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Papers by Catherine Vidal
Brain Pathology, 2017
In prion diseases, the brain lesion profile is influenced by the prion “strain” properties, the i... more In prion diseases, the brain lesion profile is influenced by the prion “strain” properties, the invasion route to the brain, and still unknown host cell‐specific parameters. To gain insight into those endogenous factors, we analyzed the histopathological alterations induced by distinct prion strains in the mouse cerebellum. We show that 22L and ME7 scrapie prion proteins (PrP22L, PrPME7), but not bovine spongiform encephalopathy PrP6PB1, accumulate in a reproducible parasagittal banding pattern in the cerebellar cortex of infected mice. Such banding pattern of PrP22L aggregation did not depend on the neuroinvasion route, but coincided with the parasagittal compartmentation of the cerebellum mostly defined by the expression of zebrins, such as aldolase C and the excitatory amino acid transporter 4, in Purkinje cells. We provide evidence that Purkinje cells display a differential, subtype‐specific vulnerability to 22L prions with zebrin‐expressing Purkinje cells being more resistant t...
Journal of Orthopaedic Research, 2009
Postmenopausal osteoporosis is a common disorder that results from increased osteoclastic activit... more Postmenopausal osteoporosis is a common disorder that results from increased osteoclastic activity caused by estrogen deficiency. Whether postmenopausal bone remodeling can alter the response to particulate debris is unknown. The purpose of this study was to evaluate the bone response to polyethylene particles in an ovariectomized murine model. Polyethylene particles were implanted onto the calvaria of seven control mice and seven ovariectomized (OVX) mice, as compared with calvaria from sham‐operated and OVX mice. Calvaria were harvested after 14 days. Skulls were analyzed with a high‐resolution micro‐CT and by histomorphometry after staining with Stevenel blue and picrofuschine, and for tartrate‐specific alkaline phosphatase. As assessed by micro‐CT, particle implantation induced a significant decrease in bone thickness in control mice, while bone thickness remained stable in OVX mice. In particle‐implanted animals, the osteoclast number was 2.84 ± 0.3 in control mice and 1.74 ± 0...
European Journal of Oral Sciences, 2011
Harichane Y, Dimitrova‐Nakov S, Marchadier A, Collet C, Baudry A, Vidal C, Kamoun‐Goldrat A, Kell... more Harichane Y, Dimitrova‐Nakov S, Marchadier A, Collet C, Baudry A, Vidal C, Kamoun‐Goldrat A, Kellermann O, Goldberg M. Enamel alterations in serotonin 2B receptor knockout mice. Eur J Oral Sci 2011; 119 (Suppl. 1): 177–184. © 2011 Eur J Oral SciThe role of the serotonin 2B receptor (5‐HT2BR) in enamel formation and mineralization was explored in adult 5HT2BR knockout (KO) mice compared with wild‐type (WT) mice. In the molar, quantitative data obtained by micro‐computed tomography imaging showed that the overall volume of the enamel layer was firmly reduced in KO mice. Defective mineralization was ascertained by energy‐dispersive X‐ray microanalysis. We also observed, using scanning electron microscopy, that parazones in the KO mice included two or three helicoidally twisted rods within Hunter–Schreger bands, instead of a single rod, as found in the WT mice. Minor disturbances were also detected in the incisors of KO mice. Structural modifications, thinner enamel crystallites, and ...
Brain Pathology, 2017
In prion diseases, the brain lesion profile is influenced by the prion “strain” properties, the i... more In prion diseases, the brain lesion profile is influenced by the prion “strain” properties, the invasion route to the brain, and still unknown host cell‐specific parameters. To gain insight into those endogenous factors, we analyzed the histopathological alterations induced by distinct prion strains in the mouse cerebellum. We show that 22L and ME7 scrapie prion proteins (PrP22L, PrPME7), but not bovine spongiform encephalopathy PrP6PB1, accumulate in a reproducible parasagittal banding pattern in the cerebellar cortex of infected mice. Such banding pattern of PrP22L aggregation did not depend on the neuroinvasion route, but coincided with the parasagittal compartmentation of the cerebellum mostly defined by the expression of zebrins, such as aldolase C and the excitatory amino acid transporter 4, in Purkinje cells. We provide evidence that Purkinje cells display a differential, subtype‐specific vulnerability to 22L prions with zebrin‐expressing Purkinje cells being more resistant t...
Journal of Orthopaedic Research, 2009
Postmenopausal osteoporosis is a common disorder that results from increased osteoclastic activit... more Postmenopausal osteoporosis is a common disorder that results from increased osteoclastic activity caused by estrogen deficiency. Whether postmenopausal bone remodeling can alter the response to particulate debris is unknown. The purpose of this study was to evaluate the bone response to polyethylene particles in an ovariectomized murine model. Polyethylene particles were implanted onto the calvaria of seven control mice and seven ovariectomized (OVX) mice, as compared with calvaria from sham‐operated and OVX mice. Calvaria were harvested after 14 days. Skulls were analyzed with a high‐resolution micro‐CT and by histomorphometry after staining with Stevenel blue and picrofuschine, and for tartrate‐specific alkaline phosphatase. As assessed by micro‐CT, particle implantation induced a significant decrease in bone thickness in control mice, while bone thickness remained stable in OVX mice. In particle‐implanted animals, the osteoclast number was 2.84 ± 0.3 in control mice and 1.74 ± 0...
European Journal of Oral Sciences, 2011
Harichane Y, Dimitrova‐Nakov S, Marchadier A, Collet C, Baudry A, Vidal C, Kamoun‐Goldrat A, Kell... more Harichane Y, Dimitrova‐Nakov S, Marchadier A, Collet C, Baudry A, Vidal C, Kamoun‐Goldrat A, Kellermann O, Goldberg M. Enamel alterations in serotonin 2B receptor knockout mice. Eur J Oral Sci 2011; 119 (Suppl. 1): 177–184. © 2011 Eur J Oral SciThe role of the serotonin 2B receptor (5‐HT2BR) in enamel formation and mineralization was explored in adult 5HT2BR knockout (KO) mice compared with wild‐type (WT) mice. In the molar, quantitative data obtained by micro‐computed tomography imaging showed that the overall volume of the enamel layer was firmly reduced in KO mice. Defective mineralization was ascertained by energy‐dispersive X‐ray microanalysis. We also observed, using scanning electron microscopy, that parazones in the KO mice included two or three helicoidally twisted rods within Hunter–Schreger bands, instead of a single rod, as found in the WT mice. Minor disturbances were also detected in the incisors of KO mice. Structural modifications, thinner enamel crystallites, and ...