Catriona O'Sullivan - Profile on Academia.edu (original) (raw)

Papers by Catriona O'Sullivan

Rhabdoid tumor: the Irish experience 1986–2013

Cancer Genetics, 2014

Nomenclature for the three recognized forms of rhabdoid tumor reflect their anatomic localization... more Nomenclature for the three recognized forms of rhabdoid tumor reflect their anatomic localization and include malignant rhabdoid tumor of the kidney (MRTK), extrarenal extracranial rhabdoid tumor (EERT), and atypical teratoid rhabdoid tumor (ATRT) involving the central nervous system. A strikingly simple karyotype belies the fact that rhabdoid tumors are among the most lethal human cancers, and now early strides are beginning to elucidate their molecular pathogenesis. Rhabdoid tumors are largely confined to the pediatric population, where they occur preferentially during infancy. Given the rarity of this tumor, international consensus on best treatment has only recently been achieved in conjunction with the establishment of the European Rhabdoid Tumor Registry. Between 1986 and 2013, 25 pediatric patients were diagnosed with rhabdoid tumor in the Republic of Ireland. Of these patients, 13 presented with ATRT, eight had MRTK, and four had EERT. The mean age at diagnosis was 38.8 months, with an equal sex incidence. Because of the lack of a standardized treatment strategy for rhabdoid tumors, these patients have been treated largely according to anatomic site, based on sarcoma, renal, or brain tumor protocols contemporary to their diagnoses. Of the patients, 84% received chemotherapy, 80% underwent surgery, and 44% had radiation therapy. The outcome overall was poor, independent of anatomic location. The overall survival rate was 24%, and mean time to death was just under 9 months.

Radiotherapy and Oncology, 2004

Background and Purpose: To prospectively assess the feasibility and efficacy of a hypofractionate... more Background and Purpose: To prospectively assess the feasibility and efficacy of a hypofractionated accelerated radiotherapy regimen (72 Gy in 24 daily fractions, 3Gy per fraction) in patients (pts) with non-resectable non-small-cell lung cancer (NSCLC).

OC-0079: CTV-to-PTV margin for treatment setup errors: paediatric vs adult

Radiotherapy and Oncology, 2015

Facet Specific Gold Tip Growth on Semiconductor Nanorods

ECS Transactions, 2009

Abstract High quality CdS-Au and CdSe-Au hybrid nanocrystals have been developed via facile appro... more Abstract High quality CdS-Au and CdSe-Au hybrid nanocrystals have been developed via facile approaches. Gold tip growth onto II-VI nanorods has been shown to occur instantaneously both via a solution and spin cast method. Gold tip size and multiplicity can be varied by changing the starting gold chloride concentration or the reaction duration. Gold tip growth typically occurs at one end of the nanorod, however we recently observed that a variation in the reaction temperature leads to the growth of a tip on both ends of the ...

Electrophoretic Deposition of Spherical and Rod-Shaped Nanocrystals into Close Packed Superlattices

ECS Transactions, 2009

Abstract Ordered nanocrystal assemblies are an exciting new class of materials where electronic, ... more Abstract Ordered nanocrystal assemblies are an exciting new class of materials where electronic, optical or magnetic properties can be dictated by tuning the position and ligand environment of each nanocrystal structural unit. Device integration in both nanoelectronics and nanophotonics relies on the ability to locate these ensembles with nanoscale accuracy exactly where they are needed. In this paper we overview our recent work in the area of electrophoretic deposition of charged nanocrystals from toluene.(1, 2) The systems ...

Rhabdoid tumor: the Irish experience 1986–2013

Cancer Genetics, 2014

Nomenclature for the three recognized forms of rhabdoid tumor reflect their anatomic localization... more Nomenclature for the three recognized forms of rhabdoid tumor reflect their anatomic localization and include malignant rhabdoid tumor of the kidney (MRTK), extrarenal extracranial rhabdoid tumor (EERT), and atypical teratoid rhabdoid tumor (ATRT) involving the central nervous system. A strikingly simple karyotype belies the fact that rhabdoid tumors are among the most lethal human cancers, and now early strides are beginning to elucidate their molecular pathogenesis. Rhabdoid tumors are largely confined to the pediatric population, where they occur preferentially during infancy. Given the rarity of this tumor, international consensus on best treatment has only recently been achieved in conjunction with the establishment of the European Rhabdoid Tumor Registry. Between 1986 and 2013, 25 pediatric patients were diagnosed with rhabdoid tumor in the Republic of Ireland. Of these patients, 13 presented with ATRT, eight had MRTK, and four had EERT. The mean age at diagnosis was 38.8 months, with an equal sex incidence. Because of the lack of a standardized treatment strategy for rhabdoid tumors, these patients have been treated largely according to anatomic site, based on sarcoma, renal, or brain tumor protocols contemporary to their diagnoses. Of the patients, 84% received chemotherapy, 80% underwent surgery, and 44% had radiation therapy. The outcome overall was poor, independent of anatomic location. The overall survival rate was 24%, and mean time to death was just under 9 months.

Radiotherapy and Oncology, 2004

Background and Purpose: To prospectively assess the feasibility and efficacy of a hypofractionate... more Background and Purpose: To prospectively assess the feasibility and efficacy of a hypofractionated accelerated radiotherapy regimen (72 Gy in 24 daily fractions, 3Gy per fraction) in patients (pts) with non-resectable non-small-cell lung cancer (NSCLC).

Nanoscale, 2011

A facile spin cast route was developed to convert perpendicularly aligned nanorod assemblies of c... more A facile spin cast route was developed to convert perpendicularly aligned nanorod assemblies of cadmium chalcogenides into their silver and copper analogues. The assemblies are rapidly cation exchanged without affecting 10

Activating point mutations of thegsp oncogene in human thyroid adenomas

Molecular Carcinogenesis, 1991

ABSTRACT

Langmuir, 2011

Colloidal carbon spheres were synthesized by the carbonization of squalane, a nonvolatile hydroca... more Colloidal carbon spheres were synthesized by the carbonization of squalane, a nonvolatile hydrocarbon solvent, in supercritical carbon dioxide. Precise pressure modulation of the fluid medium led to size controlled growth of carbon spheres ranging from 300 to 1500 nm in diameter. This unique synthetic approach of carbonizing a hydrocarbon suspension in supercritical fluid is found to suppress any particle aggregation, resulting in excellent sphere monodispersity. CoreÀshell hybrid structures of CÀGe were subsequently formed by inducing the growth of 10À40 nm sized germanium nanocrystals from the spheres in a hierarchical bottomup approach. Extensive characterization of the spheres and nanocrystals was conducted using transmission and scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, Raman, and thermogravametric analysis. Assemblies of nanocrystal modified carbon colloids impart outstanding superhydrophobic properties due to the combined nano-and microstructuring of the particle arrays.

Journal of the American Chemical Society, 2009

Spontaneous elongation from nanorod to nanowire in the presence of an amine is reported for nanoc... more Spontaneous elongation from nanorod to nanowire in the presence of an amine is reported for nanocrystals of cadmium sulfide and silver sulfide (cation exchanged from CdS). Elongation occurs instantaneously where the final aspect ratio is a controllable multiple of the original nanorod length.

Spinal cord tumors in children: long-term results of combined surgical and radiation treatment

Journal of Neurosurgery, 1994

The authors report a series of 31 children under 17 years of age with primary spinal cord tumors ... more The authors report a series of 31 children under 17 years of age with primary spinal cord tumors who underwent radiation treatment following decompression laminectomy with or without tumor resection between 1959 and 1990. The tumors consisted of 15 astrocytomas, 11 ependymomas, one mixed glioma, one gangliolioma, and three of unknown histology. Ten- and 20-year survival rates and 10- and 20-year relapse-free survival rates for the 28 patients with known histology were 80% and 53%, and 73% and 67%, respectively. Eleven patients (35%) had no resection, 14 (45%) had a partial resection, and six (19%) had a grossly complete resection. Eight patients (26%) are dead: five due to recurrent tumor, two due to a second malignant tumor, and one due to intercurrent disease. primary tumor relapse or progression occurred in nine patients (29%), four of whom were salvaged. A second malignant tumor developed in four patients (13%), two of whom died. Local control of the tumor was finally achieved in 26 cases (84%), despite either grossly incomplete or no resection in 25 of these cases (81%). These statistics suggest that radiation treatment without resection may achieve long-term control in children with astrocytoma or ependymoma of the spinal cord.

Journal of Materials Chemistry, 2010

Gold tip size and multiplicity is controlled in hybrid gold-semiconductor nanorods (CdS-Au, CdSe-... more Gold tip size and multiplicity is controlled in hybrid gold-semiconductor nanorods (CdS-Au, CdSe-Au and CdTe-Au) in fast reaction times of less than 2 minutes by optimising precursor type, concentration, and temperature. Controllable gold tips up to as large as 40 nm on a rod diameter of 7 nm are reported with the tip size shown to be directly related to the redox potentials of the dangling atoms on the nanorod and the gold chloride precursors (mono or trivalent). The preference for symmetric (both ends) over asymmetric (single end) is achieved by simply elevating the reaction temperature to 80ºC without changing the reaction time. TEM and XRD analysis were preformed to verify both the gold nanoparticle size and crystallinity of the hybrid nanostructures. Increased quenching of nanorod emission is observed as the size of the gold tip increases suggesting optimisation of charge transfer between the semiconductor and the metal.

Journal of Materials Chemistry, 2010

High yields of both single-crystalline Si and Ge/SiO x core-shell nanowires were nucleated and gr... more High yields of both single-crystalline Si and Ge/SiO x core-shell nanowires were nucleated and grown in metal reactor cells under high-pressure supercritical fluid conditions, without the addition of catalyst particle seeds or a porous template. Nanowire growth was only achieved when the fluid medium of supercritical CO 2 and the organometallic precursors were used in conjunction with a coordinating solvent, trioctylphosphine. The diameter and length of the nanowires are found to be in the ranges of 30 to 60 nm and 1 to 10 mm, respectively. The correlation of nanowire growth with the eutectic binary phase diagrams of the semiconductor-metal and the presence of metal impurities at the base of the synthesized nanowires suggest a supercritical fluid-solid-solid growth mechanism occurring from the reaction cell walls. The nanowires are characterized by transmission electron microscopy, energydispersive X-ray spectroscopy, X-ray photoelectron spectroscopy and scanning electron microscopy. The electrical characteristics for individually picked nanowires are also investigated by means of mechanical nanoprobing.

CR-13RADIATION-INDUCED Glioblastoma Multiforme Within 4 Years of Cranial Irradiation for Paediatric Craniopharyngioma - Case Report and Review of the Literature

Neuro-Oncology, 2016

Rhabdoid tumor: the Irish experience 1986–2013

Cancer Genetics, 2014

Nomenclature for the three recognized forms of rhabdoid tumor reflect their anatomic localization... more Nomenclature for the three recognized forms of rhabdoid tumor reflect their anatomic localization and include malignant rhabdoid tumor of the kidney (MRTK), extrarenal extracranial rhabdoid tumor (EERT), and atypical teratoid rhabdoid tumor (ATRT) involving the central nervous system. A strikingly simple karyotype belies the fact that rhabdoid tumors are among the most lethal human cancers, and now early strides are beginning to elucidate their molecular pathogenesis. Rhabdoid tumors are largely confined to the pediatric population, where they occur preferentially during infancy. Given the rarity of this tumor, international consensus on best treatment has only recently been achieved in conjunction with the establishment of the European Rhabdoid Tumor Registry. Between 1986 and 2013, 25 pediatric patients were diagnosed with rhabdoid tumor in the Republic of Ireland. Of these patients, 13 presented with ATRT, eight had MRTK, and four had EERT. The mean age at diagnosis was 38.8 months, with an equal sex incidence. Because of the lack of a standardized treatment strategy for rhabdoid tumors, these patients have been treated largely according to anatomic site, based on sarcoma, renal, or brain tumor protocols contemporary to their diagnoses. Of the patients, 84% received chemotherapy, 80% underwent surgery, and 44% had radiation therapy. The outcome overall was poor, independent of anatomic location. The overall survival rate was 24%, and mean time to death was just under 9 months.

Radiotherapy and Oncology, 2004

Background and Purpose: To prospectively assess the feasibility and efficacy of a hypofractionate... more Background and Purpose: To prospectively assess the feasibility and efficacy of a hypofractionated accelerated radiotherapy regimen (72 Gy in 24 daily fractions, 3Gy per fraction) in patients (pts) with non-resectable non-small-cell lung cancer (NSCLC).

OC-0079: CTV-to-PTV margin for treatment setup errors: paediatric vs adult

Radiotherapy and Oncology, 2015

Facet Specific Gold Tip Growth on Semiconductor Nanorods

ECS Transactions, 2009

Abstract High quality CdS-Au and CdSe-Au hybrid nanocrystals have been developed via facile appro... more Abstract High quality CdS-Au and CdSe-Au hybrid nanocrystals have been developed via facile approaches. Gold tip growth onto II-VI nanorods has been shown to occur instantaneously both via a solution and spin cast method. Gold tip size and multiplicity can be varied by changing the starting gold chloride concentration or the reaction duration. Gold tip growth typically occurs at one end of the nanorod, however we recently observed that a variation in the reaction temperature leads to the growth of a tip on both ends of the ...

Electrophoretic Deposition of Spherical and Rod-Shaped Nanocrystals into Close Packed Superlattices

ECS Transactions, 2009

Abstract Ordered nanocrystal assemblies are an exciting new class of materials where electronic, ... more Abstract Ordered nanocrystal assemblies are an exciting new class of materials where electronic, optical or magnetic properties can be dictated by tuning the position and ligand environment of each nanocrystal structural unit. Device integration in both nanoelectronics and nanophotonics relies on the ability to locate these ensembles with nanoscale accuracy exactly where they are needed. In this paper we overview our recent work in the area of electrophoretic deposition of charged nanocrystals from toluene.(1, 2) The systems ...

Rhabdoid tumor: the Irish experience 1986–2013

Cancer Genetics, 2014

Nomenclature for the three recognized forms of rhabdoid tumor reflect their anatomic localization... more Nomenclature for the three recognized forms of rhabdoid tumor reflect their anatomic localization and include malignant rhabdoid tumor of the kidney (MRTK), extrarenal extracranial rhabdoid tumor (EERT), and atypical teratoid rhabdoid tumor (ATRT) involving the central nervous system. A strikingly simple karyotype belies the fact that rhabdoid tumors are among the most lethal human cancers, and now early strides are beginning to elucidate their molecular pathogenesis. Rhabdoid tumors are largely confined to the pediatric population, where they occur preferentially during infancy. Given the rarity of this tumor, international consensus on best treatment has only recently been achieved in conjunction with the establishment of the European Rhabdoid Tumor Registry. Between 1986 and 2013, 25 pediatric patients were diagnosed with rhabdoid tumor in the Republic of Ireland. Of these patients, 13 presented with ATRT, eight had MRTK, and four had EERT. The mean age at diagnosis was 38.8 months, with an equal sex incidence. Because of the lack of a standardized treatment strategy for rhabdoid tumors, these patients have been treated largely according to anatomic site, based on sarcoma, renal, or brain tumor protocols contemporary to their diagnoses. Of the patients, 84% received chemotherapy, 80% underwent surgery, and 44% had radiation therapy. The outcome overall was poor, independent of anatomic location. The overall survival rate was 24%, and mean time to death was just under 9 months.

Radiotherapy and Oncology, 2004

Background and Purpose: To prospectively assess the feasibility and efficacy of a hypofractionate... more Background and Purpose: To prospectively assess the feasibility and efficacy of a hypofractionated accelerated radiotherapy regimen (72 Gy in 24 daily fractions, 3Gy per fraction) in patients (pts) with non-resectable non-small-cell lung cancer (NSCLC).

Nanoscale, 2011

A facile spin cast route was developed to convert perpendicularly aligned nanorod assemblies of c... more A facile spin cast route was developed to convert perpendicularly aligned nanorod assemblies of cadmium chalcogenides into their silver and copper analogues. The assemblies are rapidly cation exchanged without affecting 10

Activating point mutations of thegsp oncogene in human thyroid adenomas

Molecular Carcinogenesis, 1991

ABSTRACT

Langmuir, 2011

Colloidal carbon spheres were synthesized by the carbonization of squalane, a nonvolatile hydroca... more Colloidal carbon spheres were synthesized by the carbonization of squalane, a nonvolatile hydrocarbon solvent, in supercritical carbon dioxide. Precise pressure modulation of the fluid medium led to size controlled growth of carbon spheres ranging from 300 to 1500 nm in diameter. This unique synthetic approach of carbonizing a hydrocarbon suspension in supercritical fluid is found to suppress any particle aggregation, resulting in excellent sphere monodispersity. CoreÀshell hybrid structures of CÀGe were subsequently formed by inducing the growth of 10À40 nm sized germanium nanocrystals from the spheres in a hierarchical bottomup approach. Extensive characterization of the spheres and nanocrystals was conducted using transmission and scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, Raman, and thermogravametric analysis. Assemblies of nanocrystal modified carbon colloids impart outstanding superhydrophobic properties due to the combined nano-and microstructuring of the particle arrays.

Journal of the American Chemical Society, 2009

Spontaneous elongation from nanorod to nanowire in the presence of an amine is reported for nanoc... more Spontaneous elongation from nanorod to nanowire in the presence of an amine is reported for nanocrystals of cadmium sulfide and silver sulfide (cation exchanged from CdS). Elongation occurs instantaneously where the final aspect ratio is a controllable multiple of the original nanorod length.

Spinal cord tumors in children: long-term results of combined surgical and radiation treatment

Journal of Neurosurgery, 1994

The authors report a series of 31 children under 17 years of age with primary spinal cord tumors ... more The authors report a series of 31 children under 17 years of age with primary spinal cord tumors who underwent radiation treatment following decompression laminectomy with or without tumor resection between 1959 and 1990. The tumors consisted of 15 astrocytomas, 11 ependymomas, one mixed glioma, one gangliolioma, and three of unknown histology. Ten- and 20-year survival rates and 10- and 20-year relapse-free survival rates for the 28 patients with known histology were 80% and 53%, and 73% and 67%, respectively. Eleven patients (35%) had no resection, 14 (45%) had a partial resection, and six (19%) had a grossly complete resection. Eight patients (26%) are dead: five due to recurrent tumor, two due to a second malignant tumor, and one due to intercurrent disease. primary tumor relapse or progression occurred in nine patients (29%), four of whom were salvaged. A second malignant tumor developed in four patients (13%), two of whom died. Local control of the tumor was finally achieved in 26 cases (84%), despite either grossly incomplete or no resection in 25 of these cases (81%). These statistics suggest that radiation treatment without resection may achieve long-term control in children with astrocytoma or ependymoma of the spinal cord.

Journal of Materials Chemistry, 2010

Gold tip size and multiplicity is controlled in hybrid gold-semiconductor nanorods (CdS-Au, CdSe-... more Gold tip size and multiplicity is controlled in hybrid gold-semiconductor nanorods (CdS-Au, CdSe-Au and CdTe-Au) in fast reaction times of less than 2 minutes by optimising precursor type, concentration, and temperature. Controllable gold tips up to as large as 40 nm on a rod diameter of 7 nm are reported with the tip size shown to be directly related to the redox potentials of the dangling atoms on the nanorod and the gold chloride precursors (mono or trivalent). The preference for symmetric (both ends) over asymmetric (single end) is achieved by simply elevating the reaction temperature to 80ºC without changing the reaction time. TEM and XRD analysis were preformed to verify both the gold nanoparticle size and crystallinity of the hybrid nanostructures. Increased quenching of nanorod emission is observed as the size of the gold tip increases suggesting optimisation of charge transfer between the semiconductor and the metal.

Journal of Materials Chemistry, 2010

High yields of both single-crystalline Si and Ge/SiO x core-shell nanowires were nucleated and gr... more High yields of both single-crystalline Si and Ge/SiO x core-shell nanowires were nucleated and grown in metal reactor cells under high-pressure supercritical fluid conditions, without the addition of catalyst particle seeds or a porous template. Nanowire growth was only achieved when the fluid medium of supercritical CO 2 and the organometallic precursors were used in conjunction with a coordinating solvent, trioctylphosphine. The diameter and length of the nanowires are found to be in the ranges of 30 to 60 nm and 1 to 10 mm, respectively. The correlation of nanowire growth with the eutectic binary phase diagrams of the semiconductor-metal and the presence of metal impurities at the base of the synthesized nanowires suggest a supercritical fluid-solid-solid growth mechanism occurring from the reaction cell walls. The nanowires are characterized by transmission electron microscopy, energydispersive X-ray spectroscopy, X-ray photoelectron spectroscopy and scanning electron microscopy. The electrical characteristics for individually picked nanowires are also investigated by means of mechanical nanoprobing.

CR-13RADIATION-INDUCED Glioblastoma Multiforme Within 4 Years of Cranial Irradiation for Paediatric Craniopharyngioma - Case Report and Review of the Literature

Neuro-Oncology, 2016