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Papers by Maisuri Chalid

Indonesian Journal of Obstetrics & Gynecology Science

Objective: To determine the relationship between ferritin levels and the incidence of uterine ine... more Objective: To determine the relationship between ferritin levels and the incidence of uterine inertia in pregnant women. Method: This study uses a prospective cohort design. The study was conducted on all pregnant women aged 20-40 years who had antenatal care and be in labor at the Teaching Hospital in the Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University. Data were analyzed with the chi-square test and the Mann-Whitney test. Results: Obtained 76 pregnant women where 44.7% of them had uterine inertia. The average ferritin level in the uterine inertia group was significantly lower (3.80 ± 2.84 ng/mL) than without the uterine inertia group (12.99 ± 11.40 ng/mL) with a value p<0.001. The average ferritin level in the mild anemia group was significantly higher (9.83 ± 10.35 ng/mL) than in the moderate anemia group (3.82 ± 2.51 ng/mL) with a p-value <0.05. Pregnant women with moderate anemia were found to be 4.68 more susceptible uterine inertia th...

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Zinc is an important nutrient for humans at all stages of life, whose needs increase ... more BACKGROUND: Zinc is an important nutrient for humans at all stages of life, whose needs increase during pregnancy and lactation. Zinc concentrations in breast milk are considered adequate for the first 6 months of life, despite an increase in the volume of milk consumed, zinc in breast milk is likely to be sufficient if there is no diet. weaning (9). Zinc levels in breast milk cannot compensate for the increased zinc requirements of the premature neonate due to higher than normal zinc requirements, small liver size with reduced zinc stores and a shortened digestive system. AIM:This study aims to measure serum zinc levels, IGF-1, and growth of infants aged 6 months in short adolescent mothers who are breastfeeding and have been intervened with zinc supplementation. MATERIAL AND METHOD: This study is a quantitative study using a quasi-experimental design, and a pretest-posttest approach with a control group. The sampling technique used purposive sampling with inclusion criteria, namel...

Asian Pacific Journal of Reproduction, 2018

Objective: To compare the Bishop score and cervical length measured by transvaginal ultrasound co... more Objective: To compare the Bishop score and cervical length measured by transvaginal ultrasound concerned with prediction over the success of labor induction. Methods: This cross-sectional observational analytical study was conducted from May 2017 to October 2017 at several teaching hospitals of Obstetrics and Gynecology Department, Faculty of Medicine Hasanuddin University of Makassar, India. There were 110 samples of pregnant women undergoing labor induction process including 79 samples of successful induction and 31 samples of induction failure. The data analysis used Pearson Chi-square test and multivariate logistic regression to see the effect of Bishop score and measurement of cervical length with successful induction of labor. Results: Number of samples with successful labor induction with Bishop score ⩾3 was 25 (31.6%) and Bishop score was 54 (68.4%), with rate ratio=3.714 and P=0.000. With measurement of cervical length (cut-off point 2.98 cm), number of samples with successful labor induction with cervical length ⩽2.98 cm was 12 (15.2%) and cervical length >2.98 cm was 67 (84.8%), with rate ratio=3.124 and P=0.000. Multivahate analysis of logistic regression was found to be more influential in the predicted success of labor induction (P=0.014 with Bishop score <3, odds ratio=1.000 and Bishop score ⩾3, odds ratio=3.779. Conclusions: Bishop score is better in predicting the success of labor induction compared to the measurement of cervical length through transvaginal ultrasound.

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Preeclampsia (PE) is still a global public health issue in developed and developing c... more BACKGROUND: Preeclampsia (PE) is still a global public health issue in developed and developing countries. It is a major contributor to maternal and fetal morbidity and mortality. The pathophysiology of preeclampsia during pregnancy is unclear, but the WHO reported that PE is higher in developing countries than developed ones due to lifestyle and nutritional status. AIM: This study aimed to describe the influence of macro- and micronutrients of junk food on PE. METHODS: This case–control study was carried out on 148 samples, including pregnant women with preeclampsia (n = 74) and normal pregnant women (n = 74) with gestational age > 20 weeks. Data on junk food intake were collected using the SQ-FFQ form and then estimated using the Nutri Survey. Data were analyzed in SPSS version 17 using descriptive statistics. Pearson correlation coefficient was used to observe the correlation between variables with p < 0.05 and 95% confidence interval. RESULTS: Binary logistic regression re...

Maternal hepatitis B e Antigen (HBeAg) positivity poses a risk for hepatitis B virus (HBV) mother... more Maternal hepatitis B e Antigen (HBeAg) positivity poses a risk for hepatitis B virus (HBV) mother-to-child transmission (MTCT). In resource-constrained settings, HBeAg testing is recommended as an alternative to HBV DNA testing to establish antiviral prophylaxis eligibility. Nevertheless, the high prevalence of HBeAg-negative chronic hepatitis B (e-CHB) in many countries should not be overlooked. We studied HBV characteristics and explored the potential MTCT risk among HBeAg-negative/ HBsAg-positive expectant mothers in an area prevalent of e-CHB. Among 1348 pregnant mothers screened for HBV infection, 81 (6.0%) were HBsAg-positive. These women were examined for HBeAg, HBV DNA, and cord blood HBV DNA. Sixteen (19.8%) of the HBsAg-positive mothers were HBeAg-positive, whereas 65 (80.2%) were HBeAg-negative, including eight inactive carriers (HBsAg <100 IU/ml, HBV DNA ≤ 2000 IU/ml, and ALT < 40 IU/L). Of the remaining 57 HBeAg-negative mothers, ten revealed HBV Basal Core Promoter or Precore mutations, with three having high viremia (HBV DNA > 200 000 IU/mL), which is associated with a high MTCT risk and therefore qualifies them for antiviral prophylaxis. This pilot study provides a cautionary note to the interpretation of negative HBeAg test results when determining eligibility for MTCT antiviral prophylaxis in situations with limited resources and in regions where e-CHB is prevalent.

Indonesian Journal of Obstetrics and Gynecology

Objective: To determine the role of TLR-7 expression on intrauterine vertical transmission in pre... more Objective: To determine the role of TLR-7 expression on intrauterine vertical transmission in pregnancy through identification of serum hepatitis B markers in both maternal and umbilical cord blood. Methods: Analysis of TLR expression was performed on 38 paraffin block samples of placental tissue acquired from mothers with HBV using TLR immunohistochemical staining. Results: 16 of 38 samples were acquired from mothers aged 26-30 years-old. Most of the samples were from primiparous mothers (52.6%). This study found no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood (p = 1.000). However, we found a significant association between placental TLR-7 expression and maternal HBV DNA (p = 0.034). Meanwhile, placental HBeAg and HBV DNA were not associated with placental TLR-7 expression (p = 0.082; p = 1.000). Conclusion: There was no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood, but we found a signific...

Indonesian Journal of Obstetrics and Gynecology, 2016

Objective: To investigate the role of A1298C polymorphism of fetal methylenetetrahydrofolate redu... more Objective: To investigate the role of A1298C polymorphism of fetal methylenetetrahydrofolate reductase (MTHFR) gene in spontaneous abortion. Method: The case control study design recruited 96 subjects in Siti Fatimah and Pertiwi mother and child hospital, Dr. Wahidin Sudirohusodo, Pelamonia, Bhayangkara, Syekh Yusuf, Haji and Labuang Baji hospital from March to September 2014. All subjects fulfilling the inclusion criteria were taken tissue samples from mothers experiencing spontaneous abortion and blood samples from normally born baby. The data were analyzed using Pearson chi-square with significant rate of 5% (p

Indonesian Journal of Obstetrics and Gynecology, 2017

Objective: To determine the effect of artesunate on peripheral parasitaemia in pregnant women wit... more Objective: To determine the effect of artesunate on peripheral parasitaemia in pregnant women with Plasmodium falciparum infection. Methods: Pregnant women in second and third trimester with Plasmodium falciparum infection and their newborns were included in cohort prospective study in Sorong West Papua from September 2015 to February 2016. All pregnant women received 200 mg orally artesunate monotherapy for 7 days. Their newborns examined for weight at delivery and parasitaemia in placenta and cord blood. Parasitaemia diagnosis by Rapid Diagnostic Test and blood smear microscopy. Results: After artesunatemonotherapy, 82.5% (33/40) malariainfected pregnant women had negative parasitaemia (p=0.000) although 17.5% (7/40) of the pregnant women had positive parasitaemia. Parasitaemia also found in 10% (4/40) of placenta and 7.5% (3/40) of umbilical cord from newborns of malaria-infected pregnant women treated with artesunate. 70% (28/40) of the newborns in this study had normal weight. ...

Indonesian Journal of Obstetrics and Gynecology, 2021

Objective: To compare the outcomes of mothers and newborns in emergency cesarean section and elec... more Objective: To compare the outcomes of mothers and newborns in emergency cesarean section and elective cesarean section. Methods: A prospective cohort study included 120 pregnant women consists of 60 women who performed an emergency cesarean section and 60 women who underwent elective cesarean section. Age, education level, occupation, income, history of comorbidities, history of abortion or miscarriage, antenatal care history, decision-making time until surgery is performed along with other components required, duration of operation, outcome of mother and fetal were obtained through interviews and questionnaires. Data were analyzed regarding fetal outcome and cesarean sections indications. Results: The maternal and fetal outcome between emergency and elective cesarean section were not signifi cantly different regarding on hospital stay, dehiscence, NICU admission, Apgar score and newborn status (dead or alive). Blood transfusion is the main difference signifi cant indication for mat...

Citation: Andi Cakra, Nasrudin AM, Eddy Tiro, et al. A Comparison of Vascular Endothelial Growth ... more Citation: Andi Cakra, Nasrudin AM, Eddy Tiro, et al. A Comparison of Vascular Endothelial Growth Factors (Vegf) Levels in Menstrual Blood Between Women with and Without Endometriosis. Gynecol Reprod Health. 2020; 4(6): 1-5. *Correspondence: Nasrudin Andi Mappaware, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Muslim Indonesia, Jend. Urip Sumoharjo Street Makassar, 90245, Tel: +62 8124257274.

Gynecology & Reproductive Health, 2020

Aimed: To evaluate menstrual blood endoglin levels between women with endometriosis and without e... more Aimed: To evaluate menstrual blood endoglin levels between women with endometriosis and without endometriosis. Methods: A cross-sectional study was performed on 52 eligible women. Endometriosis was confirmed with laparoscopy or laparotomy. Menstrual blood collected in the first or the third day of menstrual cycle using a menstrual cup. Endoglin levels from menstrual blood serum were measured with the ELISA method. Results: Menstrual blood endoglin levels in mild endometriosis were significantly higher compared with control (22.903 pg/ml vs 5.250 pg/ml; p<0.05) as well as the endoglin levels between severe endometriosis compared with mild endometriosis showed endoglin levels significantly higher in severe endometriosis (31.957 pg/ml vs. 22.903 pg/ml; p<0.05). Conclusion: Menstrual blood endoglin levels positively correlated with endometriosis stage.

Indonesian Journal of Obstetrics and Gynecology, 2018

Objective: To determine the role of matrix metalloproteinase-2(MMP-2) in serum and peritoneal flu... more Objective: To determine the role of matrix metalloproteinase-2(MMP-2) in serum and peritoneal fluid of endometrioticpatients.Methods: Research’s design using cross-sectional method in Dr.Wahidin Sudirohusodo hospital and several other hospitals inMakassar within May 2015 until May 2016. Subjects were chosenusing consecutive sampling technique. The examination usingthe ELISA method. The data were analysed using Fisher exact,t-independent, Mann-Whitney, and Spearman association.Results: A total of 50 subjects were recruited in this study. Mostlythe value of MMP-2 serum and peritoneal fluid in endometriosisgroup was higher compare to study control. There was significantdifferent between the total of MMP-2 serum and peritoneal fluid.There was also a significant association between the value ofMMP-2 serum and peritoneal fluid with endometriosis.Conclusion: The value of MMP-2 serum and peritoneal fluid werehigher in endometriotic patients compared to those withoutendometriosis. The higher...

Indonesian Journal of Obstetrics and Gynecology, 2018

Objective: to find out the correlation between lipid profille at trimester II of pregnancy and t... more Objective: to find out the correlation between lipid profille at trimester II of pregnancy and the incidence.of preeclampsia Method : The research was conducted in the Polyclinic of Hasanuddin University Teaching Hospital, Department of Obstetrics and Gynecology of the Faculty of Medicine, and it network in Makassar city from March, 2015 through March, 2016. The research used was the prospective cohort design. Results : The examination of the lipid levels of 115 pregnant mothers, aged 24-28 weeks. The mothers were then observed whether they experienced preeclampsia up to the time they gave birth or not. In the end, 8 subjects (6.9%) experienced preeclampsia and 107 subjects (93.1%) have no preeclampsia. The statistical analyses used Fisher’s Exact test and Mann Whitney test. The research results indicated that the mean value of the total cholesterol and Low Density Lipoprotein (LDL) was higher in the preeclampsia group compared to the non-preeclampsia group: 267.37 ± 64.12 : 23...

Indonesian Journal of Obstetrics and Gynecology, 2018

Objective : To determine the effect of vitamin B6 (pyridoxine) the levels of prostaglandins and i... more Objective : To determine the effect of vitamin B6 (pyridoxine) the levels of prostaglandins and intensity of pain in primary dysmenorrheal. Methods : The levels of prostaglandin (PGF2α) in plasma measured by ELISA and pain intensity by verbal rating scales conducted on 35 women with primary dysmenorrheal (n=35) supplemented with vitamin B6 100mg for 4 days and controls with placebo (n=35). Results : Prostaglandin levels decreased significantly after vitamin B6 supplementation (2212.9+1374.2 vs 1490.3+1119.0; p<0.05) followed by a significant reduction in pain intensity (4.29+0.7 vs 1.71+0.5; p<0.05) in the test group compared to control. Conclusion : Due to vitamin B6 effects on decreasing prostaglandin levels and pain of primary dysmenorrheal, so that B6 vitamin can become the treatment for the primary dysmenorrheal. Keywords : Primary dysmenorrheal, pyridoxine, prostaglandin Tujuan: Untuk mengetahui pengaruh pemberian vitamin B6 (piridoksin) terhadap kadar prostaglandin d...

Gynecology & Reproductive Health, 2019

Background: Maternal Mortality Rate (MMR) is one indicator to see the health status of women AKI ... more Background: Maternal Mortality Rate (MMR) is one indicator to see the health status of women AKI is also one of the targets set in the Millennium Development Goals (MDGs), namely improving maternal health where the target to be achieved until 2015 is reducing to ¾ the risk of maternal mortality. Objective: Finding out whether the psychosocial determinants and obstetric medico effect on decision making refers to complications in the obstetric field. Method: The type of research used was observational research with cross sectional study design. The population of the study were all maternity patients and referred to the 70-school network education hospital with the sample of 70 respondents.

Indonesian Journal of Obstetrics and Gynecology, 2019

Objective: To analyse the predictive value of HE4 in ovarian cancer patients according to their r... more Objective: To analyse the predictive value of HE4 in ovarian cancer patients according to their resistance and menopausal status Methods: Thirteen premenopausal and twenty-five menopausal ovarian cancer patients were measured for HE4 levels measured using automated chemiluminescent microparticle immunoassay ARCHITECT HE4. Patients categorized into resistant and non-resistant after six cycles of chemotherapy in addition to their clinical symptoms and ultrasound image of cancer. Results: The mean HE4 levels were higher in the resistant group compared with a non-resistant group (274.97 pmol/l vs 128.83 pmol/l; p=0.015). Five menopausal resistant women with HE4 levels >140 pmol/l compared with two women in the non-resistant group. In the pre-menopause group, eight resistant women with HE level >70 pmol/l whereas four women in the non-resistant group. HE levels in menopausal and premenopausal for both ovarian cancers resistant and non-resistant were not significantly different (p&g...

Indonesian Journal of Obstetrics and Gynecology, 2019

Objective: To determine the correlation between the perineal body length and the pelvic organ pro... more Objective: To determine the correlation between the perineal body length and the pelvic organ prolapse (POP) in menopausal women. Methods: The total vaginal length (TVL), genital hiatus (GH), and perineal body (PB) length as the POP-Q component were measured at 60 menopausal women enrolled in a cross-sectional study. Results: Menopausal women with POP have the shorter perineal body (63.3%; <3 cm) compared with menopausal women without POP (36.7%; ≥3 cm). The mean length of the perineal body in menopausal women who suffer POP 2.81 ± 0.26 cm while in women without POP is 3.23±0.17 cm. POP risk was 25 times in menopausal women with a perineal body length <3 cm compared with longer perineal body (p = 0.01; OR = 25.4; 95% CI 3.1-209.1).Conclusion: Perineal body length is a risk factor for pelvic organ prolapse in menopausal women.Keywords: perineal body, prolapse, pelvic organ prolapsed Abstrak Tujuan: Menentukan korelasi panjang perineal body dengan kejadian prolaps organ panggul ...

Indonesian Journal of Obstetrics & Gynecology Science

Objective: To determine the relationship between ferritin levels and the incidence of uterine ine... more Objective: To determine the relationship between ferritin levels and the incidence of uterine inertia in pregnant women. Method: This study uses a prospective cohort design. The study was conducted on all pregnant women aged 20-40 years who had antenatal care and be in labor at the Teaching Hospital in the Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University. Data were analyzed with the chi-square test and the Mann-Whitney test. Results: Obtained 76 pregnant women where 44.7% of them had uterine inertia. The average ferritin level in the uterine inertia group was significantly lower (3.80 ± 2.84 ng/mL) than without the uterine inertia group (12.99 ± 11.40 ng/mL) with a value p<0.001. The average ferritin level in the mild anemia group was significantly higher (9.83 ± 10.35 ng/mL) than in the moderate anemia group (3.82 ± 2.51 ng/mL) with a p-value <0.05. Pregnant women with moderate anemia were found to be 4.68 more susceptible uterine inertia th...

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Zinc is an important nutrient for humans at all stages of life, whose needs increase ... more BACKGROUND: Zinc is an important nutrient for humans at all stages of life, whose needs increase during pregnancy and lactation. Zinc concentrations in breast milk are considered adequate for the first 6 months of life, despite an increase in the volume of milk consumed, zinc in breast milk is likely to be sufficient if there is no diet. weaning (9). Zinc levels in breast milk cannot compensate for the increased zinc requirements of the premature neonate due to higher than normal zinc requirements, small liver size with reduced zinc stores and a shortened digestive system. AIM:This study aims to measure serum zinc levels, IGF-1, and growth of infants aged 6 months in short adolescent mothers who are breastfeeding and have been intervened with zinc supplementation. MATERIAL AND METHOD: This study is a quantitative study using a quasi-experimental design, and a pretest-posttest approach with a control group. The sampling technique used purposive sampling with inclusion criteria, namel...

Asian Pacific Journal of Reproduction, 2018

Objective: To compare the Bishop score and cervical length measured by transvaginal ultrasound co... more Objective: To compare the Bishop score and cervical length measured by transvaginal ultrasound concerned with prediction over the success of labor induction. Methods: This cross-sectional observational analytical study was conducted from May 2017 to October 2017 at several teaching hospitals of Obstetrics and Gynecology Department, Faculty of Medicine Hasanuddin University of Makassar, India. There were 110 samples of pregnant women undergoing labor induction process including 79 samples of successful induction and 31 samples of induction failure. The data analysis used Pearson Chi-square test and multivariate logistic regression to see the effect of Bishop score and measurement of cervical length with successful induction of labor. Results: Number of samples with successful labor induction with Bishop score ⩾3 was 25 (31.6%) and Bishop score was 54 (68.4%), with rate ratio=3.714 and P=0.000. With measurement of cervical length (cut-off point 2.98 cm), number of samples with successful labor induction with cervical length ⩽2.98 cm was 12 (15.2%) and cervical length >2.98 cm was 67 (84.8%), with rate ratio=3.124 and P=0.000. Multivahate analysis of logistic regression was found to be more influential in the predicted success of labor induction (P=0.014 with Bishop score <3, odds ratio=1.000 and Bishop score ⩾3, odds ratio=3.779. Conclusions: Bishop score is better in predicting the success of labor induction compared to the measurement of cervical length through transvaginal ultrasound.

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Preeclampsia (PE) is still a global public health issue in developed and developing c... more BACKGROUND: Preeclampsia (PE) is still a global public health issue in developed and developing countries. It is a major contributor to maternal and fetal morbidity and mortality. The pathophysiology of preeclampsia during pregnancy is unclear, but the WHO reported that PE is higher in developing countries than developed ones due to lifestyle and nutritional status. AIM: This study aimed to describe the influence of macro- and micronutrients of junk food on PE. METHODS: This case–control study was carried out on 148 samples, including pregnant women with preeclampsia (n = 74) and normal pregnant women (n = 74) with gestational age > 20 weeks. Data on junk food intake were collected using the SQ-FFQ form and then estimated using the Nutri Survey. Data were analyzed in SPSS version 17 using descriptive statistics. Pearson correlation coefficient was used to observe the correlation between variables with p < 0.05 and 95% confidence interval. RESULTS: Binary logistic regression re...

Maternal hepatitis B e Antigen (HBeAg) positivity poses a risk for hepatitis B virus (HBV) mother... more Maternal hepatitis B e Antigen (HBeAg) positivity poses a risk for hepatitis B virus (HBV) mother-to-child transmission (MTCT). In resource-constrained settings, HBeAg testing is recommended as an alternative to HBV DNA testing to establish antiviral prophylaxis eligibility. Nevertheless, the high prevalence of HBeAg-negative chronic hepatitis B (e-CHB) in many countries should not be overlooked. We studied HBV characteristics and explored the potential MTCT risk among HBeAg-negative/ HBsAg-positive expectant mothers in an area prevalent of e-CHB. Among 1348 pregnant mothers screened for HBV infection, 81 (6.0%) were HBsAg-positive. These women were examined for HBeAg, HBV DNA, and cord blood HBV DNA. Sixteen (19.8%) of the HBsAg-positive mothers were HBeAg-positive, whereas 65 (80.2%) were HBeAg-negative, including eight inactive carriers (HBsAg <100 IU/ml, HBV DNA ≤ 2000 IU/ml, and ALT < 40 IU/L). Of the remaining 57 HBeAg-negative mothers, ten revealed HBV Basal Core Promoter or Precore mutations, with three having high viremia (HBV DNA > 200 000 IU/mL), which is associated with a high MTCT risk and therefore qualifies them for antiviral prophylaxis. This pilot study provides a cautionary note to the interpretation of negative HBeAg test results when determining eligibility for MTCT antiviral prophylaxis in situations with limited resources and in regions where e-CHB is prevalent.

Indonesian Journal of Obstetrics and Gynecology

Objective: To determine the role of TLR-7 expression on intrauterine vertical transmission in pre... more Objective: To determine the role of TLR-7 expression on intrauterine vertical transmission in pregnancy through identification of serum hepatitis B markers in both maternal and umbilical cord blood. Methods: Analysis of TLR expression was performed on 38 paraffin block samples of placental tissue acquired from mothers with HBV using TLR immunohistochemical staining. Results: 16 of 38 samples were acquired from mothers aged 26-30 years-old. Most of the samples were from primiparous mothers (52.6%). This study found no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood (p = 1.000). However, we found a significant association between placental TLR-7 expression and maternal HBV DNA (p = 0.034). Meanwhile, placental HBeAg and HBV DNA were not associated with placental TLR-7 expression (p = 0.082; p = 1.000). Conclusion: There was no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood, but we found a signific...

Indonesian Journal of Obstetrics and Gynecology, 2016

Objective: To investigate the role of A1298C polymorphism of fetal methylenetetrahydrofolate redu... more Objective: To investigate the role of A1298C polymorphism of fetal methylenetetrahydrofolate reductase (MTHFR) gene in spontaneous abortion. Method: The case control study design recruited 96 subjects in Siti Fatimah and Pertiwi mother and child hospital, Dr. Wahidin Sudirohusodo, Pelamonia, Bhayangkara, Syekh Yusuf, Haji and Labuang Baji hospital from March to September 2014. All subjects fulfilling the inclusion criteria were taken tissue samples from mothers experiencing spontaneous abortion and blood samples from normally born baby. The data were analyzed using Pearson chi-square with significant rate of 5% (p

Indonesian Journal of Obstetrics and Gynecology, 2017

Objective: To determine the effect of artesunate on peripheral parasitaemia in pregnant women wit... more Objective: To determine the effect of artesunate on peripheral parasitaemia in pregnant women with Plasmodium falciparum infection. Methods: Pregnant women in second and third trimester with Plasmodium falciparum infection and their newborns were included in cohort prospective study in Sorong West Papua from September 2015 to February 2016. All pregnant women received 200 mg orally artesunate monotherapy for 7 days. Their newborns examined for weight at delivery and parasitaemia in placenta and cord blood. Parasitaemia diagnosis by Rapid Diagnostic Test and blood smear microscopy. Results: After artesunatemonotherapy, 82.5% (33/40) malariainfected pregnant women had negative parasitaemia (p=0.000) although 17.5% (7/40) of the pregnant women had positive parasitaemia. Parasitaemia also found in 10% (4/40) of placenta and 7.5% (3/40) of umbilical cord from newborns of malaria-infected pregnant women treated with artesunate. 70% (28/40) of the newborns in this study had normal weight. ...

Indonesian Journal of Obstetrics and Gynecology, 2021

Objective: To compare the outcomes of mothers and newborns in emergency cesarean section and elec... more Objective: To compare the outcomes of mothers and newborns in emergency cesarean section and elective cesarean section. Methods: A prospective cohort study included 120 pregnant women consists of 60 women who performed an emergency cesarean section and 60 women who underwent elective cesarean section. Age, education level, occupation, income, history of comorbidities, history of abortion or miscarriage, antenatal care history, decision-making time until surgery is performed along with other components required, duration of operation, outcome of mother and fetal were obtained through interviews and questionnaires. Data were analyzed regarding fetal outcome and cesarean sections indications. Results: The maternal and fetal outcome between emergency and elective cesarean section were not signifi cantly different regarding on hospital stay, dehiscence, NICU admission, Apgar score and newborn status (dead or alive). Blood transfusion is the main difference signifi cant indication for mat...

Citation: Andi Cakra, Nasrudin AM, Eddy Tiro, et al. A Comparison of Vascular Endothelial Growth ... more Citation: Andi Cakra, Nasrudin AM, Eddy Tiro, et al. A Comparison of Vascular Endothelial Growth Factors (Vegf) Levels in Menstrual Blood Between Women with and Without Endometriosis. Gynecol Reprod Health. 2020; 4(6): 1-5. *Correspondence: Nasrudin Andi Mappaware, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Muslim Indonesia, Jend. Urip Sumoharjo Street Makassar, 90245, Tel: +62 8124257274.

Gynecology & Reproductive Health, 2020

Aimed: To evaluate menstrual blood endoglin levels between women with endometriosis and without e... more Aimed: To evaluate menstrual blood endoglin levels between women with endometriosis and without endometriosis. Methods: A cross-sectional study was performed on 52 eligible women. Endometriosis was confirmed with laparoscopy or laparotomy. Menstrual blood collected in the first or the third day of menstrual cycle using a menstrual cup. Endoglin levels from menstrual blood serum were measured with the ELISA method. Results: Menstrual blood endoglin levels in mild endometriosis were significantly higher compared with control (22.903 pg/ml vs 5.250 pg/ml; p<0.05) as well as the endoglin levels between severe endometriosis compared with mild endometriosis showed endoglin levels significantly higher in severe endometriosis (31.957 pg/ml vs. 22.903 pg/ml; p<0.05). Conclusion: Menstrual blood endoglin levels positively correlated with endometriosis stage.

Indonesian Journal of Obstetrics and Gynecology, 2018

Objective: To determine the role of matrix metalloproteinase-2(MMP-2) in serum and peritoneal flu... more Objective: To determine the role of matrix metalloproteinase-2(MMP-2) in serum and peritoneal fluid of endometrioticpatients.Methods: Research’s design using cross-sectional method in Dr.Wahidin Sudirohusodo hospital and several other hospitals inMakassar within May 2015 until May 2016. Subjects were chosenusing consecutive sampling technique. The examination usingthe ELISA method. The data were analysed using Fisher exact,t-independent, Mann-Whitney, and Spearman association.Results: A total of 50 subjects were recruited in this study. Mostlythe value of MMP-2 serum and peritoneal fluid in endometriosisgroup was higher compare to study control. There was significantdifferent between the total of MMP-2 serum and peritoneal fluid.There was also a significant association between the value ofMMP-2 serum and peritoneal fluid with endometriosis.Conclusion: The value of MMP-2 serum and peritoneal fluid werehigher in endometriotic patients compared to those withoutendometriosis. The higher...

Indonesian Journal of Obstetrics and Gynecology, 2018

Objective: to find out the correlation between lipid profille at trimester II of pregnancy and t... more Objective: to find out the correlation between lipid profille at trimester II of pregnancy and the incidence.of preeclampsia Method : The research was conducted in the Polyclinic of Hasanuddin University Teaching Hospital, Department of Obstetrics and Gynecology of the Faculty of Medicine, and it network in Makassar city from March, 2015 through March, 2016. The research used was the prospective cohort design. Results : The examination of the lipid levels of 115 pregnant mothers, aged 24-28 weeks. The mothers were then observed whether they experienced preeclampsia up to the time they gave birth or not. In the end, 8 subjects (6.9%) experienced preeclampsia and 107 subjects (93.1%) have no preeclampsia. The statistical analyses used Fisher’s Exact test and Mann Whitney test. The research results indicated that the mean value of the total cholesterol and Low Density Lipoprotein (LDL) was higher in the preeclampsia group compared to the non-preeclampsia group: 267.37 ± 64.12 : 23...

Indonesian Journal of Obstetrics and Gynecology, 2018

Objective : To determine the effect of vitamin B6 (pyridoxine) the levels of prostaglandins and i... more Objective : To determine the effect of vitamin B6 (pyridoxine) the levels of prostaglandins and intensity of pain in primary dysmenorrheal. Methods : The levels of prostaglandin (PGF2α) in plasma measured by ELISA and pain intensity by verbal rating scales conducted on 35 women with primary dysmenorrheal (n=35) supplemented with vitamin B6 100mg for 4 days and controls with placebo (n=35). Results : Prostaglandin levels decreased significantly after vitamin B6 supplementation (2212.9+1374.2 vs 1490.3+1119.0; p<0.05) followed by a significant reduction in pain intensity (4.29+0.7 vs 1.71+0.5; p<0.05) in the test group compared to control. Conclusion : Due to vitamin B6 effects on decreasing prostaglandin levels and pain of primary dysmenorrheal, so that B6 vitamin can become the treatment for the primary dysmenorrheal. Keywords : Primary dysmenorrheal, pyridoxine, prostaglandin Tujuan: Untuk mengetahui pengaruh pemberian vitamin B6 (piridoksin) terhadap kadar prostaglandin d...

Gynecology & Reproductive Health, 2019

Background: Maternal Mortality Rate (MMR) is one indicator to see the health status of women AKI ... more Background: Maternal Mortality Rate (MMR) is one indicator to see the health status of women AKI is also one of the targets set in the Millennium Development Goals (MDGs), namely improving maternal health where the target to be achieved until 2015 is reducing to ¾ the risk of maternal mortality. Objective: Finding out whether the psychosocial determinants and obstetric medico effect on decision making refers to complications in the obstetric field. Method: The type of research used was observational research with cross sectional study design. The population of the study were all maternity patients and referred to the 70-school network education hospital with the sample of 70 respondents.

Indonesian Journal of Obstetrics and Gynecology, 2019

Objective: To analyse the predictive value of HE4 in ovarian cancer patients according to their r... more Objective: To analyse the predictive value of HE4 in ovarian cancer patients according to their resistance and menopausal status Methods: Thirteen premenopausal and twenty-five menopausal ovarian cancer patients were measured for HE4 levels measured using automated chemiluminescent microparticle immunoassay ARCHITECT HE4. Patients categorized into resistant and non-resistant after six cycles of chemotherapy in addition to their clinical symptoms and ultrasound image of cancer. Results: The mean HE4 levels were higher in the resistant group compared with a non-resistant group (274.97 pmol/l vs 128.83 pmol/l; p=0.015). Five menopausal resistant women with HE4 levels >140 pmol/l compared with two women in the non-resistant group. In the pre-menopause group, eight resistant women with HE level >70 pmol/l whereas four women in the non-resistant group. HE levels in menopausal and premenopausal for both ovarian cancers resistant and non-resistant were not significantly different (p&g...

Indonesian Journal of Obstetrics and Gynecology, 2019

Objective: To determine the correlation between the perineal body length and the pelvic organ pro... more Objective: To determine the correlation between the perineal body length and the pelvic organ prolapse (POP) in menopausal women. Methods: The total vaginal length (TVL), genital hiatus (GH), and perineal body (PB) length as the POP-Q component were measured at 60 menopausal women enrolled in a cross-sectional study. Results: Menopausal women with POP have the shorter perineal body (63.3%; <3 cm) compared with menopausal women without POP (36.7%; ≥3 cm). The mean length of the perineal body in menopausal women who suffer POP 2.81 ± 0.26 cm while in women without POP is 3.23±0.17 cm. POP risk was 25 times in menopausal women with a perineal body length <3 cm compared with longer perineal body (p = 0.01; OR = 25.4; 95% CI 3.1-209.1).Conclusion: Perineal body length is a risk factor for pelvic organ prolapse in menopausal women.Keywords: perineal body, prolapse, pelvic organ prolapsed Abstrak Tujuan: Menentukan korelasi panjang perineal body dengan kejadian prolaps organ panggul ...