Chama Belkhiria - Profile on Academia.edu (original) (raw)
Papers by Chama Belkhiria
Supra-Threshold LS CE-Chirp Auditory Brainstem Response in the Elderly
Audiology & neuro-otology, Mar 4, 2024
Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss
Alzheimer's & dementia. Diagnosis, assessment & disease monitoring, 2024
HAL (Le Centre pour la Communication Scientifique Directe), Mar 1, 2014
The aim of this study was to compare the results ofmaximal voluntary contraction (MVC) and maxima... more The aim of this study was to compare the results ofmaximal voluntary contraction (MVC) and maximal rate of force development (MRFD) in women andmen during handgrip exercise performed following three different instructions:Oral instruction (OI):Started with audible tripping andaccompanied by encouragement during the whole muscle contraction. Triggered instruction (TI): Same as oral instruction, but without encouragement. Self-initiated instruction (SI): The subject himself decided to start and to stop the contraction.Women's MVC and MRFD withOI were higherthan SI. No significant differencehas been found between instructions in men. Our results suggested that women are more sensitive to the instructioneffect compared to men. Further explanations will be proposed using surface EMG and fMRI measurements.
Age-related hearing loss (presbycusis) at moderate levels (>40 dB HL) has been recognized as a... more Age-related hearing loss (presbycusis) at moderate levels (>40 dB HL) has been recognized as an important risk factor for cognitive decline. However, whether individuals with mild hearing loss (audiogram thresholds between 25 and 40 dB HL) or even those with normal audiograms (<25 dB HL) have a higher risk of dementia, is still debated. Importantly, these early stages of presbycusis are the most common among the elderly, indicating the need to screen and identify individuals with early presbycusis that have an increased risk of cognitive decline. Unfortunately, in this group of patients, audiogram thresholds are not sufficiently sensitive to detect all the hearing impairments that are related to cognitive decline. Consequently, at the individual level, audiogram thresholds are not good estimators of the dementia risk in the group with mild hearing loss or normal hearing thresholds. Here, we propose to use distortion product otoacoustic emissions (DPOAE), as an objective and se...
Does the instruction influence voluntary force production regardless of gender during a handgrip exercise ?
Le Centre pour la Communication Scientifique Directe - HAL - Université Paris Descartes, Mar 1, 2014
Exploration and analysis of brain-skeletal muscles relationship during motor preparation and execution
Les travaux de cette thèse s’inscrivent à la frontière des neurosciences et de la physiologie mus... more Les travaux de cette thèse s’inscrivent à la frontière des neurosciences et de la physiologie musculaire. Trois études se sont articulées de la préparation et l’exécution motrice. La première étude (A) a relié l'activité cérébrale à l'activité musculaire lors de la préparation motrice. Les résultats ont montré que des régions, telles que le cortex moteur primaire et l’aire motrice supplémentaire sont impliquées dans l'activité du muscle fléchisseur (FDS) alors que d’autres régions, telles que les ganglions de la base, les aires fronto-pariétales et le cervelet, sont impliquées dans l'activité du muscle extenseur (EDC). L’étude (B) a exploré le rôle du réseau cérébro-cérébelleux et du réseau striatal lors de l’exécution d’une tâche cognitive et motivationnelle. Les données ont révélé que la partie antérieure du lobule VI droit était activée par l'exécution motrice tandis que sa partie postérieure était spécifiquement activée par les encouragements verbaux. Les mes...
Le Centre pour la Communication Scientifique Directe - HAL - memSIC, 2015
Frontiers in Aging Neuroscience, 2022
Presbycusis or age-related hearing loss is a prevalent condition in the elderly population, which... more Presbycusis or age-related hearing loss is a prevalent condition in the elderly population, which affects oral communication, especially in background noise, and has been associated with social isolation, depression, and cognitive decline. However, the mechanisms that relate hearing loss with cognition are complex and still elusive. Importantly, recent studies show that the use of hearing aids in presbycusis, which is its standard management, can induce neuroplasticity and modify performance in cognitive tests. As the majority of the previous studies on audition and cognition obtained their results from a mixed sample of subjects, including presbycusis individuals fitted and not fitted with hearing aids, here, we revisited the associations between hearing loss and cognition in a controlled sample of unaided presbycusis. We performed a cross-sectional study in 116 non-demented Chilean volunteers aged ≥65 years from the Auditory and Dementia study cohort. Specifically, we explored ass...
Sensors
Electro-oculography (EOG)-based brain–computer interface (BCI) is a relevant technology influenci... more Electro-oculography (EOG)-based brain–computer interface (BCI) is a relevant technology influencing physical medicine, daily life, gaming and even the aeronautics field. EOG-based BCI systems record activity related to users’ intention, perception and motor decisions. It converts the bio-physiological signals into commands for external hardware, and it executes the operation expected by the user through the output device. EOG signal is used for identifying and classifying eye movements through active or passive interaction. Both types of interaction have the potential for controlling the output device by performing the user’s communication with the environment. In the aeronautical field, investigations of EOG-BCI systems are being explored as a relevant tool to replace the manual command and as a communicative tool dedicated to accelerating the user’s intention. This paper reviews the last two decades of EOG-based BCI studies and provides a structured design space with a large set o...
Turbulence impact on EEG and touchscreen vigilance
Cognitive, Affective, & Behavioral Neuroscience, 2020
In this study, we employed a visuo-motor imagery task of alertness as a mental training to examin... more In this study, we employed a visuo-motor imagery task of alertness as a mental training to examine temporal processing of motor responses within healthy young adults. Participants were divided into two groups (group 1; n = 20 who performed the mental training before the real physical task and a control group who performed the physical task without mental training). We vary the time interval between the imperative stimulus and the preceding one (fore-period) in which temporal preparation and arousal increase briefly. Our behavioural results provide clear evidence that mental training reinforces both temporal preparation and arousal, by shortening reaction time (RT), especially for the shortest fore-periods (FP) within exogenous "FP 250 ms" (p = 0.008) and endogenous alertness "FP 650 ms" (p = 0.001). We investigated how the brain controls such small temporal changes. We focus our neural hypothesis on three brain regions: anterior insula, dorsolateral prefrontal cortex, and anterior cingulate cortex and three putative circuits: one top-down (from dorsolateral prefrontal cortex to anterior cingulate cortex) and two bottom-up (from anterior insula to dorsolateral prefrontal cortex and anterior cingulate cortex). In fMRI, effective connectivity is strengthened during exogenous alertness between anterior insula and dorsolateral prefrontal cortex (p = 0.001), between anterior insula and cingulate cortex (p = 0.01), and during endogenous alertness between dorsolateral prefrontal cortex and anterior cingulate cortex (p = 0.05). We suggest that attentional reinforcement induced by an intensive and short session of mental training induces a temporal deployment of attention and allow optimizing the time pressure by maintaining a high state of arousal and ameliorating temporal preparation. Keywords Attention . Arousal . Mental training . Time pressure . Connectivity Accurate timing of future events is a fundamental ability that we routinely apply in various activities that our environment This work was partly supported by LINP2 (
Neural links between facial emotion recognition and cognitive impairment in presbycusis
International Journal of Geriatric Psychiatry, 2021
Facial emotion recognition (FER) is impaired in people with dementia and with severe to profound ... more Facial emotion recognition (FER) is impaired in people with dementia and with severe to profound hearing loss, probably reflecting common neural changes. Here, we aim to study the association between brain structures and FER impairment in mild to moderate age‐related hearing loss participants.
Exploration et analyse de la relation cerveau-muscles squelettiques lors de la préparation et de l’exécution motrice
Les travaux de cette these s’inscrivent a la frontiere des neurosciences et de la physiologie mus... more Les travaux de cette these s’inscrivent a la frontiere des neurosciences et de la physiologie musculaire. Trois etudes se sont articulees de la preparation et l’execution motrice. La premiere etude (A) a relie l'activite cerebrale a l'activite musculaire lors de la preparation motrice. Les resultats ont montre que des regions, telles que le cortex moteur primaire et l’aire motrice supplementaire sont impliquees dans l'activite du muscle flechisseur (FDS) alors que d’autres regions, telles que les ganglions de la base, les aires fronto-parietales et le cervelet, sont impliquees dans l'activite du muscle extenseur (EDC). L’etude (B) a explore le role du reseau cerebro-cerebelleux et du reseau striatal lors de l’execution d’une tâche cognitive et motivationnelle. Les donnees ont revele que la partie anterieure du lobule VI droit etait activee par l'execution motrice tandis que sa partie posterieure etait specifiquement activee par les encouragements verbaux. Les mes...
EOG metrics for cognitive workload detection
Procedia Computer Science
Electro-Encephalography and Electro-Oculography in Aeronautics: A Review Over the Last Decade (2010–2020)
Frontiers in Neuroergonomics
Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological m... more Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological monitoring that have potentially fruitful applications in neuroscience, clinical exploration, the aeronautical industry, and other sectors. These methods are often the most straightforward way of evaluating brain oscillations and eye movements, as they use standard laboratory or mobile techniques. This review describes the potential of EEG and EOG systems and the application of these methods in aeronautics. For example, EEG and EOG signals can be used to design brain-computer interfaces (BCI) and to interpret brain activity, such as monitoring the mental state of a pilot in determining their workload. The main objectives of this review are to, (i) offer an in-depth review of literature on the basics of EEG and EOG and their application in aeronautics; (ii) to explore the methodology and trends of research in combined EEG-EOG studies over the last decade; and (iii) to provide methodologica...
Electro-Encephalography and Electro-Oculography in Aeronautics: A Review Over the Last Decade (2010–2020)
Frontiers in Neuroergonomics
Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological m... more Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological monitoring that have potentially fruitful applications in neuroscience, clinical exploration, the aeronautical industry, and other sectors. These methods are often the most straightforward way of evaluating brain oscillations and eye movements, as they use standard laboratory or mobile techniques. This review describes the potential of EEG and EOG systems and the application of these methods in aeronautics. For example, EEG and EOG signals can be used to design brain-computer interfaces (BCI) and to interpret brain activity, such as monitoring the mental state of a pilot in determining their workload. The main objectives of this review are to, (i) offer an in-depth review of literature on the basics of EEG and EOG and their application in aeronautics; (ii) to explore the methodology and trends of research in combined EEG-EOG studies over the last decade; and (iii) to provide methodologica...
The Cerebellum, Jun 7, 2016
The cerebellum is involved not only in motor coordination, training, and memory, but also in cogn... more The cerebellum is involved not only in motor coordination, training, and memory, but also in cognition and emotion. Lobule VI in particular belongs to sensorimotor, salience, and executive cerebellar networks. This study aims to determine whether lobule VI would constitute an integrative interface between motor and cognitive/emotional circuits during a motor task with verbal encouragement, likely in conjunction with the basal ganglia (reward and motivational system). We used fMRI to identify specific recruitment of cerebellar and striatal systems during physical performance using two motor tasks with and without encouragement. We found that: (i) Force results were higher during verbal encouragement than during basal condition in all participants. (ii) The anterior part of the right lobule VI was activated by motor execution in both tasks, while its posterior part was specifically activated by verbal encouragement. (iii) The closed-connectivity loop maintained motivation induced by verbal encouragement between cerebral and cerebellar through the red nucleus and striatal network. Therefore, right lobule VI is a hubcontrolling sensorimotor and motivates aspects of motor performance in relation with the red nucleus and the ventral striatum. These results could have important implications for extrapyramidal and multisystem degenerative diseases.
Reduced suprathreshold auditory nerve responses are associated with slower processing speed and thinner temporal and parietal cortex in presbycusis
PLOS ONE
Effects of Mental Effort on Premotor Muscle Activity and Maximal Grip Force
Journal of Motor Behavior
Insula and Amygdala Atrophy Are Associated With Functional Impairment in Subjects With Presbycusis
Frontiers in Aging Neuroscience
Supra-Threshold LS CE-Chirp Auditory Brainstem Response in the Elderly
Audiology & neuro-otology, Mar 4, 2024
Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss
Alzheimer's & dementia. Diagnosis, assessment & disease monitoring, 2024
HAL (Le Centre pour la Communication Scientifique Directe), Mar 1, 2014
The aim of this study was to compare the results ofmaximal voluntary contraction (MVC) and maxima... more The aim of this study was to compare the results ofmaximal voluntary contraction (MVC) and maximal rate of force development (MRFD) in women andmen during handgrip exercise performed following three different instructions:Oral instruction (OI):Started with audible tripping andaccompanied by encouragement during the whole muscle contraction. Triggered instruction (TI): Same as oral instruction, but without encouragement. Self-initiated instruction (SI): The subject himself decided to start and to stop the contraction.Women's MVC and MRFD withOI were higherthan SI. No significant differencehas been found between instructions in men. Our results suggested that women are more sensitive to the instructioneffect compared to men. Further explanations will be proposed using surface EMG and fMRI measurements.
Age-related hearing loss (presbycusis) at moderate levels (>40 dB HL) has been recognized as a... more Age-related hearing loss (presbycusis) at moderate levels (>40 dB HL) has been recognized as an important risk factor for cognitive decline. However, whether individuals with mild hearing loss (audiogram thresholds between 25 and 40 dB HL) or even those with normal audiograms (<25 dB HL) have a higher risk of dementia, is still debated. Importantly, these early stages of presbycusis are the most common among the elderly, indicating the need to screen and identify individuals with early presbycusis that have an increased risk of cognitive decline. Unfortunately, in this group of patients, audiogram thresholds are not sufficiently sensitive to detect all the hearing impairments that are related to cognitive decline. Consequently, at the individual level, audiogram thresholds are not good estimators of the dementia risk in the group with mild hearing loss or normal hearing thresholds. Here, we propose to use distortion product otoacoustic emissions (DPOAE), as an objective and se...
Does the instruction influence voluntary force production regardless of gender during a handgrip exercise ?
Le Centre pour la Communication Scientifique Directe - HAL - Université Paris Descartes, Mar 1, 2014
Exploration and analysis of brain-skeletal muscles relationship during motor preparation and execution
Les travaux de cette thèse s’inscrivent à la frontière des neurosciences et de la physiologie mus... more Les travaux de cette thèse s’inscrivent à la frontière des neurosciences et de la physiologie musculaire. Trois études se sont articulées de la préparation et l’exécution motrice. La première étude (A) a relié l'activité cérébrale à l'activité musculaire lors de la préparation motrice. Les résultats ont montré que des régions, telles que le cortex moteur primaire et l’aire motrice supplémentaire sont impliquées dans l'activité du muscle fléchisseur (FDS) alors que d’autres régions, telles que les ganglions de la base, les aires fronto-pariétales et le cervelet, sont impliquées dans l'activité du muscle extenseur (EDC). L’étude (B) a exploré le rôle du réseau cérébro-cérébelleux et du réseau striatal lors de l’exécution d’une tâche cognitive et motivationnelle. Les données ont révélé que la partie antérieure du lobule VI droit était activée par l'exécution motrice tandis que sa partie postérieure était spécifiquement activée par les encouragements verbaux. Les mes...
Le Centre pour la Communication Scientifique Directe - HAL - memSIC, 2015
Frontiers in Aging Neuroscience, 2022
Presbycusis or age-related hearing loss is a prevalent condition in the elderly population, which... more Presbycusis or age-related hearing loss is a prevalent condition in the elderly population, which affects oral communication, especially in background noise, and has been associated with social isolation, depression, and cognitive decline. However, the mechanisms that relate hearing loss with cognition are complex and still elusive. Importantly, recent studies show that the use of hearing aids in presbycusis, which is its standard management, can induce neuroplasticity and modify performance in cognitive tests. As the majority of the previous studies on audition and cognition obtained their results from a mixed sample of subjects, including presbycusis individuals fitted and not fitted with hearing aids, here, we revisited the associations between hearing loss and cognition in a controlled sample of unaided presbycusis. We performed a cross-sectional study in 116 non-demented Chilean volunteers aged ≥65 years from the Auditory and Dementia study cohort. Specifically, we explored ass...
Sensors
Electro-oculography (EOG)-based brain–computer interface (BCI) is a relevant technology influenci... more Electro-oculography (EOG)-based brain–computer interface (BCI) is a relevant technology influencing physical medicine, daily life, gaming and even the aeronautics field. EOG-based BCI systems record activity related to users’ intention, perception and motor decisions. It converts the bio-physiological signals into commands for external hardware, and it executes the operation expected by the user through the output device. EOG signal is used for identifying and classifying eye movements through active or passive interaction. Both types of interaction have the potential for controlling the output device by performing the user’s communication with the environment. In the aeronautical field, investigations of EOG-BCI systems are being explored as a relevant tool to replace the manual command and as a communicative tool dedicated to accelerating the user’s intention. This paper reviews the last two decades of EOG-based BCI studies and provides a structured design space with a large set o...
Turbulence impact on EEG and touchscreen vigilance
Cognitive, Affective, & Behavioral Neuroscience, 2020
In this study, we employed a visuo-motor imagery task of alertness as a mental training to examin... more In this study, we employed a visuo-motor imagery task of alertness as a mental training to examine temporal processing of motor responses within healthy young adults. Participants were divided into two groups (group 1; n = 20 who performed the mental training before the real physical task and a control group who performed the physical task without mental training). We vary the time interval between the imperative stimulus and the preceding one (fore-period) in which temporal preparation and arousal increase briefly. Our behavioural results provide clear evidence that mental training reinforces both temporal preparation and arousal, by shortening reaction time (RT), especially for the shortest fore-periods (FP) within exogenous "FP 250 ms" (p = 0.008) and endogenous alertness "FP 650 ms" (p = 0.001). We investigated how the brain controls such small temporal changes. We focus our neural hypothesis on three brain regions: anterior insula, dorsolateral prefrontal cortex, and anterior cingulate cortex and three putative circuits: one top-down (from dorsolateral prefrontal cortex to anterior cingulate cortex) and two bottom-up (from anterior insula to dorsolateral prefrontal cortex and anterior cingulate cortex). In fMRI, effective connectivity is strengthened during exogenous alertness between anterior insula and dorsolateral prefrontal cortex (p = 0.001), between anterior insula and cingulate cortex (p = 0.01), and during endogenous alertness between dorsolateral prefrontal cortex and anterior cingulate cortex (p = 0.05). We suggest that attentional reinforcement induced by an intensive and short session of mental training induces a temporal deployment of attention and allow optimizing the time pressure by maintaining a high state of arousal and ameliorating temporal preparation. Keywords Attention . Arousal . Mental training . Time pressure . Connectivity Accurate timing of future events is a fundamental ability that we routinely apply in various activities that our environment This work was partly supported by LINP2 (
Neural links between facial emotion recognition and cognitive impairment in presbycusis
International Journal of Geriatric Psychiatry, 2021
Facial emotion recognition (FER) is impaired in people with dementia and with severe to profound ... more Facial emotion recognition (FER) is impaired in people with dementia and with severe to profound hearing loss, probably reflecting common neural changes. Here, we aim to study the association between brain structures and FER impairment in mild to moderate age‐related hearing loss participants.
Exploration et analyse de la relation cerveau-muscles squelettiques lors de la préparation et de l’exécution motrice
Les travaux de cette these s’inscrivent a la frontiere des neurosciences et de la physiologie mus... more Les travaux de cette these s’inscrivent a la frontiere des neurosciences et de la physiologie musculaire. Trois etudes se sont articulees de la preparation et l’execution motrice. La premiere etude (A) a relie l'activite cerebrale a l'activite musculaire lors de la preparation motrice. Les resultats ont montre que des regions, telles que le cortex moteur primaire et l’aire motrice supplementaire sont impliquees dans l'activite du muscle flechisseur (FDS) alors que d’autres regions, telles que les ganglions de la base, les aires fronto-parietales et le cervelet, sont impliquees dans l'activite du muscle extenseur (EDC). L’etude (B) a explore le role du reseau cerebro-cerebelleux et du reseau striatal lors de l’execution d’une tâche cognitive et motivationnelle. Les donnees ont revele que la partie anterieure du lobule VI droit etait activee par l'execution motrice tandis que sa partie posterieure etait specifiquement activee par les encouragements verbaux. Les mes...
EOG metrics for cognitive workload detection
Procedia Computer Science
Electro-Encephalography and Electro-Oculography in Aeronautics: A Review Over the Last Decade (2010–2020)
Frontiers in Neuroergonomics
Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological m... more Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological monitoring that have potentially fruitful applications in neuroscience, clinical exploration, the aeronautical industry, and other sectors. These methods are often the most straightforward way of evaluating brain oscillations and eye movements, as they use standard laboratory or mobile techniques. This review describes the potential of EEG and EOG systems and the application of these methods in aeronautics. For example, EEG and EOG signals can be used to design brain-computer interfaces (BCI) and to interpret brain activity, such as monitoring the mental state of a pilot in determining their workload. The main objectives of this review are to, (i) offer an in-depth review of literature on the basics of EEG and EOG and their application in aeronautics; (ii) to explore the methodology and trends of research in combined EEG-EOG studies over the last decade; and (iii) to provide methodologica...
Electro-Encephalography and Electro-Oculography in Aeronautics: A Review Over the Last Decade (2010–2020)
Frontiers in Neuroergonomics
Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological m... more Electro-encephalography (EEG) and electro-oculography (EOG) are methods of electrophysiological monitoring that have potentially fruitful applications in neuroscience, clinical exploration, the aeronautical industry, and other sectors. These methods are often the most straightforward way of evaluating brain oscillations and eye movements, as they use standard laboratory or mobile techniques. This review describes the potential of EEG and EOG systems and the application of these methods in aeronautics. For example, EEG and EOG signals can be used to design brain-computer interfaces (BCI) and to interpret brain activity, such as monitoring the mental state of a pilot in determining their workload. The main objectives of this review are to, (i) offer an in-depth review of literature on the basics of EEG and EOG and their application in aeronautics; (ii) to explore the methodology and trends of research in combined EEG-EOG studies over the last decade; and (iii) to provide methodologica...
The Cerebellum, Jun 7, 2016
The cerebellum is involved not only in motor coordination, training, and memory, but also in cogn... more The cerebellum is involved not only in motor coordination, training, and memory, but also in cognition and emotion. Lobule VI in particular belongs to sensorimotor, salience, and executive cerebellar networks. This study aims to determine whether lobule VI would constitute an integrative interface between motor and cognitive/emotional circuits during a motor task with verbal encouragement, likely in conjunction with the basal ganglia (reward and motivational system). We used fMRI to identify specific recruitment of cerebellar and striatal systems during physical performance using two motor tasks with and without encouragement. We found that: (i) Force results were higher during verbal encouragement than during basal condition in all participants. (ii) The anterior part of the right lobule VI was activated by motor execution in both tasks, while its posterior part was specifically activated by verbal encouragement. (iii) The closed-connectivity loop maintained motivation induced by verbal encouragement between cerebral and cerebellar through the red nucleus and striatal network. Therefore, right lobule VI is a hubcontrolling sensorimotor and motivates aspects of motor performance in relation with the red nucleus and the ventral striatum. These results could have important implications for extrapyramidal and multisystem degenerative diseases.
Reduced suprathreshold auditory nerve responses are associated with slower processing speed and thinner temporal and parietal cortex in presbycusis
PLOS ONE
Effects of Mental Effort on Premotor Muscle Activity and Maximal Grip Force
Journal of Motor Behavior
Insula and Amygdala Atrophy Are Associated With Functional Impairment in Subjects With Presbycusis
Frontiers in Aging Neuroscience