Céline Bugli - Academia.edu (original) (raw)

Papers by Céline Bugli

SUMMARY The dierential eects of basic visual or auditory stimuli on electroencephalograms (EEG), ... more SUMMARY The dierential eects of basic visual or auditory stimuli on electroencephalograms (EEG), named event related potentials (ERPs), are often used to evaluate the impact of treatments on brain performances. In the present paper, we propose a P-splines based model that can be used to evaluate treatment eect on the timing and the amplitude of some peaks of the ERPs curves. Functional ANOVA is an adaptation of linear model or analysis of variance to analyse functional observations. The changes in the functional of interest eects are generally described using smoothing splines. Eilers and Marx proposed to work with P-splines, a combination of B-splines and dierence penalties on coecients. We dene a P- splines model for ERPs curves combined with random eects. In particular, we show that it is a useful alternative to classical strategies requiring the visual and usually imprecise localization of specic ERP peaks from curves with a low signal-to-noise ratio. Copyright ? 2005 John Wiley...

Therapeutic Advances in Endocrinology and Metabolism

Objective: To evaluate the residual effect of partial remission (PR) on immediate post-PR glycemi... more Objective: To evaluate the residual effect of partial remission (PR) on immediate post-PR glycemic control according to its occurrence and duration in a cohort of children with type 1 diabetes mellitus (T1DM). Patients and Methods: Values of glycemic control parameters [i.e. HbA1C, insulin dose–adjusted hemoglobin A1C (IDAA1C), glycemic target–adjusted HbA1C (GTAA1C)] and data from glucose monitoring devices from 189 pediatric patients with new-onset type 1 diabetes were collected retrospectively from 24 months. Patients were characterized according to their remission status (PR+ and PR−). PR+ patients were subdivided into three subgroups regarding PR duration [i.e. short (⩾3–⩽6 months), intermediate (>6–⩽12 months), and long PR (>12–⩽14 months)]. We compared glycemic control data from each PR+ subgroup at +6 and +12 months post-PR with PR− patients at the same postdiagnosis time. Second, PR+ subgroups were compared with each other. Results: PR+ patients showed improved glycem...

Revue D Epidemiologie Et De Sante Publique, May 1, 2022

$Research paper thumbnail of Value of a radiographic score for the assessment of healing of nailed femoral and tibial shaft fractures: A retrospective preliminary study$

European journal of radiology, 2018

To assess the value of a radiographic score for the detection of delayed union in nailed fracture... more To assess the value of a radiographic score for the detection of delayed union in nailed fractures. The modified radiographic union score (mRUS) values were determined by three separate radiologists on 259 radiographic sets of 58 nailed tibial or femoral fractures obtained at different timepoints after fracture (mean of 4.5 radiographic sets per fracture). A surgeon determined fracture outcome (normal or delayed union) at a mean of 192days after injury. Mean radiographic scores obtained at different timepoints after fracture were compared between fractures with normal or abnormal healing at follow-up. The mean score values increased significantly over time for fractures with normal healing for all readers (p<0.001). The mean score values determined 11-14 weeks after injury were higher in fractures with normal healing than in fractures with delayed union at follow-up (p<0.05). Scoring of radiographs obtained at about 3 months after injury or later enabled detection of fractures...

Journal Français d'Ophtalmologie, 2021

PURPOSE To assess the predictive value for functional recovery of Ganglion Cell Complex Layer (GC... more PURPOSE To assess the predictive value for functional recovery of Ganglion Cell Complex Layer (GCC) and Retinal Nerve Fiber Layer (RNFL) measurements obtained by Optical Coherence Tomography (OCT) in patients undergoing chiasmal decompression and to define potential OCT thresholds for visual recovery. METHODS We measured preoperative GCC and RNFL thickness in patients with a sellar and/or perisellar tumor compressing the optic chiasm. Visual recovery was defined as recovery of mean deviation (MD) and pattern standard deviation (PSD) using Humphrey visual field testing after 12 successful decompressions (24 eyes). Receiver operating characteristic curve (ROC) analysis was used to identify the best thresholds. RESULTS Robust global and focal OCT thresholds were found. Superior GCC≥63μm had the best functional prognostic value (AUC=1) for visual improvement. Mean GCC ≥ 67μm and mean RNFL≥75μm also had excellent predictive values (AUC>0.9). CONCLUSION In this preliminary study, significant preoperative OCT thresholds for early visual recovery after chiasmal decompression were identified, mainly regarding GCC measurements. Further studies on larger cohorts with closely scheduled follow-up could refine our results.

Supplemental material, MSJ943785_supplemental_table for The central vein sign in multiple scleros... more Supplemental material, MSJ943785_supplemental_table for The central vein sign in multiple sclerosis patients with vascular comorbidities by François Guisset, Valentina Lolli, Céline Bugli, Gaetano Perrotta, Julie Absil, Bernard Dachy, Caroline Pot, Marie Théaudin, Marco Pasi, Vincent van Pesch and Pietro Maggi in Multiple Sclerosis Journal

Since its first use in human in 1929, the electroencephalogram (EEG) has become one of the most i... more Since its first use in human in 1929, the electroencephalogram (EEG) has become one of the most important diagnostic tool in clinical neurophysiology. However, their use in clinical studies is limited because the huge quantity of collected information is complicated to treat. Indeed, it is very difficult to have an overall picture of this multivariate problem. In addition to the impressive quantity of data to be treated, an intrinsic problem with electroencephalograms is that the signals are "contaminated" by body signals not directly related to cerebral activity. However, these signals do not interest us directly to evaluate treatment effect on the brain. Removing these signals known as "parasitic noise" from electroencephalograms is a difficult task. We use clinical data kindly made available by the pharmaceutical company Eli Lilly (Lilly Clinical Operations S.A., Louvain-la-Neuve, Belgium). Particular types of analyses were already carried out on these data, m...

Journal of Cancer Education, 2020

General practitioners (GPs) are among the main actors involved in early melanoma diagnosis. Howev... more General practitioners (GPs) are among the main actors involved in early melanoma diagnosis. However, melanoma diagnostic accuracy and management are reported to be insufficient among GPs in Europe. The primary aim of this observational prospective study was to shed light on melanoma diagnostic practices among French-speaking Belgian GPs. The second aim was to specifically analyse these GPs’ pigmented skin lesion diagnostic accuracy and management. GPs from the five French-speaking districts of Belgium were asked to complete a questionnaire, before taking part in a melanoma diagnostic training session. First, we assessed the GPs’ current melanoma diagnostic practices. Then, their pigmented skin lesion diagnostic accuracy and management were evaluated, through basic theoretical questions and clinical images. These results were subsequently analysed, according to the GPs’ sociodemographic characteristics and medical practice type. In total, 89 GPs completed the questionnaire. Almost half of the GPs (43%; CI = [33;54]) were confronted with a suspicious skin lesion as the main reason for consultation once every 3 months, while 33% (CI = [24;43]) were consulted for a suspicious lesion as a secondary reason once a month. Prior to training, one-third of the GPs exhibited suboptimal diagnostic accuracy in at least one of six “life-threatening” clinical cases among two sets of 10 clinical images of pigmented skin lesions, which can lead to inadequate patient management (i.e. incorrect treatment and/or inappropriate reinsurance). This study underlines the need to train GPs in melanoma diagnosis. GPs’ pigmented skin lesion diagnostic accuracy and management should be improved to increase early melanoma detection.

Multiple Sclerosis Journal, 2020

Background: The central vein sign (CVS) is an imaging biomarker able to differentiate multiple sc... more Background: The central vein sign (CVS) is an imaging biomarker able to differentiate multiple sclerosis (MS) from other conditions causing similar appearance lesions on magnetic resonance imaging (MRI), including cerebral small vessel disease (CSVD). However, the impact of vascular risk factors (VRFs) for CSVD on the percentage of CVS positive (CVS+) lesions in MS has never been evaluated. Objective: To investigate the association between different VRFs and the percentage of CVS+ lesions in MS. Methods: In 50 MS patients, 3T brain MRIs (including high-resolution 3-dimensional T2*-weighted images) were analyzed for the presence of the CVS and MRI markers of CSVD. A backward stepwise regression model was used to predict the combined predictive effect of VRF (i.e. age, hypertension, diabetes, obesity, ever-smoking, and hypercholesterolemia) and MRI markers of CSVD on the CVS. Results: The median frequency of CVS+ lesions was 71% (range: 35%–100%). In univariate analysis, age ( p < ...

Allergy, 2019

This article has been accepted for publication and undergone full peer review but has not been th... more This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

Revue des Maladies Respiratoires

A national surveillance programme of occupational asthma was set up to estimate the incidence and... more A national surveillance programme of occupational asthma was set up to estimate the incidence and identify the causes of this disorder in Belgium. The programme was based on the voluntary notification of new cases of occupational asthma by chest specialists and occupational physicians during the period 2000-2002. 92% of the reported cases included occupational asthma of an immunological type and 8% bronchial irritability. According to the opinion of the reporting physicians the diagnosis was considered certain in 39%, probable in 29% and possible in 32% of cases. On the basis of these notifications the mean annual incidence of occupational asthma is estimated as 23.5 cases per million workers (95% confidence interval 19.2-28.8). The most frequently incriminated substances were isocyanates (16%), cereals (12%) and latex (10%). At the time of diagnosis 38% of patients had not applied for compensation. The results of this programme of notification of occupational asthma agree with the ...

Revue des Maladies Respiratoires, 2005

Introduction Un programme national de surveillance de l'asthme professionnel a été instauré afin ... more Introduction Un programme national de surveillance de l'asthme professionnel a été instauré afin d'estimer l'incidence et d'identifier les causes de cette affection en Belgique. Matériel et méthodes Le programme était basé sur la déclaration volontaire des nouveaux cas d'asthme professionnel par les pneumologues et les médecins du travail pendant la période 2000-2002. Résultats Les cas déclarés incluaient 92 % d'asthmes professionnels de type « immunologique » et 8 % de syndromes d'irritation des bronches. Selon l'opinion exprimée par les médecins déclarants, le diagnostic était considéré comme certain dans 39 % cas, probable dans 29 % des cas et possible dans 32 % des cas. Sur base des déclarations, l'incidence annuelle moyenne de l'asthme professionnel peut être estimée à 23,5 (intervalle de confiance à 95 % : 19,2-28,8) cas par million de travailleurs. Les substances les plus fréquemment incriminés étaient les isocyanates (16 %), les céréales (12 %) et le latex (10 %). Au moment du diagnostic, 38 % des patients n'avaient pas introduit de demande d'indemnisation. Conclusion Les résultats de ce programme de déclaration de l'asthme professionnel concordent avec les données disponibles dans d'autres pays et apportent des informations complémentaires par rapport aux statistiques médico-légales.

Statistics in Medicine, 2006

The differential effects of basic visual or auditory stimuli on electroencephalograms (EEG), name... more The differential effects of basic visual or auditory stimuli on electroencephalograms (EEG), named event related potentials (ERPs), are often used to evaluate the impact of treatments on brain performances. In the present paper, we propose a P-splines based model that can be used to evaluate treatment effect on the timing and the amplitude of some peaks of the ERPs curves. Functional ANOVA is an adaptation of linear model or analysis of variance to analyse functional observations. The changes in the functional of interest effects are generally described using smoothing splines. Eilers and Marx proposed to work with P-splines, a combination of B-splines and difference penalties on coefficients. We define a P-splines model for ERPs curves combined with random effects. In particular, we show that it is a useful alternative to classical strategies requiring the visual and usually imprecise localization of specific ERP peaks from curves with a low signal-to-noise ratio.

$Research paper thumbnail of Curve registration using fractional polynomials with application to electroencephalograms analysis$

Please be patient while the object screen loads. Changez de vue : Choisir un site… UCL FUNDP FUSL... more Please be patient while the object screen loads. Changez de vue : Choisir un site… UCL FUNDP FUSL FUCaM. ...

Environmental Science & Technology, 2007

Environmental Research, 2013

Polychlorobiphenyls (PCBs), polybromodiphenylethers (PBDEs) and organochlorine pesticides (OCPs),... more Polychlorobiphenyls (PCBs), polybromodiphenylethers (PBDEs) and organochlorine pesticides (OCPs), such as dichlorodiphenyltrichloroethane (DDT) and hexachlorobenzene (HCB), are considered as endocrine disruptors in laboratory and wild animals. This study investigated whether these compounds and their hydroxylated metabolites (HO-PCBs and HO-PBDEs) may affect the homoeostasis of vitamin A, a dietary hormone, in the blubber and serum of twenty lactating grey seals sampled at early and late lactation on the Isle of May, Scotland. The effect of naturally produced compounds such as the methoxylated (MeO)-PBDEs was also examined. Vitamin A levels in inner blubber (37 7 9 mg/g wet weight (ww) and 92 7 32 mg/g ww at early and late lactation, respectively) and serum (408 7 143 and 390 7 98 ng/ml at early and late lactation, respectively) appeared to be positively related to SPCBs, SPBDEs and several individual PCB and PBDE congeners in inner blubber and serum. These findings may suggest enhanced mobilisation of hepatic retinoid stores and redistribution in the blubber, a storage site for vitamin A in marine mammals. We have also reported that serum concentrations of SHO-PCBs and 4-OH-CB107 tended to increase with circulating vitamin A levels. Although the direction of the relationships may sometimes differ from those reported in the literature, our results are in agreement with previous findings highlighting a disruption of vitamin A homoeostasis in the blubber and bloodstream following exposure to environmental pollutants. The fact that vitamin A and PCBs appeared to share common mechanisms of mobilisation and transfer during lactation in grey seals (Debier et al., 2004; Vanden Berghe et al., 2010) may also play a role in the different relationships observed between vitamin A and lipophilic pollutants.