Cemalettin Ulusoy - Academia.edu (original) (raw)
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Papers by Cemalettin Ulusoy
Türk biyokimya dergisi, 2016
Objective: The etiology of bronchopulmonary dysplasia (BPD) which is the most important unwanted ... more Objective: The etiology of bronchopulmonary dysplasia (BPD) which is the most important unwanted consequence of premature delivery at long term has not been determined clearly yet.. Insulin-like growth factor-1 (IGF-1) is involved in both prenatal and postnatal lung growth. Our aim is to characterize postnatal changes in serum IGF-1 in relation to development of BPD in preterms. Method: Sixty-seven preterm newborns were evaluated prospectively in order to investigate independent risk factors associated with BPD and to determine the relation between serum IGF-1 levels and BPD. Infants included in the study were divided into two groups as those that developed (Group 1; n=12) and did not develop BPD (Group 2; n=55). Serum IGF-1 levels were measured from venous blood samples of each infant on days 1, 7, 14 and 28 after birth. Results: When the variables showing significant differences in the comparisons between the two groups were evaluated in different logistic regression models, according to the most significant model; presence of chorioamnionitis did not contribute significantly to the development of BPD. It was found that 1 week increase in gestational week reduced the risk of BPD formation by half, while the presence of RDS or sepsis increased the risk of development of BPD by 14.4, and 9.6 times, respectively. ROC analysis with serial measurements of IGF-1 showed that IGF-1 was not a determinant of BPD development. Conclusion: We could not find any relation between development of BPD and serum IGF-1 levels in our study and concluded that the smaller number of newborn who developed BPD could have limited the evaluation of this association.
Graefes Archive for Clinical and Experimental Ophthalmology, Feb 25, 2014
Background To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief... more Background To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief of severe dry eye syndrome (DES), as compared to conventional preservativefree artificial tears (PFAT). Methods This prospective double-blind randomized crossover study used the Ocular Surface Disease Index (OSDI), tear film break-up time (TBUT), Schirmer's Test, and OX-FORD Scale at baseline and after each of two 1-month treatment periods to measure the effect of 20 % diluted AS eye drops vs. PFAT in 20 consecutive severe DES patients that were refractory to conventional treatment. Results The study included 20 (18 female and two male) severe DES patients (40 eyes). Significantly higher TBUT (P<0.001, Wilcoxon signed-rank test) and a greater decrease in OSDI score (55.18 % decrease in the AS treatment group vs. 19.50 % decrease in the PFAT treatment group) (P<0.001, Student's paired samples t-test) were observed in the AS treatment group after 1 month of treatment. There wasn't a significant difference in Schirmer's test and OXFORD conjunctival and corneal vital dying grading scores between the two treatment groups after 1 month of treatment (P>0.05 [Mann-Whitney U test]). Conclusions AS eye drops were more effective than conventional eye drops for improving tear film stability and subjective comfort in patients with severe DES.
Turkish Journal of Biochemistry, 2016
Objective: Decreased serum insulin-like growth factor-1 (IGF-1) and insulin like growth factor bi... more Objective: Decreased serum insulin-like growth factor-1 (IGF-1) and insulin like growth factor binding protein-3 (IGFBP-3) levels have been found in patients with chronic liver disease of different etiologies, but these factors have not been studied extensively in patients with hepatitis B virus (HBV)-induced chronic liver disease.Methods: We have investigated serum IGF-1 and IGFBP-3 levels in 40 patients with chronic HBV and 40 patients with HBV-induced cirrhosis. According to Child-Pugh classification cirrhotic patients were divided into three groups. Forty age-and sex-matched healthy subjects served as controls. IGF-1 and IGFBP-3 levels were measured by immunochemiluminescence. The results were compared with those for serum albumin, total bilirubin, transaminase activity, and with prothrombin time.Results: IGF-1 and IGFBP-3 levels were significantly lower in patients with cirrhosis than in those with chronic HBV and in controls (p<0.001). In chronic HBV patients, IGFBP-3 level...
Graefe's Archive for Clinical and Experimental Ophthalmology, 2014
Background To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief... more Background To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief of severe dry eye syndrome (DES), as compared to conventional preservativefree artificial tears (PFAT). Methods This prospective double-blind randomized crossover study used the Ocular Surface Disease Index (OSDI), tear film break-up time (TBUT), Schirmer's Test, and OX-FORD Scale at baseline and after each of two 1-month treatment periods to measure the effect of 20 % diluted AS eye drops vs. PFAT in 20 consecutive severe DES patients that were refractory to conventional treatment. Results The study included 20 (18 female and two male) severe DES patients (40 eyes). Significantly higher TBUT (P<0.001, Wilcoxon signed-rank test) and a greater decrease in OSDI score (55.18 % decrease in the AS treatment group vs. 19.50 % decrease in the PFAT treatment group) (P<0.001, Student's paired samples t-test) were observed in the AS treatment group after 1 month of treatment. There wasn't a significant difference in Schirmer's test and OXFORD conjunctival and corneal vital dying grading scores between the two treatment groups after 1 month of treatment (P>0.05 [Mann-Whitney U test]). Conclusions AS eye drops were more effective than conventional eye drops for improving tear film stability and subjective comfort in patients with severe DES.
Türk biyokimya dergisi, 2016
Objective: The etiology of bronchopulmonary dysplasia (BPD) which is the most important unwanted ... more Objective: The etiology of bronchopulmonary dysplasia (BPD) which is the most important unwanted consequence of premature delivery at long term has not been determined clearly yet.. Insulin-like growth factor-1 (IGF-1) is involved in both prenatal and postnatal lung growth. Our aim is to characterize postnatal changes in serum IGF-1 in relation to development of BPD in preterms. Method: Sixty-seven preterm newborns were evaluated prospectively in order to investigate independent risk factors associated with BPD and to determine the relation between serum IGF-1 levels and BPD. Infants included in the study were divided into two groups as those that developed (Group 1; n=12) and did not develop BPD (Group 2; n=55). Serum IGF-1 levels were measured from venous blood samples of each infant on days 1, 7, 14 and 28 after birth. Results: When the variables showing significant differences in the comparisons between the two groups were evaluated in different logistic regression models, according to the most significant model; presence of chorioamnionitis did not contribute significantly to the development of BPD. It was found that 1 week increase in gestational week reduced the risk of BPD formation by half, while the presence of RDS or sepsis increased the risk of development of BPD by 14.4, and 9.6 times, respectively. ROC analysis with serial measurements of IGF-1 showed that IGF-1 was not a determinant of BPD development. Conclusion: We could not find any relation between development of BPD and serum IGF-1 levels in our study and concluded that the smaller number of newborn who developed BPD could have limited the evaluation of this association.
Graefes Archive for Clinical and Experimental Ophthalmology, Feb 25, 2014
Background To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief... more Background To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief of severe dry eye syndrome (DES), as compared to conventional preservativefree artificial tears (PFAT). Methods This prospective double-blind randomized crossover study used the Ocular Surface Disease Index (OSDI), tear film break-up time (TBUT), Schirmer's Test, and OX-FORD Scale at baseline and after each of two 1-month treatment periods to measure the effect of 20 % diluted AS eye drops vs. PFAT in 20 consecutive severe DES patients that were refractory to conventional treatment. Results The study included 20 (18 female and two male) severe DES patients (40 eyes). Significantly higher TBUT (P<0.001, Wilcoxon signed-rank test) and a greater decrease in OSDI score (55.18 % decrease in the AS treatment group vs. 19.50 % decrease in the PFAT treatment group) (P<0.001, Student's paired samples t-test) were observed in the AS treatment group after 1 month of treatment. There wasn't a significant difference in Schirmer's test and OXFORD conjunctival and corneal vital dying grading scores between the two treatment groups after 1 month of treatment (P>0.05 [Mann-Whitney U test]). Conclusions AS eye drops were more effective than conventional eye drops for improving tear film stability and subjective comfort in patients with severe DES.
Turkish Journal of Biochemistry, 2016
Objective: Decreased serum insulin-like growth factor-1 (IGF-1) and insulin like growth factor bi... more Objective: Decreased serum insulin-like growth factor-1 (IGF-1) and insulin like growth factor binding protein-3 (IGFBP-3) levels have been found in patients with chronic liver disease of different etiologies, but these factors have not been studied extensively in patients with hepatitis B virus (HBV)-induced chronic liver disease.Methods: We have investigated serum IGF-1 and IGFBP-3 levels in 40 patients with chronic HBV and 40 patients with HBV-induced cirrhosis. According to Child-Pugh classification cirrhotic patients were divided into three groups. Forty age-and sex-matched healthy subjects served as controls. IGF-1 and IGFBP-3 levels were measured by immunochemiluminescence. The results were compared with those for serum albumin, total bilirubin, transaminase activity, and with prothrombin time.Results: IGF-1 and IGFBP-3 levels were significantly lower in patients with cirrhosis than in those with chronic HBV and in controls (p<0.001). In chronic HBV patients, IGFBP-3 level...
Graefe's Archive for Clinical and Experimental Ophthalmology, 2014
Background To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief... more Background To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief of severe dry eye syndrome (DES), as compared to conventional preservativefree artificial tears (PFAT). Methods This prospective double-blind randomized crossover study used the Ocular Surface Disease Index (OSDI), tear film break-up time (TBUT), Schirmer's Test, and OX-FORD Scale at baseline and after each of two 1-month treatment periods to measure the effect of 20 % diluted AS eye drops vs. PFAT in 20 consecutive severe DES patients that were refractory to conventional treatment. Results The study included 20 (18 female and two male) severe DES patients (40 eyes). Significantly higher TBUT (P<0.001, Wilcoxon signed-rank test) and a greater decrease in OSDI score (55.18 % decrease in the AS treatment group vs. 19.50 % decrease in the PFAT treatment group) (P<0.001, Student's paired samples t-test) were observed in the AS treatment group after 1 month of treatment. There wasn't a significant difference in Schirmer's test and OXFORD conjunctival and corneal vital dying grading scores between the two treatment groups after 1 month of treatment (P>0.05 [Mann-Whitney U test]). Conclusions AS eye drops were more effective than conventional eye drops for improving tear film stability and subjective comfort in patients with severe DES.