Catalina Jaramillo - Academia.edu (original) (raw)

Papers by Catalina Jaramillo

Infectio

Se presenta el caso de un paciente a quien se le diagnosticó una Infección de Transmisión Sexual ... more Se presenta el caso de un paciente a quien se le diagnosticó una Infección de Transmisión Sexual (ITS) por la técnica de PCR múltiple y en quién se logró por esta técnica, detectar cuatro agentes diferentes simultáneamente: Neisseria gonorreae, Mycoplasma hominis, Ureaplasma urealyticum/parvum y Trichomonas vaginalis, situación esta, que no hubiera sido posible utilizando el procedimiento estándar.

Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica

Los síndromes periódicos asociados con criopirinas (Cryopyrin Associated Periodic Syndromes, CAPS... more Los síndromes periódicos asociados con criopirinas (Cryopyrin Associated Periodic Syndromes, CAPS), o criopirinopatías, son enfermedades raras que hacen parte de los síndromes autoinflamatorios, caracterizados por episodios de fiebre recurrente e inflamación sin etiología autoinmunitaria, neoplásica ni infecciosa. Entre estos síndromes, los CAPS incluyen tres entidades: el síndrome autoinflamatorio familiar por frío (Familial Cold Autoinflammatory Syndrome, FCAS), el síndrome de Muckle-Wells y la enfermedad multisistémica inflamatoria de inicio neonatal (Neonatal Onset Multisystem Inflammatory Disease, NOMID), también conocida como síndrome articular, cutáneo y neurológico crónico infantil (Chronic Infantile Neurological Cutaneous and Articular (CINCA) syndrome). Se han identificado mutaciones en el gen NLRP3 como etiología de estos síndromes, con un patrón de herencia autosómico dominante en la mayoría de los casos. El diagnóstico suele hacerse por sus manifestaciones clínicas, c...

Revista de Derecho Administrativo Económico

Journal of Pediatric Gastroenterology and Nutrition

BACKGROUND/RATIONALE Biliary atresia (BA) is a cholangiopathy characterized by bile flow obstruct... more BACKGROUND/RATIONALE Biliary atresia (BA) is a cholangiopathy characterized by bile flow obstruction due to destruction of the biliary tree. Without surgical correction with Kasai portoenterostomy (KPE), BA leads to death or liver transplant (LTx). Early-onset, progressive liver fibrosis is a defining characteristic of BA. Collagen hybridizing peptide (CHP) is a synthetic peptide which binds to denatured collagen strands allowing quantification of fibrosis. This technique has not been used on human liver tissue. The aim of this pilot study was to evaluate the utility of CHP as a measurement of quantitative fibrosis to allow earlier survival with native liver (SNL) prognostication. RESULTS We identified 21 patients with wedge liver biopsies available, of which 14 required LTx. No deaths occurred. Patients requiring LTx tended to be female with a significantly different mean bilirubin (p = 0.002), albumin (p = 0.001) and ALT (p = 0.03) at 3-months post-KPE. By 1-year post-KPE, 50% of patients in the high-CHP intensity group required LTx versus 27% in the low-CHP. Overall, fibrosis as quantified by CHP at time of KPE was associated with more than three-times the risk of requiring LTx by 4-years of age (HR 3.6, 95%CI 1.15-10.93, p = 0.03). When controlling for gender and TB > 2 mg/dL and albumin at 3-months post-KPE, it predicted nearly seven times the risk of LTx (HR 6.89, 95%CI 1.38-34.32, p = 0.02). CONCLUSION Our results suggest that quantitative assessment of fibrosis at the time of KPE holds promise as an earlier predictor of LTx requirement in BA. A larger study is justified to assess quantitative fibrosis as a BA prognostic tool.

Blood

Key Points CD137 deficiency is a novel inborn error of immunity with immune dysregulation and EBV... more Key Points CD137 deficiency is a novel inborn error of immunity with immune dysregulation and EBV-associated lymphomagenesis Our study highlights the key role of CD137 for immune homeostasis with relevance to immunodeficiency and cancer immunotherapy

ACG Case Reports Journal

Solid organ transplant recipients are at increased risk of malignancy. Pediatric transplant recip... more Solid organ transplant recipients are at increased risk of malignancy. Pediatric transplant recipients particularly have a potentially higher risk given the young age of immunosuppression initiation. Posttransplant malignancies are the main cause of death in 5%-16% of liver transplantation patients. The frequency of de novo malignancies in pediatric liver transplant recipients has been reported to be 13%. Synovial sarcoma is a malignant mesenchymal neoplasm that has not been previously reported after liver transplantation. We report the case of an adolescent liver transplant recipient who was diagnosed with synovial sarcoma 14 years after liver transplantation.

World Journal of Hepatology

BACKGROUND Congenital dyserythropoietic anemia type 1 (CDA1) is an autosomal recessive disorder o... more BACKGROUND Congenital dyserythropoietic anemia type 1 (CDA1) is an autosomal recessive disorder of ineffective erythropoiesis, resulting in increased iron storage. CDA1 is usually diagnosed in children and adolescents but can rarely present in the neonatal period with severe anemia at birth. There are no prior reports of neonatal liver histologic findings of CDA1. We report a case of CDA1 in a newborn presenting with severe anemia, cholestasis and liver failure, where liver biopsy helped confirm the diagnosis. CASE SUMMARY A term infant, born via emergency Cesarean section, presented with cholestasis, hepatosplenomegaly, multiorgan failure and severe anemia at birth. A prior pregnancy was significant for fetal demise at 35 wk without autopsy or known etiology for the fetal demise. Parents are both healthy and there is no history of consanguinity. On further evaluation, the patient was found to have severe ferritin elevation and pulmonary hypertension. An extensive infectious and metabolic work-up was negative. Salivary gland biopsy was negative for iron deposition. At 2 wk of age, a liver biopsy showed findings consistent with CDA1. A genome rapid sequencing panel revealed novel variants in the CDAN1 gene. The patient's liver dysfunction, cholestasis and organomegaly resolved, however she remains transfusion-dependent. CONCLUSION We report liver pathology findings of CDA1 with a novel genetic mutation for the first time in a newborn.

Colombia Médica

Bi-allelic mutations in LRBA (from Lipopolysaccharide-responsive and beige-like anchor protein) r... more Bi-allelic mutations in LRBA (from Lipopolysaccharide-responsive and beige-like anchor protein) result in a primary immunodeficiency with clinical features ranging from hypogammaglobulinemia and lymphoproliferative syndrome to inflammatory bowel disease and heterogeneous autoimmune manifestations. LRBA deficiency has been shown to affect vesicular trafficking, autophagy and apoptosis, which may lead to alterations of several molecules and processes that play key roles for immunity. In this review, we will discuss the relationship of LRBA with the endovesicular system in the context of receptor trafficking, autophagy and apoptosis. Since these mechanisms of homeostasis are inherent to all living cells and not only limited to the immune system and also, because they are involved in physiological as well as pathological processes such as embryogenesis or tumoral transformation, we envisage advancing in the identification of potential pharmacological agents to manipulate these processes.

Journal of pediatric gastroenterology and nutrition, Jan 17, 2017

Nuevas Hojas De Lectura, 2008

Clinical Nutrition ESPEN, 2015

Under nutrition and growth failure are common findings in children with cerebral palsy (CP) and n... more Under nutrition and growth failure are common findings in children with cerebral palsy (CP) and neurologically impairments. Electrolyte and micronutrient abnormalities have also been documented. Gastrointestinal (GI) diseases like gastro esophageal reflux disease (GERD), feeding difficulties and constipation have been associated with increased frequency of these derangements. The goal of this study was to determine the prevalence of malnutrition, metabolic and electrolyte abnormalities in pediatric patients with cerebral palsy and gastrointestinal disorders. A retrospective review of 172 medical records was performed out of which 45 subjects did not have any GI problem, 69 patients had constipation and 58 patients either had GERD, esophagitis, gastrostomy and feeding difficulties. Data collected included: weight, length and body mass index, pre-albumin, albumin, vitamin D, potassium, chloride, bicarbonate, calcium, magnesium (Mg), phosphorus. The results demonstrate a significant difference (p = 0.0126) in the values of albumin in children with CP with GI disorders vs. those without. Additionally, a significant difference (p = 0.0129) was found in Mg levels between CP children with constipation vs. GERD/esophagitis/feeding issues/gastrostomy. Results suggest that children with CP and GI disorders have decreased levels of albumin, but normal pre-albumin. The mechanism for this is not completely clear and although we acknowledge importance of nutritional intake for albumin level support, other mechanisms such as low grade chronic inflammation and increased gut and vascular permeability may play a role. The lower levels of Mg in children with CP and constipation could be secondary to the use of laxatives. Further prospective studies looking at nutritional protein intake, gut and vascular permeability and laxative use in this patient population are important for future optimization of health care management.

Ecos De Economia, 1999

Este trabajo tiene como objetivo estudiar la evolución del sector metalmecánico en Colombia, en e... more Este trabajo tiene como objetivo estudiar la evolución del sector metalmecánico en Colombia, en el periodo posterior a la implementación del modelo de Apertura Económica., comparándolo con la evolución del sector durante la posguerra, época en la cual predominaba el modelo sustitutivo de importaciones. Pretende analizar los diferentes problemas y las ventaja que presenta el sector metalmecánico y evaluar las diferentes propuestas generadas dentro del sector, especialmente las hechas por parte de FEDEMETAL, para hacer frente a la crisis en la que ese encuentra el sector, todo esto sin dejar de resaltar su importancia dentro del proceso productivo nacional, debido al papel que cumple como difusor del cambio técnico en la generación de dinamismo sobre el resto de la economía.

RESUMEN Cuando existe un esfuerzo mecánico sobre un metal o aleación que se encuentre en un medio... more RESUMEN Cuando existe un esfuerzo mecánico sobre un metal o aleación que se encuentre en un medio corrosivo, puede originarse el debilitamiento del material metálico y posteriormente su rotura por Corrosión Asistida por Esfuerzo (SCC), estos problemas se presentan frecuentemente en componentes automotrices y aeronáuticos, en este último caso principalmente en el fuselaje y superficies remachadas de los aviones. Uno de los materiales más ampliamente utilizados en este ramo es el aluminio, debido a sus características de resistencia a la corrosión y baja densidad. El objetivo de este estudio es la evaluación del comportamiento tensión-deformación y la susceptibilidad de aluminio 6061-T6 a sufrir corrosión asistida por esfuerzo en ambientes salinos y cáusticos. Se realizaron ensayos de Corrosión Asistida por Esfuerzo con la máquina CERT (Constant Extension Rate Test), aplicando de forma simultánea pruebas de impedancia y de ruido electroquímico en corriente y en potencial, para determi...

utp.edu.co

El presente artículo muestra el análisis de la fragilidad en azul del acero ASSAB SUPRA 709 cuand... more El presente artículo muestra el análisis de la fragilidad en azul del acero ASSAB SUPRA 709 cuando se somete a tratamiento térmico (temple y revenido), se estudiaron las variables que afectan el revenido como son tiempo de sostenimiento y velocidad de enfriamiento y ...