Chama Belkhiria - Academia.edu (original) (raw)

Papers by Chama Belkhiria

Age-related hearing loss (presbycusis) at moderate levels (>40 dB HL) has been recognized as a... more Age-related hearing loss (presbycusis) at moderate levels (>40 dB HL) has been recognized as an important risk factor for cognitive decline. However, whether individuals with mild hearing loss (audiogram thresholds between 25 and 40 dB HL) or even those with normal audiograms (<25 dB HL) have a higher risk of dementia, is still debated. Importantly, these early stages of presbycusis are the most common among the elderly, indicating the need to screen and identify individuals with early presbycusis that have an increased risk of cognitive decline. Unfortunately, in this group of patients, audiogram thresholds are not sufficiently sensitive to detect all the hearing impairments that are related to cognitive decline. Consequently, at the individual level, audiogram thresholds are not good estimators of the dementia risk in the group with mild hearing loss or normal hearing thresholds. Here, we propose to use distortion product otoacoustic emissions (DPOAE), as an objective and se...

Le Centre pour la Communication Scientifique Directe - HAL - Université Paris Descartes, Mar 1, 2014

Les travaux de cette thèse s’inscrivent à la frontière des neurosciences et de la physiologie mus... more Les travaux de cette thèse s’inscrivent à la frontière des neurosciences et de la physiologie musculaire. Trois études se sont articulées de la préparation et l’exécution motrice. La première étude (A) a relié l'activité cérébrale à l'activité musculaire lors de la préparation motrice. Les résultats ont montré que des régions, telles que le cortex moteur primaire et l’aire motrice supplémentaire sont impliquées dans l'activité du muscle fléchisseur (FDS) alors que d’autres régions, telles que les ganglions de la base, les aires fronto-pariétales et le cervelet, sont impliquées dans l'activité du muscle extenseur (EDC). L’étude (B) a exploré le rôle du réseau cérébro-cérébelleux et du réseau striatal lors de l’exécution d’une tâche cognitive et motivationnelle. Les données ont révélé que la partie antérieure du lobule VI droit était activée par l'exécution motrice tandis que sa partie postérieure était spécifiquement activée par les encouragements verbaux. Les mes...

Le Centre pour la Communication Scientifique Directe - HAL - memSIC, 2015

Frontiers in Aging Neuroscience, 2022

Presbycusis or age-related hearing loss is a prevalent condition in the elderly population, which... more Presbycusis or age-related hearing loss is a prevalent condition in the elderly population, which affects oral communication, especially in background noise, and has been associated with social isolation, depression, and cognitive decline. However, the mechanisms that relate hearing loss with cognition are complex and still elusive. Importantly, recent studies show that the use of hearing aids in presbycusis, which is its standard management, can induce neuroplasticity and modify performance in cognitive tests. As the majority of the previous studies on audition and cognition obtained their results from a mixed sample of subjects, including presbycusis individuals fitted and not fitted with hearing aids, here, we revisited the associations between hearing loss and cognition in a controlled sample of unaided presbycusis. We performed a cross-sectional study in 116 non-demented Chilean volunteers aged ≥65 years from the Auditory and Dementia study cohort. Specifically, we explored ass...

Sensors

Electro-oculography (EOG)-based brain–computer interface (BCI) is a relevant technology influenci... more Electro-oculography (EOG)-based brain–computer interface (BCI) is a relevant technology influencing physical medicine, daily life, gaming and even the aeronautics field. EOG-based BCI systems record activity related to users’ intention, perception and motor decisions. It converts the bio-physiological signals into commands for external hardware, and it executes the operation expected by the user through the output device. EOG signal is used for identifying and classifying eye movements through active or passive interaction. Both types of interaction have the potential for controlling the output device by performing the user’s communication with the environment. In the aeronautical field, investigations of EOG-BCI systems are being explored as a relevant tool to replace the manual command and as a communicative tool dedicated to accelerating the user’s intention. This paper reviews the last two decades of EOG-based BCI studies and provides a structured design space with a large set o...

Cognitive, Affective, & Behavioral Neuroscience, 2020

International Journal of Geriatric Psychiatry, 2021

Facial emotion recognition (FER) is impaired in people with dementia and with severe to profound ... more Facial emotion recognition (FER) is impaired in people with dementia and with severe to profound hearing loss, probably reflecting common neural changes. Here, we aim to study the association between brain structures and FER impairment in mild to moderate age‐related hearing loss participants.

Les travaux de cette these s’inscrivent a la frontiere des neurosciences et de la physiologie mus... more Les travaux de cette these s’inscrivent a la frontiere des neurosciences et de la physiologie musculaire. Trois etudes se sont articulees de la preparation et l’execution motrice. La premiere etude (A) a relie l'activite cerebrale a l'activite musculaire lors de la preparation motrice. Les resultats ont montre que des regions, telles que le cortex moteur primaire et l’aire motrice supplementaire sont impliquees dans l'activite du muscle flechisseur (FDS) alors que d’autres regions, telles que les ganglions de la base, les aires fronto-parietales et le cervelet, sont impliquees dans l'activite du muscle extenseur (EDC). L’etude (B) a explore le role du reseau cerebro-cerebelleux et du reseau striatal lors de l’execution d’une tâche cognitive et motivationnelle. Les donnees ont revele que la partie anterieure du lobule VI droit etait activee par l'execution motrice tandis que sa partie posterieure etait specifiquement activee par les encouragements verbaux. Les mes...

Procedia Computer Science

Frontiers in Neuroergonomics

Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological m... more Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological monitoring that have potentially fruitful applications in neuroscience, clinical exploration, the aeronautical industry, and other sectors. These methods are often the most straightforward way of evaluating brain oscillations and eye movements, as they use standard laboratory or mobile techniques. This review describes the potential of EEG and EOG systems and the application of these methods in aeronautics. For example, EEG and EOG signals can be used to design brain-computer interfaces (BCI) and to interpret brain activity, such as monitoring the mental state of a pilot in determining their workload. The main objectives of this review are to, (i) offer an in-depth review of literature on the basics of EEG and EOG and their application in aeronautics; (ii) to explore the methodology and trends of research in combined EEG-EOG studies over the last decade; and (iii) to provide methodologica...

Frontiers in Neuroergonomics

Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological m... more Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological monitoring that have potentially fruitful applications in neuroscience, clinical exploration, the aeronautical industry, and other sectors. These methods are often the most straightforward way of evaluating brain oscillations and eye movements, as they use standard laboratory or mobile techniques. This review describes the potential of EEG and EOG systems and the application of these methods in aeronautics. For example, EEG and EOG signals can be used to design brain-computer interfaces (BCI) and to interpret brain activity, such as monitoring the mental state of a pilot in determining their workload. The main objectives of this review are to, (i) offer an in-depth review of literature on the basics of EEG and EOG and their application in aeronautics; (ii) to explore the methodology and trends of research in combined EEG-EOG studies over the last decade; and (iii) to provide methodologica...

The Cerebellum, Jun 7, 2016

The cerebellum is involved not only in motor coordination, training, and memory, but also in cogn... more The cerebellum is involved not only in motor coordination, training, and memory, but also in cognition and emotion. Lobule VI in particular belongs to sensorimotor, salience, and executive cerebellar networks. This study aims to determine whether lobule VI would constitute an integrative interface between motor and cognitive/emotional circuits during a motor task with verbal encouragement, likely in conjunction with the basal ganglia (reward and motivational system). We used fMRI to identify specific recruitment of cerebellar and striatal systems during physical performance using two motor tasks with and without encouragement. We found that: (i) Force results were higher during verbal encouragement than during basal condition in all participants. (ii) The anterior part of the right lobule VI was activated by motor execution in both tasks, while its posterior part was specifically activated by verbal encouragement. (iii) The closed-connectivity loop maintained motivation induced by verbal encouragement between cerebral and cerebellar through the red nucleus and striatal network. Therefore, right lobule VI is a hubcontrolling sensorimotor and motivates aspects of motor performance in relation with the red nucleus and the ventral striatum. These results could have important implications for extrapyramidal and multisystem degenerative diseases.

Journal of Motor Behavior

Frontiers in Aging Neuroscience

Epidemiological evidence shows an association between hearing loss and dementia in elderly people... more Epidemiological evidence shows an association between hearing loss and dementia in elderly people. However, the mechanisms that connect hearing impairments and cognitive decline are still unknown. Here we propose that a suprathreshold auditory-nerve impairment is associated with cognitive decline and brain atrophy. Methods: audiological, neuropsychological, and brain structural 3-Tesla MRI data were obtained from elders with different levels of hearing loss recruited in the ANDES cohort. The amplitude of waves I (auditory nerve) and V (midbrain) from auditory brainstem responses were measured at 80 dB nHL. We also calculated the ratio between wave V and I as a proxy of a suprathreshold brainstem function. Results: we included a total of 101 subjects (age: 73.5 ± 5.2 years (mean ± SD), mean education: 9.5 ± 4.2 years, and mean audiogram thresholds (0.5-4 kHz): 25.5 ± 12.0 dB HL). We obtained reliable suprathreshold waves V in all subjects (n=101), while replicable waves I were obtain...

Frontiers in Aging Neuroscience

Age-related hearing loss (presbycusis) at moderate levels (>40 dB HL) has been recognized as a... more Age-related hearing loss (presbycusis) at moderate levels (>40 dB HL) has been recognized as an important risk factor for cognitive decline. However, whether individuals with mild hearing loss (audiogram thresholds between 25 and 40 dB HL) or even those with normal audiograms (<25 dB HL) have a higher risk of dementia, is still debated. Importantly, these early stages of presbycusis are the most common among the elderly, indicating the need to screen and identify individuals with early presbycusis that have an increased risk of cognitive decline. Unfortunately, in this group of patients, audiogram thresholds are not sufficiently sensitive to detect all the hearing impairments that are related to cognitive decline. Consequently, at the individual level, audiogram thresholds are not good estimators of the dementia risk in the group with mild hearing loss or normal hearing thresholds. Here, we propose to use distortion product otoacoustic emissions (DPOAE), as an objective and se...

Le Centre pour la Communication Scientifique Directe - HAL - Université Paris Descartes, Mar 1, 2014

Les travaux de cette thèse s’inscrivent à la frontière des neurosciences et de la physiologie mus... more Les travaux de cette thèse s’inscrivent à la frontière des neurosciences et de la physiologie musculaire. Trois études se sont articulées de la préparation et l’exécution motrice. La première étude (A) a relié l'activité cérébrale à l'activité musculaire lors de la préparation motrice. Les résultats ont montré que des régions, telles que le cortex moteur primaire et l’aire motrice supplémentaire sont impliquées dans l'activité du muscle fléchisseur (FDS) alors que d’autres régions, telles que les ganglions de la base, les aires fronto-pariétales et le cervelet, sont impliquées dans l'activité du muscle extenseur (EDC). L’étude (B) a exploré le rôle du réseau cérébro-cérébelleux et du réseau striatal lors de l’exécution d’une tâche cognitive et motivationnelle. Les données ont révélé que la partie antérieure du lobule VI droit était activée par l'exécution motrice tandis que sa partie postérieure était spécifiquement activée par les encouragements verbaux. Les mes...

Le Centre pour la Communication Scientifique Directe - HAL - memSIC, 2015

Frontiers in Aging Neuroscience, 2022

Presbycusis or age-related hearing loss is a prevalent condition in the elderly population, which... more Presbycusis or age-related hearing loss is a prevalent condition in the elderly population, which affects oral communication, especially in background noise, and has been associated with social isolation, depression, and cognitive decline. However, the mechanisms that relate hearing loss with cognition are complex and still elusive. Importantly, recent studies show that the use of hearing aids in presbycusis, which is its standard management, can induce neuroplasticity and modify performance in cognitive tests. As the majority of the previous studies on audition and cognition obtained their results from a mixed sample of subjects, including presbycusis individuals fitted and not fitted with hearing aids, here, we revisited the associations between hearing loss and cognition in a controlled sample of unaided presbycusis. We performed a cross-sectional study in 116 non-demented Chilean volunteers aged ≥65 years from the Auditory and Dementia study cohort. Specifically, we explored ass...

Sensors

Electro-oculography (EOG)-based brain–computer interface (BCI) is a relevant technology influenci... more Electro-oculography (EOG)-based brain–computer interface (BCI) is a relevant technology influencing physical medicine, daily life, gaming and even the aeronautics field. EOG-based BCI systems record activity related to users’ intention, perception and motor decisions. It converts the bio-physiological signals into commands for external hardware, and it executes the operation expected by the user through the output device. EOG signal is used for identifying and classifying eye movements through active or passive interaction. Both types of interaction have the potential for controlling the output device by performing the user’s communication with the environment. In the aeronautical field, investigations of EOG-BCI systems are being explored as a relevant tool to replace the manual command and as a communicative tool dedicated to accelerating the user’s intention. This paper reviews the last two decades of EOG-based BCI studies and provides a structured design space with a large set o...

Cognitive, Affective, & Behavioral Neuroscience, 2020

International Journal of Geriatric Psychiatry, 2021

Facial emotion recognition (FER) is impaired in people with dementia and with severe to profound ... more Facial emotion recognition (FER) is impaired in people with dementia and with severe to profound hearing loss, probably reflecting common neural changes. Here, we aim to study the association between brain structures and FER impairment in mild to moderate age‐related hearing loss participants.

Les travaux de cette these s’inscrivent a la frontiere des neurosciences et de la physiologie mus... more Les travaux de cette these s’inscrivent a la frontiere des neurosciences et de la physiologie musculaire. Trois etudes se sont articulees de la preparation et l’execution motrice. La premiere etude (A) a relie l'activite cerebrale a l'activite musculaire lors de la preparation motrice. Les resultats ont montre que des regions, telles que le cortex moteur primaire et l’aire motrice supplementaire sont impliquees dans l'activite du muscle flechisseur (FDS) alors que d’autres regions, telles que les ganglions de la base, les aires fronto-parietales et le cervelet, sont impliquees dans l'activite du muscle extenseur (EDC). L’etude (B) a explore le role du reseau cerebro-cerebelleux et du reseau striatal lors de l’execution d’une tâche cognitive et motivationnelle. Les donnees ont revele que la partie anterieure du lobule VI droit etait activee par l'execution motrice tandis que sa partie posterieure etait specifiquement activee par les encouragements verbaux. Les mes...

Procedia Computer Science

Frontiers in Neuroergonomics

Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological m... more Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological monitoring that have potentially fruitful applications in neuroscience, clinical exploration, the aeronautical industry, and other sectors. These methods are often the most straightforward way of evaluating brain oscillations and eye movements, as they use standard laboratory or mobile techniques. This review describes the potential of EEG and EOG systems and the application of these methods in aeronautics. For example, EEG and EOG signals can be used to design brain-computer interfaces (BCI) and to interpret brain activity, such as monitoring the mental state of a pilot in determining their workload. The main objectives of this review are to, (i) offer an in-depth review of literature on the basics of EEG and EOG and their application in aeronautics; (ii) to explore the methodology and trends of research in combined EEG-EOG studies over the last decade; and (iii) to provide methodologica...

Frontiers in Neuroergonomics

Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological m... more Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological monitoring that have potentially fruitful applications in neuroscience, clinical exploration, the aeronautical industry, and other sectors. These methods are often the most straightforward way of evaluating brain oscillations and eye movements, as they use standard laboratory or mobile techniques. This review describes the potential of EEG and EOG systems and the application of these methods in aeronautics. For example, EEG and EOG signals can be used to design brain-computer interfaces (BCI) and to interpret brain activity, such as monitoring the mental state of a pilot in determining their workload. The main objectives of this review are to, (i) offer an in-depth review of literature on the basics of EEG and EOG and their application in aeronautics; (ii) to explore the methodology and trends of research in combined EEG-EOG studies over the last decade; and (iii) to provide methodologica...

The Cerebellum, Jun 7, 2016

The cerebellum is involved not only in motor coordination, training, and memory, but also in cogn... more The cerebellum is involved not only in motor coordination, training, and memory, but also in cognition and emotion. Lobule VI in particular belongs to sensorimotor, salience, and executive cerebellar networks. This study aims to determine whether lobule VI would constitute an integrative interface between motor and cognitive/emotional circuits during a motor task with verbal encouragement, likely in conjunction with the basal ganglia (reward and motivational system). We used fMRI to identify specific recruitment of cerebellar and striatal systems during physical performance using two motor tasks with and without encouragement. We found that: (i) Force results were higher during verbal encouragement than during basal condition in all participants. (ii) The anterior part of the right lobule VI was activated by motor execution in both tasks, while its posterior part was specifically activated by verbal encouragement. (iii) The closed-connectivity loop maintained motivation induced by verbal encouragement between cerebral and cerebellar through the red nucleus and striatal network. Therefore, right lobule VI is a hubcontrolling sensorimotor and motivates aspects of motor performance in relation with the red nucleus and the ventral striatum. These results could have important implications for extrapyramidal and multisystem degenerative diseases.

Journal of Motor Behavior

Frontiers in Aging Neuroscience

Epidemiological evidence shows an association between hearing loss and dementia in elderly people... more Epidemiological evidence shows an association between hearing loss and dementia in elderly people. However, the mechanisms that connect hearing impairments and cognitive decline are still unknown. Here we propose that a suprathreshold auditory-nerve impairment is associated with cognitive decline and brain atrophy. Methods: audiological, neuropsychological, and brain structural 3-Tesla MRI data were obtained from elders with different levels of hearing loss recruited in the ANDES cohort. The amplitude of waves I (auditory nerve) and V (midbrain) from auditory brainstem responses were measured at 80 dB nHL. We also calculated the ratio between wave V and I as a proxy of a suprathreshold brainstem function. Results: we included a total of 101 subjects (age: 73.5 ± 5.2 years (mean ± SD), mean education: 9.5 ± 4.2 years, and mean audiogram thresholds (0.5-4 kHz): 25.5 ± 12.0 dB HL). We obtained reliable suprathreshold waves V in all subjects (n=101), while replicable waves I were obtain...

Frontiers in Aging Neuroscience