Cavit Kazaz - Academia.edu (original) (raw)
Papers by Cavit Kazaz
Medicinal Chemistry Research, Apr 23, 2022
Chemistry & Biodiversity, Jul 19, 2023
In this study, methanol, ethanol, methanol‐dichloromethane (1 : 1, v/v), acetone, ethyl acetate, ... more In this study, methanol, ethanol, methanol‐dichloromethane (1 : 1, v/v), acetone, ethyl acetate, diethyl ether, and chloroform extracts of lavender (Lavandula stoechas L. subsp. stoechas) were prepared by maceration, and the ursolic acid contents in the extracts were determined quantitatively by HPLC analyses. The present results show that the methanol‐dichloromethane (1 : 1, v/v) solvent system is the most efficient solvent system for the extraction of ursolic acid from the plant sample with the highest yield (2.22 g/100 g plant sample). In the present study, a new practical method for the isolation of ursolic acid from polar extracts was also demonstrated for the first time. The inhibition effects of the extracts and ursolic acid were also revealed on α‐glycosidase, acetylcholinesterase, butyrylcholinesterase, and human carbonic anhydrase I and II enzymes by determining IC50 values for the first time. The extracts and ursolic acid acted as potent antidiabetic agents by strongly inhibiting the α‐glycosidase activity, whereas they were found to be very weak neuroprotective agents. In view of the present results, L. stoechas and its major metabolite, ursolic acid, can be recommended as a herbal source to control postprandial blood sugar levels and prevent diabetes by delaying the digestion of starch in food.
Records of Natural Products, 2015
Planta Medica, Dec 14, 2016
Main Group Metal Chemistry, 2009
Natural Product Research, Nov 17, 2018
European journal of medicinal chemistry, Feb 1, 2006
A series of Schiff bases, combining 2,4-disubstituted thiazole and cyclobutane rings, and hydrazo... more A series of Schiff bases, combining 2,4-disubstituted thiazole and cyclobutane rings, and hydrazone moieties in the same molecule, was synthesized, characterized and evaluated for screening antibacterial and antifungal activities on microorganisms, respectively, on four bacteria and Candida tropicalis. The structures of original compounds were confirmed by analytical and spectroscopic (FT-IR, (1)H NMR and (13)C NMR) methods and elemental analysis. Both the antibacterial and antifungal activities and MIC values of compounds were reported. Among the tested compounds, the most effective compound providing a MIC value of 16 microg ml(-1) are 2 against C. tropicalis and Bacillus subtilis and 3 against B. subtilis only.
ChemInform, Aug 18, 2011
The majority of the synthesized compounds show better potency than 5-fluorouracil against human H... more The majority of the synthesized compounds show better potency than 5-fluorouracil against human Huh-7 hepatoma cells.
Chemistry & Biodiversity, Aug 1, 2014
The dried rhizomes of Veratrum album were individually extracted with CHCl3 , acetone, and NH4 OH... more The dried rhizomes of Veratrum album were individually extracted with CHCl3 , acetone, and NH4 OH/benzene to test the toxic effects against the Colorado potato beetle, Leptinotarsa decemlineata, which is an important agricultural pest. Fifteen compounds in various amounts were isolated from the extracts using column and thin-layer chromatography. The chemical structures of 14 compounds were characterized as octacosan-1-ol (1), β-sitosterol (2), stearic acid (3), diosgenin (4), resveratrol (5), wittifuran X (6), oxyresveratrol (7), β-sitosterol 3-O-β-D-glucopyranoside (8), diosgenin 3-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyronoside (9), oxyresveratrol 3-O-β-D-glucopyranoside (10), jervine (11), pseudojervine (13), 5,6-dihydro-1-hydroxyjervine (14), and saccharose (15) using UV, IR, MS, (1) H- and (13)C-NMR, and 2D-NMR spectroscopic methods. However, the chemical structure of 12, an oligosaccharide, has not fully been elucidated. Compounds 4, 6, 9, and 10 were isolated from V. album rhizomes for the first time in the current study. The toxic effects of three extracts (acetone, CHCl3 , and NH4 OH/benzene) and six metabolites, 2, 2+4, 5, 7, 8, and 11, were evaluated against the Colorado potato beetle. The assay revealed that all three extracts, and compounds 7, 8, and 11 exhibited potent toxic effects against this pest. This is the first report on the evaluation of the toxic effects of the extracts and secondary metabolites of V. album rhizomes against L. decemlineata. Based on these results, it can be concluded that the extracts can be used as natural insecticides.
Applied sciences, Jan 23, 2023
Planta Medica, Aug 24, 2010
The genus Pimpinella is represented by 23 species in the flora of Turkey, 5 of them are endemic. ... more The genus Pimpinella is represented by 23 species in the flora of Turkey, 5 of them are endemic. Pimpinella species have carminative, expectorant, sedative, antidepressant, antiseptic, insecticidal, antiviral, antispasmodic, nematocidal, mutagenic, analgesic, antifungal, antibacterial, diuretic, estrogenic, antimalarial, pectoral, stimulant. The essential oils from the fruits of some Pimpinella species are also valuable in perfumery and in medicine. Earlier investigations of Pimpinella resulted in the isolation of terpenoids, lipids, alkaloids, coumarins, flavonoids and phenylpropanoids. Pimpinella are reported to contain iridoids, diterpenoids, essential oils, ketosteroids and flavonoids. In this study, dried and powdered flowering stems of Pimpinella kotschyana were extracted with MeOH. Methanolic extract was dissolved in H2O and partitioned with CH2Cl2 followed by n-BuOH. Firstly, the n-BuOH phase (57g) was fractionated on a silica gel column. The subfractions were further chromatographed over silica gel, reversed phase silica gel and Sephadex LH-20 to give two new acylated flavonol glycosides together with four known flavonol glycosides: Kaempherol 3-O-α -L-2″- E-feruloyl, 3″- E-p-coumaroyl) rhamnopyranoside, kaempherol 3-O-α-L-(3″-E-feruloyl) rhamnopyranoside, kaempherol 3-O-rutinoside, quercetin-3-O-α-L-rhamnopyranoside, quercetin-3-O-rutinoside, isorhamnetin 3-O-α-L- rhamnopyranoside. The structure elucidation of the isolated compounds were done by spectroscopic methods [1D and 2D NMR spectra and MS data interpretation] and by comparison of their physical and spectroscopical data with literature values. This is the first report describing the isolation of flavonoids from the aerial parts of Pimpinella kotschyana.
DergiPark (Istanbul University), Apr 1, 2006
ChemInform, May 2, 2006
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
ChemInform, Jul 8, 2008
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Materials Today Chemistry, Jun 1, 2022
Beilstein Journal of Organic Chemistry
Previously we reported on the bromination of endo-7-bromonorbornene at different temperatures yie... more Previously we reported on the bromination of endo-7-bromonorbornene at different temperatures yielding mixtures of addition products. The structural elucidations of the formed compounds were achieved by NMR spectroscopy. Particularly, the γ-gauche effect and long-range couplings were instrumental in assigning the stereochemistry of the adducts. However, in a recent paper, Novitskiy and Kutateladze claimed that based on an applied machine learning-augmented DFT method for computational NMR that the structure of the product, (1R,2R,3S,4S,7s)-2,3,7-tribromobicyclo[2.2.1]heptane was wrong. With the aid of their computational method, they revised a number of published structures, including ours, and assigned our product the structure (1R,2S,3R,4S,7r)-2,3,7-tribromobicyclo[2.2.1]heptane. To fit their revised structure, they proposed an alternative mechanism featuring a skeletal rearrangement without the intermediacy of a carbocation. Herein, we are not only confirming the structure origin...
Social Science Research Network, 2023
Medicinal Chemistry Research, Apr 23, 2022
Chemistry & Biodiversity, Jul 19, 2023
In this study, methanol, ethanol, methanol‐dichloromethane (1 : 1, v/v), acetone, ethyl acetate, ... more In this study, methanol, ethanol, methanol‐dichloromethane (1 : 1, v/v), acetone, ethyl acetate, diethyl ether, and chloroform extracts of lavender (Lavandula stoechas L. subsp. stoechas) were prepared by maceration, and the ursolic acid contents in the extracts were determined quantitatively by HPLC analyses. The present results show that the methanol‐dichloromethane (1 : 1, v/v) solvent system is the most efficient solvent system for the extraction of ursolic acid from the plant sample with the highest yield (2.22 g/100 g plant sample). In the present study, a new practical method for the isolation of ursolic acid from polar extracts was also demonstrated for the first time. The inhibition effects of the extracts and ursolic acid were also revealed on α‐glycosidase, acetylcholinesterase, butyrylcholinesterase, and human carbonic anhydrase I and II enzymes by determining IC50 values for the first time. The extracts and ursolic acid acted as potent antidiabetic agents by strongly inhibiting the α‐glycosidase activity, whereas they were found to be very weak neuroprotective agents. In view of the present results, L. stoechas and its major metabolite, ursolic acid, can be recommended as a herbal source to control postprandial blood sugar levels and prevent diabetes by delaying the digestion of starch in food.
Records of Natural Products, 2015
Planta Medica, Dec 14, 2016
Main Group Metal Chemistry, 2009
Natural Product Research, Nov 17, 2018
European journal of medicinal chemistry, Feb 1, 2006
A series of Schiff bases, combining 2,4-disubstituted thiazole and cyclobutane rings, and hydrazo... more A series of Schiff bases, combining 2,4-disubstituted thiazole and cyclobutane rings, and hydrazone moieties in the same molecule, was synthesized, characterized and evaluated for screening antibacterial and antifungal activities on microorganisms, respectively, on four bacteria and Candida tropicalis. The structures of original compounds were confirmed by analytical and spectroscopic (FT-IR, (1)H NMR and (13)C NMR) methods and elemental analysis. Both the antibacterial and antifungal activities and MIC values of compounds were reported. Among the tested compounds, the most effective compound providing a MIC value of 16 microg ml(-1) are 2 against C. tropicalis and Bacillus subtilis and 3 against B. subtilis only.
ChemInform, Aug 18, 2011
The majority of the synthesized compounds show better potency than 5-fluorouracil against human H... more The majority of the synthesized compounds show better potency than 5-fluorouracil against human Huh-7 hepatoma cells.
Chemistry & Biodiversity, Aug 1, 2014
The dried rhizomes of Veratrum album were individually extracted with CHCl3 , acetone, and NH4 OH... more The dried rhizomes of Veratrum album were individually extracted with CHCl3 , acetone, and NH4 OH/benzene to test the toxic effects against the Colorado potato beetle, Leptinotarsa decemlineata, which is an important agricultural pest. Fifteen compounds in various amounts were isolated from the extracts using column and thin-layer chromatography. The chemical structures of 14 compounds were characterized as octacosan-1-ol (1), β-sitosterol (2), stearic acid (3), diosgenin (4), resveratrol (5), wittifuran X (6), oxyresveratrol (7), β-sitosterol 3-O-β-D-glucopyranoside (8), diosgenin 3-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyronoside (9), oxyresveratrol 3-O-β-D-glucopyranoside (10), jervine (11), pseudojervine (13), 5,6-dihydro-1-hydroxyjervine (14), and saccharose (15) using UV, IR, MS, (1) H- and (13)C-NMR, and 2D-NMR spectroscopic methods. However, the chemical structure of 12, an oligosaccharide, has not fully been elucidated. Compounds 4, 6, 9, and 10 were isolated from V. album rhizomes for the first time in the current study. The toxic effects of three extracts (acetone, CHCl3 , and NH4 OH/benzene) and six metabolites, 2, 2+4, 5, 7, 8, and 11, were evaluated against the Colorado potato beetle. The assay revealed that all three extracts, and compounds 7, 8, and 11 exhibited potent toxic effects against this pest. This is the first report on the evaluation of the toxic effects of the extracts and secondary metabolites of V. album rhizomes against L. decemlineata. Based on these results, it can be concluded that the extracts can be used as natural insecticides.
Applied sciences, Jan 23, 2023
Planta Medica, Aug 24, 2010
The genus Pimpinella is represented by 23 species in the flora of Turkey, 5 of them are endemic. ... more The genus Pimpinella is represented by 23 species in the flora of Turkey, 5 of them are endemic. Pimpinella species have carminative, expectorant, sedative, antidepressant, antiseptic, insecticidal, antiviral, antispasmodic, nematocidal, mutagenic, analgesic, antifungal, antibacterial, diuretic, estrogenic, antimalarial, pectoral, stimulant. The essential oils from the fruits of some Pimpinella species are also valuable in perfumery and in medicine. Earlier investigations of Pimpinella resulted in the isolation of terpenoids, lipids, alkaloids, coumarins, flavonoids and phenylpropanoids. Pimpinella are reported to contain iridoids, diterpenoids, essential oils, ketosteroids and flavonoids. In this study, dried and powdered flowering stems of Pimpinella kotschyana were extracted with MeOH. Methanolic extract was dissolved in H2O and partitioned with CH2Cl2 followed by n-BuOH. Firstly, the n-BuOH phase (57g) was fractionated on a silica gel column. The subfractions were further chromatographed over silica gel, reversed phase silica gel and Sephadex LH-20 to give two new acylated flavonol glycosides together with four known flavonol glycosides: Kaempherol 3-O-α -L-2″- E-feruloyl, 3″- E-p-coumaroyl) rhamnopyranoside, kaempherol 3-O-α-L-(3″-E-feruloyl) rhamnopyranoside, kaempherol 3-O-rutinoside, quercetin-3-O-α-L-rhamnopyranoside, quercetin-3-O-rutinoside, isorhamnetin 3-O-α-L- rhamnopyranoside. The structure elucidation of the isolated compounds were done by spectroscopic methods [1D and 2D NMR spectra and MS data interpretation] and by comparison of their physical and spectroscopical data with literature values. This is the first report describing the isolation of flavonoids from the aerial parts of Pimpinella kotschyana.
DergiPark (Istanbul University), Apr 1, 2006
ChemInform, May 2, 2006
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
ChemInform, Jul 8, 2008
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Materials Today Chemistry, Jun 1, 2022
Beilstein Journal of Organic Chemistry
Previously we reported on the bromination of endo-7-bromonorbornene at different temperatures yie... more Previously we reported on the bromination of endo-7-bromonorbornene at different temperatures yielding mixtures of addition products. The structural elucidations of the formed compounds were achieved by NMR spectroscopy. Particularly, the γ-gauche effect and long-range couplings were instrumental in assigning the stereochemistry of the adducts. However, in a recent paper, Novitskiy and Kutateladze claimed that based on an applied machine learning-augmented DFT method for computational NMR that the structure of the product, (1R,2R,3S,4S,7s)-2,3,7-tribromobicyclo[2.2.1]heptane was wrong. With the aid of their computational method, they revised a number of published structures, including ours, and assigned our product the structure (1R,2S,3R,4S,7r)-2,3,7-tribromobicyclo[2.2.1]heptane. To fit their revised structure, they proposed an alternative mechanism featuring a skeletal rearrangement without the intermediacy of a carbocation. Herein, we are not only confirming the structure origin...
Social Science Research Network, 2023