT) of the abdomen after the administration of intravenous contrast material revealed a cystic mass, 12.4 cm by 6.1 cm by 6.2 cm, in the posterior mediastinum above the gastroesophageal junction, which displaced the inferior vena cava, the heart, and the distal esophagus; hepatic steatosis and trace bilateral pleural effusions were also present. Morphine (5 mg) was administered intravenously with transient improvement (the patient rated the pain at 3 out of 10) within 4 minutes; ranitidine and normal saline were also given. The patient was transferred to this hospital by ambulance for further evaluation; morphine (4 mg) was administered for recurrent pain en route. On arrival, the patient described the pain as sharp; radiating to his back; worsening with movement, deep inspirations, and swallowing; and improving slightly with sitting upright. He reported having the sensation of food sticking in his throat and having a mild cough and sore throat for 2 to 3 days. Blood-pressure recordings and serum levels of glycated hemoglobin and insulin had reportedly been elevated Case 10-2012: A 16-Year-Old Boy with Epigastric Pain and a Mediastinal Mass

Research paper thumbnail of Gender Homophily in Interphysician Referrals to Surgeons

Journal of Surgical Research, Mar 1, 2023

Research paper thumbnail of Disparity in prehospital scene time for geriatric trauma patients

American Journal of Surgery, Jun 1, 2022

BACKGROUND Geriatric patients face disparities in prehospital trauma care. We hypothesized that g... more BACKGROUND Geriatric patients face disparities in prehospital trauma care. We hypothesized that geriatric trauma patients are more likely to experience prolonged prehospital scene time than younger adults. METHODS Retrospective analysis of the 2017 National Emergency Medical Services Information System. Patients who met anatomic or physiologic trauma criteria based on national triage guidelines were included (n = 16,356). Geriatric patients (age≥65, n = 3594) were compared to younger adults (age 18-64). The primary outcome was prolonged scene time (>10 min). Multivariable logistic regression was performed, controlling for patient demographics, on-scene treatments, and injury severity. RESULTS Geriatric patients were more likely to experience prolonged scene time than younger adults after controlling for other factors (OR 1.78, 95% CI 1.57-2.04, p < 0.001). The likelihood of prolonged scene time reached OR 2.29 (95% CI 1.85-2.84) for patients age 70-79 and OR 2.66 (95% CI 2.07-3.42) for patients age 80-89, relative to age 18-29. CONCLUSIONS Geriatric trauma patients are more likely than younger adults to have prolonged prehospital scene time. This disparity may be caused by delayed recognition of injury severity or age-related cognitive biases.

Research paper thumbnail of Application of an infant spinal anesthesia protocol in infants presenting for inguinal herniorrhaphy improves operating room and postanesthesia recovery unit utilization

Pediatric Anesthesia, Aug 1, 2019

Research paper thumbnail of Contribution of unequal new patient referrals to female surgeon under-employment

American Journal of Surgery, Oct 1, 2021

BACKGROUND The literature shows that female surgeons have lower operative volumes than male surge... more BACKGROUND The literature shows that female surgeons have lower operative volumes than male surgeons. Since volume is dependent on new patient referrals for most surgeons, inequities in referrals may contribute to this employment disparity. METHODS Using 1997-2018 data from a large medical center, we examined the number of new patient referrals for surgeons. Multivariate linear analysis was performed, adjusting for surgeon race, calendar year, seniority, and clinical subspecialty. RESULTS A total of 121 surgeons across 12,410 surgeon-months were included. Overall, surgeons had a median of 14 new patient referrals per month (interquartile range (IQR) = 7, 27). On adjusted analysis, female surgeons saw 5.4 fewer new patient referrals per month (95% CI -6.4 to -4.5). CONCLUSION Female surgeons, with equal training and seniority, received fewer new patient referrals than their male peers, and this may contribute to female surgeon under-employment. Surgeon gender may be one of the factors contributing to this differential referral pattern.

Research paper thumbnail of A Longitudinal Population Analysis of Cumulative Risks of Circumcision

Journal of Surgical Research, 2019

Research paper thumbnail of Solid pseudopapillary and malignant pancreatic tumors in childhood: A systematic review and evidence quality assessment

Pediatric Blood & Cancer, Apr 26, 2018

Research paper thumbnail of A Novel <i>In Vitro</i> Model to Study Alveologenesis

American Journal of Respiratory Cell and Molecular Biology, Feb 1, 2014

Research paper thumbnail of Adnexal Masses in Children and Adolescents

Clinical Obstetrics and Gynecology, Mar 1, 2015

Adnexal masses in children encompass a variety of lesions of the ovaries and fallopian tubes, inc... more Adnexal masses in children encompass a variety of lesions of the ovaries and fallopian tubes, including ovarian cysts and tumors (benign or malignant), fallopian tube cysts and abscesses, paratubal cysts, and endometriomas. When developing a differential diagnosis for adnexal masses in childhood, the clinician must have a broad understanding of adnexal pathology and consider the patient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s age, presenting complaints, physical examination findings, and imaging results to generate a list of possible diagnoses and the appropriate treatment plan. We review the clinical presentation of these lesions and discuss the current recommendations for their management.

Research paper thumbnail of Clinical outcomes in children with adrenal neuroblastoma undergoing open versus laparoscopic adrenalectomy

Journal of Pediatric Surgery, Aug 1, 2013

Research paper thumbnail of Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway

Proceedings of the National Academy of Sciences of the United States of America, Feb 1, 2016

Research paper thumbnail of Engineering extracellular matrix through nanotechnology

Journal of the Royal Society Interface, Sep 22, 2010

Research paper thumbnail of Neonatal abdominal wall defects

Seminars in fetal & neonatal medicine, Jun 1, 2011

Research paper thumbnail of Workforce Attrition Among Male and Female Physicians Working in US Academic Hospitals, 2014-2019

JAMA network open, Jul 17, 2023

Research paper thumbnail of Identification of CIS-acting DNA elements in the FGF-5 gene promoter in proliferating and differentiated human rpe cells

Investigative Ophthalmology & Visual Science, 1997

Research paper thumbnail of Equal Work for Equal Pay

Annals of Surgery, Oct 20, 2022

Research paper thumbnail of Functional identification in human RPE cells of cis-acting sequences in the FGF-5 gene promoter

Investigative Ophthalmology & Visual Science, Feb 15, 1996

Research paper thumbnail of The Leaky Pipeline: Female Physician Attrition from Academic Medicine Across the US

Journal of The American College of Surgeons, Oct 17, 2022

Research paper thumbnail of Mesenchymal Cell Fate is Influenced by Elastin Signaling During Lung Alveolarization

Journal of Surgical Research, Feb 1, 2014

Research paper thumbnail of Standardizing the Evaluation and Management of Necrotizing Enterocolitis in a Level IV NICU

Research paper thumbnail of Case 10-2012

The New England Journal of Medicine, Mar 29, 2012

Dr. Jennifer C. Hensley (Pediatrics): A 16-year-old boy was admitted to this hospital because of ... more Dr. Jennifer C. Hensley (Pediatrics): A 16-year-old boy was admitted to this hospital because of abdominal pain and a mediastinal mass. The patient had been well until 4 days before admission, when he began to feel vaguely ill. The next day, nonbloody emesis occurred. Two days before admission, epigastric pain, nausea, decreased appetite, and constipation developed. On the morning of admission, he took laxatives and acetaminophen, without relief. He saw his pediatrician; a tentative diagnosis of pancreatitis was made, and the patient was sent to the emergency department at an affiliated hospital. On arrival, he rated the pain at 10 on a scale of 0 to 10 (with 10 indicating the most severe pain). He had not had fever, additional episodes of vomiting, or diarrhea. On examination, the weight was 138.5 kg, the temperature 36.7°C, the blood pressure 155/75 mm Hg, the pulse 88 beats per minute, the respiratory rate 36 breaths per minute, and the oxygen saturation 100% while he was breathing ambient air. The abdomen was soft, with moderate tenderness in the epigastrium and right upper quadrant; the remainder of the examination was normal. Levels of platelets, electrolytes, albumin, alkaline phosphatase, calcium, creatine kinase isoenzymes, and troponin I were normal, as were tests of renal function; other test results are shown in Table 1. An electrocardiogram was normal. Computed tomography (CT) of the abdomen after the administration of intravenous contrast material revealed a cystic mass, 12.4 cm by 6.1 cm by 6.2 cm, in the posterior mediastinum above the gastroesophageal junction, which displaced the inferior vena cava, the heart, and the distal esophagus; hepatic steatosis and trace bilateral pleural effusions were also present. Morphine (5 mg) was administered intravenously with transient improvement (the patient rated the pain at 3 out of 10) within 4 minutes; ranitidine and normal saline were also given. The patient was transferred to this hospital by ambulance for further evaluation; morphine (4 mg) was administered for recurrent pain en route. On arrival, the patient described the pain as sharp; radiating to his back; worsening with movement, deep inspirations, and swallowing; and improving slightly with sitting upright. He reported having the sensation of food sticking in his throat and having a mild cough and sore throat for 2 to 3 days. Blood-pressure recordings and serum levels of glycated hemoglobin and insulin had reportedly been elevated Case 10-2012: A 16-Year-Old Boy with Epigastric Pain and a Mediastinal Mass

Research paper thumbnail of Gender Homophily in Interphysician Referrals to Surgeons

Journal of Surgical Research, Mar 1, 2023

Research paper thumbnail of Disparity in prehospital scene time for geriatric trauma patients

American Journal of Surgery, Jun 1, 2022

BACKGROUND Geriatric patients face disparities in prehospital trauma care. We hypothesized that g... more BACKGROUND Geriatric patients face disparities in prehospital trauma care. We hypothesized that geriatric trauma patients are more likely to experience prolonged prehospital scene time than younger adults. METHODS Retrospective analysis of the 2017 National Emergency Medical Services Information System. Patients who met anatomic or physiologic trauma criteria based on national triage guidelines were included (n = 16,356). Geriatric patients (age≥65, n = 3594) were compared to younger adults (age 18-64). The primary outcome was prolonged scene time (>10 min). Multivariable logistic regression was performed, controlling for patient demographics, on-scene treatments, and injury severity. RESULTS Geriatric patients were more likely to experience prolonged scene time than younger adults after controlling for other factors (OR 1.78, 95% CI 1.57-2.04, p < 0.001). The likelihood of prolonged scene time reached OR 2.29 (95% CI 1.85-2.84) for patients age 70-79 and OR 2.66 (95% CI 2.07-3.42) for patients age 80-89, relative to age 18-29. CONCLUSIONS Geriatric trauma patients are more likely than younger adults to have prolonged prehospital scene time. This disparity may be caused by delayed recognition of injury severity or age-related cognitive biases.

Research paper thumbnail of Application of an infant spinal anesthesia protocol in infants presenting for inguinal herniorrhaphy improves operating room and postanesthesia recovery unit utilization

Pediatric Anesthesia, Aug 1, 2019

Research paper thumbnail of Contribution of unequal new patient referrals to female surgeon under-employment

American Journal of Surgery, Oct 1, 2021

BACKGROUND The literature shows that female surgeons have lower operative volumes than male surge... more BACKGROUND The literature shows that female surgeons have lower operative volumes than male surgeons. Since volume is dependent on new patient referrals for most surgeons, inequities in referrals may contribute to this employment disparity. METHODS Using 1997-2018 data from a large medical center, we examined the number of new patient referrals for surgeons. Multivariate linear analysis was performed, adjusting for surgeon race, calendar year, seniority, and clinical subspecialty. RESULTS A total of 121 surgeons across 12,410 surgeon-months were included. Overall, surgeons had a median of 14 new patient referrals per month (interquartile range (IQR) = 7, 27). On adjusted analysis, female surgeons saw 5.4 fewer new patient referrals per month (95% CI -6.4 to -4.5). CONCLUSION Female surgeons, with equal training and seniority, received fewer new patient referrals than their male peers, and this may contribute to female surgeon under-employment. Surgeon gender may be one of the factors contributing to this differential referral pattern.

Research paper thumbnail of A Longitudinal Population Analysis of Cumulative Risks of Circumcision

Journal of Surgical Research, 2019

Research paper thumbnail of Solid pseudopapillary and malignant pancreatic tumors in childhood: A systematic review and evidence quality assessment

Pediatric Blood & Cancer, Apr 26, 2018

Research paper thumbnail of A Novel <i>In Vitro</i> Model to Study Alveologenesis

American Journal of Respiratory Cell and Molecular Biology, Feb 1, 2014

Research paper thumbnail of Adnexal Masses in Children and Adolescents

Clinical Obstetrics and Gynecology, Mar 1, 2015

Adnexal masses in children encompass a variety of lesions of the ovaries and fallopian tubes, inc... more Adnexal masses in children encompass a variety of lesions of the ovaries and fallopian tubes, including ovarian cysts and tumors (benign or malignant), fallopian tube cysts and abscesses, paratubal cysts, and endometriomas. When developing a differential diagnosis for adnexal masses in childhood, the clinician must have a broad understanding of adnexal pathology and consider the patient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s age, presenting complaints, physical examination findings, and imaging results to generate a list of possible diagnoses and the appropriate treatment plan. We review the clinical presentation of these lesions and discuss the current recommendations for their management.

Research paper thumbnail of Clinical outcomes in children with adrenal neuroblastoma undergoing open versus laparoscopic adrenalectomy

Journal of Pediatric Surgery, Aug 1, 2013

Research paper thumbnail of Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway

Proceedings of the National Academy of Sciences of the United States of America, Feb 1, 2016

Research paper thumbnail of Engineering extracellular matrix through nanotechnology

Journal of the Royal Society Interface, Sep 22, 2010

Research paper thumbnail of Neonatal abdominal wall defects

Seminars in fetal & neonatal medicine, Jun 1, 2011