Cesar Raffin - Academia.edu (original) (raw)
Papers by Cesar Raffin
Arquivos de Neuro-Psiquiatria, 2006
Este artigo apresenta as conclusões sobre revascularização clínica e intervencionista no acidente... more Este artigo apresenta as conclusões sobre revascularização clínica e intervencionista no acidente vascular cerebral isquêmico agudo, um dos temas discutidos na reunião "Opinião Nacional sobre o Tratamento do AVC". Tratou-se de reunião promovida e coordenada pela Sociedade Brasileira de Doenças Cerebrovasculares, com neurologistas especializados em doenças cerebrovasculares, que analisaram e discutiram as evidências e experiências atuais sobre o uso de trombólise e técnicas intervencionistas em pacientes com acidente vascular cerebral isquêmico agudo.
Arq. bras. endocrinol. metab, 1985
... Id: 2595. Autor: Jorge, Paulo Tannus; Raffin, Cesar Noronha. Título: Convulsöes focais por hi... more ... Id: 2595. Autor: Jorge, Paulo Tannus; Raffin, Cesar Noronha. Título: Convulsöes focais por hipocalcemia 30 anos após tiroidectomia: relato de um caso / Focal convulsions due to hypocalcemia 30 years after thyroidectomy: report of a case. Fonte: Arq. bras. endocrinol. ...
ABSTRACT- C e rebral infarctions of cardiac etiology are observed in around 20 % of patients with... more ABSTRACT- C e rebral infarctions of cardiac etiology are observed in around 20 % of patients with ischemic s t roke. Cerebral ischemia is the first clinical manifestation in 1/3 of cases of atrial myxomas. Although almost half of patients with atrial myxoma show changes at neurological exam, non-hemorrhagic cere b r a l i n f a rction is seen in computed tomography in practically all cases. We present the case of a 40 year- o l d woman whose first clinical manifestation of atrial myxoma was an ischemic stroke. We point out to the possibility of silent cerebral infarction in atrial myxoma patients. KEY WORDS: brain embolism, atrial myxoma, ischemic stroke. Isquemia cerebral como manifestação neurológica inicial de mixoma atrial: relato de caso RESUMO- I n f a rtos cerebrais de etiologia cardíaca são observados em cerca de 20 % dos pacientes com aci-dente vascular cerebral isquêmico. Infarto cerebral ocorre como manifestação clínica inicial em um terço dos casos de mixoma atrial. Embo...
Brazilian guideline for the management of acute stroke ABSTRACT - The cerebrovascular diseases ha... more Brazilian guideline for the management of acute stroke ABSTRACT - The cerebrovascular diseases have a high incidence, and they cause an enormous social and economic burden. With the increasing knowledge of the pathophysiology of the ischemic insult, and the possibility of the thrombolysis in the acute phase, the management of the stroke patients is considered an emergency. This consensus is the result of a recent meeting to establish a better approach to these patients. This is the official guideline for the management of patients with acute stroke of the Brazilian Cerebrovascular Disease Society.
Cerebral infarctions of cardiac etiology are observed in around 20% of patients with ischemic str... more Cerebral infarctions of cardiac etiology are observed in around 20% of patients with ischemic stroke. Cerebral ischemia is the first clinical manifestation in 1/3 of cases of atrial myxomas. Although almost half of patients with atrial myxoma show changes at neurological exam, non-hemorrhagic cerebral infarction is seen in computed tomography in practically all cases. We present the case of a 40 year-old woman whose first clinical manifestation of atrial myxoma was an ischemic stroke. We point out to the possibility of silent cerebral infarction in atrial myxoma patients.
![Research paper thumbnail of [Clinical and interventional revascularization in the acute ischemic stroke: national opinion]](https://attachments.academia-assets.com/75108461/thumbnails/1.jpg)
](The Brazilian Stroke Society constituted a committee composed by specialists from different areas... more The Brazilian Stroke Society constituted a committee composed by specialists from different areas of Brazil that emitted a viewpoint called "National Opinion," considering the interventional procedures and thrombolysis in the treatment of the acute ischemic stroke. This study presents the conclusions of this committee.
The Sociedade Brasileira de Doenças Cerebrovasculares (SBDCV) encompasses the Scientific Departme... more The Sociedade Brasileira de Doenças Cerebrovasculares (SBDCV) encompasses the Scientific Department of Cerebrovascular Diseases of the Brazilian Academy of Neurology (ABN), and is, therefore, the body that represents specialists in cerebrovascular diseases in Brazil. The SBDCV was spawned from the Working Group in Cerebrovascular Pathology of the ABN, the name formerly used by the ABN to group scholars of different subspecialties. These working groups are now referred to as Scientific Departments, whose mission it is to foster scientific development and help organize Brazilian Neurology meetings. BEGINNINGS The Cerebrovascular Diseases Working Group was set up in 1982, under the leadership of Prof. Dr. Roberto Melaragno Filho, an eminent neurologist deeply involved with cerebrovascular diseases. Professor Melaragno was tasked with the initial structuring of the group of neurologists interested in cerebrovascular diseases. This working group had the following coordinators, with two-year tenures:
Arquivos de Neuro-Psiquiatria
The Brazilian Stroke Society constituted a committee composed by specialists from different areas... more The Brazilian Stroke Society constituted a committee composed by specialists from different areas of Brazil that emitted a viewpoint called "National Opinion," considering the interventional procedures and thrombolysis in the treatment of the acute ischemic stroke. This study presents the conclusions of this committee.
Journal of Cerebral Blood Flow and Metabolism, 1991
Cerebral ischemia provokes sequential changes that include EEG suppression, anoxic depolar izatio... more Cerebral ischemia provokes sequential changes that include EEG suppression, anoxic depolar ization (AD) with maximal increases in extracellular po tassium ion activity (K + 0) ' and anoxia with maximal de creases in tissue oxygen tension (tPOz) and increases in the reduction/oxidation (redox) ratios of the mitochon drial electron transport carriers. Studies were directed toward relationships among these events during cerebral ischemia ("four-vessel occlusion model") in pentobar bital anesthetized rats. Results demonstrate that EEG suppression and anoxic depolarization do not occur as a simple function of progressive oxygen decline during ce rebral ischemia. Rates of K + elevation, tPOz decline, and
The participation of genetic factors in the origin of convulsive disorders is a controversial mat... more The participation of genetic factors in the origin of convulsive disorders is a controversial matter. In an attempt to study the influence of heredity in a selected group of patients, we evaluated 128 subjects that presented febrile febrile convulsions. Of these, 18 (14,3 % of the sample) had at least one relative affected by the same problem. Even though a more definite conclusion depends on sample enlargement and on setting up a control group, pedigree observation suggests the participation of an autosomal dominant gene, with incomplete and probably low penetrance, in the etiology of febrile convulsions.
Arquivos De Neuro Psiquiatria, Jun 1, 1996
Linfomas não Hodgkin de alto grau são comumente relatados em pacientes com a síndrome da imunodef... more Linfomas não Hodgkin de alto grau são comumente relatados em pacientes com a síndrome da imunodeficiência adquirida (AIDS). Comprometendo com grande freqüência o sistema nervoso central, particularmente as leptomeninges e os hemisférios cerebrais. O acometimento epidural é pouco freqüente, variando de 3,5% a 8,3% de acordo com os registros da literatura. Os autores relatam o caso de um paciente de 27 anos de idade com AIDS, cuja manifestação clínica inicial da doença linfomatosa disseminada foi a mielite transversa associada à mielopatia vacuolar. Destaca-se a importância do diagnóstico diferencial precoce das mielopatias na AIDS, em virtude da alta malignidade da neoplasia e da evolução extremamente rápida nesses pacientes.
Arquivos de Neuro-Psiquiatria
The present article provides the historical background of the Sociedade Brasileira de Doenças Cer... more The present article provides the historical background of the Sociedade Brasileira de Doenças Cerebrovasculares (Brazilian Society for Cerebrovascular Diseases), including details on its function, structure, challenges and main achievements.
Arquivos de neuro-psiquiatria, 2006
The Brazilian Stroke Society constituted a committee composed by specialists from different areas... more The Brazilian Stroke Society constituted a committee composed by specialists from different areas of Brazil that emitted a viewpoint called "National Opinion," considering the interventional procedures and thrombolysis in the treatment of the acute ischemic stroke. This study presents the conclusions of this committee.
RESUMO-Este texto apresenta a síntese das conclusões do Iº Consenso Brasileiro do Tratamento da F... more RESUMO-Este texto apresenta a síntese das conclusões do Iº Consenso Brasileiro do Tratamento da Fase Aguda do Acidente Vascular Cerebral (AVC). Tratou-se de reunião patrocinada e coordenada pela Sociedade Brasileira de Doenças Cerebrovasculares, com neurologistas especializados nas doenças cerebrovasculares, que analisaram os principais itens da conduta dos AVC. PALAVRAS-CHAVE: acidente vascular cerebral, doença cerebrovascular, tratamento, consenso brasileiro. Brazilian guideline for the management of acute stroke ABSTRACT-The cerebrovascular diseases have a high incidence, and they cause an enormous social and economic burden. With the increasing knowledge of the pathophysiology of the ischemic insult, and the possibility of the thrombolysis in the acute phase, the management of the stroke patients is considered an emergency. This consensus is the result of a recent meeting to establish a better approach to these patients. This is the official guideline for the management of patients with acute stroke of the Brazilian Cerebrovascular Disease Society. Princípios baseados em evidências devem ser a base para a introdução de novos trata-mentos; tratamentos contraditórios não devem ser utilizados (Declaração de Helsingborg).
Arquivos de Neuro-Psiquiatria, 2009
Resumo -A hemorragia intraparenquimatosa cerebral (HIC) é o subtipo de AVC de pior prognóstico e ... more Resumo -A hemorragia intraparenquimatosa cerebral (HIC) é o subtipo de AVC de pior prognóstico e com tratamento ainda controverso em diversos aspectos. O comitê executivo da Sociedade Brasileira de Doenças Cerebrovasculares, através de uma revisão ampla dos artigos publicados em revistas indexadas, elaborou sugestões e recomendações que são aqui descritas com suas respectivas classificações de níveis de evidência. Estas diretrizes foram elaboradas com o objetivo de prover o leitor de um racional para o manejo apropriado dos pacientes com HIC, baseado em evidências clínicas.
Journal of Cerebral Blood Flow and Metabolism, Dec 1, 1988
To examine the relationships between brain glycolysis, ion transport, and mitochondrial reduction... more To examine the relationships between brain glycolysis, ion transport, and mitochondrial reduction/ oxidation (redox) activity, extracellular potassium ion ac tivity (K + 0) and redox shifts of cytochrome oxidase (cy tochrome a,a3) were recorded previous to and during su perfusion of rat cerebral cortex with the glycolytic inhibitor iodoacetic acid (lAA) . IAA produced oxidation of cytochrome a,a3' increased local oxygenation, in creased K + 0, and, in response to neuronal activation, slowed rates of K + 0 reaccumulation. Rates of rereduction of cytochrome a,a3, after the oxidation of this cy tochrome by stimulation, were also slowed by IAA.
Background and Purpose—The purpose of this research was to evaluate whether an association exists... more Background and Purpose—The purpose of this research was to evaluate whether an association exists between the presence of atherosclerotic plaque in the thoracic aorta and left ventricular hypertrophy (LVH) in patients with a cerebrovascular event. Methods—We included 116 consecutive patients (79 men; mean age, 6212.4 years) with previous history of stroke or transient ischemic attack in a cross-sectional study. Transthoracic
Revista do Instituto de Medicina Tropical de São Paulo, 1993
We report the case of a 52-year-old male heterosexual patient with acquired immunodeficiency synd... more We report the case of a 52-year-old male heterosexual patient with acquired immunodeficiency syndrome (AIDS) and reactivation of Chagas' disease manifested by meningoencephalitis and myocarditis, diagnosed post-mortem. Unexplained reactivation of Chagas' disease should be included among the diagnostic criteria of AIDS in human immunodeficiency virus positive patients. On the other hand, AIDS should be considered in the differential diagnosis of patients with unexplained reactivation of Chagas' disease.
Arquivos de Neuro-Psiquiatria, 2006
Este artigo apresenta as conclusões sobre revascularização clínica e intervencionista no acidente... more Este artigo apresenta as conclusões sobre revascularização clínica e intervencionista no acidente vascular cerebral isquêmico agudo, um dos temas discutidos na reunião "Opinião Nacional sobre o Tratamento do AVC". Tratou-se de reunião promovida e coordenada pela Sociedade Brasileira de Doenças Cerebrovasculares, com neurologistas especializados em doenças cerebrovasculares, que analisaram e discutiram as evidências e experiências atuais sobre o uso de trombólise e técnicas intervencionistas em pacientes com acidente vascular cerebral isquêmico agudo.
Arq. bras. endocrinol. metab, 1985
... Id: 2595. Autor: Jorge, Paulo Tannus; Raffin, Cesar Noronha. Título: Convulsöes focais por hi... more ... Id: 2595. Autor: Jorge, Paulo Tannus; Raffin, Cesar Noronha. Título: Convulsöes focais por hipocalcemia 30 anos após tiroidectomia: relato de um caso / Focal convulsions due to hypocalcemia 30 years after thyroidectomy: report of a case. Fonte: Arq. bras. endocrinol. ...
ABSTRACT- C e rebral infarctions of cardiac etiology are observed in around 20 % of patients with... more ABSTRACT- C e rebral infarctions of cardiac etiology are observed in around 20 % of patients with ischemic s t roke. Cerebral ischemia is the first clinical manifestation in 1/3 of cases of atrial myxomas. Although almost half of patients with atrial myxoma show changes at neurological exam, non-hemorrhagic cere b r a l i n f a rction is seen in computed tomography in practically all cases. We present the case of a 40 year- o l d woman whose first clinical manifestation of atrial myxoma was an ischemic stroke. We point out to the possibility of silent cerebral infarction in atrial myxoma patients. KEY WORDS: brain embolism, atrial myxoma, ischemic stroke. Isquemia cerebral como manifestação neurológica inicial de mixoma atrial: relato de caso RESUMO- I n f a rtos cerebrais de etiologia cardíaca são observados em cerca de 20 % dos pacientes com aci-dente vascular cerebral isquêmico. Infarto cerebral ocorre como manifestação clínica inicial em um terço dos casos de mixoma atrial. Embo...
Brazilian guideline for the management of acute stroke ABSTRACT - The cerebrovascular diseases ha... more Brazilian guideline for the management of acute stroke ABSTRACT - The cerebrovascular diseases have a high incidence, and they cause an enormous social and economic burden. With the increasing knowledge of the pathophysiology of the ischemic insult, and the possibility of the thrombolysis in the acute phase, the management of the stroke patients is considered an emergency. This consensus is the result of a recent meeting to establish a better approach to these patients. This is the official guideline for the management of patients with acute stroke of the Brazilian Cerebrovascular Disease Society.
Cerebral infarctions of cardiac etiology are observed in around 20% of patients with ischemic str... more Cerebral infarctions of cardiac etiology are observed in around 20% of patients with ischemic stroke. Cerebral ischemia is the first clinical manifestation in 1/3 of cases of atrial myxomas. Although almost half of patients with atrial myxoma show changes at neurological exam, non-hemorrhagic cerebral infarction is seen in computed tomography in practically all cases. We present the case of a 40 year-old woman whose first clinical manifestation of atrial myxoma was an ischemic stroke. We point out to the possibility of silent cerebral infarction in atrial myxoma patients.
The Brazilian Stroke Society constituted a committee composed by specialists from different areas... more The Brazilian Stroke Society constituted a committee composed by specialists from different areas of Brazil that emitted a viewpoint called "National Opinion," considering the interventional procedures and thrombolysis in the treatment of the acute ischemic stroke. This study presents the conclusions of this committee.
The Sociedade Brasileira de Doenças Cerebrovasculares (SBDCV) encompasses the Scientific Departme... more The Sociedade Brasileira de Doenças Cerebrovasculares (SBDCV) encompasses the Scientific Department of Cerebrovascular Diseases of the Brazilian Academy of Neurology (ABN), and is, therefore, the body that represents specialists in cerebrovascular diseases in Brazil. The SBDCV was spawned from the Working Group in Cerebrovascular Pathology of the ABN, the name formerly used by the ABN to group scholars of different subspecialties. These working groups are now referred to as Scientific Departments, whose mission it is to foster scientific development and help organize Brazilian Neurology meetings. BEGINNINGS The Cerebrovascular Diseases Working Group was set up in 1982, under the leadership of Prof. Dr. Roberto Melaragno Filho, an eminent neurologist deeply involved with cerebrovascular diseases. Professor Melaragno was tasked with the initial structuring of the group of neurologists interested in cerebrovascular diseases. This working group had the following coordinators, with two-year tenures:
Arquivos de Neuro-Psiquiatria
The Brazilian Stroke Society constituted a committee composed by specialists from different areas... more The Brazilian Stroke Society constituted a committee composed by specialists from different areas of Brazil that emitted a viewpoint called "National Opinion," considering the interventional procedures and thrombolysis in the treatment of the acute ischemic stroke. This study presents the conclusions of this committee.
Journal of Cerebral Blood Flow and Metabolism, 1991
Cerebral ischemia provokes sequential changes that include EEG suppression, anoxic depolar izatio... more Cerebral ischemia provokes sequential changes that include EEG suppression, anoxic depolar ization (AD) with maximal increases in extracellular po tassium ion activity (K + 0) ' and anoxia with maximal de creases in tissue oxygen tension (tPOz) and increases in the reduction/oxidation (redox) ratios of the mitochon drial electron transport carriers. Studies were directed toward relationships among these events during cerebral ischemia ("four-vessel occlusion model") in pentobar bital anesthetized rats. Results demonstrate that EEG suppression and anoxic depolarization do not occur as a simple function of progressive oxygen decline during ce rebral ischemia. Rates of K + elevation, tPOz decline, and
The participation of genetic factors in the origin of convulsive disorders is a controversial mat... more The participation of genetic factors in the origin of convulsive disorders is a controversial matter. In an attempt to study the influence of heredity in a selected group of patients, we evaluated 128 subjects that presented febrile febrile convulsions. Of these, 18 (14,3 % of the sample) had at least one relative affected by the same problem. Even though a more definite conclusion depends on sample enlargement and on setting up a control group, pedigree observation suggests the participation of an autosomal dominant gene, with incomplete and probably low penetrance, in the etiology of febrile convulsions.
Arquivos De Neuro Psiquiatria, Jun 1, 1996
Linfomas não Hodgkin de alto grau são comumente relatados em pacientes com a síndrome da imunodef... more Linfomas não Hodgkin de alto grau são comumente relatados em pacientes com a síndrome da imunodeficiência adquirida (AIDS). Comprometendo com grande freqüência o sistema nervoso central, particularmente as leptomeninges e os hemisférios cerebrais. O acometimento epidural é pouco freqüente, variando de 3,5% a 8,3% de acordo com os registros da literatura. Os autores relatam o caso de um paciente de 27 anos de idade com AIDS, cuja manifestação clínica inicial da doença linfomatosa disseminada foi a mielite transversa associada à mielopatia vacuolar. Destaca-se a importância do diagnóstico diferencial precoce das mielopatias na AIDS, em virtude da alta malignidade da neoplasia e da evolução extremamente rápida nesses pacientes.
Arquivos de Neuro-Psiquiatria
The present article provides the historical background of the Sociedade Brasileira de Doenças Cer... more The present article provides the historical background of the Sociedade Brasileira de Doenças Cerebrovasculares (Brazilian Society for Cerebrovascular Diseases), including details on its function, structure, challenges and main achievements.
Arquivos de neuro-psiquiatria, 2006
The Brazilian Stroke Society constituted a committee composed by specialists from different areas... more The Brazilian Stroke Society constituted a committee composed by specialists from different areas of Brazil that emitted a viewpoint called "National Opinion," considering the interventional procedures and thrombolysis in the treatment of the acute ischemic stroke. This study presents the conclusions of this committee.
RESUMO-Este texto apresenta a síntese das conclusões do Iº Consenso Brasileiro do Tratamento da F... more RESUMO-Este texto apresenta a síntese das conclusões do Iº Consenso Brasileiro do Tratamento da Fase Aguda do Acidente Vascular Cerebral (AVC). Tratou-se de reunião patrocinada e coordenada pela Sociedade Brasileira de Doenças Cerebrovasculares, com neurologistas especializados nas doenças cerebrovasculares, que analisaram os principais itens da conduta dos AVC. PALAVRAS-CHAVE: acidente vascular cerebral, doença cerebrovascular, tratamento, consenso brasileiro. Brazilian guideline for the management of acute stroke ABSTRACT-The cerebrovascular diseases have a high incidence, and they cause an enormous social and economic burden. With the increasing knowledge of the pathophysiology of the ischemic insult, and the possibility of the thrombolysis in the acute phase, the management of the stroke patients is considered an emergency. This consensus is the result of a recent meeting to establish a better approach to these patients. This is the official guideline for the management of patients with acute stroke of the Brazilian Cerebrovascular Disease Society. Princípios baseados em evidências devem ser a base para a introdução de novos trata-mentos; tratamentos contraditórios não devem ser utilizados (Declaração de Helsingborg).
Arquivos de Neuro-Psiquiatria, 2009
Resumo -A hemorragia intraparenquimatosa cerebral (HIC) é o subtipo de AVC de pior prognóstico e ... more Resumo -A hemorragia intraparenquimatosa cerebral (HIC) é o subtipo de AVC de pior prognóstico e com tratamento ainda controverso em diversos aspectos. O comitê executivo da Sociedade Brasileira de Doenças Cerebrovasculares, através de uma revisão ampla dos artigos publicados em revistas indexadas, elaborou sugestões e recomendações que são aqui descritas com suas respectivas classificações de níveis de evidência. Estas diretrizes foram elaboradas com o objetivo de prover o leitor de um racional para o manejo apropriado dos pacientes com HIC, baseado em evidências clínicas.
Journal of Cerebral Blood Flow and Metabolism, Dec 1, 1988
To examine the relationships between brain glycolysis, ion transport, and mitochondrial reduction... more To examine the relationships between brain glycolysis, ion transport, and mitochondrial reduction/ oxidation (redox) activity, extracellular potassium ion ac tivity (K + 0) and redox shifts of cytochrome oxidase (cy tochrome a,a3) were recorded previous to and during su perfusion of rat cerebral cortex with the glycolytic inhibitor iodoacetic acid (lAA) . IAA produced oxidation of cytochrome a,a3' increased local oxygenation, in creased K + 0, and, in response to neuronal activation, slowed rates of K + 0 reaccumulation. Rates of rereduction of cytochrome a,a3, after the oxidation of this cy tochrome by stimulation, were also slowed by IAA.
Background and Purpose—The purpose of this research was to evaluate whether an association exists... more Background and Purpose—The purpose of this research was to evaluate whether an association exists between the presence of atherosclerotic plaque in the thoracic aorta and left ventricular hypertrophy (LVH) in patients with a cerebrovascular event. Methods—We included 116 consecutive patients (79 men; mean age, 6212.4 years) with previous history of stroke or transient ischemic attack in a cross-sectional study. Transthoracic
Revista do Instituto de Medicina Tropical de São Paulo, 1993
We report the case of a 52-year-old male heterosexual patient with acquired immunodeficiency synd... more We report the case of a 52-year-old male heterosexual patient with acquired immunodeficiency syndrome (AIDS) and reactivation of Chagas' disease manifested by meningoencephalitis and myocarditis, diagnosed post-mortem. Unexplained reactivation of Chagas' disease should be included among the diagnostic criteria of AIDS in human immunodeficiency virus positive patients. On the other hand, AIDS should be considered in the differential diagnosis of patients with unexplained reactivation of Chagas' disease.